Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain
Tài liệu tham khảo
Selkoe, 2001, Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein, J Alzheimers Dis, 3, 75, 10.3233/JAD-2001-3111
Nishitomi, 2006, BACE1 inhibition reduces endogenous abeta and alters APP processing in wild-type mice, J Neurochem, 99, 1555, 10.1111/j.1471-4159.2006.04178.x
Vassar, 2002, β-Secretase (BACE) as a drug target for Alzheimer's disease, Adv Drug Del Rev, 54, 1589, 10.1016/S0169-409X(02)00157-6
Iwata, 2003, Amyloid-beta peptide metabolism and Alzheimer's disease, Nippon Yakurigaku Zasshi, 122, 5, 10.1254/fpj.122.5
Selkoe, 1996, Amyloid beta-protein and the genetics of Alzheimer's disease, J Biol Chem, 271, 18295, 10.1074/jbc.271.31.18295
Vassar, 2005, Beta-secretase, APP, and abeta in Alzheimer's disease, Subcell Biochem, 38, 79, 10.1007/0-387-23226-5_4
Behl, 1994, Hydrogen peroxide mediates amyloid beta protein toxicity, Cell, 77, 817, 10.1016/0092-8674(94)90131-7
Selkoe, 1994, Alzheimer's disease: a central role for amyloid, J Neuropathol Exp Neurol, 53, 438, 10.1097/00005072-199409000-00003
Mattson, 1993, Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF, Brain Res, 621, 35, 10.1016/0006-8993(93)90295-X
Harada, 1999, Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons, Brain Res, 842, 311, 10.1016/S0006-8993(99)01808-9
Busciglio, 1995, Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding, Neuron, 14, 879, 10.1016/0896-6273(95)90232-5
Wang, 2008, Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins, Proc Natl Acad Sci USA, 105, 19318, 10.1073/pnas.0804871105
Busciglio, 1993, Beta-amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins, J Neurochem, 61, 1565, 10.1111/j.1471-4159.1993.tb13658.x
Pigino, 2001, Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation, J Neurosci, 21, 834, 10.1523/JNEUROSCI.21-03-00834.2001
Kienlen-Campard, 2002, Intracellular amyloid-beta 1–42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis, J Biol Chem, 277, 15666, 10.1074/jbc.M200887200
Casas, 2004, Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model, Am J Patho, 165, 1289, 10.1016/S0002-9440(10)63388-3
Bernardo, 2007, Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet, Neurobiol Aging, 28, 1195, 10.1016/j.neurobiolaging.2006.05.035
Iwatsubo, 2000, Beta-amyloid cascade: current status and future directions, Clin Neurol, 40, 1228
Gandy, 1993, Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein, Ann NY Acad Sci, 695, 117, 10.1111/j.1749-6632.1993.tb23038.x
Lee, 2003, APP processing is regulated by cytoplasmic phosphorylation, J Cell Biol, 163, 83, 10.1083/jcb.200301115
Pierrot, 2006, Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation, J Biol Chem, 281, 39907, 10.1074/jbc.M606015200
Clarke, 1998, Folate, vitamin B12, and serum total levels in confirmed Alzheimer disease, Arch Neurol, 55, 1449, 10.1001/archneur.55.11.1449
McCaddon, 1998, Total serum homocysteine in senile dementia of Alzheimer type, Int J Geriatr Psychiatry, 13, 235, 10.1002/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8
Obeid, 2006, Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia, FEBS Lett, 580, 2994, 10.1016/j.febslet.2006.04.088
Ravaglia, 2005, Homocysteine and folacin as risk factors for dementia and Alzheimer disease, Am J Clin Nutr, 82, 636, 10.1093/ajcn/82.3.636
Seshadri, 2002, Plasma homocysteine as a risk factor for dementia and Alzheimer's disease, N Engl J Med, 346, 476, 10.1056/NEJMoa011613
Levitt, 1992, Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease, Acta Psychiatr Scand, 86, 301, 10.1111/j.1600-0447.1992.tb03270.x
Fowler, 2005, Homocysteine: overview of biochemistry, molecular biology, and role in disease processes, Semin Vasc Med, 5, 77, 10.1055/s-2005-872394
Zhang, 2008, Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus, Neurobiol Aging, 29, 1654, 10.1016/j.neurobiolaging.2007.04.015
Pacheco-Quinto, 2006, Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels, Neurobiol Dis, 22, 651, 10.1016/j.nbd.2006.01.005
Hultberg, 2000, Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines, Toxicology, 147, 69, 10.1016/S0300-483X(00)00189-X
Kruman, 2000, Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity, J Neurosci, 20, 6920, 10.1523/JNEUROSCI.20-18-06920.2000
Kruman, 2002, Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease, J Neurosci, 22, 1752, 10.1523/JNEUROSCI.22-05-01752.2002
Sasaki, 2003, Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation, J Am Coll Cardiol, 42, 364, 10.1016/S0735-1097(03)00629-6
Sun, 2002, Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines, NeurobiolAging, 23, 195
Wang, 1999, The levels of soluble versus insoluble brain abeta distinguish Alzheimer's disease from normal and pathologic aging, Exp Neurol, 158, 328, 10.1006/exnr.1999.7085
Zhang, 2006, Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms, FASEB J, 20, 1431, 10.1096/fj.05-5223com
Liu, 2003, Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory, J Neurochem, 87, 1333, 10.1046/j.1471-4159.2003.02070.x
Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat, J Neurosci Methods, 11, 47, 10.1016/0165-0270(84)90007-4
DeGiorgio, 2002, Transient appearance of amyloid precursor protein plaques in the brain of thymectomized rats after human leptomeningeal cell grafts, Neurosci Letters, 322, 62, 10.1016/S0304-3940(02)00065-4
