Cerebellar networks with basal ganglia: feasibility for tracking cerebello‐pallidal and subthalamo‐cerebellar projections in the human brain

European Journal of Neuroscience - Tập 38 Số 8 - Trang 3106-3114 - 2013
Esther A. Pelzer1,2, Andreas Hintzen2, Mathias Goldau3,2, D. Yves von Cramon2, Lars Timmermann1, Marc Tittgemeyer2
1Department of Neurology, University Hospital Cologne, Kerpener Strasse 62, Cologne, 50937 Germany
2Max-Planck Institute for Neurological Research Cologne, Cologne, Germany
3Institute of Informatics, University Leipzig, Leipzig, Germany

Tóm tắt

AbstractNeuroanatomical studies using transneuronal virus tracers in macaque monkeys recently demonstrated that substantial interactions exist between basal ganglia and the cerebellum. To what extent these interactions are present in the human brain remains unclear; however, these connections are thought to provide an important framework for understanding cerebellar contributions to the manifestation of basal ganglia disorders, especially with respect to tremor genesis in movement disorders such as Parkinson's disease. Here, we tested the feasibility of assessing these connections in vivo and non‐invasively in the human brain with diffusion magnetic resonance imaging and tractography. After developing a standardized protocol for manual segmentation of basal ganglia and cerebellar structures, masks for diffusion tractography were defined based on structural magnetic resonance images. We tested intra‐ and inter‐observer stability and carried out tractography for dentato‐pallidal and subthalamo‐cerebellar projections. After robustly achieving connection probabilities per tract, the connectivity values and connectional fingerprints were calculated in a group of healthy volunteers. Probabilistic diffusion tractography was applicable to probe the inter‐connection of the cerebellum and basal ganglia. Our data confirmed that dentato‐thalamo‐striato‐pallidal and subthalamo‐cerebellar connections also exist in the human brain at a level similar to those that were recently suggested by transneuronal tracing studies in non‐human primates. Standardized segmentation protocols made these findings reproducible with high stability. We have demonstrated that diffusion tractography in humans in vivo is capable of revealing the structural bases of cerebellar networks with the basal ganglia. These findings support the role of the cerebellum as a satellite system of established cortico‐basal ganglia networks in humans.

Từ khóa


Tài liệu tham khảo

Andersson J.L.R. Jenkinson M. Smith S.&Andersson J.(2007)Non‐linear registration aka spatial normalization: FMRIB technical report TR07JA2.FMRIB Analysis Group of the University of Oxford.

10.1002/mrm.10609

10.1038/nn1075

10.1002/mrm.10609

10.1016/j.neuroimage.2011.08.077

10.1073/pnas.1000496107

10.1016/j.tics.2013.03.003

10.1523/JNEUROSCI.1486-08.2008

10.1016/j.conb.2012.12.002

10.1016/j.neuroimage.2007.06.022

Goldau M., 2011, IEEE Proceedings BioVis 2011, 23

10.1371/journal.pone.0005101

10.1093/brain/aws023

10.1038/nn1544

10.1016/S0006-8993(00)02744-X

10.1089/brain.2011.0033

10.1016/S1361-8415(01)00036-6

10.1006/nimg.2002.1132

10.1093/cercor/bhh105

10.1016/j.neuroimage.2007.05.012

10.3389/fnana.2012.00014

Larsell O., 1972, The Comparative Anatomy and Histology of the Cerebellum: The Human Cerebellum, Cerebellar Connections, and Cerebellar Cortex

10.1006/nimg.2000.0552

Mai J.K., 1997, Atlas of the Human Brain

10.1016/j.neuroimage.2011.10.016

10.1016/S0165-0173(99)00040-5

10.3109/9781420016796

10.1007/978-3-211-73971-6

10.1016/0165-0173(96)00003-3

10.1002/mrm.10308

10.1002/(SICI)1096-9861(19960429)368:2<215::AID-CNE4>3.0.CO;2-6

10.1002/hbm.21404

Schaltenbrand G., 1977, Atlas for Stereotaxy of the Human Brain, 84

10.1006/nimg.1999.0459

10.1093/cercor/bhs036

10.1016/j.neuroimage.2009.05.096

10.1016/S1053-8119(03)00044-2

10.1093/brain/aws360

10.1016/j.neuroimage.2006.09.026

Thông tin
Thông tin xuất bản

European Journal of Neuroscience

Tập 38 Số 8

3106-3114

Thông tin tác giả