Reducing the weight of cancer: mechanistic targets for breaking the obesity–carcinogenesis link

Macaulay, 1992, Insulin-like growth factors and cancer, British Journal of Cancer, 65, 311, 10.1038/bjc.1992.65 LeRoith, 1995, Insulin-like growth factors and cancer, Annals of Internal Medicine, 122, 54, 10.7326/0003-4819-122-1-199501010-00009 Singh, 1996, Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II, Endocrinology, 137, 1764, 10.1210/en.137.5.1764 Fenton, 2005, Leptin, insulin-like growth factor-1, and insulin-like growth factor-2 are mitogens in ApcMin/+ but not Apc+/+ colonic epithelial cell lines, Cancer Epidemiological Biomarkers & Prevention, 14, 1646, 10.1158/1055-9965.EPI-04-0916 Buckbinder, 1995, Induction of the growth inhibitor IGF-binding protein 3 by p53, Nature, 377, 646, 10.1038/377646a0 Takahashi, 1993, Association of insulin-like growth-factor-I-induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF-7 cells, International Journal of Cancer, 55, 453, 10.1002/ijc.2910550322 Le Roith, 2001, The somatomedin hypothesis: 2001, Endocrine Reviews, 22, 53, 10.1210/er.22.1.53 Hursting, 1993, The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats, Cancer Research, 53, 2750 Resnicoff, 1995, The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo, Cancer Research, 55, 2463 Dunn, 1998, A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer, Cancer Research, 58, 3353 Hursting, 2003, Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans, Annual Review of Medicine, 54, 131, 10.1146/annurev.med.54.101601.152156 Gems, 2001, Insulin/IGF signalling and ageing: seeing the bigger picture, Current Opinion in Genetics & Development, 11, 287, 10.1016/S0959-437X(00)00192-1 Atkinson, 2004, Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women, Cancer Epidemiological Biomarkers & Prevention, 13, 868, 10.1158/1055-9965.868.13.5 Schmitz, 2002, Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women, Cancer Epidemiological Biomarkers & Prevention, 11, 1597 Colbert, 2003, Exercise and intestinal polyp development in APCMin mice, Medicine and Science in Sports and Exercise, 35, 1662, 10.1249/01.MSS.0000089349.54813.41 Calle, 2004, Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms, Nature Reviews, 4, 579, 10.1038/nrc1408 Yakar, 2005, The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models, Cytokine & Growth Factor Reviews, 16, 407, 10.1016/j.cytogfr.2005.01.010 Abate, 1996, Insulin resistance and obesity. The role of fat distribution pattern, Diabetes Care, 19, 292, 10.2337/diacare.19.3.292 Grimm, 1999, Interaction of physical activity and diet: implications for insulin-glucose dynamics, Public Health Nutrition, 2, 363, 10.1017/S136898009900049X Carling, 2004, The AMP-activated protein kinase cascade – a unifying system for energy control, Trends in Biochemical Sciences, 29, 18, 10.1016/j.tibs.2003.11.005 Hardie, 1998, The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?, Annual Review of Biochemistry, 67, 821, 10.1146/annurev.biochem.67.1.821 Johnson, 1996, Active and inactive protein kinases: structural basis for regulation, Cell, 85, 149, 10.1016/S0092-8674(00)81092-2 Hawley, 2003, Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, Journal of Biology, 2, 28, 10.1186/1475-4924-2-28 Woods, 2003, LKB1 is the upstream kinase in the AMP-activated protein kinase cascade, Current Biology, 13, 2004, 10.1016/j.cub.2003.10.031 Brazil, 2004, Advances in protein kinase B signalling: AKTion on multiple fronts, Trends in Biological Science, 29, 233, 10.1016/j.tibs.2004.03.006 Guertin, 2005, An expanding role for mTOR in cancer, Trends in Molecular Medicine, 11, 353, 10.1016/j.molmed.2005.06.007 Shaw, 2004, The LKB1 tumor suppressor negatively regulates mTOR signaling, Cancer Cell, 6, 91, 10.1016/j.ccr.2004.06.007 Corradetti, 2004, Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome, Genes & Development, 18, 1533, 10.1101/gad.1199104 Shaw, 2004, The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress, Proceedings of the National Academy of Sciences of the United States of America, 101, 3329, 10.1073/pnas.0308061100 Inoki, 2005, Dysregulation of the TSC-mTOR pathway in