Rap1 GTPases: An emerging role in the cardiovasculature

Life Sciences - Tập 88 - Trang 645-652 - 2011
Selvi C. Jeyaraj1, Nicholas T. Unger1, Maqsood A. Chotani1,2
1Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205–2664, United States
2Department of Pediatrics, The Ohio State University, Columbus, OH 43210, United States

Tài liệu tham khảo

Arora, 2008, Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A, Mol Biol Cell, 19, 5032, 10.1091/mbc.E08-04-0430 Bivona, 2004, Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion, J Cell Biol, 164, 461, 10.1083/jcb.200311093 Block, 2001, Raynaud's phenomenon, Lancet, 357, 2042, 10.1016/S0140-6736(00)05118-7 Bos, 2005, Linking Rap to cell adhesion, Curr Opin Cell Biol, 17, 123, 10.1016/j.ceb.2005.02.009 Bos, 2001, Rap1 signalling: adhering to new models, Nat Rev Mol Cell Biol, 2, 369, 10.1038/35073073 Bourne, 1990, The GTPase superfamily: a conserved switch for diverse cell functions, Nature, 348, 125, 10.1038/348125a0 Carmona, 2008, Activation of Epac stimulates integrin-dependent homing of progenitor cells, Blood, 111, 2640, 10.1182/blood-2007-04-086231 Carmona, 2009, Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis, Blood, 113, 488, 10.1182/blood-2008-02-138438 Chotani, 2005, Distinct cAMP signaling pathways differentially regulate α2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells, Am J Physiol Heart Circ Physiol, 288, H69, 10.1152/ajpheart.01223.2003 Chrzanowska-Wodnicka, 2005, Rap1b is required for normal platelet function and hemostasis in mice, J Clin Invest, 115, 680, 10.1172/JCI22973 Chrzanowska-Wodnicka, 2008, Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice, Blood, 111, 2647, 10.1182/blood-2007-08-109710 Chu, 2008, Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity, J Immunol, 181, 3373, 10.4049/jimmunol.181.5.3373 Cullere, 2005, Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase, Blood, 105, 1950, 10.1182/blood-2004-05-1987 de Rooij, 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature, 396, 474, 10.1038/24884 de Rooij, 2000, Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs, J Biol Chem, 275, 20829, 10.1074/jbc.M001113200 Dodge-Kafka, 2005, The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways, Nature, 437, 574, 10.1038/nature03966 Doebele, 2009, A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis, Blood, 114, 4592, 10.1182/blood-2009-04-217042 Duchniewicz, 2006, Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion, Mol Cell Biol, 26, 643, 10.1128/MCB.26.2.643-653.2006 Ehses, 2003, Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase, Endocrinology, 144, 4433, 10.1210/en.2002-0068 Eid, 2007, Estrogen increases smooth muscle expression of α2C-adrenoceptors and cold-induced constriction of cutaneous arteries, Am J Physiol Heart Circ Physiol, 293, H1955, 10.1152/ajpheart.00306.2007 Eid, 2008, Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors, Am J Physiol Heart Circ Physiol, 295, H266, 10.1152/ajpheart.00084.2008 Flavahan, 2000, Increased α2-adrenergicr constriction of isolated arterioles in diffuse scleroderma, Arthritis Rheum, 43, 1886, 10.1002/1529-0131(200008)43:8<1886::AID-ANR27>3.0.CO;2-S Flavahan, 2003, The vasculopathy of Raynaud's phenomenon and scleroderma, Rheum Dis Clin North Am, 29, 275, 10.1016/S0889-857X(03)00021-8 Guo, 2001, A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2, J Biol Chem, 276, 25568, 10.1074/jbc.M101277200 Hariharan, 1991, The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination, Cell, 67, 717, 10.1016/0092-8674(91)90066-8 Hassona, 2010, Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries, Am J Physiol Heart Circ Physiol, 298, H2112, 10.1152/ajpheart.00016.2010 Hattori, 2003, Rap1 GTPase: functions, regulation, and malignancy, J Biochem, 134, 479, 10.1093/jb/mvg180 He, 