Pharmacological blockade of KV1.3 channel as a promising treatment in autoimmune diseases

Journal of Translational Autoimmunity - Tập 5 - Trang 100146 - 2022
Carlos A. Cañas1,2, Santiago Castaño-Valencia3, Fernando Castro-Herrera3
1Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali, Colombia
2Unit of Rheumatology, Fundación Valle del Lili, Cali, Colombia
3Department of Physiological Sciences, Department of Health Sciences, Universidad del Valle, Cali, Colombia

Tài liệu tham khảo

Invernizzi, 2010, Definition of human autoimmunity--autoantibodies versus autoimmune disease, Autoimmun. Rev., 9, A259, 10.1016/j.autrev.2009.12.002 Angum, 2020, The prevalence of autoimmune disorders in women: a narrative review, Cureus, 12 Rosenblum, 2015, Mechanisms of human autoimmunity, J. Clin. Invest., 125, 2228, 10.1172/JCI78088 Castiblanco, 2013, What is next after the genes for autoimmunity?, BMC Med., 11, 197, 10.1186/1741-7015-11-197 Feske, 2015, Ion channels in innate and adaptive immunity, Annu. Rev. Immunol., 33, 291, 10.1146/annurev-immunol-032414-112212 Cahalan, 2009, The functional network of ion channels in T lymphocytes, Immunol. Rev., 231, 59, 10.1111/j.1600-065X.2009.00816.x Wulff, 2007, Targeting effector memory T-cells with Kv1.3 blockers, Curr. Opin. Drug Discov. Dev, 10, 438 Veytia-Bucheli, 2018, Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation, Cell Commun. Signal.: CCS, 16, 45, 10.1186/s12964-018-0257-7 Beeton, 2006, Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases, Proc. Natl. Acad. Sci. U. S. A, 103, 17414, 10.1073/pnas.0605136103 Tarcha, 2017, Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: a randomized phase 1b trial, PLoS One, 12, 10.1371/journal.pone.0180762 Hille, 1989, The Sharpey-Schafer Lecture. Ionic channels: evolutionary origins and modern roles, Q. J. Exp. Physiol., 74, 785, 10.1113/expphysiol.1989.sp003349 Martinac, 2008, Ion channels in microbes, Physiol. Rev., 88, 1449, 10.1152/physrev.00005.2008 Moran, 2015, Evolution of voltage-gated ion channels at the emergence of Metazoa, J. Exp. Biol., 218, 515, 10.1242/jeb.110270 Shen, 1995, Molecular recognition and assembly sequences involved in the subfamily-specific assembly of voltage-gated K+ channel subunit proteins, Neuron, 14, 625, 10.1016/0896-6273(95)90319-4 Murata, 2005, Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor, Nature, 435, 1239, 10.1038/nature03650 Ramsey, 2006, A voltage-gated proton-selective channel lacking the pore domain, Nature, 440, 1213, 10.1038/nature04700 Li, 1992, Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel, Science (New York, N.Y.), 257, 1225, 10.1126/science.1519059 Heinemann, 1996, Functional characterization of Kv channel beta-subunits from rat brain, J. Physiol., 493, 625, 10.1113/jphysiol.1996.sp021409 Hoshi, 1990, Biophysical and molecular mechanisms of Shaker potassium channel inactivation, Science (New York, N.Y.), 250, 533, 10.1126/science.2122519 Cuello, 2010, Structural mechanism of C-type inactivation in K(+) channels, Nature, 466, 203, 10.1038/nature09153 Misonou, 2004, Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons, Crit. Rev. Biochem. Mol. Biol., 39, 125, 10.1080/10409230490475417 Roberds, 1991, Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart, Proc. Natl. Acad. Sci. U. S. A, 88, 1798, 10.1073/pnas.88.5.1798 Cahalan, 1985, A voltage-gated potassium channel in human T lymphocytes, J. Physiol., 358, 197, 10.1113/jphysiol.1985.sp015548 Plattner, 2014, Calcium regulation in the protozoan model, Paramecium tetraurelia, J. Eukaryot. Microbiol., 61, 95, 10.1111/jeu.12070 Plattner, 2013, Ca2+ signalling early in evolution--all but primitive, J. Cell Sci., 126, 2141 Dudev, 2014, Evolution of eukaryotic ion channels: principles underlying the conversion of Ca2⁺-selective to Na⁺-selective channels, J. Am. Chem. Soc., 136, 3553, 10.1021/ja4121132 Liebeskind, 2011, Evolution of sodium channels predates the origin of nervous systems in animals, Proc. Natl. Acad. Sci. U. S. A, 108, 9154, 10.1073/pnas.1106363108 Heinemann, 1992, Calcium channel characteristics conferred on the sodium channel by single mutations, Nature, 356, 441, 10.1038/356441a0 Chopra, 2007, Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates, BMC Evol. Biol., 7, 113, 10.1186/1471-2148-7-113 Feske, 2015, Ion channels in innate and adaptive immunity, Annu. Rev. Immunol., 33, 291, 10.1146/annurev-immunol-032414-112212 Brutkiewicz, 2016, Cell signaling pathways that regulate antigen presentation, J. Immunol. (Baltimore, Md, 197, 2971, 10.4049/jimmunol.1600460 Arthur, 2013, Mitogen-activated protein kinases in innate immunity, Nat. Rev. Immunol., 13, 679, 10.1038/nri3495 Yu, 2004, J. Immunol. (Baltimore, Md, 172, 6047, 10.4049/jimmunol.172.10.6047 Perez-Villar, 1999, Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes, J. Immunol. (Baltimore, Md. : 1950, 163, 6435, 10.4049/jimmunol.163.12.6435 Prakriya, 2015, Store-operated calcium channels, Physiol. Rev., 95, 1383, 10.1152/physrev.00020.2014 Qi, 2007, Keeping the (kinase) party going: SLP-76 and ITK dance to the beat, Sci. STKE : Signal Transduct. Knowl. Environ., pe39 Vaeth, 2020, CRAC channels and calcium signaling in T cell-mediated immunity, Trends Immunol., 41, 878, 