Comment évaluer l’efficacité clinique de la thérapeutique homéopathique ? A propos du rapport de la Haute Autorité de Santé

National Health and Medical Research Council, 2015 Poitevin, 2016, Rapport du gouvernement australien sur l’efficacité clinique de l’homéopathie : analyse et propositions, Rev homeopathie, 7, 105, 10.1016/j.revhom.2016.07.018 Haute Autorité de Santé. Commission de la transparence évaluation des médicaments homéopathiques soumis à la procédure d’enregistrement prévue à l’article l.5121-13 du csp https://www.has-sante.fr/upload/docs/application/pdf/2019-06/homeopathie_pic_avis3_cteval415.pdf consulté le 20/09/2019. Fisher, 1998, Un concept plutôt qu’une technique, La Recherche, 310, 59 Whitmarsch, 2013, Phenomenology and homeopathy, Homeopathy, 102, 225, 10.1016/j.homp.2013.05.003 Waisse, 2012, The Science of high dilutions in historical context, Homeopathy, 101, 129, 10.1016/j.homp.2012.01.001 Hahnemann, 1921 Chikramane, 2010, Extreme homeopathic dilutions retains starting materials: a nanoparticulate perspective, Homeopathy, 99, 231, 10.1016/j.homp.2010.05.006 Demangeat, 2018, Towards a Rational Insight into the Paradox of Homeopathy, Adv Complement Alt Med, 2, 1 Kleijnen, 1991, Clinical trials of Homeopathy, BMJ, 302, 316, 10.1136/bmj.302.6772.316 Vandenbroucke, 2005, Homeopathy and the “growth of truth”, Lancet, 366, 691, 10.1016/S0140-6736(05)67151-6 Shang, 2005, Are the clinical effects of homoeopathy placebo effects ? Comparative study of placebo-controlled trials of homoeopathy and allopathy, Lancet, 366, 726, 10.1016/S0140-6736(05)67177-2 Fisher, 2015, Ultra High dilution. Physiology and Physics comes of age, Homeopathy, 104, 221, 10.1016/j.homp.2015.10.005 Endler, 2015, The ultra high dilution 1994” revisited 2015 – the state of follow-up research, Homeopathy, 104, 223, 10.1016/j.homp.2015.07.005 Endler, 2015, Replications of fundamental research models in ultra high dilutions 1994 and 2015 - update on a bibliometric study, Homeopathy, 104, 234, 10.1016/j.homp.2015.10.003 Jager, 2015, The use of plant-based bioassays in homeopathic basic research, Homeopathy, 104, 277, 10.1016/j.homp.2015.06.009 Bonamin, 2015, The use of animal models in homeopathic research e a review of 2010–2014 PubMed indexed papers, Homeopathy, 104, 283, 10.1016/j.homp.2015.06.002 Endler, 2015, Amphibians and ultra high diluted thyroxine e further experiments and re-analysis of data, Homeopathy, 104, 250, 10.1016/j.homp.2015.10.001 Bonamin, 2015, Immunological models in high dilutionresearch following M Bastide, Homeopathy, 104, 263, 10.1016/j.homp.2015.08.004 Poitevin, 2015, Survey of immuno-allergological ultra high dilutionresearch, Homeopathy, 104, 269, 10.1016/j.homp.2015.06.007 Poitevin, 2012, La rhinite allergique. Possibilités de l’homéopathie, Rev Homeopathie, 3, 44, 10.1016/j.revhom.2012.04.004 Poitevin, 2014, Asthme : la thérapeutique homéopathique (3re partie), Rev Homeopathie, 5, 2, 10.1016/j.revhom.2014.01.011 Dangoumeau, 1998, Peut-on évaluer l’homéopathie en clinique ?, La Recherche, 310, 79 Pignarre, 1998, Insu et double Insu, La Recherche, 310, 83 Linde, 1999, Impact of study quality on outcome in placebo-controlled trials of Homeopathy, J Clin Epidemiol, 52, 631, 10.1016/S0895-4356(99)00048-7 Cucherat, 2000, Evidence of clinical efficacy of Homeopathy. A meta-analysis of clinical trials. HMRAG. Homeopathic Medicines Research Advisory Group, Eur J Clin Pharmacol, 56, 27, 10.1007/s002280050716 Riley, 2001, Open label trial of Homeopathy vs. conventional medicine for respiratory and ear complaints seen in primary care settings, J Altern Complement Med, 7, 149, 10.1089/107555301750164226 Haidvogl, 2007, Homeopathic and conventional treatment for acute respiratory and ear complaints: a comparative study on outcome in the primary care setting, BMC