Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

Ambros, 2004, The functions of animal microRNAs, Nature, 431, 350, 10.1038/nature02871

Berezikov, 2006, Diversity of microRNAs in human and chimpanzee brain, Nat. Genet., 38, 1375, 10.1038/ng1914

Bernstein, 2001, Role for a bidentate ribonuclease in the initiation step of RNA interference, Nature, 409, 363, 10.1038/35053110

Birmingham, 2006, 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets, Nat. Methods, 3, 199, 10.1038/nmeth854

Brennecke, 2003, bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila, Cell, 113, 25, 10.1016/S0092-8674(03)00231-9

Brennecke, 2005, Principles of microRNA-target recognition, PLoS Biol., 3, e85, 10.1371/journal.pbio.0030085

Buckingham, 2005, Building the mammalian heart from two sources of myocardial cells, Nat. Rev. Genet., 6, 826, 10.1038/nrg1710

Chen, 2006, The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation, Nat. Genet., 38, 228, 10.1038/ng1725

Cheng, 2003, Genetic modifiers of cardiac arrhythmias, Trends Mol. Med., 9, 59, 10.1016/S1471-4914(03)00004-2

Cohen, 2006, Denoising feedback loops by thresholding–a new role for microRNAs, Genes Dev., 20, 2769, 10.1101/gad.1484606

Costantini, 2005, The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient, Cell, 123, 347, 10.1016/j.cell.2005.08.004

Desai, 2006, Prognostic Significance of Quantitative QRS Duration, Am. J. Med., 119, 600, 10.1016/j.amjmed.2005.08.028

Didiano, 2006, Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions, Nat. Struct. Mol. Biol., 13, 849, 10.1038/nsmb1138

Du, 2005, microPrimer: The biogenesis and function of microRNA, Development, 132, 4645, 10.1242/dev.02070

Fischer, 2003, Hey genes in cardiovascular development, Trends Cardiovasc. Med., 13, 221, 10.1016/S1050-1738(03)00082-3

Garg, 2003, GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5, Nature, 424, 443, 10.1038/nature01827

Garg, 2005, Mutations in NOTCH1 cause aortic valve disease, Nature, 437, 270, 10.1038/nature03940

Gottlieb, 2002, Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis, Nat. Genet., 31, 25, 10.1038/ng866

Gourdie, 1999, Conducting the embryonic heart: Orchestrating development of specialized cardiac tissues, Trends Cardiovasc. Med., 9, 18, 10.1016/S1050-1738(98)00035-8

Harfe, 2005, The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb, Proc. Natl. Acad. Sci. USA, 102, 10898, 10.1073/pnas.0504834102

Hoffman, 2004, Prevalence of congenital heart disease, Am. Heart J., 147, 425, 10.1016/j.ahj.2003.05.003

Hornstein, 2005, The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development, Nature, 438, 671, 10.1038/nature04138

Jackson, 2006, Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity, RNA, 12, 1179, 10.1261/rna.25706

Johnston, 2003, A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans, Nature, 426, 845, 10.1038/nature02255

Kim, 2006, Muscle-specific microRNA miR-206 promotes muscle differentiation, J. Cell Biol., 174, 677, 10.1083/jcb.200603008

Kloosterman, 2006, The diverse functions of microRNAs in animal development and disease, Dev. Cell, 11, 441, 10.1016/j.devcel.2006.09.009

Koo, 2005, Mind bomb 1 is essential for generating functional Notch ligands to activate Notch, Development, 132, 3459, 10.1242/dev.01922

Kwon, 2005, MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling, Proc. Natl. Acad. Sci. USA, 102, 18986, 10.1073/pnas.0509535102

Lagos-Quintana, 2001, Identification of novel genes coding for small expressed RNAs, Science, 294, 853, 10.1126/science.1064921

Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 843, 10.1016/0092-8674(93)90529-Y

Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15, 10.1016/j.cell.2004.12.035

Li, 1996, Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development, J. Mol. Cell. Cardiol., 28, 1737, 10.1006/jmcc.1996.0163

Liao, 2004, Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage, Hum. Mol. Genet., 13, 1577, 10.1093/hmg/ddh176

Lim, 2005, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, 433, 769, 10.1038/nature03315

MacLellan, 2000, Genetic dissection of cardiac growth control pathways, Annu. Rev. Physiol., 62, 289, 10.1146/annurev.physiol.62.1.289

