IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Journal of Clinical Investigation - Tập 127 Số 8 - Trang 2930-2940 - 2017
Mark Ayers1, Jared Lunceford1, Michael Nebozhyn1, Erin Murphy1, Andrey Loboda1, David R. Kaufman1, Andrew Albright1, Jonathan D. Cheng1, Shijun Kang1, Veena Shankaran2, Sarina A. Piha‐Paul3, Jennifer H. Yearley1, Tanguy Y. Seiwert4, Antoni Ribas5, Terrill K. McClanahan1
1Merck & Co., Inc., Kenilworth, New Jersey, USA
2University of Washington, Seattle, Washington USA
3University of Texas MD Anderson Cancer Center, Houston, Texas, USA
4University of Chicago Chicago, Illinois, USA
5UCLA, Los Angeles, California, USA.

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1038/nrc3239

10.1016/j.immuni.2013.07.012

10.1146/annurev.immunol.26.021607.090331

10.1038/nature13954

10.1038/ni1443

10.1056/NEJMoa1305133

10.1038/nature09666

10.1126/science.aaa1348

Faridi, 2011, Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer, Virol J, 8, 10.1186/1743-422X-8-269

10.1016/S1359-6101(01)00038-7

10.1158/2159-8290.CD-13-0458

10.1002/eji.200324228

10.1038/bjc.2015.101

10.1080/2162402X.2015.1008824

Spranger, 2013, Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells, Sci Transl Med, 5, 10.1126/scitranslmed.3006504

10.1056/NEJMoa1501824

10.1038/nature14011

Wallden, 2016, Development and analytical performance of a molecular diagnostic for anti-PD1 response on the nCounter Dx Analysis System, J Clin Oncol, 34

10.1016/S1470-2045(16)30066-3

10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3

10.1158/0008-5472.CAN-08-2281

Taube, 2012, Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape, Sci Transl Med, 4, 10.1126/scitranslmed.3003689

10.1126/science.aaa8172

10.1158/2159-8290.CD-15-0563

10.1038/nature14404

10.1073/pnas.1320318110

10.1038/nm.3541

Zou, 2005, Regularization and variable selection via the elastic net, J Royal Statist Soc B, 67, 301, 10.1111/j.1467-9868.2005.00503.x