Complement Altern Med, 7, 7, 10.1186/1472-6882-7-7 Grimaldi-Bensouda, 2014, Management of upper respiratory tract infections by different medical practices, including homeopathy, and consumption of antibiotics in primary care: the EPI3 cohort study in France 2007–2008, PLoS ONE, 9, 10.1371/journal.pone.0089990 De Lange, 1994, Effect of homeopathic medicines on daily burden of symptoms in children with recurrent upper respiratory tract infections, BMJ, 309, 1329, 10.1136/bmj.309.6965.1329 Linde, 1998, Randomized controlled trials of individualized homeopathy: a state-of-the-art review, J Altern Complement Med, 4, 371, 10.1089/acm.1998.4.371 Altunc, 2007, Homeopathy for childhood and adolescence ailments: systematic review of randomized clinical trials, Mayo Clin Proc, 82, 69, 10.1016/S0025-6196(11)60969-5 Steinsbekk, 2005, Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory tract infections in children. A double-blind randomized placebo controlled trial, Br J Clin Pharmacol, 59, 447, 10.1111/j.1365-2125.2005.02336.x Steinsbekk, 2005, Homeopathic care for the prevention of upper respiratory tract infections in children: a pragmatic, randomised, controlled trial comparing individualised homeopathic care and waiting-list controls, Complement Ther Med, 13, 231, 10.1016/j.ctim.2005.06.007 Jacobs, 2001, Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trial, Pediatr Infect Dis J, 20, 177, 10.1097/00006454-200102000-00012 Sinha, 2012, Randomized controlled pilot study to compare homeopathy and conventional therapy in acute otitis media, Homeopathy, 101, 5, 10.1016/j.homp.2011.08.003 Taylor, 2011, Homeopathic ear drops as an adjunct to standard therapy in children with acute otitis media, Homeopathy, 100, 109, 10.1016/j.homp.2011.03.002 Taylor, 2014, Homeopathic ear drops as an adjunct in reducing antibiotic usage in children with acute otitis media, Global Pediatric Health, 1 Schafer, 2002, Alternative medicines in allergies – prevalence, patterns of use and costs, Allergy, 57, 694, 10.1034/j.1398-9995.2002.23469.x Reilly, 1986, Is Homeopathy a placebo response? Controlled trial of Homeopathy potency with pollen in hayfever as model, Lancet, ii, 881, 10.1016/S0140-6736(86)90410-1 Taylor, 2000, T.C Randomised controlled trial of Homeopathy versus placebo in perennial allergic rhinitis with overview of four trial series, BMJ, 321, 471, 10.1136/bmj.321.7259.471 Reilly, 1994, Is evidence for Homeopathy reproducible?, Lancet, 344, 1601, 10.1016/S0140-6736(94)90407-3 Poitevin, 2011, Place de l’Isothérapie dans le traitement des allergies, Rev Homeopathie, 2, 73, 10.1016/S1878-9730(11)70078-0 Wiesenauer, 1996, A meta-analysis of the homeopathic treatment of pollinosis with Galphimia Glauca, Fursch Komplementärmed, 3, 230 Mc Carney, 2004, Homeopathy for chronic asthma, Cochrane Database of Systematic Reviews, 1 Shafei, 2012, Individualized homeopathy in a group of Egyptian asthmatic children, Homeopathy, 101, 224, 10.1016/j.homp.2012.08.006 Pilkington, 2006, Homeopathy for anxiety and anxiety disorders: a systematic review of the research, Homeopathy, 95, 151, 10.1016/j.homp.2006.05.005 Pilkington, 2005, Homeopathy for depression: a systematic review of the research evidence, Homeopathy, 94, 153, 10.1016/j.homp.2005.04.003 Grimaldi-Bensouda, 2016, Homeopathic medical practice for anxiety and depression in primary care: the EPI3 cohort study, BMC Complement Altern Med, 16, 125, 10.1186/s12906-016-1104-2 Danno, 2018, Management of anxiety and depressive disorders in patients≥65 years of age by Homeopath general practitioners vs conventional general practitioners, with overview of the EPI3-LASER study results, Homeopathy, 107, 081, 10.1055/s-0038-1636536 Macias-Cortes, 2015, “Individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP study)”, PLoS One, 10, e0118440, 