human disease, Nature Genetics, 37, 19, 10.1038/ng1494 Tee, 2005, mTOR, translational control and human disease, Seminars in Cell & Developmental Biology, 16, 29, 10.1016/j.semcdb.2004.11.005 Eng, 2003, PTEN: one gene, many syndromes, Human Mutation, 22, 183, 10.1002/humu.10257 Woods, 1998, Signals that regulate food intake and energy homeostasis, Science, 280, 1378, 10.1126/science.280.5368.1378 Zhang, 1998, Molecular physiology of leptin and its receptor, New England Journal of Medicine, 14, 17 Jiang, 2008, Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver, Cancer Research, 68, 5492, 10.1158/0008-5472.CAN-07-6721 Moore T, Carbijal S, Strom S, et al, Dietary energy balance modulates signaling through the Akt/mTOR pathway in multiple tissues. Cancer Prevention Research 2008; 1: 65--78. Moore, 2008, Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating IGF-1 levels, Cancer Research, 68, 3680, 10.1158/0008-5472.CAN-07-6271 Lonnqvist, 1997, Relationship between circulating leptin and peripheral fat distribution in obese subjects, International Journal of Obesity, 21, 255, 10.1038/sj.ijo.0800394 Montague, 1997, Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution, Diabetes, 46, 342, 10.2337/diabetes.46.3.342 Wilding, 1997, Neurobiology, British Medical Bulletin, 53, 286, 10.1093/oxfordjournals.bmb.a011614 Stattin, 2004, Obesity and colon cancer: does leptin provide a link?, International Journal of Cancer, 109, 149, 10.1002/ijc.11668 Chang, 2001, Leptin and prostate cancer, The Prostate, 46, 62, 10.1002/1097-0045(200101)46:1<62::AID-PROS1009>3.0.CO;2-V Saglam, 2003, Leptin influences cellular differentiation and progression in prostate cancer, The Journal of Urology, 169, 1308, 10.1097/01.ju.0000055903.18400.25 Bouloumie, 1998, Leptin, the product of Ob gene, promotes angiogenesis, Circulation Research, 83, 1059, 10.1161/01.RES.83.10.1059 Ostlund, 1996, Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates, The Journal of Clinical Endocrinology and Metabolism, 81, 3909, 10.1210/jc.81.11.3909 Rajala, 2003, Minireview: the adipocyte – at the crossroads of energy homeostasis, inflammation, and atherosclerosis, Endocrinology, 144, 3765, 10.1210/en.2003-0580 Gonzalez, 2006, Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2), The Journal of Biological Chemistry, 281, 26320, 10.1074/jbc.M601991200 Loffreda, 1998, Leptin regulates proinflammatory immune responses, The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 12, 57, 10.1096/fasebj.12.1.57 Bråkenhielm, 2004, Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis, Proceedings of the National Academy of Sciences of the United States of America, 101, 2476, 10.1073/pnas.0308671100 Diker, 2006, Impact of gastric banding on plasma adiponectin levels, Obesity Surgery, 9, 1057, 10.1381/096089206778026244 Ryan, 2003, Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women, International Journal of Obesity, 27, 1066, 10.1038/sj.ijo.0802387 Amitabha, 2007, Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status, International Journal of Oncology, 6, 1499 Grossmann, 2008, Effects of adiponectin on breast cancer cell growth and signaling, British Journal of Cancer, 98, 370, 10.1038/sj.bjc.6604166 Kaaks, 2002, Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review, Cancer Epidemiology, Biomarkers & Prevention, 11, 1531 Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322 Sohal, 1996, Oxidative stress, caloric restriction, and aging, Science, 273, 59, 10.1126/science.273.5271.59 Tilg, 1997, IL-6 and APPs: anti-inflammatory and immunosuppressive mediators, Immunology Today, 18, 428, 10.1016/S0167-5699(97)01103-1 Dinarello, 2000, The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1, The New England Journal of Medicine, 343, 732, 10.1056/NEJM200009073431011 Moore, 1993, Interleukin-10, Annual Review of Immunology, 11, 165, 10.1146/annurev.iy.11.040193.001121 Pretolani, 1999, Interleukin-10: an anti-inflammatory cytokine with therapeutic potential, Clinical and Experimental Allergy, 29, 1164, 10.1046/j.1365-2222.1999.00456.x Dobbs, 1999, Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism, Acta Neurologica Scandinavica, 