Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNAMALAT1in ApoE−/−mice

Cardiovascular Research - Tập 115 Số 2 - Trang 302-314 - 2019
Martina Gast1, Bernhard Rauch2,3, Shinichi Nakagawa4,5, Arash Haghikia1,6, Andrzej Jasina1, Jan Haas7,8, Neetika Nath9,10, Lars Jørn Jensen9,10, Andrea Stroux11, Andreas Böhm3, Julian Friebel1, Ursula Rauch1, Carsten Skurk1, Stefan Blankenberg12,13, Tanja Zeller12,13, Kannanganattu V. Prasanth14, Benjamin Meder7,8, Andreas W. Kuß9,10, Ulf Landmesser15,1,6, Wolfgang Poller16,1,6
1Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, Berlin, Germany
2German Center for Cardiovascular Research (DZHK), Felix-Hausdorff-Strasse 3, Greifswald, Germany
3Institute for Pharmacology, Universitätsmedizin Greifswald, Felix-Hausdorff-Strasse 3, Greifswald, Germany
4Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12 jo, Nishi 6-chome, Kita-ku, Sapporo, Japan
5RNA Biology Laboratory, RIKEN Advanced Research Institute, Wako, Saitama, Japan
6German Center for Cardiovascular Research (DZHK), Hindenburgdamm 30, Berlin, Germany
7German Center for Cardiovascular Research (DZHK), Im Neuenheimer Feld 669, Heidelberg, Germany
8Institute for Cardiomyopathies, Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 669, Heidelberg, Germany
9Institute for Bioinformatics, Universitätsmedizin Greifswald, Walther-Rathenau-Strasse 48, Greifswald, Germany
10Interfaculty Institute for Genetics and Functional Genome Research, University of Greifswald, Felix-Hausdorff-Strasse 8, Greifswald, Germany
11Institute for Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Chariteplatz 1, Berlin, Germany
12Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Martinistrasse 52, Hamburg, Germany
13German Center for Cardiovascular Research (DZHK), Site Hamburg/Lübeck/Kiel, Martinistrasse 52, Hamburg, Germany
14Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Chemical and Life Sciences Laboratory, 601 S. Goodwin Avenue, Urbana, IL, USA
15Berlin Institute of Health, Anna-Louisa-Karsch-Strasse 2, Berlin, Germany
16Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany

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Tài liệu tham khảo

Libby, 2011, Progress and challenges in translating the biology of atherosclerosis, Nature, 473, 317, 10.1038/nature10146

Swirski, 2009, Identification of splenic reservoir monocytes and their deployment to inflammatory sites, Science, 325, 612, 10.1126/science.1175202

Poller, 2018, Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives, Eur Heart J, 39, 2704, 10.1093/eurheartj/ehx165

Poller, 2013, Cardiovascular RNA interference therapy: the broadening tool and target spectrum, Circ Res, 113, 588, 10.1161/CIRCRESAHA.113.301056

Gast, 2016, Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity, J Mol Cell Biol, 8, 178, 10.1093/jmcb/mjw003

Imamura, 2014, Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli, Mol Cell, 53, 393, 10.1016/j.molcel.2014.01.009

Bar, 2016, Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy, Circulation, 134, 1484, 10.1161/CIRCULATIONAHA.116.023686

Hirose, 2016, Clues to long noncoding RNA taxonomy, Biochim Biophys Acta, 1859, 1, 10.1016/j.bbagrm.2015.11.011

Sanbonmatsu, 2016, Towards structural classification of long non-coding RNAs, Biochim Biophys Acta, 1859, 41, 10.1016/j.bbagrm.2015.09.011

Wilusz, 2016, Long noncoding RNAs: re-writing dogmas of RNA processing and stability, Biochim Biophys Acta, 1859, 128, 10.1016/j.bbagrm.2015.06.003

Chujo, 2016, Architectural RNAs (arcRNAs): a class of long noncoding RNAs that function as the scaffold of nuclear bodies, Biochim Biophys Acta, 1859, 139, 10.1016/j.bbagrm.2015.05.007

