TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia

Experimental Hematology - Tập 53 - Trang 7-15 - 2017
Takaomi Sanda1,2, Wei Zhong Leong1
1Cancer Science Institute of Singapore, National University of Singapore, Singapore
2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Tài liệu tham khảo

Pui, 2008, Acute lymphoblastic leukaemia, Lancet, 371, 1030, 10.1016/S0140-6736(08)60457-2 Armstrong, 2005, Molecular genetics of acute lymphoblastic leukemia, J Clin Oncol, 23, 6306, 10.1200/JCO.2005.05.047 Look, 1997, Oncogenic transcription factors in the human acute leukemias, Science, 278, 1059, 10.1126/science.278.5340.1059 Shannon, 1998, Genetic predispositions and childhood cancer, Environ Health Perspect, 106 Suppl 3, 801 Olsen, 1995, Cancer in the parents of children with cancer, N Engl J Med, 333, 1594, 10.1056/NEJM199512143332403 Rudant, 2007, Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin's lymphoma: the ESCALE study (SFCE), Int J Cancer, 121, 119, 10.1002/ijc.22624 Lawrence, 2014, Discovery and saturation analysis of cancer genes across 21 tumour types, Nature, 505, 495, 10.1038/nature12912 Alexandrov, 2013, Signatures of mutational processes in human cancer, Nature, 500, 415, 10.1038/nature12477 Mullighan, 2009, Global genomic characterization of acute lymphoblastic leukemia, Semin Hematol, 46, 3, 10.1053/j.seminhematol.2008.09.005 Aifantis, 2008, Molecular pathogenesis of T-cell leukaemia and lymphoma, Nat Rev Immunol, 8, 380, 10.1038/nri2304 Belver, 2016, The genetics and mechanisms of T cell acute lymphoblastic leukaemia, Nat Rev Cancer, 16, 494, 10.1038/nrc.2016.63 Iacobucci, 2017, Genetic basis of acute lymphoblastic leukemia, J Clin Oncol, 35, 975, 10.1200/JCO.2016.70.7836 Ferrando, 2003, Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation, Blood, 102, 262, 10.1182/blood-2002-10-3221 Ferrando, 2002, Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia, Cancer Cell, 1, 75, 10.1016/S1535-6108(02)00018-1 Yeoh, 2002, Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling, Cancer Cell, 1, 133, 10.1016/S1535-6108(02)00032-6 Homminga, 2011, Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia, Cancer Cell, 19, 484, 10.1016/j.ccr.2011.02.008 Weng, 2004, Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia, Science, 306, 269, 10.1126/science.1102160 Okuda, 1995, Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia, Blood, 85, 2321, 10.1182/blood.V85.9.2321.bloodjournal8592321 Thompson, 2007, The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia, J Exp Med, 204, 1825, 10.1084/jem.20070872 O'Neil, 2007, FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors, J Exp Med, 204, 1813, 10.1084/jem.20070876 Pear, 1996, Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles, J Exp Med, 183, 2283, 10.1084/jem.183.5.2283 Li, 2008, Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1, J Exp Med, 205, 2851, 10.1084/jem.20081561 Palomero, 2006, NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth, Proc Natl Acad Sci U S A, 103, 18261, 10.1073/pnas.0606108103 Sharma, 2006, Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc, Mol Cell Biol, 26, 8022, 10.1128/MCB.01091-06 Weng, 2006, c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma, Genes Dev, 20, 2096, 10.1101/gad.1450406 Sanda, 2010, Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia, Blood, 115, 1735, 10.1182/blood-2009-07-235143 Mullighan, 2007, Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia, Nature, 446, 758, 10.1038/nature05690 Li, 2014, Cyclin C is a haploinsufficient tumour suppressor, Nat Cell Biol, 16, 1080, 10.1038/ncb3046 O'Neil, 2007, Alu elements mediate MYB gene tandem duplication in human T-ALL, J Exp Med, 204, 3059, 10.1084/jem.20071637 Lahortiga, 2007, Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia, Nat Genet, 39, 593, 10.1038/ng2025 Gutierrez, 2011, The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia, Blood, 118, 4169, 10.1182/blood-2010-11-318873 Gutierrez, 2009, High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia, Blood, 114, 647, 10.1182/blood-2009-02-206722 Gutierrez, 2010, Inactivation of LEF1 in T-cell acute lymphoblastic leukemia, Blood, 115, 2845, 10.1182/blood-2009-07-234377 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Comeaux, 2017, TP53 Mutations in hypodiploid acute lymphoblastic leukemia, Cold Spring Harb Perspect Med, 7, a026286, 10.1101/cshperspect.a026286 McCormack, 