100, 34, 10.1111/j.1600-0404.1999.tb00721.x Coppack, 2001, Pro-inflammatory cytokines and adipose tissue, The Proceedings of the Nutrition Society, 60, 349, 10.1079/PNS2001110 Dandona, 2004, Inflammation: the link between insulin resistance, obesity and diabetes, Trends in Immunology, 25, 4, 10.1016/j.it.2003.10.013 Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, The Journal of Clinical Investigation, 112, 1796, 10.1172/JCI200319246 Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, The Journal of Clinical Investigation, 112, 1821, 10.1172/JCI200319451 Ballou, 1996, Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons, Age and Ageing, 25, 224, 10.1093/ageing/25.3.224 Paolisso, 1998, Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha, The American Journal of Physiology, 275, E294 Bruunsgaard, 1999, Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans, Life Sciences, 65, 2623, 10.1016/S0024-3205(99)00531-7 Bruunsgaard, 2000, Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis, Clinical and Experimental Immunology, 121, 255, 10.1046/j.1365-2249.2000.01281.x Bruunsgaard, 2004, The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans, Experimental Gerontology, 39, 255, 10.1016/j.exger.2003.10.012 Vgontzas, 2000, Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia, The Journal of Clinical Endocrinology and Metabolism, 85, 1151, 10.1210/jc.85.3.1151 Feingold, 1992, Role of cytokines in inducing hyperlipidemia, Diabetes, 41, 97, 10.2337/diab.41.2.S97 Winkler, 1998, Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in Type 2 diabetics and patients with android type obesity, Diabetes Research and Clinical Practice, 42, 169, 10.1016/S0168-8227(98)00109-0 Mishima, 2001, Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus, Diabetes Research and Clinical Practice, 52, 119, 10.1016/S0168-8227(00)00247-3 Harris, 1997, Carrying the burden of cardiovascular risk in old age: associations of weight and weight change with prevalent cardiovascular disease, risk factors, and health status in the Cardiovascular Health Study, The American Journal of Clinical Nutrition, 66, 837, 10.1093/ajcn/66.4.837 Volpato, 2001, Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study, Circulation, 103, 947, 10.1161/01.CIR.103.7.947 Erlinger, 2004, C-reactive protein and the risk of incident colorectal cancer, JAMA : The Journal of the American Medical Association, 291, 585, 10.1001/jama.291.5.585 Lehrer, 2005, C-reactive protein is significantly associated with prostate-specific antigen and metastatic disease in prostate cancer, British Journal of Urology International, 95, 961, 10.1111/j.1464-410X.2005.05447.x King, 2003, Inflammatory markers and exercise: differences related to exercise type, Medicine and Science in Sports and Exercise, 35, 575, 10.1249/01.MSS.0000058440.28108.CC Wannamethee, 2002, Physical activity and hemostatic and inflammatory variables in elderly men, Circulation, 105, 1785, 10.1161/hc1502.107117 Abramson, 2002, Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults, Archives of Internal Medicine, 162, 1286, 10.1001/archinte.162.11.1286 Geffken, 2001, Association between physical activity and markers of inflammation in a healthy elderly population, American Journal of Epidemiology, 153, 242, 10.1093/aje/153.3.242 Smith, 1999, Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease, JAMA : The Journal of the American Medical Association, 281, 1722, 10.1001/jama.281.18.1722 Mattusch, 2000, Reduction of the plasma concentration of C-reactive protein following nine months of endurance training, International Journal of Sports Medicine, 21, 21, 10.1055/s-2000-8852 Taaffe, 2000, Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging, The Journals of Gerontology, 55, M709, 10.1093/gerona/55.12.M709 Fallon, 2001, The acute phase response and exercise: court and field sports, British Journal of Sports Medicine, 35, 170, 10.1136/bjsm.35.3.170 Wendel, 2004, Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy, Nature, 428, 332, 10.1038/nature02369 deGraffenried, 2003, Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity, Annals of Oncology, 14, 1051, 10.1093/annonc/mdg291