Nanomaterials may call for a reconsideration of the present Japanese chemical regulatory system
Tóm tắt
The nanoscience world has gained the attention of science and technology and is expected to enable the increased understanding and regulation of material science. Although it is not clear what influence nanotechnology development will have on human society, it is necessary to address concerns for both users of the technology and citizens about its influence on the environment and health. Research on the implication of this technology on both health and the environment began with research and development activities of various nanotechnologies in the US and EU, including discussions of proper regulations. The Japanese system of chemical risk control for human health and environment protection, including the Industrial Occupational Safety and Health Law and the Chemical Substances Control Law, may not have sufficient flexibility for new substances, such as nanomaterials, derived from this emerging technology. We have paid little attention to either size-dependent risk or surface treatment/function of chemical substances. As for the certain range of material sizes, one needs to confirm whether such a definition is meaningful from the viewpoint of risk evaluation and control of chemical materials. One must conduct the risk evaluation of each nanomaterial in accordance with the process of existing chemical risk evaluation systems. The assessment of the risk of such nanomaterials will suggest a reconsideration of the existing systems.
Tài liệu tham khảo
Baggs RB, Ferin J, Oberdörster G (1997) Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet Pathol 34(6):592–597
Colvin VL (2003) The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21(10):1166–1170
Council for Science and Technology Policy (CSTP) (2004) Current progress report of science and technology basic plan (2001–2005) Special Committee for Promotion Strategy of Major Area
Donaldson K, Stone V, Gilmour PS, Brown DM, MacNee WNE (2000) Ultrafine particles: mechanisms of lung injury. Phil. Trans. The Royal Society London. A Math Phys Eng Sci 358:2741–2748
Driscoll KE, Maurer JK (1991) Cytokine and growth factor release by alveolar macrophages potential biomarkers of pulmonary toxicity. Toxicol Pathol 19(4):398–405
Durrenberger F, Hock J, Hohener K (2004) Overview of completed and ongoing activities in the field: safety and risks of Nanotechnology TEMAS AG
EC (2004) A Preliminary Risk Analysis on the basis of a WS in Brussels (2004, 3) The Health and Consumer Protection DG
EU Commission (2004) Towards a European strategy for Nanotechnology, communication from the commission, COM 338
Ferin J, Oberdorster G, Soderholm SC, Gelein R (1991) Pulmonary tissue access of ultrafine particles. J Aerosol Med 4(1):57–68
Li XY, Brown D, Smith S, MacNee W, Donaldson K (1999) Short–term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal Toxicol 11:709–731
Malsch I, Gleiche M, Hoffschulz H, Locatelli S, Nicollet C, Guilbert JC, Bogedal M, Morrison M, Oud M (2004) Benefits, risks, ethical, legal and social aspects of Nanotechnology, fourth Nanoforum Report
Meridian Institute and Woodrow Wilson International Center for Scholars (2003) Summary of the first session of the dialogue series on Nanotechnology and federal regulation
Murphy SA, BeruBe KA, Richards RJ (1999) Bioreactivity of carbon black and diesel exhaust particles to primary Clara and type II epithelial cell cultures. Occup Environ Med 56:813–819
National Science and Technology Council (NSTC) (2004) The National Nanotechnology Initiative, Strategic Plan, Nanoscale Science, Engineering and Technology Subcommittee, Committee on Technology
National Science and Technology Council (NSTC) (2005) The National Nanotechnology Initiative, Research and Development Leading to a Revolution in Technology and Industry, Supplement to the President’s FY2006 Budget. Nanoscale Science, Engineering and Technology Subcommittee, Committee on Technology
NIOSH Aerosol Program Assessment Committee Report (2003)
NIOSH CURRENT INTELLIGENCE BULLETIN (2005) Evaluation of health hazard and recommendations for occupational exposure to titanium dioxide. (DRAFT)
Oberdorster G, Gelein RM, Ferin J, Weiss B (1995) Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal Toxicol 7:111–124
Oberdorster G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1–8
President’s Council of Advisors on Science and Technology (PCAST) (2005) The National Nanotechnology initiative at five years. Assessment and Recommendations of the National Nanotechnology Advisory Panel
Renwick LC, Brown D, Clouter A, Donaldson K (2004) Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 61(5):442–447
Roco MC, Bainbridge WS (ed) (2001) Societal Implications of Nanoscience and Nanotechnology NSET Workshop Report
Roco MC (2003) Broader societal issues of nanotechnology. J Nanopart Res 5:181–189
The Royal Society and The Royal Academy of Engineering (RS and RAE) (2004) Nanoscience and Nanotechnologies: opportunities and uncertainties
UK Government (2005) Response to The Royal Society and Academy of Engineering Report
Warheit DB (2004) Nanoparticles: health impacts? Materials Today Feb 2004, pp 32–35
Zhang Q, Kusaka Y, Zhu X, Sato K, Mo Y, Kluz T, Donaldson K (2003) Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. J Occup Health 45(1):23–30