Antileishmanial activity evaluation of adunchalcone, a new prenylated dihydrochalcone from Piper aduncum L.

Liese, 2010, Programmes, partnerships, and governance for elimination and control of neglected tropical diseases, Lancet, 375, 67, 10.1016/S0140-6736(09)61749-9 World Health Organization (WHO) Stuart, 2008, Kinetoplastids: related protozoan pathogens, different diseases, J Clin Invest, 118, 1301, 10.1172/JCI33945 Grecco, 2010, Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae), Parasitol Res, 106, 1245, 10.1007/s00436-010-1771-8 Croft, 2006, Drug resistance in leishmaniasis, Clin Microbiol Rev, 19, 111, 10.1128/CMR.19.1.111-126.2006 Soares-Bezerra, 2004, Recentes avanços da quimioterapia das leishmanioses: moléculas intracelulares como alvo de fármacos, Braz J Pharm Sci, 40, 139 Rosenthal, 2003, Recent understanding in the treatment of visceral leishmaniasis, Postgrad Med, 49, 61, 10.4103/0022-3859.926 Flores, 2008, Benzoic acid derivatives from Piper species and their antiparasitic activity, J Nat Prod, 71, 1538, 10.1021/np800104p Flores, 2009, Antiparasitic activity of prenylated benzoic acid derivatives from Piper species, Phytochemistry, 70, 621, 10.1016/j.phytochem.2009.03.010 Sousa, 2008, Avaliação toxicológica do óleo essencial de Piper aduncum L, Braz J Pharmacogn, 18, 217, 10.1590/S0102-695X2008000200013 Lago, 2004, Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum, J Nat Prod, 67, 1783, 10.1021/np030530j Parmar, 1997, Phytochemistry of the genus Piper, Phytochemistry, 46, 597, 10.1016/S0031-9422(97)00328-2 Hermoso, 2003, Antileishmanial activities of dihydrochalcones from Piper elongatum and synthetic related compounds. Structural requirements for activity, Bioorg Med Chem, 11, 3975, 10.1016/S0968-0896(03)00406-1 Cabanillas, 2012, Dihydrochalcones and benzoic acid derivatives from Piper dennisii, Planta Med, 78, 914, 10.1055/s-0031-1298459 Lorenzi, 2002, 544 Braga, 2007, Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil, J Ethnopharmacol, 111, 396, 10.1016/j.jep.2006.12.006 Torres-Santos, 1999, Selective effect of 2′,6′-dihydroxy-4′-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis, Antimicrob Agents Chemother, 43, 1234, 10.1128/AAC.43.5.1234 Rea, 2013, Lago JHG Soulamarin isolated from Calophyllum brasiliense (Clusiaceae) induces plasma membrane permeabilization of Trypanosoma cruzi and mytochondrial dysfunction, PLoS Negl Trop Dis, 7, e2556, 10.1371/journal.pntd.0002556 Yamamoto, 2014, Treatment with triterpenic fraction purified from Baccharis uncinella leaves inhibits Leishmania (Leishmania) amazonensis spreading and improves Th1 immune response in infected mice, Parasitol Res, 113, 333, 10.1007/s00436-013-3659-x Grecco, 2012, In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae), Exp Parasitol, 130, 141, 10.1016/j.exppara.2011.11.002 Joshi, 2001, Dihydrochalcones from Piper longicaudatum, Planta Med, 67, 186, 10.1055/s-2001-11517 Huang, 2003, Identification of an antioxidant, ethyl protocatechuate, in peanut seed testa, J Agric Food Chem, 51, 2380, 10.1021/jf0210019 Orjala, 1993, Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves, Planta Med, 59, 546, 10.1055/s-2006-959758 Franceschelli, 2011, Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-Interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression, Molecules, 16, 5720, 10.3390/molecules16075720 Nielsen, 1998, Modifications of the α, β-double bond in chalcones only marginally affect the antiprotozoal activities, Bioorg Med Chem, 6, 937, 10.1016/S0968-0896(98)00051-0 Kayser, 2001, In vitro leishmanicidal activity of naturally occurring chalcones, Phytother Res, 15, 148, 10.1002/ptr.701 Green, 1990, Activated macrophages destroy intracellular Leishmania major amastigotes by an l-arginine-dependent killing mechanism, J Immunol, 144, 278, 10.4049/jimmunol.144.1.278 Poorrajab, 2009, Selective leishmanicidal effect of 1,3,4-thiadiazole derivatives and possible mechanism of action against Leishmania species, Exp Parasitol, 121, 323, 10.1016/j.exppara.2008.12.004 Passero, 2009, Ex vivo and in vivo biological behavior of Leishmania (Viannia) shawi, Parasitol Res, 105, 1741, 10.1007/s00436-009-1614-7