10.1371/journal.pone.0118440 Jacobs, 1994, Treatment of acute childhood diarrhea with homeopathic medicine: a randomized clinical trial in Nicaragua, Pediatrics, 93, 719, 10.1542/peds.93.5.719 Jacobs, 2000, Homeopathic treatment of acute childhood diarrhea: results from a clinical trial in Nepal, J Altern Compl Med, 6, 131, 10.1089/acm.2000.6.131 Jacobs, 2003, Homeopathy for childhood diarrhea: combined results and meta-analysis from three randomized, controlled trails, Pediat Infect Dis, 22, 229, 10.1097/01.inf.0000055096.25724.48 Jacobs, 2006, Homeopathic combination remedy in the treatment of acute childhood diarrhea in Honduras, J Altern Complement Med, 12, 723, 10.1089/acm.2006.12.723 Rossignol, 2012, Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort, Pharmacoepidemiol Drug Saf, 21, 1093, 10.1002/pds.3316 Danno, 2014, “Physician practicing preferences for conventional or homeopathic medicines in elderly subjects with musculoskeletal disorders in the EPI3-MSD cohort”, Clin Epidemiol, 333, 10.2147/CLEP.S64049 Relton, 2009, Healthcare provided by a homeopath as an adjunct to usual care for Fibromyalgia (FMS): results of a pilot Randomised Controlled Trial, Homeopathy, 98, 77, 10.1016/j.homp.2008.12.004 Bell, 2004, Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo, Rheumatology, 43, 377, 10.1093/rheumatology/keh111 Fisher, 1989, Effect of homeopathic treatment on fibrositis (primary fibromyalgia), BMJ, 299, 365, 10.1136/bmj.299.6695.365 Langhorst, 2009, Qualitative systemic review of randomized control-led trials on complementary and alternative medicine treatments in fibromyalgia, Rheumatol Int, 30, 1, 10.1007/s00296-009-0977-5 De Silva, 2010, Evidence for the efficacy of complementary and alternative medi-cines in the management of fibromyalgia: a systematic review, Rheumatology (UK), 49, 1063, 10.1093/rheumatology/keq025 Mathie, 2017, Randomised, doubleblind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis, Syst Rev, 6, 634, 10.1186/s13643-017-0445-3 Mathie, 2014, Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis, Syst Rev, 3, 142, 10.1186/2046-4053-3-142 Linde, 1997, Are the clinical effects of homoeopathy placebo effects? A meta-analysis of placebo-controlled trials, Lancet, 50, 834, 10.1016/S0140-6736(97)02293-9 2005, The Lancet. The end of Homeopathy, Lancet, 366, 690, 10.1016/S0140-6736(05)67149-8 Poitevin, 2006, French Doctors’ response, Homeopathy, 95, 63, 10.1016/j.homp.2005.11.015 The Effectiveness of Homeopathy: an overview review of secondary evidence, https://www.hri-research.org/wp-content/uploads/2019/08/Draft-annotated-2012-homeopathy-report.pdf. Lüdtke, 2008, The conclusions on the effectiveness of Homeopathy highly depend on the set of analyzed trials, J Clin Epidemiol, 61, 1197, 10.1016/j.jclinepi.2008.06.015 Klein, 2018, Physicochemical Investigations of Homeopathic Preparations: A Systematic Review and Bibliometric Analysis — Part 1, J Altern Complement Med, 1 Demangeat, 2015, Gaz nanobubbles and aqueous supertructures: the crucial role of dynamisation, Homeopathy, 104, 101, 10.1016/j.homp.2015.02.001 Demangeat J.L. Towards a Rational Insight into the Paradox of Homeopathy. Adv Complement Alt Med. 2(2). ACAM. 000534.2018. Hibou, 2017, Could the study of cavitation luminescence be useful in high dilution research?, Homeopathy, 106, 181, 10.1016/j.homp.2017.05.001 Rey, 2003, Thermolumisnescence of ultra-high dilutions of lithium chloride and sodium chloride, Physica A, 323, 67, 10.1016/S0378-4371(03)00047-5 Van Wassenhoven, 2017, Nuclear Magnetic Resonance characterization of traditional homeopathically manufactured copper (Cuprum metallicum) and plant (Gelsemium sempervirens) medicines and controls, Homeopathy, 106, 223, 10.1016/j.homp.2017.08.001 Poitevin, 1999, Integrating homoeopathy in health systems, Bull World Health Organ, 77, 160