NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

Adey, 2000, Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding, Cancer Res., 60, 35 Bakkers, 2005, Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo, Cell Cycle, 4, 790, 10.4161/cc.4.6.1694 Blot, 2004, Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding, J. Cell Sci., 117, 2357, 10.1242/jcs.01095 Bond, 2005, MDM2 is a central node in the p53 pathway: 12 years and counting, Curr. Cancer Drug Targets, 5, 3, 10.2174/1568009053332627 Brooks, 2003, Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation, Curr. Opin. Cell Biol., 15, 164, 10.1016/S0955-0674(03)00003-6 Chen, 2005, Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis, Nature, 436, 725, 10.1038/nature03918 Ciechanover, 1984, The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation, J. Cell. Biochem., 24, 27, 10.1002/jcb.240240104 Di Cristofano, 1998, Pten is essential for embryonic development and tumour suppression, Nat. Genet., 19, 348, 10.1038/1235 Fostier, 1998, Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling, Genetics, 150, 1477, 10.1093/genetics/150.4.1477 Gentleman, 2004, Bioconductor: open software development for computational biology and bioinformatics, Genome Biol., 5, R80, 10.1186/gb-2004-5-10-r80 Gray, 1998, Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN, Br. J. Cancer, 78, 1296, 10.1038/bjc.1998.674 Hershko, 1998, The ubiquitin system, Annu. Rev. Biochem., 67, 425, 10.1146/annurev.biochem.67.1.425 Ingham, 2004, The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture, Oncogene, 23, 1972, 10.1038/sj.onc.1207436 Irizarry, 2003, Exploration, normalization, and summaries of high density oligonucleotide array probe level data, Biostatistics, 4, 249, 10.1093/biostatistics/4.2.249 Jacks, 1994, Tumor spectrum analysis in p53-mutant mice, Curr. Biol., 4, 1, 10.1016/S0960-9822(00)00002-6 Kamynina, 2001, Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation, Am. J. Physiol. Renal Physiol., 281, F469, 10.1152/ajprenal.2001.281.3.F469 Kim, 2005, DJ-1, a novel regulator of the tumor suppressor PTEN, Cancer Cell, 7, 263, 10.1016/j.ccr.2005.02.010 Kwabi-Addo, 2001, Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression, Proc. Natl. Acad. Sci. USA, 98, 11563, 10.1073/pnas.201167798 Leslie, 2004, PTEN function: how normal cells control it and tumour cells lose it, Biochem. J., 382, 1, 10.1042/BJ20040825 Li, 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 275, 1943, 10.1126/science.275.5308.1943 Luo, 2003, Targeting the PI3K-Akt pathway in human cancer: rationale and promise, Cancer Cell, 4, 257, 10.1016/S1535-6108(03)00248-4 Maehama, 2001, PTEN and myotubularin: novel phosphoinositide phosphatases, Annu. Rev. Biochem., 70, 247, 10.1146/annurev.biochem.70.1.247 Michael, 2002, The p53 and Mdm2 families in cancer, Curr. Opin. Genet. Dev., 12, 53, 10.1016/S0959-437X(01)00264-7 Nagase, 1995, Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1, DNA Res., 2, 37, 10.1093/dnares/2.1.37 Pao, 2003, Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance, Proc. Natl. Acad. Sci. USA, 100, 8764, 10.1073/pnas.1133333100 Raftopoulou, 2004, Regulation of cell migration by the C2 domain of the tumor suppressor PTEN, Science, 303, 1179, 10.1126/science.1092089 Rogers, 1986, Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis, Science, 234, 364, 10.1126/science.2876518 Rougier, 2005, Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins, Am. J. Physiol. Cell Physiol., 288, C692, 10.1152/ajpcell.00460.2004 Sambrook, 2001 Sansal, 2004, The biology and clinical relevance of the PTEN tumor suppressor pathway, J. Clin. Oncol., 22, 2954, 10.1200/JCO.2004.02.141 Shen, 2007, Essential role of PTEN in the maintenance of chromosomal integrity, Cell, 128, 157, 10.1016/j.cell.2006.11.042 Stambolic, 1998, Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN, Cell, 95, 29, 10.1016/S0092-8674(00)81780-8 Steck, 1997, Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers, Nat. Genet., 15, 356, 10.1038/ng0497-356 Strack, 2000, A role for ubiquitin ligase recruitment in retrovirus release, Proc. Natl. Acad. Sci. USA, 97, 13063, 10.1073/pnas.97.24.13063 Tamura, 1998, Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN, Science, 280, 1614, 10.1126/science.280.5369.1614 Torres, 2001, The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation, J. Biol. Chem., 276, 993, 10.1074/jbc.M009134200 Treier, 1994, Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain, Cell, 78, 787, 10.1016/S0092-8674(94)90502-9 Trotman, 2003, Pten dose dictates cancer progression in the prostate, PLoS Biol., 1, E59, 10.1371/journal.pbio.0000059 Trotman, 2007, Ubiquitination regulates PTEN nuclear import and tumor suppression, Cell, 128, 141, 10.1016/j.cell.2006.11.040 Vazquez, 2000, Phosphorylation of the PTEN tail regulates protein stability and function, Mol. Cell. Biol., 20, 5010, 10.1128/MCB.20.14.5010-5018.2000 Whang, 1998, Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression, Proc. Natl. Acad. Sci. USA, 95, 5246, 10.1073/pnas.95.9.5246 Wu, 2003, Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells, J. Biol. Chem., 278, 28258, 10.1074/jbc.M303318200