10.1016/j.it.2020.06.012 Zhang, 2005, STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane, Nature, 437, 902, 10.1038/nature04147 Vaeth, 2018, NFAT control of immune function, New Front. Abid. Trooper. F1000Res., 7, 260, 10.12688/f1000research.13426.1 Cahalan, 2009, The functional network of ion channels in T lymphocytes, Immunol. Rev., 231, 59, 10.1111/j.1600-065X.2009.00816.x Ledderose, 2020, The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes, Sci. Signal., 13, 10.1126/scisignal.aba3300 Schenk, 2011, ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors, Sci. Signal., 4, ra12, 10.1126/scisignal.2001270 Jin, 2008, Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis, Science (New York, N.Y.), 322, 756, 10.1126/science.1163493 Patocka, 2021, Cyclosporine A: chemistry and toxicity - a review, Curr. Med. Chem., 28, 3925, 10.2174/0929867327666201006153202 Zhang, 2015, Discovery and structural optimization of 1-phenyl-3-(1-phenylethyl)urea derivatives as novel inhibitors of CRAC channel, Acta Pharmacol. Sin., 36, 1137, 10.1038/aps.2015.52 Chung, 1994, Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes, Br. J. Pharmacol., 113, 861, 10.1111/j.1476-5381.1994.tb17072.x Maruyama, 1997, 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release, J. Biochem., 122, 498, 10.1093/oxfordjournals.jbchem.a021780 Prakriya, 2001, Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors, J. Physiol., 536, 3, 10.1111/j.1469-7793.2001.t01-1-00003.x Ishikawa, 2003, A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes, J. Immunol. (Baltimore, Md, 170, 4441, 10.4049/jimmunol.170.9.4441 Zitt, 2004, Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2, J. Biol. Chem., 279, 12427, 10.1074/jbc.M309297200 Chen, 2013, Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions, Mol. Immunol., 54, 355, 10.1016/j.molimm.2012.12.011 Sadaghiani, 2014, Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays, Chem. Biol., 21, 1278, 10.1016/j.chembiol.2014.08.016 Pevarello, 2014, Ca(2+) release-activated Ca(2+) channel inhibitors, Pharma. Patent Anal., 3, 171, 10.4155/ppa.14.7 Wang, 2010, 105 Lin, 2013, Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease, J. Pharmacol. Exp. Therapeut., 345, 225, 10.1124/jpet.112.202788 Aki, 2020, Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation, FASEB bioAdv., 2, 478, 10.1096/fba.2020-00008 Cox, 2013, Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function, PLoS One, 8, 10.1371/journal.pone.0082944 Wulff, 2003, The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS, J. Clin. Invest., 111, 1703, 10.1172/JCI16921 Beeton, 2005, Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases, Mol. Pharmacol., 67, 1369, 10.1124/mol.104.008193 Chiang, 2017, Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions, Nat. Commun., 8, 14644, 10.1038/ncomms14644 Land, 2017, Kv1.3 channel blockade modulates the effector function of B cells in granulomatosis with polyangiitis, Front. Immunol., 8, 1205, 10.3389/fimmu.2017.01205 Veytia-Bucheli, 2018, Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation, Cell Commun. Signal. : CCS, 16, 45, 10.1186/s12964-018-0257-7 Yuan, 2018, A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis, CNS Neurosci. Ther., 24, 967, 10.1111/cns.12848 Tanner, 2017, Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog, Clin. Immunol. (Orlando, Fla, 180, 45, 10.1016/j.clim.2017.03.014 Garcia-Calvo, 1993, Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels, J. Biol. Chem., 268, 18866, 10.1016/S0021-9258(17)46707-X Bednenko, 2018, A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3, mAbs, 10, 636, 10.1080/19420862.2018.1445451 Khodoun, 2020, Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus, Sci. Adv., 6, 10.1126/sciadv.abd1471 Grissmer, 1994, Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines, Mol. Pharmacol., 45, 1227 Varga, 2012, Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells, Mol. Pharmacol., 82, 372, 10.1124/mol.112.078006 Gurrola, 2012, Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes, Biochemistry, 51, 4049, 10.1021/bi300060n Beeton, 2011, Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases, Inflamm. Allergy - Drug Targets, 10, 313, 10.2174/187152811797200641 Teisseyre, 2019, Voltage-gated potassium channel Kv1.3 as a target in therapy of cancer, Front. Oncol., 9, 933, 10.3389/fonc.2019.00933 Castañeda, 1995, Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus, Toxicon : Off. J. Int. Soc. Toxinol., 33, 603, 10.1016/0041-0101(95)00013-C Matheu, 2008, Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block, Immunity, 29, 602, 10.1016/j.immuni.2008.07.015 Kazama, 2016, Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs, Allergy Asthma Clin. Immunol. : Off. J. Can. Soc. Allerg. Clin. Immunol., 12, 60, 10.1186/s13223-016-0168-3 Kazama, 2015, Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: novel therapeutic implications for inflammatory bowel disease, Med. Hypotheses, 85, 61, 10.1016/j.mehy.2015.03.023 Rangaraju, 2015, Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease, J. Alzheim. Dis. : JAD, 44, 797, 10.3233/JAD-141704 Tajti, 2020, The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides, Biochem. Pharmacol., 114146, 10.1016/j.bcp.2020.114146