Free radicals and antioxidants in normal physiological functions and human disease

Abe, 1999, Fyn and JAK2 mediate Ras activation by reactive oxygen species, J. Biol. Chem., 274, 21003, 10.1074/jbc.274.30.21003 Acker, 1995, Mechanisms of O-2 sensing in the carotid-body in comparison with other O-2 sensing cells, News Physiol. Sci., 10, 211 Adams, 2003, Ways of dying: Multiple pathways to apoptosis, Genes Dev., 17, 2481, 10.1101/gad.1126903 Aikens, 1991, Perhydroxyl radical (HOO) Initiated lipid-peroxidation—The role of fatty-acid hydroperoxides, J. Biol. Chem., 266, 15091, 10.1016/S0021-9258(18)98591-1 Albelda, 1994, Adhesion molecules and inflammatory injury, FASEB J., 8, 504, 10.1096/fasebj.8.8.8181668 Albina, 1998, Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis, Cancer Metast. Rev., 17, 39, 10.1023/A:1005904704618 Amiri, 2005, Role of nuclear factor-kappa B in melanoma, Cancer Metast. Rev., 24, 301, 10.1007/s10555-005-1579-7 Andersen, 2004, Oxidative stress in neurodegeneration: Cause or consequence?, Nat. Rev. Neurosci., 5, S18, 10.1038/nrn1434 Archer, 1993, Measurement of nitric-oxide in biological models, FASEB J., 7, 349, 10.1096/fasebj.7.2.8440411 Arrigo, 1999, Gene expression and the thiol redox state, Free Radic. Biol. Med., 27, 936, 10.1016/S0891-5849(99)00175-6 Aslund, 1999, Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thioldisulfide status, Proc. Natl. Acad. Sci. U.S.A., 96, 6161, 10.1073/pnas.96.11.6161 Babior, 1999, NADPH oxidase: An update, Blood, 93, 1464, 10.1182/blood.V93.5.1464 Baker, 1997, Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo, Cancer Res., 57, 5162 Barnett, 1995, Investigation of antioxidant status. DNA-repair capacity and mutation as a function of age in humans, Mut. Res., 338, 115, 10.1016/0921-8734(95)00017-Z Baud, 2001, Signal transduction by tumor necrosis factor and its relatives, Trends Cell. Biol., 11, 372, 10.1016/S0962-8924(01)02064-5 Bauerova, 1999, Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis, Gen. Physiol. Biophys., 18, 15 Becker, 2004, New concepts in reactive oxygen species and cardiovascular reperfusion physiology, Cardiovasc. Res., 61, 461, 10.1016/j.cardiores.2003.10.025 Behrend, 2003, Reactive oxygen species in oncogenic transformation, Biochem. Soc. Trans., 31, 1441, 10.1042/bst0311441 Bergendi, 1999, Chemistry, physiology and pathology of free radicals, Life Sci., 65, 1865, 10.1016/S0024-3205(99)00439-7 Berry, 2004, Xanthine oxidoreductase in the cardiovascular system: Molecular mechanisms and pathophysiologic implications, J. Physiol., 555, 589, 10.1113/jphysiol.2003.055913 Borges, 2002, Progress towards the discovery of xanthine oxidase inhibitors, Curr. Med. Chem., 9, 195, 10.2174/0929867023371229 Brash, 1999, Lipoxygenases: Occurrence, functions, catalysis, and acquisition of substrate, J. Biol. Chem., 274, 23679, 10.1074/jbc.274.34.23679 Bredt, 1991, Cloned and expressed nitric oxide synthase structurally resembles cytochrome 450 Reductase, Nature, 351, 714, 10.1038/351714a0 Brown, 2001, Nitric oxide, mitochondria, and cell death, IUBMB Life, 52, 189, 10.1080/15216540152845993 Brownlee, 1981, The biochemistry of the complications of diabetes-mellitus, Ann. Rev. Biochem., 50, 385, 10.1146/annurev.bi.50.070181.002125 Brune, 1997, Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis, J. Biol. Chem., 272, 7253, 10.1074/jbc.272.11.7253 Buchanan, 2002, Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women, Diabetes, 51, 2796, 10.2337/diabetes.51.9.2796 Burton, 1984, Beta-carotene—An unusual type of lipid antioxidant, Science, 224, 569, 10.1126/science.6710156 Bush, 2003, The metallobiology of Alzheimer's disease, Trends Neurosci., 26, 207, 10.1016/S0166-2236(03)00067-5 Butler, 2000, Thermodynamic considerations of free radical reactions, 437 Butler, 2000, Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension, Hypertension, 35, 746, 10.1161/01.HYP.35.3.746 Butterfield, 2002, Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death, Neurobiol. Aging, 23, 655, 10.1016/S0197-4580(01)00340-2 Cadenas, 1997, Basic mechanisms of antioxidant activity, Biofactors, 6, 391, 10.1002/biof.5520060404 Cadenas, 2000, Mitochondrial free radical generation, oxidative stress, and aging, Free Radic. Biol. Med., 29, 222, 10.1016/S0891-5849(00)00317-8 Cadenas, 1998, The lag phase, Free. Radic. Res., 28, 601, 10.3109/10715769809065816 Cai, 1998, Communication – superoxide in apoptosis – mitochondrial generation triggered by Cytochrome c