Kashi, 2016, Discovery and functional analysis of lncRNAs: methodologies to investigate an uncharacterized transcriptome, Biochim Biophys Acta, 1859, 3, 10.1016/j.bbagrm.2015.10.010

Shafik, 2016, The emerging epitranscriptomics of long noncoding RNAs, Biochim Biophys Acta, 1859, 59, 10.1016/j.bbagrm.2015.10.019

Yoshimoto, 2016, MALAT1 long non-coding RNA in cancer, Biochim Biophys Acta, 1859, 192, 10.1016/j.bbagrm.2015.09.012

Jiang, 2017, NEAT1 scaffolds RNA-binding proteins and the microprocessor to globally enhance pri-miRNA processing, Nat Struct Mol Biol, 24, 816, 10.1038/nsmb.3455

Zhang, 1992, Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E, Science, 258, 468, 10.1126/science.1411543

Piedrahita, 1992, Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells, Proc Natl Acad Sci USA, 89, 4471, 10.1073/pnas.89.10.4471

Nakagawa, 2012, Malat1 is not an essential component of nuclear speckles in mice, RNA, 18, 1487, 10.1261/rna.033217.112

Nakagawa, 2016, Lessons from reverse-genetic studies of lncRNAs, Biochim Biophys Acta, 1859, 177, 10.1016/j.bbagrm.2015.06.011

Zong, 2016, Natural antisense RNA promotes 3' end processing and maturation of MALAT1 lncRNA, Nucleic Acids Res, 44, 2898, 10.1093/nar/gkw047

Nakagawa, 2014, The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice, Development, 141, 4618, 10.1242/dev.110544

Heimesaat, 2017, Small Intestinal pro-inflammatory immune responses following campylobacter jejuni infection of secondary abiotic IL-10(-/-) mice lacking nucleotide-oligomerization-domain-2, Eur J Microbiol Immunol (Bp), 7, 138, 10.1556/1886.2017.00005

Bobbert, 2011, Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control, Eur Heart J, 32, 1134, 10.1093/eurheartj/ehq498

Zhang, 2018, Multimodal molecular imaging demonstrates myeloperoxidase regulation of matrix metalloproteinase activity in neuroinflammation, Mol Neurobiol

Zhang, 2012, The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult, Cell Rep, 2, 111, 10.1016/j.celrep.2012.06.003

Zhang, 2017, Long noncoding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke, J Neurosci, 37, 1797, 10.1523/JNEUROSCI.3389-16.2017

Tabas, 2016, Macrophage phenotype and function in different stages of atherosclerosis, Circ Res, 118, 653, 10.1161/CIRCRESAHA.115.306256

Huangfu, 2018, LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating beta-catenin, Biochem Biophys Res Commun, 495, 2111, 10.1016/j.bbrc.2017.12.086

Han, 2018, Low-dose sinapic acid abates the pyroptosis of macrophages by downregulation of lncRNA-MALAT1 in rats with diabetic atherosclerosis, J Cardiovasc Pharmacol, 71, 104, 10.1097/FJC.0000000000000550

Huang-Fu, 2018, Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation, Mol Med Rep, 17, 3092

Nahrendorf, 2018, Myeloid cell contributions to cardiovascular health and disease, Nat Med, 24, 711, 10.1038/s41591-018-0064-0

Yang, 2011, ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs, Cell, 147, 773, 10.1016/j.cell.2011.08.054

Stojic, 2018, Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis, Nucleic Acids Res, 46, 5950, 10.1093/nar/gky437

Michalik, 2014, Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ Res, 114, 1389, 10.1161/CIRCRESAHA.114.303265

Eißmann, 2012, Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development, RNA Biol, 9, 1076, 10.4161/rna.21089

Gutschner, 2013, The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells, Cancer Res, 73, 1180, 10.1158/0008-5472.CAN-12-2850

Arun, 2016, Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss, Genes Dev, 30, 34, 10.1101/gad.270959.115

West, 2014, The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites, Mol Cell, 55, 791, 10.1016/j.molcel.2014.07.012

West, 2016, Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization, J Cell Biol, 214, 817, 10.1083/jcb.201601071