Recent progress in asymmetric Biginelli reaction

Molecular Diversity - Tập 17 - Trang 389-407 - 2013
Majid M. Heravi1, Shima Asadi1, Boshra Malekzadeh Lashkariani1
1Department of Chemistry, School of Sciences, Alzahra University, Vanak, Iran

Tóm tắt

The Biginelli reaction, which involves the interaction of ethyl acetoacetate, urea, and an appropriate aryl aldehyde, was first discovered by Pietro Biginelli about 120 years ago. The Biginelli products (3,4-dihydropyrimidin-2(1 $$H$$ )-ones) are interesting materials due to their significant pharmacological and structural profiles. In the last decades, the asymmetric synthesis as a powerful tool has an effective impact on the Biginelli products and has increased their potencies and applications as drugs. Having the importance of this subject in mind, in this review we wish to present the recent rapid progress of asymmetric Biginelli reaction.

Tài liệu tham khảo

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