Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans

Albright, 1995, Transcriptional control of IL-2 and IL-4 in T cells of young and old mice, Cell Immunol., 164, 170, 10.1006/cimm.1995.1158

Bernstein, 1998, Cytokine production after influenza vaccination in a healthy elderly population, Vaccine, 16, 1722, 10.1016/S0264-410X(98)00140-6

Bruunsgaard, 1999, A high plasma concentration of TNF-alpha is associated with dementia in centenarians, J. Gerontol. A: Biol. Sci. Med. Sci., 54, M357, 10.1093/gerona/54.7.M357

Bruunsgaard, 2003, Elevated levels of tumor necrosis factor alpha and mortality in centenarians, Am. J. Med., 11, 278, 10.1016/S0002-9343(03)00329-2

Candore, 1993, γ-interferon, interleukin-4 and interleukin-6 in vitro production in old subjects, Autoimmunity, 16, 275, 10.3109/08916939309014646

Caruso, 2000, HLA, ageing, and longevity: a critical reappraisal, Hum. Immunol., 61, 942, 10.1016/S0198-8859(00)00168-3

Collins, 1998, T-lymphocytes functionality assessed by analysis of cytokine receptor expression, intracellular cytokine expression and fentomolar detection of cytokine secretion by quantitative flow cytometry, Cytometry, 33, 249, 10.1002/(SICI)1097-0320(19981001)33:2<249::AID-CYTO21>3.0.CO;2-T

Cossarizza, 1996, CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory, Mech. Ageing Dev., 86, 173, 10.1016/0047-6374(95)01691-0

Crossley, 1996, Infections in the elderly, Clin. Infect. Dis., 22, 209, 10.1093/clinids/22.2.209

Di Iorio, 2003, Serum IL-1beta levels in health and disease: a population-based study. The InCHIANTI study, Cytokine, 22, 198, 10.1016/S1043-4666(03)00152-2

Effros, 2000, Costimulatory mechanisms in the elderly, Vaccine, 18, 1661, 10.1016/S0264-410X(99)00503-4

Fagiolo, 1993, Increased cytokine production in mononuclear cells of healthy elderly people, Eur. J. Immunol., 23, 2375, 10.1002/eji.1830230950

Fagnoni, 1996, Expansion of cytotoxic CD8+CD28− T cells in healthy aged people and centenarians, Immunology, 88, 501, 10.1046/j.1365-2567.1996.d01-689.x

Fagnoni, 2000, Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging, Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868

Ferrucci, 1999, Serum IL-6 level and the development of disability in older persons, J. Am. Geriatr. Soc., 47, 578, 10.1111/j.1532-5415.1999.tb01583.x

Franceschi, 1995, Immunosenescence in humans: deterioration or remodelling, Intern. Rev. Immunol., 12, 57, 10.3109/08830189509056702

Franceschi, 2000, The network and the remodeling theories of aging, Exp. Gerontol., 35, 879, 10.1016/S0531-5565(00)00172-8

Franceschi, 2000, Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE), Aging Clin. Exp. Res., 12, 77, 10.1007/BF03339894

Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N.Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x

Franceschi, 2005, Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians, Mech. Ageing Dev., 126, 351, 10.1016/j.mad.2004.08.028

Gardner, 2002, Age-related changes in Type 1 and Type 2 cytokine production in humans, Biogerontology, 3, 271, 10.1023/A:1020151401826

Gerli, 2000, Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians, Mech. Ageing Dev., 20, 37

Hamann, 1997, Phenotypic and functional separation of memory and effector human CD8+ T cells, J. Exp. Med., 186, 1407, 10.1084/jem.186.9.1407

Han, 1995, Age-related enhancement of tumor necrosis factor (TNF) production in mice, Mech. Ageing Dev., 84, 39, 10.1016/0047-6374(95)01634-C

Hobbs, 1993, Patterns of cytokine gene expression by CD4+ T cells from young and old mice, J. Immunol., 150, 3602, 10.4049/jimmunol.150.8.3602

