Pharmacophore mapping studies on indolizine derivatives as 15-LOX inhibitors

Vikas Sharma1, Vipin Kumar1,2
1Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India
2Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer 305801, Rajasthan, India

Tài liệu tham khảo

Funk, 1996, The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice, Biochim Biophys Acta Lipids Lipid Metab, 1304, 65, 10.1016/S0005-2760(96)00107-5 Cyrus, 2001, Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice, Circulation, 103, 2277, 10.1161/01.CIR.103.18.2277 George, 2001, 12/15-lipoxygenase gene disruption attenuates atherogenesis in ldl receptor–deficient mice, Circulation, 104, 1646, 10.1161/hc3901.095772 Witztum, 2001, The oxidative modification hypothesis of atherosclerosis: does it hold for humans, Trends Cardiovasc Med, 11, 93, 10.1016/S1050-1738(01)00111-6 Funk, 2001, 12/15-Lipoxygenase, oxidative modification of LDL and atherogenesis, Trends Cardiovasc Med, 11, 116, 10.1016/S1050-1738(01)00096-2 Weaver, 2001, Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells, Free Radical Biol Med, 30, 299, 10.1016/S0891-5849(00)00466-4 Kelavkar, 2000, Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with gleason staging, Carcinogenesis, 21, 1777, 10.1093/carcin/21.10.1777 Kelavkar, 2001, Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis, Carcinogenesis, 22, 1765, 10.1093/carcin/22.11.1765 Shureiqi, 1999, Decreased 13-S-hydroxyoctadecadienoic acid levels and 15- lipoxygenase-1 expression in human colon cancers, Carcinogenesis, 120, 1985, 10.1093/carcin/20.10.1985 Sharma, 2014, Indolizine: a biologically active moiety, Med Chem Res, 23, 3593, 10.1007/s00044-014-0940-1 Sharma, 2010, Biological importance of the indole nucleus in recent years: a comprehensive review, J Het Chem, 47, 491 Sharma, 2013, Heterocyclic chalcone analogues as potential anticancer agents, Anticancer Agents Med Chem, 13, 422 Gundersen, 2003, Indolizines as novel potent inhibitors of 15-lipoxygenase, Bioorg Med Chem, 11, 5409, 10.1016/j.bmc.2003.09.033 Wermuth, 1998, Glossary of Terms Used in Medicinal Chemistry (IUPAC Recommendations 1997), Ann Rep Med Chem, 33, 385, 10.1016/S0065-7743(08)61101-X Yang, 2010, Pharmacophore modeling and applications in drug discovery: challenges and recent advances, Drug Discovery Today, 15, 444, 10.1016/j.drudis.2010.03.013 Cruz, 2014, 3D-QSAR as a tool for understanding and improving single-site polymerization catalysts. a review, Organometallics, 33, 2944, 10.1021/om400721v Hariprasad, 1996, A proposed common spatial pharmacophore and the corresponding active conformations of some peptide leukotriene receptor antagonists, J Comp Aid Mol Des, 10, 284, 10.1007/BF00124498 Maestro, Version 8.5, Schrodinger, LLC, NY2008. PHASE, Version 3.0, Schrodinger, LLC, NY2008. Kaushik, 2012, Computation of pharmacophore models for the prediction of mitogen-activated protein kinase activated protein kinase-2 inhibitory activity of pyrrolopyridines, Med Chem Res, 21, 3777, 10.1007/s00044-011-9910-z Rani, 2011, Development of pharmacophore models for predicting HIV-1 reverse transcriptase inhibitory activity of pyridinone derivatives, Pharm Chem J, 45, 36, 10.1007/s11094-011-0556-4 Goyal, 2011, Pharmacophore modeling studies on aryl thioxothiazolidinones as ADAMTS-5 (Aggrecanase-2) inhibitors, Der Pharma Chem, 3, 448