Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects

European Journal of Pharmaceutical Sciences - Tập 2 Số 3 - Trang 213-219 - 1994
Ruggero Bettini1, Paolo Colombo1, Gina Massimo1, Pier Luigi Catellani1, T Vitali1
1Pharmaceutical Department, University of Parma, Viale delle Scienze, 43100 Parma, Italy

Tóm tắt

Từ khóa


Tài liệu tham khảo

Colombo, 1990, Drug release modulation by physical restrictions of matrix swelling, Int. J. Pharm., 63, 43, 10.1016/0378-5173(90)90099-P

Colombo, 1992, Swelling characteristics of hydrophilic matrices for controlled release. New dimensionless number to describe the swelling and release behavior, Int. J. Pharm., 88, 99, 10.1016/0378-5173(92)90307-N

Harland, 1988, Drug/polymer matrix swelling and dissolution, Pharm. Res., 5, 488, 10.1023/A:1015913207052

Mitchell, 1993, The influence of substitution type on the performance of methylcellulose and hydroxypropylcellulose in gels and matrices, Int. J. Pharm., 100, 143, 10.1016/0378-5173(93)90085-T

Peppas, 1989, A simple equation for the description of solute release. III. Coupling of diffusion and relaxation, Int. J. Pharm., 57, 169, 10.1016/0378-5173(89)90306-2