loss, J. Biol. Chem., 273, 11401, 10.1074/jbc.273.19.11401 Cameron, 1976, Supplemental ascorbate in supportive treatment of cancer – prolongation of survival times in terminal human cancer. Part 1, Proc. Natl. Acad. Sci. U.S.A., 73, 3685, 10.1073/pnas.73.10.3685 Carmeliet, 2000, Angiogenesis in cancer and other diseases, Nature, 407, 249, 10.1038/35025220 Carr, 1999, Does Vitamin C act as a pro-oxidant under physiological conditions?, FASEB J., 13, 1007, 10.1096/fasebj.13.9.1007 Carr, 2000, Oxidation of LDL by myeloperoxidase and reactive nitrogen species-reaction pathways and antioxidant protection, Arterioscl. Thromb. Vasc. Biol., 20, 1716, 10.1161/01.ATV.20.7.1716 Catani, 2001, Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage, Biochem. J., 356, 77, 10.1042/0264-6021:3560077 Ceriello, 2004, Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited, Arteriosc. Thromb. Vasc. Biol., 24, 816, 10.1161/01.ATV.0000122852.22604.78 Chapple, 1997, Reactive oxygen species and antioxidants in inflammatory diseases, J. Clin. Periodontol., 24, 287, 10.1111/j.1600-051X.1997.tb00760.x Chen, 1998, Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice, J. Mol. Cell. Cardiol., 30, 2281, 10.1006/jmcc.1998.0789 Chiueh, 1999, Neuroprotective properties of nitric oxide, Ann. N.Y. Acad. Sci., 890, 301, 10.1111/j.1749-6632.1999.tb08007.x Clancy, 1992, Nitric-oxide, an endothelial-cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase, J. Clin. Invest., 90, 1116, 10.1172/JCI115929 Commoner, 1954, Free radicals in biological materials, Nature, 174, 689, 10.1038/174689a0 Cote, 1996, Regulation of intracellular xanthine oxidase by endothelial-derived nitric oxide, Am. J. Physiol. Lung Cell. Mol. Physiol., 15, L869, 10.1152/ajplung.1996.271.5.L869 Cuajungco, 2003, Zinc takes the center stage: Its paradoxical role in Alzheimer's disease, Brain Res. Rev., 41, 44, 10.1016/S0165-0173(02)00219-9 Cuajungco, 2000, Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of A beta by zinc, J. Biol. Chem., 275, 19439, 10.1074/jbc.C000165200 Cuajungco, 1998, Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus, Brain Res., 799, 97, 10.1016/S0006-8993(98)00482-X Cunnane, 2001, Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis, Arth. Rheumat., 44, 2263, 10.1002/1529-0131(200110)44:10<2263::AID-ART389>3.0.CO;2-1 Dalle-Donne, 2003, Protein carbonylation in human diseases, Trends Mol. Med., 9, 169, 10.1016/S1471-4914(03)00031-5 Dalle-Donne, 2006, Biomarkers of oxidative damage in human disease, Clin. Chem., 52, 601, 10.1373/clinchem.2005.061408 Dalle-Donne, 2005, Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics, Mass Spectrom. Rev., 24, 55, 10.1002/mas.20006 Damy, 2004, Increased neuronal nitric oxide synthase-derived NO production in the failing human heart, Lancet, 363, 1365, 10.1016/S0140-6736(04)16048-0 Danial, 2004, Cell death: Critical control points, Cell, 116, 205, 10.1016/S0092-8674(04)00046-7 Das, 1999, Reactive oxygen species function as second messenger during ischemic preconditioning of heart, Mol. Cell. Biochem., 196, 59, 10.1023/A:1006966128795 De Grey, 2002, HO2: The forgotten radical, DNA Cell Biol., 21, 251, 10.1089/104454902753759672 DeCoursey, 2005, Regulation and termination of NADPH oxidase activity, Cell. Mol. Life Sci., 62, 2173, 10.1007/s00018-005-5177-1 Dempsey, 2000, Protein kinase C isozymes and the regulation of diverse cell responses, Am. J. Physiol.-Lung Cell. Mol. Physiol., 279, L429, 10.1152/ajplung.2000.279.3.L429 Dhalla, 2000, Role of oxidative stress in cardiovascular diseases, J. Hypertens., 18, 655, 10.1097/00004872-200018060-00002 Dikalov, 2004, Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical, Free Radic. Biol. Med., 36, 340, 10.1016/j.freeradbiomed.2003.11.004 Dodge-Kafka, 2005, The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways, Nature, 437, 574, 10.1038/nature03966 Dreher, 1996, Role of oxygen free radicals in cancer development, Eur. J. Cancer., 32A, 30, 10.1016/0959-8049(95)00531-5 Drevs, 2003, Receptor tyrosine kinases: The main targets for new anticancer therapy, Curr. Drug Targ., 4, 113, 10.2174/1389450033346885 Dröge, 2002, Free radicals in the physiological control of cell function, Physiol. Rev., 82, 47, 10.1152/physrev.00018.2001 El-Agamey, 2004, Carotenoid radical chemistry and antioxidant/pro-oxidant properties, Arch. Biochem. Biophys., 430, 37, 10.1016/j.abb.2004.03.007 Evans, 2003, Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?, Diabetes, 52, 1, 10.2337/diabetes.52.1.1 Evens, 2004, Motexafin gadolinium: A redox-active tumor selective agent for the treatment of cancer, Curr. Opin. Oncol., 16, 576, 10.1097/01.cco.0000142073.29850.98 Fedtke, 1990, Vinyl chloride-induced DNA adducts. 