Solving the Mystery of the Human Cerebellum
Tóm tắt
The mystery of the human cerebellum is this: Why did it enlarge so dramatically in the last million years of human evolution, concomitantly with the greater enlargement of the cerebral cortex? A solution to this mystery was proposed in the 20th century as a result of research by several groups of scientists who investigated the contributions of the cerebellum to the cerebral cortex. In contrast to the 19th century investigations, which were focused on the motor functions of the cerebellum, the focus of the subsequent investigations was expanded to include some mental functions because evidence was produced that the cerebellum contributes to cognition. It was proposed that the combination in the cerebellum of motor and mental capabilities enables the cerebellum to confer on humans some adaptive advantages of great value, and this ability would explain why the human cerebellum has continued to enlarge so dramatically. A valuable adaptive advantage that is included in the proposal is the possibility that the cerebellum couples the motor function of articulating speech to the mental function that selects the language to be spoken, thus helping to produce fluent human speech and language. The validity of this proposal about linguistic processing has not yet been verified. Therefore the mystery of cerebellar enlargement in humans is not yet solved and requires further research.
Tài liệu tham khảo
Andersen, B. B., Korbo, L., & Pakkenberg, B. (1992). A quantitative study of the human cerebellum with unbiased stereological techniques. The Journal of Comparative Neurology, 326, 549–560.
Blakeslee, S. (1994). Theory on human brain hints how its unique traits arose. New York: New York Times.
Bloedel, J. R. (1992). Functional heterogeneity with structural homogeneity: how does the cerebellum operate? The Behavioral and Brain Sciences, 15, 666–678.
Dow, R. S. (1974). Some novel concepts of cerebellar physiology. The Mount Sinai Journal of Medicine, 41, 103–119.
Dow, R. S. (1988). Contribution of electrophysiological studies to cerebellar physiology. Journal of Clinical Neurophysiology, 5, 307–323.
Dow, R. S. (1995). Cerebellar cognition. Neurology, 45, 1785–1786.
Eccles, J. C., Ito, M., & Szentagothai, J. (1967). The cerebellum as a neuronal machine. Berlin: Springer-Verlag.
Fiez, J. A. (1996). Cerebellar contributions to cognition. Neuron, 16, 13–15.
Fiez, J. A., & Raichle, M. E. (1997). Linguistic processing. International Review of Neurobiology, 41, 233–254.
Ito, M. (1984). The cerebellum and neural control. New York: Raven Press.
Kim, S. G., Ugurbil, K., & Strick, P. L. (1994). Activation of a cerebellar output nucleus during cognitive processing. Science, 265, 949–951.
Leiner, H. C., & Leiner, A. L. (1997). How fibers subserve computing capabilities: similarities between brains and machines. International Review of Neurobiology, 41, 535–553.
Leiner, H. C., Leiner, A. L., & Dow, R. S. (1986). Does the cerebellum contribute to mental skills? Behavioral Neuroscience, 100, 443–454.
Leiner, H. C., Leiner, A. L., & Dow, R. S. (1987). Cerebro-cerebellar learning loops in apes and humans. Italian Journal of Neurological Sciences, 8, 425–436.
Leiner, H. C., Leiner, A. L., & Dow, R. S. (1989). Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? Behavioral Neuroscience, 103, 998–1008.
Leiner, H. C., Leiner, A. L., & Dow, R. S. (1993). Cognitive and language functions of the human cerebellum. Trends in Neurosciences, 16, 444–447.
Leiner, H. C., Leiner, A. L., & Dow, R. S. (1995). The underestimated cerebellum. Human Brain Mapping, 2, 244–254.
Middleton, F. A., & Strick, P. L. (1994). Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science, 266, 458–461.
Passingham, R. E. (1975). Changes in the size and organisation of the brain in man and his ancestors. Brain, Behavior and Evolution, 11, 73–90.
Petersen, S. E., Fox, P. T., Posner, M. I., Mintun, M., & Raichle, M. E. (1989). Positron emission tomographic studies of the processing of single words. Journal of Cognitive Neuroscience, 1, 153–170.
Schmahmann, J. D. (1997). The cerebellum and cognition. San Diego: Academic.
Spicer D (2004) Oral history of Alan and Henrietta Leiner. In: Computer History Museum, ed. Mountain View, California.
United Press. (1947). New giant ‘Brain’ does wizard work. Washington: New York Times.
Washburn, S. L., & Harding, R. S. (1970). Evolution of primate behavior. In F. O. Schmitt (Ed.), The neurosciences: Second study program (pp. 39–47). New York: Rockefeller University Press.