2004, Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency, N Engl J Med, 350, 913, 10.1056/NEJMra032207 Hacein-Bey-Abina, 2002, Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy, N Engl J Med, 346, 1185, 10.1056/NEJMoa012616 Hacein-Bey-Abina, 2003, A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency, N Engl J Med, 348, 255, 10.1056/NEJM200301163480314 Hacein-Bey-Abina, 2003, LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1, Science, 302, 415, 10.1126/science.1088547 Howe, 2008, Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients, J Clin Invest, 118, 3143, 10.1172/JCI35798 Qasim, 2009, Progress and prospects: gene therapy for inherited immunodeficiencies, Gene Ther, 16, 1285, 10.1038/gt.2009.127 O'Neil, 2006, Activating Notch1 mutations in mouse models of T-ALL, Blood, 107, 781, 10.1182/blood-2005-06-2553 Zha, 2010, ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification, J Exp Med, 207, 1369, 10.1084/jem.20100285 Tremblay, 2010, Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes, Genes Dev, 24, 1093, 10.1101/gad.1897910 Eguchi-Ishimae, 2008, NOTCH1 mutation can be an early, prenatal genetic event in T-ALL, Blood, 111, 376, 10.1182/blood-2007-02-074690 Porcher, 2017, SCL/TAL1: a multifaceted regulator from blood development to disease, Blood, 129, 2051, 10.1182/blood-2016-12-754051 Begley, 1989, Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript, Proc Natl Acad Sci U S A, 86, 2031, 10.1073/pnas.86.6.2031 Shivdasani, 1995, Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL, Nature, 373, 432, 10.1038/373432a0 Porcher, 1996, The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages, Cell, 86, 47, 10.1016/S0092-8674(00)80076-8 Drake, 1997, TAL1/SCL is expressed in endothelial progenitor cells/angioblasts and defines a dorsal-to-ventral gradient of vasculogenesis, Dev Biol, 192, 17, 10.1006/dbio.1997.8751 Mouthon, 1993, Expression of tal-1 and GATA-binding proteins during human hematopoiesis, Blood, 81, 647, 10.1182/blood.V81.3.647.647 Herblot, 2000, SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression, Nat Immunol, 1, 138, 10.1038/77819 Mikkola, 2003, Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene, Nature, 421, 547, 10.1038/nature01345 Curtis, 2004, SCL is required for normal function of short-term repopulating hematopoietic stem cells, Blood, 103, 3342, 10.1182/blood-2003-09-3202 Souroullas, 2009, Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival, Cell Stem Cell, 4, 180, 10.1016/j.stem.2009.01.001 Wadman, 1997, The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins, EMBO J, 16, 3145, 10.1093/emboj/16.11.3145 Kassouf, 2010, Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells, Genome Res, 20, 1064, 10.1101/gr.104935.110 Wilson, 2010, Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators, Cell Stem Cell, 7, 532, 10.1016/j.stem.2010.07.016 Palii, 2011, Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages, EMBO J, 30, 494, 10.1038/emboj.2010.342 Porcher, 1999, Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding, Development, 126, 4603, 10.1242/dev.126.20.4603 Kassouf, 2008, Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis, Blood, 112, 1056, 10.1182/blood-2007-12-128900 El Omari, 2013, Structural basis for LMO2-driven recruitment of the SCL: E47bHLH heterodimer to hematopoietic-specific transcriptional targets, Cell Rep, 4, 135, 10.1016/j.celrep.2013.06.008 Moignard, 2013, Transcriptional hierarchies regulating early blood cell development, Blood Cells Mol Dis, 51, 239, 10.1016/j.bcmd.2013.07.007 Novershtern, 2011, Densely interconnected transcriptional circuits control cell states in human hematopoiesis, Cell, 144, 296, 10.1016/j.cell.2011.01.004 Wilson, 2009, The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development, Blood, 113, 5456, 10.1182/blood-2009-01-200048 Odom, 2006, Core transcriptional regulatory circuitry in human hepatocytes, Mol Syst Biol, 2, 2006.0017, 10.1038/msb4100059 Cole, 2008, Mapping key features of transcriptional regulatory circuitry in embryonic stem cells, Cold Spring Harb Symp Quant Biol, 73, 183, 10.1101/sqb.2008.73.027 Saint-Andre, 2016, Models of human core transcriptional regulatory circuitries, Genome Res, 26, 385, 10.1101/gr.197590.115 Boyer, 2005, Core transcriptional regulatory circuitry in human embryonic stem cells, Cell, 122, 947, 10.1016/j.cell.2005.08.020 Kim, 2008, An extended transcriptional network for pluripotency of embryonic