2. Formation and persistence of 7-2′-oxoethylguanine and n2,3-ethenoguanine in rat-tissue DNA, Carcinogenesis, 11, 1287, 10.1093/carcin/11.8.1287 Fink, 1997, Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde, Proc. Natl. Acad. Sci. U.S.A., 94, 8652, 10.1073/pnas.94.16.8652 Firestein, 1997, Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium, Proc. Natl. Acad. Sci. U.S.A., 94, 10895, 10.1073/pnas.94.20.10895 Folkman, 1995, Angiogenesis in cancer, vascular, rheumatoid and other disease, Nat. Med., 1, 27, 10.1038/nm0195-27 Fossel, 2003 Foster, 2004, New insights into protein S-nitrosylation—Mitochondria as a model system, J. Biol. Chem., 279, 25891, 10.1074/jbc.M313853200 Frenette, 1996, Adhesion molecules. Part I, N. Engl. J. Med., 334, 1526, 10.1056/NEJM199606063342308 Galis, 2002, Matrix metalloproteinases in vascular remodeling and atherogenesis—The good, the bad, and the ugly, Circ. Res., 90, 251, 10.1161/res.90.3.251 Galter, 1994, Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1, Eur. J. Biochem., 221, 639, 10.1111/j.1432-1033.1994.tb18776.x Gerich, 2003, Clinical significance, pathogenesis, and management of postprandial hyperglycemia, Arch. Int. Med., 163, 1306, 10.1001/archinte.163.11.1306 Gerschman, 1954, Oxygen poisoning and x-irradiation—A mechanism in common, Science, 119, 623, 10.1126/science.119.3097.623 Ghafourifar, 2005, Mitochondrial nitric oxide synthase, Trends Pharmacol. Sci., 26, 190, 10.1016/j.tips.2005.02.005 Gopalakrishna, 2000, Protein kinase C signaling and oxidative stress, Free Radic. Biol. Med., 28, 1349, 10.1016/S0891-5849(00)00221-5 Granger, 2001, Splanchnic ischaemia-reperfusion injury: Mechanistic insights provided by mutant mice, Acta Physiol. Scand., 173, 83, 10.1046/j.1365-201X.2001.00888.x Grankvist, 1981, CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione-peroxidase in pancreatic-islets and other tissues in the mouse, Biochem. J., 199, 393, 10.1042/bj1990393 Griendling, 2000, Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology, Arterioscler. Thromb. Vasc. Biol., 20, 2175, 10.1161/01.ATV.20.10.2175 Hale, 1996, Apoptosis: Molecular regulation of cell death, Eur. J. Biochem., 236, 1, 10.1111/j.1432-1033.1996.00001.x Halliwell, 1999 Hamuro, 1999, The triggering and healing of tumor stromal inflammatory reactions regulated by oxidative and reductive macrophages, Gann. Monograph Cancer Res., 48, 153 Han, 2005, Sites and mechanisms of aconitase inactivation by peroxynitrite: Modulation by citrate and glutathione, Biochemistry, 44, 11986, 10.1021/bi0509393 Hardy, 1992, Alzheimer's disease: The amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067 Hare, 2005, NO/redox disequilibrium in the failing heart and cardiovascular system, J. Clin. Invest., 115, 509, 10.1172/JCI200524459 Harman, 1956, Aging—A theory based on free-radical and radiation-chemistry, J. Gerontol., 11, 298, 10.1093/geronj/11.3.298 Hayashi, 1998, Effects of gamma-glutamylcysteine ethyl ester on heart mitochondrial creatine kinase activity: Involvement of sulfhydryl groups, Eur. J. Pharmacol., 349, 133, 10.1016/S0014-2999(98)00266-0 Hayat, 2004, Diabetic cardiomyopathy: Mechanisms, diagnosis and treatment, Clin. Sci., 107, 539, 10.1042/CS20040057 Hayflick, 1998, How and why we age, Exp. Gerontol., 33, 639, 10.1016/S0531-5565(98)00023-0 Hehner, 2000, Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool, J. Immunol., 165, 4319, 10.4049/jimmunol.165.8.4319 Hengartner, 2000, The biochemistry of apoptosis, Nature, 407, 770, 10.1038/35037710 Hilenski, 2004, Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells, Arterioscler. Thromb. Vasc. Biol., 24, 677, 10.1161/01.ATV.0000112024.13727.2c Hink, 2001, Mechanisms underlying endothelial dysfunction in diabetes mellitus, Circ. Res., 88, E14, 10.1161/01.RES.88.2.e14 Hirota, 1999, Distinct roles of thioredoxin in the cytoplasm and in the nucleus—A two-step mechanism of redox regulation of transcription factor NF-kappa B, J. Biol. Chem., 274, 27891, 10.1074/jbc.274.39.27891 Hofseth, 2004, p53: 25 years after its discovery, Trends Pharmacol. Sci., 25, 177, 10.1016/j.tips.2004.02.009 Hollstein, 1991, p53 mutations in human cancer, Science, 253, 49, 10.1126/science.1905840 Huang, 1999, CuII potentiation of Alzheimer