Physicians underestimate the frequency of generic carbamazepine substitution: results of a survey and review of the problem

Lesser, 2001, Buy some today. Can generics be safely substituted for brand-name drugs?, Neurology, 57, 571, 10.1212/WNL.57.4.571 Wilder, 2001, Effect of food on absorption of Dilantin Kapseals and Mylan extended phenytoin sodium capsules, Neurology, 57, 582, 10.1212/WNL.57.4.582 Nuwer, 1990, Generic substitutions for antiepileptic drugs, Neurology, 40, 1647, 10.1212/WNL.40.11.1647 Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Assessment: generic substitution for antiepileptic medication. Neurology 1990;40:1641–3 IMS NPA Plus audit year to date October 2001 Ohio Revised Code Ann. 4729.38 Texas Occupations Code 562.008 Pennsylvania statutes, 35 P.S. 960.3 http://fda.gov/cder/ogd/index.htm. FDA Center for Drug Evaluation and Research Approved drug products with therapeutic equivalence evaluations (the Orange Book), 21st ed. Washington, DC: US Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Information Technology, Division of Data Management and Services Switching to generic medications linked to renewed seizure activity. N Y J Epilepsy 1986;V(1) Gilman, 1993, Carbamazepine toxicity resulting from generic substitution, Neurology, 43, 2696, 10.1212/WNL.43.12.2696 Oles, 1992, Therapeutic bioequivalency study of brand name versus generic carbamazepine, Neurology, 42, 1147, 10.1212/WNL.42.6.1147 Hartley, 1990, Breakthrough seizures with generic carbamazepine: a consequence of poorer availability?, Br. J. Clin. Pract., 11, 270, 10.1111/j.1742-1241.1990.tb10813.x Jumao-as, 1989, Comparison of steady-state blood levels of two carbamazepine formulations, Epilepsia, 30, 67, 10.1111/j.1528-1157.1989.tb05283.x Olling, 1999, Bioavailability of carbamazepine from four different products and the occurrence of side effects, Biopharm. Drug Dispos., 20, 19, 10.1002/(SICI)1099-081X(199901)20:1<19::AID-BDD152>3.0.CO;2-Q Sachdeo RC, Belendiuk G. Generic versus branded carbamazepine. Lancet 1987 Jun 20:1432 [letter] Busch RL. Generic carbamazepine and erythema multiforme: generic-drug nonequivalency. N Engl J Med 321:692–3 [letter]