stem cells, Cell, 132, 1049, 10.1016/j.cell.2008.02.039 Loh, 2006, The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells, Nat Genet, 38, 431, 10.1038/ng1760 Batta, 2014, Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells, Cell Rep, 9, 1871, 10.1016/j.celrep.2014.11.002 Whyte, 2013, Master transcription factors and mediator establish super-enhancers at key cell identity genes, Cell, 153, 307, 10.1016/j.cell.2013.03.035 Hnisz, 2013, Super-enhancers in the control of cell identity and disease, Cell, 155, 934, 10.1016/j.cell.2013.09.053 Bernstein, 2010, The NIH Roadmap Epigenomics Mapping Consortium, Nat Biotechnol, 28, 1045, 10.1038/nbt1010-1045 Mansour, 2014, Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element, Science, 346, 1373, 10.1126/science.1259037 Breit, 1993, Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes, J Exp Med, 177, 965, 10.1084/jem.177.4.965 Kelliher, 1996, Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha, EMBO J, 15, 5160, 10.1002/j.1460-2075.1996.tb00900.x Draheim, 2011, A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice, Oncogene, 30, 1252, 10.1038/onc.2010.495 Aplan, 1997, An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice, EMBO J, 16, 2408, 10.1093/emboj/16.9.2408 O'Neil, 2004, TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB, Cancer Cell, 5, 587, 10.1016/j.ccr.2004.05.023 Abraham, 2017, Small genomic insertions form enhancers that misregulate oncogenes, Nat Commun, 8, 14385, 10.1038/ncomms14385 Li, 2017, APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL, Leukemia, 10.1038/leu.2017.75 Rahman, 2017, Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia, Blood, 129, 3221, 10.1182/blood-2016-09-742148 Hsu, 1994, Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells, Proc Natl Acad Sci U S A, 91, 3181, 10.1073/pnas.91.8.3181 Grutz, 1998, The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells, EMBO J, 17, 4594, 10.1093/emboj/17.16.4594 Sanda, 2012, Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia, Cancer Cell, 22, 209, 10.1016/j.ccr.2012.06.007 Kwiatkowski, 2014, Targeting transcription regulation in cancer with a covalent CDK7 inhibitor, Nature, 511, 616, 10.1038/nature13393 Kee, 2009, E and ID proteins branch out, Nat Rev Immunol, 9, 175, 10.1038/nri2507 Murre, 2005, Helix-loop-helix proteins and lymphocyte development, Nat Immunol, 6, 1079, 10.1038/ni1260 Engel, 2001, Early thymocyte development is regulated by modulation of E2A protein activity, J Exp Med, 194, 733, 10.1084/jem.194.6.733 Takeda, 1990, Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins, Mol Cell Biol, 10, 5027 Kee, 1998, Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12, J Exp Med, 188, 699, 10.1084/jem.188.4.699 Schwartz, 2006, Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development, Proc Natl Acad Sci U S A, 103, 9976, 10.1073/pnas.0603728103 Bain, 1997, E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas, Mol Cell Biol, 17, 4782, 10.1128/MCB.17.8.4782 Goldfarb, 1995, Inhibition of cellular differentiation by the SCL/tal oncoprotein: transcriptional repression by an Id-like mechanism, Blood, 85, 465, 10.1182/blood.V85.2.465.465 O'Neil, 2001, The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice, Oncogene, 20, 3897, 10.1038/sj.onc.1204519 Nie, 2003, Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities, EMBO J, 22, 5780, 10.1093/emboj/cdg567 Yui, 2014, Developmental gene networks: a triathlon on the course to T cell identity, Nat Rev Immunol, 14, 529, 10.1038/nri3702 Fasseu, 2007, p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis, Blood, 110, 2610, 10.1182/blood-2007-01-066209 Liau, 2017, Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia, Leukemia, 10.1038/leu.2016.392 Chen, 2009, Zebrafish blood stem cells, J Cell Biochem, 108, 35, 10.1002/jcb.22251 Wang, 2011, Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells, Proc Natl Acad Sci U S A, 108, 14908, 10.1073/pnas.1109023108 Appert, 2009, Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia, Cancer Res, 69, 4784, 10.1158/0008-5472.CAN-08-4774 Tanaka, 2011, Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain, J Biol Chem, 286, 3707, 10.1074/jbc.M110.188193 Chambers, 2015, LMO2 at 25 years: a paradigm of chromosomal translocation proteins, Open Biol, 5, 150062, 10.1098/rsob.150062 Knoechel, 2014, An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia, Nat Genet, 46, 364, 10.1038/ng.2913