A beta neurotoxicity—Correlation with cell-free hydrogen peroxide production and metal reduction, J. Biol. Chem., 274, 37111, 10.1074/jbc.274.52.37111 Ignarro, 1985, The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation, Ann. Pharmacol. Toxicol., 25, 171, 10.1146/annurev.pa.25.040185.001131 Ignarro, 2002, Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP, Nitric Oxide-Biol. Chem., 7, 83, 10.1016/S1089-8603(02)00113-1 Iles, 2002, Macrophage signaling and respiratory burst, Immunol. Res., 26, 95, 10.1385/IR:26:1-3:095 Jenner, 2003, Oxidative stress in Parkinson's disease, Ann. Neurol., 53, S26, 10.1002/ana.10483 Jin, 2006, Alpha-Synuclein aggregation and Parkinson's disease: Factors affecting the aggregation of alpha-synuclein, Prog. Biochem. Biophys., 33, 321 Jones, 2000, Redox state of glutathione in human plasma, Free Radic. Biol. Med., 28, 625, 10.1016/S0891-5849(99)00275-0 Jones, 2003, Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion, Am. J. Physiol. Heart Circ. Physiol., 284, H277, 10.1152/ajpheart.00236.2002 Jones, 1996, Expression of phagocyte NADPH oxidase components in human endothelial cells, Am. J. Physiol. Heart Circ. Physiol., 271, H1626, 10.1152/ajpheart.1996.271.4.H1626 Juranek, 2005, Controversy of free radical hypothesis: Reactive oxygen species—Cause or consequence of tissue injury?, Gen. Physiol. Biophys., 24, 263 Kakhlon, 2002, The labile iron pool: Characterization, measurement, and participation in cellular processes, Free Radic. Biol. Med., 33, 1037, 10.1016/S0891-5849(02)01006-7 Kalikiri, 2004, Ischemic and anesthetic preconditioning of the heart: An insight into the concepts and mechanisms, Internet J. Anesthesiol., 8 Kaneko, 1989, Mechanism for depression of heart sarcolemmal Ca2+ pump by oxygen free-radicals, Am. J. Physiol., 257, H804 Kaneto, 1999, Oxidative stress induces p21 expression in pancreatic islet cells: Possible implication in beta-cell dysfunction, Diabetologia, 42, 1093, 10.1007/s001250051276 Kasparova, 2005, Study of the oxidative stress in a rat model of chronic brain hypoperfusion, Neurochem. Int., 46, 601, 10.1016/j.neuint.2005.02.006 Kaur, 2003, Genetic or harmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease, Neuron, 37, 899, 10.1016/S0896-6273(03)00126-0 Keisari, 1983, The oxidative burst and related phenomena in mouse macrophages elicited by different sterile inflammatory stimuli, Immunobiology, 165, 78, 10.1016/S0171-2985(83)80048-5 Kern, 2005, Free radicals and apoptosis: Relationships with glutathione, thioredoxin and the Bcl family of proteins, Front. Biosci., 10, 1727, 10.2741/1656 Keyse, 1989, Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite, Proc. Natl. Acad. Sci. U.S.A., 86, 99, 10.1073/pnas.86.1.99 Khan, 2004, Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling, Proc. Natl. Acad. Sci. U.S.A., 101, 15944, 10.1073/pnas.0404136101 Klatt, 2000, Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress, Eur. J. Biochem., 267, 4928, 10.1046/j.1432-1327.2000.01601.x Kluck, 1997, The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis, Science, 275, 1132, 10.1126/science.275.5303.1132 Kojo, 2004, Vitamin C: Basic metabolism and its function as an index of oxidative stress, Curr. Med. Chem., 11, 1041, 10.2174/0929867043455567 Konig, 1997, Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis, Leukemia, 11, 258, 10.1038/sj.leu.2400556 Koshland, 1992, The molecule of the year, Science, 258, 1861, 10.1126/science.1470903 Kovacic, 2001, Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer, Curr. Med. Chem., 8, 773, 10.2174/0929867013373084 Kovacic, 2005, Mechanism of mitochondrial uncouplers, inhibitors, and toxins: Focus on electron transfer, free radicals, and structure–activity relationships, Curr. Med. Chem., 12, 2601, 10.2174/092986705774370646 Krauss, 2003, Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction, J. Clin. Invest., 112, 1831, 10.1172/JCI200319774 Kuge, 1994, YAP-1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides, EMBO J., 13, 655, 10.1002/j.1460-2075.1994.tb06304.x Kukreja, 1992, The oxygen free-radical system—From equations through membrane–protein interactions to cardiovascular injury and protection, Cardiovasc. Res., 26, 641, 10.1093/cvr/26.7.641 Kwong, 1998, Substrate and site specificity of hydrogen peroxide generation in mouse mitochondria, Arch. Biochem. Biophys., 350, 118, 10.1006/abbi.1997.0489 Kyriakis, 2001, Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation, Physiol. Rev., 