Hobbs, 1994, Interleukin-10 production by splenic CD4+ cells and cell subsets from young and old mice, Cell Immunol., 154, 264, 10.1006/cimm.1994.1076

Jung, 1993, Detection of intracellular cytokines by flow cytometry, J. Immunol. Meth., 26, 197, 10.1016/0022-1759(93)90158-4

Krabbe, 2004, Inflammatory mediators in the elderly, Exp. Gerontol., 39, 687, 10.1016/j.exger.2004.01.009

Luciani, 2001, A stochastic model for CD8+ T cell dynamics in human immunosenescence: implications for survival and longevity, J. Theor. Biol., 213, 587, 10.1006/jtbi.2001.2433

Mosmann, 1996, The expanding universe of T-cell subsets: Th1, Th2 and more, Immunol. Today, 17, 138, 10.1016/0167-5699(96)80606-2

Murasko, 2001, Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly, Exp. Gerontol., 37, 427, 10.1016/S0531-5565(01)00210-8

Ouyang, 2000, Reduced IFN-γ production in elderly people following in vitro stimulation with influenza vaccine and endotoxin, Mech. Ageing. Dev., 121, 131, 10.1016/S0047-6374(00)00204-9

Prussin, 1995, Detection of intracytoplasmatic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies, J. Immunol. Meth., 188, 117, 10.1016/0022-1759(95)00209-X

Prussin, 1997, Cytokine flow cytometry understanding cytokine biology at the single cell level, J. Clin. Immunol., 17, 195, 10.1023/A:1027350226435

Rink, 1998, Altered cytokine production in the elderly, Mech. Ageing Dev., 15, 199, 10.1016/S0047-6374(97)00153-X

Romagnani, 1997, The Th1/Th2 paradigm, Immunol. Today, 18, 263, 10.1016/S0167-5699(97)80019-9

Romagnani, 1998, Th1 and Th2 cells, Res. Immunol., 149, 871, 10.1016/S0923-2494(99)80016-9

Rostaing, 1999, Kinetics of intracitoplasmatic Th1 and Th2 cytokine production assessed by flow cytometry following in vitro activation of peripheral blood mononuclear cells, Cytometry, 35, 318, 10.1002/(SICI)1097-0320(19990401)35:4<318::AID-CYTO4>3.0.CO;2-4

Sadeghi, 1999, Phenotypic and functional characteristics of circulating monocytes of elderly persons, Exp. Gerontol., 34, 959, 10.1016/S0531-5565(99)00065-0

Sandmand, 2002, Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?, Clin. Exp. Immunol., 127, 267, 10.1046/j.1365-2249.2002.01736.x

Shearer, 1997, Th1/Th2 changes in aging, Mech. Ageing Dev., 94, 1

Solana, 2000, NK and NK/T cells in human senescence, Vaccine, 18, 1613, 10.1016/S0264-410X(99)00495-8

Testa, R., Olivieri, F., Bonfigli, A.R., Sirolla, C., Boemi, M., Marchegiani, F., Marra, M., Cenerelli, S., Antonicelli, R., Dolci, A., Paolisso, G., Franceschi, C., 2005. Interleukin-6-174 G>C polymorphism affects the association between IL-6 plasma levels and insulin resistance in Type 2 diabetic patients. Diabetes Res. Clin. Pract. [Epub ahead of print].

van Leeuwen, 2004, Emergence of a CD4+CD28− granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection, J. Immunol., 173, 1834, 10.4049/jimmunol.173.3.1834

Vescovini, 2004, Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells, Exp. Gerontol., 39, 1233, 10.1016/j.exger.2004.04.004

Wack, 1998, Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets, Intern. Immunol., 10, 1281, 10.1093/intimm/10.9.1281

Yoshikawa, 1997, Perspective: aging and infectious diseases: past, present, and future, J. Infect. Dis., 176, 1053, 10.1086/516547

Zanni, 2003, Marked increase with age of Type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence, Exp. Gerontol., 38, 981, 10.1016/S0531-5565(03)00160-8