SemiSPECT: A small‐animal single‐photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays

Medical Physics - Tập 33 Số 2 - Trang 465-474 - 2006
Hyunki Kim1, Lars R. Furenlid2, Michael J. Crawford1, Donald W. Wilson3, H. Bradford Barber2, Todd E. Peterson4, William C. Hunter5, Zhonglin Liu3, James M. Woolfenden3, Harrison H. Barrett2
1College of Optical Sciences, University of Arizona, Tucson, Arizona 85724
2College of Optical Sciences and Department of Radiology, University of Arizona, Tucson, Arizona 85724
3Department of Radiology, University of Arizona, Tucson, Arizona 85724
4Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232.
5Department of Physics, University of Arizona, Tucson, Arizona 85724

Tóm tắt

The first full single‐photon emission computed tomography (SPECT) imager to exploit eight compact high‐intrinsic‐resolution cadmium zinc telluride (CZT) detectors, called SemiSPECT, has been completed. Each detector consists of a CZT crystal and a customized application‐specific integrated circuit (ASIC). The CZT crystal is a slab with a continuous top electrode and a bottom electrode patterned into a array by photolithography. The ASIC is attached to the bottom of the CZT crystal by indium‐bump bonding. A bias voltage of is applied to the continuous electrode. The eight detectors are arranged in an octagonal lead‐shielded ring. Each pinhole in the eight‐pinhole aperture placed at the center of the ring is matched to each individual detector array. An object is imaged onto each detector through a pinhole, and each detector is operated independently with list‐mode acquisition. The imaging subject can be rotated about a vertical axis to obtain additional angular projections. The performance of SemiSPECT was characterized using . When a diameter pinhole is used, the spatial resolution on each axis is about as estimated by the Fourier crosstalk matrix, which provides an algorithm‐independent average resolution over the field of view. The energy resolution achieved by summing neighboring pixel signals in a window is about 10% full‐width‐at‐half‐maximum of the photopeak. The overall system sensitivity is about with the energy window of from the photopeak. Line‐phantom images are presented to visualize the spatial resolution provided by SemiSPECT, and images of bone, myocardium, and human tumor xenografts in mice demonstrate the feasibility of preclinical small‐animal studies with SemiSPECT.

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Tài liệu tham khảo

Walrand S., 2005, Evaluation of novel whole‐body high‐resolution rodent SPECT (Linoview) based on direct acquisition of linogram projections, J. Nucl. Med., 46, 1872

10.1088/0031‐9155/39/3/010

Ishizu K., 1995, Ultra‐high resolution SPECT system using four pinhole collimators for small animal studies, J. Nucl. Med., 36, 2282

Klein W. P., 1995, FASTSPECT: Electrical and mechanical design of a high‐resolution dynamic SPECT imager, Proc. Conf. Rec. IEEE NSS/MIC, 2, 931

10.1109/23.775590

Chatziioannou A. F., 1999, Performance evaluation of microPET: A high‐resolution lutetium oxyorthosilicate PET scanner for animal imaging, J. Nucl. Med., 40, 1164

10.1109/23.940169

10.1109/TNS.2003.817948

10.1109/TNS.2002.807949

10.1109/TNS.2003.812437

10.1109/TNS.2003.817950

10.1088/0031-9155/48/11/303

10.1109/TNS.2004.830975

10.1109/TNS.2004.823337

10.1109/TNS.2005.843615

Beekman F. J., 2005, U‐SPECT‐I: A novel system for submillimeter‐resolution tomography with radiolabeled molecules in mice, J. Nucl. Med., 46, 1194

10.1109/TNS.2002.803801

10.1109/23.256722

10.1109/23.682408

10.1109/23.681995

10.1109/23.506673

10.1007/s11664-997-0229-y

10.1109/TNS.2002.998747

10.1016/0168-9002(94)91637-3

2000 University of Arizona D. G. Marks Estimation methods for semiconductor gamma‐ray detectors

10.1118/1.1677252

10.1109/TMI.2002.804437

10.1364/JOSAA.12.000834

10.1088/0031‐9155/39/3/012

10.1109/TMI.2002.806595

2002 University of Arizona G. K. Kastis Multi‐modality imaging of small animals

2004 University of Arizona H. Kim SemiSPECT: A small‐animal SPECT imager based on eight CdZnTe detector arrays

Barrett H. H., 1981, Radiological imaging: The theory of imaging formation, detection, and processing

10.1016/B978-0-12-349450-4.50025-2

10.1088/0031‐9155/12/4/004

10.1103/PhysRevLett.5.156

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Medical Physics

Tập 33 Số 2

465-474

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