Sastre, 2004, Binding of cystatin C to Alzheimer's amyloid β inhibits in vitro amyloid fibril formation, Neurobiol Aging, 25, 1033, 10.1016/j.neurobiolaging.2003.11.006
Gouras, 2000, Testosterone reduces neuronal secretion of Alzheimer's β -amyloid peptides, Proc Natl Acad Sci USA, 97, 1202, 10.1073/pnas.97.3.1202
Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity, Nature, 402, 533, 10.1038/990107
Busciglio, 1992, Methodological variables in the assessmen of beta amyloid neurotoxicity, Neurobiol Aging, 13, 609, 10.1016/0197-4580(92)90065-6
Gottfties, 1998, Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease, J Neural Transm, 105, 773, 10.1007/s007020050094
Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994
Sisodia, 2002, Gamma-secretase, notch, abeta and Alzheimer's disease: where do the presenilins fit in?, Nat Rev Neurosci, 3, 281, 10.1038/nrn785
Edbauer, 2003, Reconstitution of γ -secretase activity, Nat Cell Biol, 5, 486, 10.1038/ncb960
Kimberly, 2003, Identity and function of gamma-secretase, J Neurosci Res, 74, 353, 10.1002/jnr.10736
Bergman, 1998, DNA demethylation: turning genes on, J Biol Chem, 379, 401
Razin, 1998, CpG methylation, chromatin structure and gene silencing-a three-way connection, EMBO J, 17, 4905, 10.1093/emboj/17.17.4905
Scarpa, 2003, Presenilin 1 gene silencing by S- adenosylmethionine: a treatment for Alzheimer disease?, FEBS Lett, 541, 145, 10.1016/S0014-5793(03)00277-1
Fuso, 2005, S-adenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production, Mol Cell Neurosci, 28, 195, 10.1016/j.mcn.2004.09.007
Hasegawa, 2005, Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease, J Neurosci Res, 80, 869, 10.1002/jnr.20514
Heredia, 2004, Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein, Neurobiol Dis, 16, 617, 10.1016/j.nbd.2004.04.015
Iijima, 2000, Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5, J Neurochem, 75, 1085, 10.1046/j.1471-4159.2000.0751085.x
Dewji, 1998, Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: Its significance for Alzheimer's disease, Proc Natl Acad Sci USA, 95, 5055, 10.1073/pnas.95.25.15055
Kimberly, 2005, Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation, J Neurosci, 25, 5533, 10.1523/JNEUROSCI.4883-04.2005
Rockenstein, 2007, Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation, J Neurosci, 27, 1981, 10.1523/JNEUROSCI.4321-06.2007
Ryder, 2003, Divergent roles of GSK-3 and Cdk-5 in APP processing, Biochem Biophys Res Commun, 312, 922, 10.1016/j.bbrc.2003.11.014
Standen, 2001, Phosphorylation of thr (668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3), J Neurochem, 76, 316, 10.1046/j.1471-4159.2001.00102.x
Holzer, 2000, Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons, J Neural Transm, 107, 451, 10.1007/s007020070087
Sontag, 2007, Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation, J Neurosci, 27, 2751, 10.1523/JNEUROSCI.3316-06.2007
Wang, 2008, Microtubule-associated protein tau in development, degeneration and protection of neurons, Prog Neurobiol, 85, 148, 10.1016/j.pneurobio.2008.03.002
Elias, 2000, The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort, Arch Neurol, 57, 808, 10.1001/archneur.57.6.808
Blaise, 2007, Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats, Am J Pathol, 170, 667, 10.2353/ajpath.2007.060339
Cleary, 2005, Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function, Nat Neurosci, 8, 79, 10.1038/nn1372
McDonald, 1994, Effects of an exogenous beta-amyloid peptide on retention for spatial learning, Behav Neural Biol, 62, 60, 10.1016/S0163-1047(05)80059-7
McDonald, 1996, Reversal of beta-amyloid-induced retention deficit after exposure to training and state cues, Neurobiol Learn Mem, 65, 35, 10.1006/nlme.1996.0004
Sweeney, 1997, Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze, Neurobiol Learn Mem, 68, 97, 10.1006/nlme.1997.3770
Yankner, 1990, Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides, Science, 250, 279, 10.1126/science.2218531
Arriagada, 1992, Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease, Neurology, 42, 631, 10.1212/WNL.42.3.631
Featy, 1996, Neurodegenerative disorders with extensive tau pathology: a comparative study and review, Ann Neurol, 40, 139, 10.1002/ana.410400204
Selhub, 1995, Association between plasma homocysteine concentrations andextracranial carotid-artery stenosis, N Engl J Med, 332, 286, 10.1056/NEJM199502023320502
Kim, 2002, Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain, J Nutr, 132, 3418, 10.1093/jn/132.11.3418
Lee, 2004, Effects of dietary folic acid supplementation on cerebro- vascular endothelial dysfunction in rats with induced hyperhomocysteinemia, Brain Res, 996, 139, 10.1016/j.brainres.2003.10.027
Kamath, 2006, Elevated levels of homocysteine compromise blood-brain barrier integrity in mice, Blood, 107, 591, 10.1182/blood-2005-06-2506
Schnyder, 2001, Decreased rate of coronary restenosis after lowering of plasma homocysteine levels, N Engl J Med, 345, 1593, 10.1056/NEJMoa011364
Mattson, 2003, Folacin and homocysteine metabolism in neural plasticity and neurodegenerative disorders, Trends Neurosci, 26, 137, 10.1016/S0166-2236(03)00032-8