81, 807, 10.1152/physrev.2001.81.2.807 Lamas, 1992, Endothelial nitric oxide synthase: Molecular cloning and characterization of a distinct constitutive enzyme isoform, Proc. Natl. Acad. Sci. U.S.A., 89, 6348, 10.1073/pnas.89.14.6348 Landis, 2005, Superoxide dismutase evolution and life span regulation, Mech. Ageing Dev., 126, 365, 10.1016/j.mad.2004.08.012 Laude, 2003, NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection, Am. J. Physiol. Heart Circ. Physiol., 284, H2053, 10.1152/ajpheart.00627.2002 Laursen, 1997, Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension, Circulation, 95, 588, 10.1161/01.CIR.95.3.588 Lawlor, 2001, PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?, J. Cell. Sci., 114, 2903, 10.1242/jcs.114.16.2903 Lazou, 1994, Regulation of mitogen-activated protein kinase cas-cade in adult rat heart preparations in vitro, Circ. Res., 75, 932, 10.1161/01.RES.75.5.932 Leonard, 2004, Metal-induced oxidative stress and signal transduction, Free Radic. Biol. Med., 37, 1921, 10.1016/j.freeradbiomed.2004.09.010 Li, 2000, Nitric oxide in the pathogenesis of vascular disease, J. Pathol., 190, 244, 10.1002/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2-8 Li, 2003, ROS generation by nonphagocytic NADPH oxidase: Potential relevance in diabetic nephropathy, J. Am. Soc. Nephrol., 14, S221, 10.1097/01.ASN.0000077406.67663.E7 Ling, 2001, Immunohistochemical distribution and quantitative biochemical detection of advanced glycation end products in fetal to adult rats and in rats with streptozotocin-induced diabetes, Lab. Investig., 81, 845, 10.1038/labinvest.3780294 Linsley, 1993, The role of the CD28 receptor during T cell responses to antigen, Ann. Rev. Immunol., 11, 191, 10.1146/annurev.iy.11.040193.001203 Liochev, 1994, The role of O2 in the production of HO: In vitro and in vivo, Free Radic. Biol. Med., 16, 29, 10.1016/0891-5849(94)90239-9 Liochev, 2002, The Haber–Weiss cycle—70 years later: An alternative view, Redox Rep., 7, 55, 10.1179/135100002125000190 Loft, 1996, Cancer risk and oxidative DNA damage in man, J. Mol. Med., 74, 297, 10.1007/BF00207507 Lombardi, 1998, Free radicals in rabbit spinal cord ischemia: Electron spin resonance spectroscopy and correlation with SOD activity, Cell. Mol. Neurobiol., 18, 399, 10.1023/A:1022597431593 Lopez-Ilasaca, 1997, Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma, Science, 275, 394, 10.1126/science.275.5298.394 Los, 1995, Hydrogen peroxide as a potent activator of T lymphocyte functions, Eur. J. Immunol., 25, 159, 10.1002/eji.1830250127 Lowenstein, 1994, Nitric-oxide—A physiological messenger, Ann. Intern. Med., 120, 227, 10.7326/0003-4819-120-3-199402010-00009 Makropoulos, 1996, Selenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity, Arch. Toxicol., 70, 277, 10.1007/s002040050274 Malaisse, 1982, Determinants of the selective toxicity of alloxan to the pancreatic b-cell, Proc. Natl. Acad. Sci. U.S.A., 79, 927, 10.1073/pnas.79.3.927 Mao, 1999, Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct, Proc. Natl. Acad. Sci. U.S.A., 96, 6615, 10.1073/pnas.96.12.6615 Marnett, 1999, Lipid peroxidation—DNA damage by malondialdehyde, Mut. Res-Fund. Mol. Mech Mutagen., 424, 83, 10.1016/S0027-5107(99)00010-X Marnett, 2000, Oxyradicals and DNA damage, Carcinogenesis, 21, 361, 10.1093/carcin/21.3.361 Masella, 2005, Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes, J. Nutr. Biochem., 16, 577, 10.1016/j.jnutbio.2005.05.013 Mates, 1999, Antioxidant enzymes and human diseases, Clin. Biochem., 32, 595, 10.1016/S0009-9120(99)00075-2 Matsumoto, 2003, Screening for nitric oxide-dependent protein–protein interactions, Science, 301, 657, 10.1126/science.1079319 Maurice, 1997, Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis, J. Immunol., 158, 1458, 10.4049/jimmunol.158.3.1458 McCord, 1969, Superoxide dismutase an enzymic function for erythrocuprein Hemocuprein, J. Biol. Chem., 244, 6049, 10.1016/S0021-9258(18)63504-5 McCully, 2003, Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection, Arch. Biochem. Biophys., 420, 237, 10.1016/j.abb.2003.06.003 McEligot, 2005, Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells, Ann. Rev. Nutr., 25, 261, 10.1146/annurev.nutr.25.050304.092633 Meulener, 2005, Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease, Curr. Biol., 15, 1572, 10.1016/j.cub.2005.07.064 Miller, 1990, Transition metals as catalysts of “autoxidation” reactions, Free Radic. Biol. Med., 8, 95, 10.1016/0891-5849(90)90148-C