2010, PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes, Am J Physiol Heart Circ Physiol, 298, H136, 10.1152/ajpheart.00251.2009 Karliner, 1988, β-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth, Basic Res Cardiol, 83, 655, 10.1007/BF01906960 Kawasaki, 1998, A family of cAMP-binding proteins that directly activate Rap1, Science, 282, 2275, 10.1126/science.282.5397.2275 Kitayama, 1989, A ras-related gene with transformation suppressor activity, Cell, 56, 77, 10.1016/0092-8674(89)90985-9 Kooistra, 2005, Epac1 regulates integrity of endothelial cell junctions through VE-cadherin, FEBS Lett, 579, 4966, 10.1016/j.febslet.2005.07.080 Krajnak, 2006, Acute vibration increases α2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries, J Appl Physiol, 100, 1230, 10.1152/japplphysiol.00761.2005 Kwak, 2008, PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways, Cell Signal, 20, 803, 10.1016/j.cellsig.2007.12.011 Lacabaratz-Porret, 1998, Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology, Biochem J, 332, 173, 10.1042/bj3320173 Li, 2007, Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins, J Immunol, 179, 8322, 10.4049/jimmunol.179.12.8322 Magnier, 1995, Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach, Biochem J, 310, 469, 10.1042/bj3100469 Maridonneau-Parini, 1992, Association of Rap1 and Rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation, J Biol Chem, 267, 6396, 10.1016/S0021-9258(18)42708-1 McConnachie, 2006, AKAP signaling complexes: getting to the heart of the matter, Trends Mol Med, 12, 317, 10.1016/j.molmed.2006.05.008 McLeod, 2004, The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes, J Biol Chem, 279, 12009, 10.1074/jbc.M313098200 Moustafa-Bayoumi, 2007, Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1, J Biol Chem, 282, 37632, 10.1074/jbc.M703227200 Oestreich, 2007, Epac-mediated activation of phospholipase Cε plays a critical role in β-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes, J Biol Chem, 282, 5488, 10.1074/jbc.M608495200 Oestreich, 2009, Epac and phospholipase Cε regulate Ca2+ release in the heart by activation of protein kinase Cε and calcium–calmodulin kinase II, J Biol Chem, 284, 1514, 10.1074/jbc.M806994200 Ohba, 2001, Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis, EMBO J, 20, 3333, 10.1093/emboj/20.13.3333 Paganini, 2006, Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins, Biochimie, 88, 285, 10.1016/j.biochi.2005.08.007 Panchatcharam, 2010, Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by β3 integrin signaling, Int J Biochem Cell Biol, 42, 965, 10.1016/j.biocel.2010.02.009 Raaijmakers, 2009, Specificity in Ras and Rap signaling, J Biol Chem, 284, 10995, 10.1074/jbc.R800061200 Rangarajan, 2003, Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor, J Cell Biol, 160, 487, 10.1083/jcb.200209105 Sakurai, 2006, MAGI-1 is required for Rap1 activation upon cell–cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion, Mol Biol Cell, 17, 966, 10.1091/mbc.E05-07-0647 Schmidt, 2001, A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase, Nat Cell Biol, 3, 1020, 10.1038/ncb1101-1020 Sehrawat, 2008, Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function, Mol Biol Cell, 19, 1261, 10.1091/mbc.E06-10-0972 Somekawa, 2005, Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes, Circ Res, 97, 655, 10.1161/01.RES.0000183880.49270.f9 Tsai, 2007, A Wnt-CKIε-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein, Dev Cell, 12, 335, 10.1016/j.devcel.2007.02.009 Yan, 2008, Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions, Mol Cell Biol, 28, 5803, 10.1128/MCB.00393-08 York, 2000, Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1, Mol Cell Biol, 20, 8069, 10.1128/MCB.20.21.8069-8083.2000 Zemojtel, 2010, Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity, BMC Evol Biol, 10, 55, 10.1186/1471-2148-10-55