Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease

Meng Wang1, Xiaojiao Zhang1, Li-Juan Ma1, Rui-Bing Feng1, Chunyan Yan2, Huanxing Su1, Chengwei He1, Jing X. Kang3, Baolin Liu4, Jian-Bo Wan1
1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
2College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
3Laboratory for Lipid Medicine and Technology (LLMT), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
4Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 211198, PR China

Tài liệu tham khảo

Altamirano, 2011, Alcoholic liver disease: pathogenesis and new targets for therapy, Nat. Rev. Gastroenterol. Hepatol., 8, 491, 10.1038/nrgastro.2011.134 Wang, 2016, Dietary alpha-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice, Sci. Rep., 6, 26826, 10.1038/srep26826 You, 2004, Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver, Am. J. Physiol. Gastrointest. Liver Physiol., 287, G1, 10.1152/ajpgi.00056.2004 Lakshman, 2004, Some novel insights into the pathogenesis of alcoholic steatosis, Alcohol, 34, 45, 10.1016/j.alcohol.2004.08.004 Ma, 2016, Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials, Nutr. Rev., 74, 18, 10.1093/nutrit/nuv047 Suganami, 2012, Adipose tissue inflammation and ectopic lipid accumulation, Endocr. J., 59, 849, 10.1507/endocrj.EJ12-0271 Zhong, 2012, Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis, Am. J. Pathol., 180, 998, 10.1016/j.ajpath.2011.11.017 Zechner, 2012, FAT SIGNALS–lipases and lipolysis in lipid metabolism and signaling, Cell Metab., 15, 279, 10.1016/j.cmet.2011.12.018 Egan, 1992, Mechanism of hormone-stimulated lipolysis in adipocytes: translocation of hormone-sensitive lipase to the lipid storage droplet, Proc. Natl. Acad. Sci. U. S. A., 89, 8537, 10.1073/pnas.89.18.8537 Wang, 2016, Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance, J. Lipid Res., 57, 1243, 10.1194/jlr.M067397 Green, 2004, Stimulation of lipolysis by tumor necrosis factor-alpha in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis, Diabetes, 53, 74, 10.2337/diabetes.53.1.74 Sebastian, 2011, Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice, J. Biol. Chem., 286, 35989, 10.1074/jbc.M111.254201 Tang, 2012, Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes, Alcohol. Clin. Exp. Res., 36, 214, 10.1111/j.1530-0277.2011.01607.x Wan, 2010, Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation, Arterioscler. Thromb. Vasc. Biol., 30, 2487, 10.1161/ATVBAHA.110.210054 Bellenger, 2011, High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition, Diabetes, 60, 1090, 10.2337/db10-0901 Lebbadi, 2011, Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease, J. Alzheimers Dis., 27, 853, 10.3233/JAD-2011-111010 Huang, 2013, Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines, Prostaglandins Leukot. Essent. Fat. Acids, 88, 347, 10.1016/j.plefa.2013.02.002 Wada, 2008, Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice, J. Hepatol., 49, 441, 10.1016/j.jhep.2008.04.026 Nanji, 1994, Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats, Alcohol. Clin. Exp. Res., 18, 1280, 10.1111/j.1530-0277.1994.tb00119.x Huang, 2015, Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis, Biofactors, 41, 453, 10.1002/biof.1246 Naveau, 2010, Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease, J. Hepatol., 52, 895, 10.1016/j.jhep.2010.01.029 Neuhofer, 2013, Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation, Diabetes, 62, 1945, 10.2337/db12-0828 Gotoh, 2007, The regulation of adipogenesis through GPR120, Biochem. Biophys. Res. Commun., 354, 591, 10.1016/j.bbrc.2007.01.028 Gether, 2000, Uncovering molecular mechanisms involved in activation of G protein-coupled receptors, Endocr. Rev., 21, 90, 10.1210/edrv.21.1.0390 Oh, 2010, GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects, Cell, 142, 687, 10.1016/j.cell.2010.07.041 Ichimura, 2012, Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human, Nature, 483, 350, 10.1038/nature10798 Kang, 2004, Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids, Nature, 427, 504, 10.1038/427504a Bertola, 2013, Mouse model of chronic and binge ethanol feeding (the NIAAA model), Nat. Protoc., 8, 627, 10.1038/nprot.2013.032 Zhang, 2014, Characterizing plasma phospholipid fatty acid profiles of polycystic ovary syndrome patients with and without insulin resistance using GC-MS and chemometrics approach, J. Pharm. Biomed. Anal., 95, 85, 10.1016/j.jpba.2014.02.014 Hara, 2013, Free fatty acid receptors and their role in regulation of energy metabolism, Rev. Physiol. Biochem. Pharmacol., 164, 77, 10.1007/112_2013_13 Witters, 2006, Chutes and ladders: the search for protein kinases that act on AMPK, Trends Biochem. Sci., 31, 13, 10.1016/j.tibs.2005.11.009 Fulham, 2016, Sexual dimorphism in alcohol induced adipose inflammation relates to liver injury, PLoS One, 11, 10.1371/journal.pone.0164225 Carmen, 2006, Signalling mechanisms regulating lipolysis, Cell. Signal., 18, 401, 10.1016/j.cellsig.2005.08.009 Galitzky, 1995, Differential activation of beta 1-, beta 2- and beta 3-adrenoceptors by catecholamines in white and brown adipocytes, Fundam. Clin. Pharmacol., 9, 324, 10.1111/j.1472-8206.1995.tb00506.x Van Liefde, 1992, Multiple beta adrenergic receptor subclasses mediate the l-isoproterenol-induced lipolytic response in rat adipocytes, J. Pharmacol. Exp. Ther., 262, 552 Kawakami, 1987, Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells, J. Biochem., 101, 331, 10.1093/oxfordjournals.jbchem.a121917 Hauner, 1995, Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture, Diabetologia, 38, 764, 10.1007/s001250050350 Yan, 2013, Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation, Immunity, 38, 1154, 10.1016/j.immuni.2013.05.015 Kuda, 2009, n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet, Diabetologia, 52, 941, 10.1007/s00125-009-1305-z He, 2004, Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors, Nature, 429, 188, 10.1038/nature02488 Kim, 2015, Endogenous ligand for GPR120, docosahexaenoic acid, exerts benign metabolic effects on the skeletal muscles via AMP-activated protein kinase pathway, J. Biol. Chem., 290, 20438, 10.1074/jbc.M115.657379 Ciana, 2006, The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor, EMBO J., 25, 4615, 10.1038/sj.emboj.7601341 Oka, 2009, 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55, J. Biochem., 145, 13, 10.1093/jb/mvn136 O'Neill, 2013, Metabolism of inflammation limited by AMPK and pseudo-starvation, Nature, 493, 346, 10.1038/nature11862 Itariu, 2012, Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial, Am. J. Clin. Nutr., 96, 1137, 10.3945/ajcn.112.037432 Serhan, 2010, Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not, Am. J. Pathol., 177, 1576, 10.2353/ajpath.2010.100322 Serhan, 2005, Resolution of inflammation: the beginning programs the end, Nat. Immunol., 6, 1191, 10.1038/ni1276 Johanns, 2016, AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B, Nat. Commun., 7, 10856, 10.1038/ncomms10856