Miller, 2005, Meta-analysis: High-dosage Vitamin E supplementation may increase all-cause mortality, Ann. Intern. Med., 142, 37, 10.7326/0003-4819-142-1-200501040-00110 Mittal, 1977, Activation of guanylate cyclase by superoxide-dismutase and hydroxyl radical—Physiological regulator of guanosine 3′,5′-monophosphate formation, Proc. Natl. Acad. Sci. U.S.A., 74, 4360, 10.1073/pnas.74.10.4360 Molavi, 2004, Oxidative stress in cardiovascular disease: Molecular basis of its deleterious effects, its detection, and therapeutic considerations, Curr. Opin. Cardiol., 19, 488, 10.1097/01.hco.0000133657.77024.bd Molkentin, 2001, Cytoplasmic signaling pathways that regulate cardiac hypertrophy, Ann. Rev. Physiol., 63, 391, 10.1146/annurev.physiol.63.1.391 Mortensen, 2001, The interaction of dietary carotenoids with radical species, Arch. Biochem. Biophys., 385, 13, 10.1006/abbi.2000.2172 Mulder, 2000, Role of Ras and MAPKs in TGF beta signaling, Cytokine Growth Fact. Rev., 11, 23, 10.1016/S1359-6101(99)00026-X Muller, 2004, Complex III releases superoxide to both sides of the inner mitochondrial membrane, J. Biol. Chem., 279, 49064, 10.1074/jbc.M407715200 Nagase, 2003, DesigningTIMP: Tissue inhibitor of metalloproteinases variants that are selective metalloproteinase inhibitors, Biochem. Soc. Symp., 70, 201, 10.1042/bss0700201 Nakamura, 1997, Redox regulation of cellular activation, Ann. Rev. Immunol., 15, 351, 10.1146/annurev.immunol.15.1.351 Neufeld, 1999, Vascular endothelial growth factor (VEGF) and its receptors, FASEB J., 13, 9, 10.1096/fasebj.13.1.9 Newmeyer, 2003, Mitochondria: Releasing power for life and unleashing the machineries of death, Cell, 112, 481, 10.1016/S0092-8674(03)00116-8 Niedowicz, 2005, The role of oxidative stress in diabetic complications, Cell. Biochem. Biophys., 43, 289, 10.1385/CBB:43:2:289 Nishikawa, 2000, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature, 404, 787, 10.1038/35008121 Nogueira, 2004, Organoselenium and organotellurium compounds: Toxicology and pharmacology, Chem. Rev., 104, 6255, 10.1021/cr0406559 Orrenius, 2003, Regulation of cell death: The calcium-apoptosis link, Nat. Rev. Mol. Cell. Biol., 4, 552, 10.1038/nrm1150 Packer, 1993, Vitamin-E and alpha-lipoate—Role in antioxidant recycling and activation of the NF-kappa-b transcription factor, Mol. Aspects Med., 14, 229, 10.1016/0098-2997(93)90009-3 Pande, 2005, Molecular recognition of 15-deoxy-delta(12,14)-prostaglandin J(2) by nuclear factor-kappa B and other cellular proteins, Bioorg. Med. Chem. Lett., 15, 4057, 10.1016/j.bmcl.2005.06.025 Parekh, 1997, Store depletion and calcium influx, Physiol. Rev., 77, 901, 10.1152/physrev.1997.77.4.901 Pastor, 2000, A detailed interpretation of OH radical footprints in a TBP DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding, J. Mol. Biol., 304, 55, 10.1006/jmbi.2000.4173 Pastore, 2003, Analysis of glutathione: Implication in redox and detoxification, Clin. Chim. Acta., 333, 19, 10.1016/S0009-8981(03)00200-6 Peng, 2003, The role of c-jun N-terminal kinase JNK in Parkinson's disease, IUBMB Life, 55, 267, 10.1080/1521654031000121666 Perez, 1998, Novel myofilament Ca2+-sensitizing property of xanthine oxidase inhibitors, Circul. Res., 83, 423, 10.1161/01.RES.83.4.423 Petrosillo, 2003, Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria, FASEB J., 17, 2202, 10.1096/fj.03-0012com Philchenkov, 2004, Caspases and cancer: Mechanisms of inactivation and new treatment modalities, Exp. Oncol., 26, 82 Podrez, 2000, Myeloperoxidase-generated oxidants and atherosclerosis, Free Radic. Biol. Med., 28, 1717, 10.1016/S0891-5849(00)00229-X Pogocki, 2003, Alzheimer's beta-amyloid peptide as a source of neurotoxic free radicals: The role of structural effects, Acta Neurobiol. Exp., 63, 131 Poli, 2004, Oxidative stress and cell signalling, Curr. Med. Chem., 11, 1163, 10.2174/0929867043365323 Pourahmad, 2001, Biological reactive intermediates that mediate chromium VI toxicity, Biol. React. Intermed. VI: Adv. Exp. Med. Biol., 500, 203, 10.1007/978-1-4615-0667-6_27 Pryor, 2000, Vitamin E and heart disease: Basic science to clinical intervention trials, Free Radic. Biol. Med., 28, 141, 10.1016/S0891-5849(99)00224-5 Rae, 1999, Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase, Science, 284, 805, 10.1126/science.284.5415.805 Rao, 1997, Transcription factors of the NFAT family: Regulation and function, Ann. Rev. Immunol., 15, 707, 10.1146/annurev.immunol.15.1.707 Ridnour, 