McFadden, 2005, The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner, Development, 132, 189, 10.1242/dev.01562

Moses, 2001, Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice, Genesis, 31, 176, 10.1002/gene.10022

Moss, 1997, The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA, Cell, 88, 637, 10.1016/S0092-8674(00)81906-6

Nakagawa, 1999, HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments, Dev. Biol., 216, 72, 10.1006/dbio.1999.9454

Olson, 2006, Gene regulatory networks in the evolution and development of the heart, Science, 313, 1922, 10.1126/science.1132292

Rajewsky, 2006, microRNA target predictions in animals, Nat. Genet., 38, S8, 10.1038/ng1798

Rao, 2006, Myogenic factors that regulate expression of muscle-specific microRNAs, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0602831103

Redon, 2006, Global variation in copy number in the human genome, Nature, 444, 444, 10.1038/nature05329

Reinhart, 2000, The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans, Nature, 403, 901, 10.1038/35002607

Sayed, 2007, MicroRNAs play an essential role in the development of cardiac hypertrophy, Circ. Res., 100, 416, 10.1161/01.RES.0000257913.42552.23

Shin, 2002, Modulation of cardiac growth and development by HOP, an unusual homeodomain protein, Cell, 110, 725, 10.1016/S0092-8674(02)00933-9

Sokol, 2005, Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth, Genes Dev., 19, 2343, 10.1101/gad.1356105

Soonpaa, 1998, Survey of studies examining mammalian cardiomyocyte DNA synthesis, Circ. Res., 83, 15, 10.1161/01.RES.83.1.15

Srivastava, 2006, Making or breaking the heart: From lineage determination to morphogenesis, Cell, 126, 1037, 10.1016/j.cell.2006.09.003

Srivastava, 1995, A subclass of bHLH proteins required for cardiac morphogenesis, Science, 270, 1995, 10.1126/science.270.5244.1995

Srivastava, 1997, Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND, Nat. Genet., 16, 154, 10.1038/ng0697-154

Stark, 2003, Identification of Drosophila MicroRNA targets, PLoS Biol., 1, E60, 10.1371/journal.pbio.0000060

Thom, 2006, Heart disease and stroke statistics–2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Circulation, 113, e85, 10.1161/CIRCULATIONAHA.105.171600

Torella, 2006, Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration, Nat. Clin. Pract. Cardiovasc. Med., 3, S83, 10.1038/ncpcardio0409

Valencia-Sanchez, 2006, Control of translation and mRNA degradation by miRNAs and siRNAs, Genes Dev., 20, 515, 10.1101/gad.1399806

van Rooij, 2006, A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure, Proc. Natl. Acad. Sci. USA, 103, 18255, 10.1073/pnas.0608791103

Vella, 2004, The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR, Genes Dev., 18, 132, 10.1101/gad.1165404

Wei, 1998, Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena, Proc. Natl. Acad. Sci. USA, 95, 7480, 10.1073/pnas.95.13.7480

Wienholds, 2005, MicroRNA expression in zebrafish embryonic development, Science, 309, 310, 10.1126/science.1114519

Wightman, 1993, Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans, Cell, 75, 855, 10.1016/0092-8674(93)90530-4

Xie, 2005, Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals, Nature, 434, 338, 10.1038/nature03441

Xin, 2006, A threshold of GATA4 and GATA6 expression is required for cardiovascular development, Proc. Natl. Acad. Sci. USA, 103, 11189, 10.1073/pnas.0604604103

Yamagishi, 2001, The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation, Dev. Biol., 239, 190, 10.1006/dbio.2001.0417

Yamagishi, 2003, Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer, Genes Dev., 17, 269, 10.1101/gad.1048903

Yelon, 2000, The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development, Development, 127, 2573, 10.1242/dev.127.12.2573

Yi, 2006, Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs, Nat. Genet., 38, 356, 10.1038/ng1744

Zhao, 2005, Serum response factor regulates a muscle-specific mircroRNA that targets Hand2 during cardiogenesis, Nature, 436, 214, 10.1038/nature03817

Zhao, 2007, A developmental view of microRNA function, Trends Biochem. Sci., 10.1016/j.tibs.2007.02.006

Zipes, 1998, Sudden cardiac death, Circulation, 98, 2334, 10.1161/01.CIR.98.21.2334