2005, Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1, Proc. Natl. Acad. Sci. U.S.A., 102, 13147, 10.1073/pnas.0502979102 Ridnour, 2004, The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations, Biol. Chem., 385, 1, 10.1515/BC.2004.001 Robertson, 2003, Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection, Diabetes, 52, 581, 10.2337/diabetes.52.3.581 Robertson, 1992, Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations, J. Clin. Invest., 90, 320, 10.1172/JCI115865 Robinson, 1993, Functional binding of cardiolipin to cytochrome-c-oxidase, J. Bioen. Biomembr., 25, 153, 10.1007/BF00762857 Romero, 1999, Role of angiotensin and oxidative stress in essential hypertension, Hypertension, 34, 943, 10.1161/01.HYP.34.4.943 Rosca, 2005, Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation, Am. J. Physiol.-Renal Physiol., 289, F420, 10.1152/ajprenal.00415.2004 Roy, 2002, Metabolism and toxicity of arsenic: A human carcinogen, Curr. Sci., 82, 38 Sablina, 2005, The antioxidant function of the p53 tumor suppressor, Nat. Med., 11, 1306, 10.1038/nm1320 Salmeen, 2005, Functions and mechanisms of redox regulation of cysteine-based phosphatases, Antiox. Redox. Signal., 7, 560, 10.1089/ars.2005.7.560 Santos, 2005, Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues, Chem. Biol. Interact., 151, 159, 10.1016/j.cbi.2005.01.001 Saretzki, 2002, hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines, Cancer Lett., 176, 81, 10.1016/S0304-3835(01)00644-9 Sayre, 2001, Chemistry and biochemistry of oxidative stress in neurodegenerative disease, Curr. Med. Chem., 8, 721, 10.2174/0929867013372922 Schafer, 2001, Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple, Free Radic. Biol. Med., 30, 1191, 10.1016/S0891-5849(01)00480-4 Schaller, 1992, pp125fak a structurally distinctive protein-tyrosine kinase associated with focal adhesions, Proc. Natl. Acad. Sci U.S.A., 89, 5192, 10.1073/pnas.89.11.5192 Schrauzer, 2006, Interactive effects of selenium and chromium on mammary tumor development and growth in MMTV-infected female mice and their relevance to human cancer, Biol. Trace Element Res., 109, 281, 10.1385/BTER:109:3:281 Schreck, 1991, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1, EMBO J., 10, 2247, 10.1002/j.1460-2075.1991.tb07761.x Semenza, 2000, HIF-1: Mediator of physiological and pathophysiological responses to hypoxia, J. Appl. Physiol., 88, 1474, 10.1152/jappl.2000.88.4.1474 Sharma, 2006, Diabetic cardiomyopathy: Where are we 40 years later?, Can. J. Cardiol., 22, 305, 10.1016/S0828-282X(06)70914-X Sharoni, 2004, Carotenoids and transcription, Arch. Biochem. Biophys., 430, 89, 10.1016/j.abb.2004.03.009 Shaw, 1998, The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2, Biochem. J., 336, 241, 10.1042/bj3360241 Shen, 2005, Glutathione redox state regulates mitochondrial reactive oxygen production, J. Biol. Chem., 280, 25305, 10.1074/jbc.M500095200 Sies, 1993, Strategies of antioxidant defense, Eur. J. Biochem., 215, 213, 10.1111/j.1432-1033.1993.tb18025.x Siems, 1995, 4-Hydroxynonenal formation during ischemia and reperfusion of rat small-intestine, Life Sci., 57, 785, 10.1016/0024-3205(95)02006-5 Skiles, 2004, The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors, Curr. Med. Chem., 11, 2911, 10.2174/0929867043364018 Skyschally, 2003, Attenuation of ischemic preconditioning in pigs by scavenging of free oxyradicals with ascorbic acid, Am. J. Physiol. Heart. Circ. Physiol., 284, H698, 10.1152/ajpheart.00693.2002 Smith, 2004, Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress, Curr. Med. Chem., 11, 1135, 10.2174/0929867043365387 Sowers, 2002, Hypertension, angiotensin II, and oxidative stress, New Engl. J. Med., 346, 1999, 10.1056/NEJMe020054 Stadtman, 2004, Role of oxidant species in aging, Curr. Med. Chem., 11, 1105, 10.2174/0929867043365341 Stayner, 1996, Occupational exposure to chrysotile asbestos and cancer risk: A review of the amphibole hypothesis, Am. J. Public Health, 86, 179, 10.2105/AJPH.86.2.179 Storz, 2005, Reactive oxygen species in tumor progression, Front Biosci., 10, 1881, 10.2741/1667 Stoyanovsky, 1997, Nitric oxide activates skeletal and cardiac ryanodine receptors, Cell Calcium, 21, 19, 10.1016/S0143-4160(97)90093-2 Sun, 1996, Redox regulation of transcriptional activators, Free Radic. Biol. Med., 21, 335, 10.1016/0891-5849(96)00109-8 Sundaresan, 1996, Regulation of reactive-oxygen-species generation in fibroblasts by Rac1, Biochem. J., 318, 379, 10.1042/bj3180379 Tamagno, 2006, The various aggregation states of β-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression, Free Radic. Biol. Med., 41, 202, 10.1016/j.freeradbiomed.2006.01.021 Tauber, 1983, Chronic granulomatous disease: A syndrome of phagocyte oxidase deficiencies, Medicine, 62, 286, 10.1097/00005792-198309000-00003 Thannickal, 1995, Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1, J. Biol. Chem., 270, 30334, 10.1074/jbc.270.51.30334 Thannickal, 2000, Reactive oxygen species in cell signaling, Am. J. Physiol. Lung Cell. Mol. Physiol., 279, L1005, 10.1152/ajplung.2000.279.6.L1005 Tomko, 2006, Airing out an antioxidant role for the tumor suppressor p53, Mol. Interv., 6, 23, 10.1124/mi.6.1.5 Traverso, 2002, Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver, Free Radic. Biol. Med., 32, 350, 10.1016/S0891-5849(01)00811-5 Tretter, 2004, Initiation of neuronal damage by complex I deficiency and oxidative stress in Parkinson's disease, Neurochem. Res., 29, 569, 10.1023/B:NERE.0000014827.94562.4b Valko, 2004, Role of oxygen radicals in DNA damage and cancer incidence, Mol. Cell. Biochem., 266, 37, 10.1023/B:MCBI.0000049134.69131.89 Valko, 2005, Metals, toxicity and oxidative stress, Curr. Med. Chem., 12, 1161, 10.2174/0929867053764635 Valko, 2001, Oxygen free radical generating mechanisms in the colon: Do the semiquinones of Vitamin K play a role in the aetiology of colon cancer?, Biochim. Biophys. Acta, 1527, 161, 10.1016/S0304-4165(01)00163-5 Valko, 2006, Free radicals, metals and antioxidants in oxidative stress-induced cancer, Chem. Biol. Interact., 160, 1, 10.1016/j.cbi.2005.12.009 VanderJagt, 2001, Oxidative stress indices in IDDM subjects with and without long-term diabetic complications, Clin. Biochem., 34, 265, 10.1016/S0009-9120(01)00204-1 Vicent, 2003, The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance, J. Clin. Invest., 111, 1373, 10.1172/JCI15211 Voehringer, 2000, Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis, Proc. Natl. Acad. Sci. U.S.A., 97, 2680, 10.1073/pnas.97.6.2680 Vorbach, 2003, Xanthine oxidoreductase is central to the evolution and function of the innate immune system, Trends Immunol., 24, 512, 10.1016/S1471-4906(03)00237-0 Waalkes, 2004, Mechanisms underlying arsenic carcinogenesis: Hypersensitivity of mice exposed to inorganic arsenic during gestation, Toxicology, 198, 31, 10.1016/j.tox.2004.01.017 Wakasaki, 1997, Targeted overexpression of protein kinase C beta 2 isoform in myocardium causes cardiomyopathy, Proc. Natl. Acad. Sci. U.S.A., 94, 9320, 10.1073/pnas.94.17.9320 Wang, 1996, Lipid peroxidation-induced putative malondialdehyde–DNA adducts in human breast tissues, Cancer Epidemiol. Biomark Prev., 5, 705 Wang, 1995, Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc. Natl. Acad. Sci. U.S.A., 92, 5510, 10.1073/pnas.92.12.5510 Westermarck, 1999, Regulation of matrix metalloproteinase expression in turner invasion, FASEB J., 13, 781, 10.1096/fasebj.13.8.781 Weyer, 2001, Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia, J. Clin. Endocrinol. Metab., 86, 1930, 10.1210/jc.86.5.1930 White, 1998, The IRS-signalling system: A network of docking proteins that mediate insulin action Mol, Cell. Biochem., 182, 3, 10.1023/A:1006806722619 White, 1997, Relationship between Vitamin and calcium supplement use and colon cancer, Cancer Epidemiol. Biomark. Prevent., 6, 769 Wink, 1997, Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates, J. Biol. Chem., 272, 11147, 10.1074/jbc.272.17.11147 Wolin, 1999, Roles of NADPH oxidases and reactive oxygen species in vascular oxygen sensing mechanisms, Respir. Physiol., 115, 229, 10.1016/S0034-5687(99)00023-7 Xie, 1992, Cloning and characterization of inducible nitric oxide synthase from mouse macrophages, Science, 256, 225, 10.1126/science.1373522 Xu, 1999, NO synthase in cardiac sarcoplasmic reticulum, Proc. Natl. Acad. Sci. U.S.A., 96, 657, 10.1073/pnas.96.2.657 Yamagishi, 2001, Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction, Diabetes, 50, 1491, 10.2337/diabetes.50.6.1491 Yuan, 2003, The iron hypothesis of atherosclerosis and its clinical impact, Ann. Med., 35, 578, 10.1080/07853890310016342 Zhao, 2001, Adenosine-induced late preconditioning in mouse hearts: Role of p38 MAP kinase and mitochondrial K (ATP) channels, Am. J. Physiol. Heart. Circ. Physiol., 280, H1278, 10.1152/ajpheart.2001.280.3.H1278 Zou, 2002, Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite, J. Clin. Invest., 109, 817, 10.1172/JCI0214442