Hyperhomocysteinemia Increases β-Amyloid by Enhancing Expression of γ-Secretase and Phosphorylation of Amyloid Precursor Protein in Rat Brain

The American Journal of Pathology - Tập 174 - Trang 1481-1491 - 2009
Chang-E Zhang1, Wei Wei1, Ying-Hua Liu1, Jun-Hua Peng1, Qing Tian1, Gong-Ping Liu1, Yao Zhang1, Jian-Zhi Wang1
1Department of Pathophysiology, Key Laboratory of Neurological Disease of Education Committee of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Tài liệu tham khảo

Selkoe, 2001, Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein, J Alzheimers Dis, 3, 75, 10.3233/JAD-2001-3111 Nishitomi, 2006, BACE1 inhibition reduces endogenous abeta and alters APP processing in wild-type mice, J Neurochem, 99, 1555, 10.1111/j.1471-4159.2006.04178.x Vassar, 2002, β-Secretase (BACE) as a drug target for Alzheimer's disease, Adv Drug Del Rev, 54, 1589, 10.1016/S0169-409X(02)00157-6 Iwata, 2003, Amyloid-beta peptide metabolism and Alzheimer's disease, Nippon Yakurigaku Zasshi, 122, 5, 10.1254/fpj.122.5 Selkoe, 1996, Amyloid beta-protein and the genetics of Alzheimer's disease, J Biol Chem, 271, 18295, 10.1074/jbc.271.31.18295 Vassar, 2005, Beta-secretase, APP, and abeta in Alzheimer's disease, Subcell Biochem, 38, 79, 10.1007/0-387-23226-5_4 Behl, 1994, Hydrogen peroxide mediates amyloid beta protein toxicity, Cell, 77, 817, 10.1016/0092-8674(94)90131-7 Selkoe, 1994, Alzheimer's disease: a central role for amyloid, J Neuropathol Exp Neurol, 53, 438, 10.1097/00005072-199409000-00003 Mattson, 1993, Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF, Brain Res, 621, 35, 10.1016/0006-8993(93)90295-X Harada, 1999, Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons, Brain Res, 842, 311, 10.1016/S0006-8993(99)01808-9 Busciglio, 1995, Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding, Neuron, 14, 879, 10.1016/0896-6273(95)90232-5 Wang, 2008, Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins, Proc Natl Acad Sci USA, 105, 19318, 10.1073/pnas.0804871105 Busciglio, 1993, Beta-amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins, J Neurochem, 61, 1565, 10.1111/j.1471-4159.1993.tb13658.x Pigino, 2001, Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation, J Neurosci, 21, 834, 10.1523/JNEUROSCI.21-03-00834.2001 Kienlen-Campard, 2002, Intracellular amyloid-beta 1–42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis, J Biol Chem, 277, 15666, 10.1074/jbc.M200887200 Casas, 2004, Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model, Am J Patho, 165, 1289, 10.1016/S0002-9440(10)63388-3 Bernardo, 2007, Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet, Neurobiol Aging, 28, 1195, 10.1016/j.neurobiolaging.2006.05.035 Iwatsubo, 2000, Beta-amyloid cascade: current status and future directions, Clin Neurol, 40, 1228 Gandy, 1993, Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein, Ann NY Acad Sci, 695, 117, 10.1111/j.1749-6632.1993.tb23038.x Lee, 2003, APP processing is regulated by cytoplasmic phosphorylation, J Cell Biol, 163, 83, 10.1083/jcb.200301115 Pierrot, 2006, Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation, J Biol Chem, 281, 39907, 10.1074/jbc.M606015200 Clarke, 1998, Folate, vitamin B12, and serum total levels in confirmed Alzheimer disease, Arch Neurol, 55, 1449, 10.1001/archneur.55.11.1449 McCaddon, 1998, Total serum homocysteine in senile dementia of Alzheimer type, Int J Geriatr Psychiatry, 13, 235, 10.1002/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8 Obeid, 2006, Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia, FEBS Lett, 580, 2994, 10.1016/j.febslet.2006.04.088 Ravaglia, 2005, Homocysteine and folacin as risk factors for dementia and Alzheimer disease, Am J Clin Nutr, 82, 636, 10.1093/ajcn/82.3.636 Seshadri, 2002, Plasma homocysteine as a risk factor for dementia and Alzheimer's disease, N Engl J Med, 346, 476, 10.1056/NEJMoa011613 Levitt, 1992, Folate, vitamin B12 and cognitive impairment in patients with Alzheimer's disease, Acta Psychiatr Scand, 86, 301, 10.1111/j.1600-0447.1992.tb03270.x Fowler, 2005, Homocysteine: overview of biochemistry, molecular biology, and role in disease processes, Semin Vasc Med, 5, 77, 10.1055/s-2005-872394 Zhang, 2008, Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus, Neurobiol Aging, 29, 1654, 10.1016/j.neurobiolaging.2007.04.015 Pacheco-Quinto, 2006, Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels, Neurobiol Dis, 22, 651, 10.1016/j.nbd.2006.01.005 Hultberg, 2000, Hypomethylation as a cause of homocysteine-induced cell damage in human cell lines, Toxicology, 147, 69, 10.1016/S0300-483X(00)00189-X Kruman, 2000, Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity, J Neurosci, 20, 6920, 10.1523/JNEUROSCI.20-18-06920.2000 Kruman, 2002, Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease, J Neurosci, 22, 1752, 10.1523/JNEUROSCI.22-05-01752.2002 Sasaki, 2003, Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation, J Am Coll Cardiol, 42, 364, 10.1016/S0735-1097(03)00629-6 Sun, 2002, Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines, NeurobiolAging, 23, 195 Wang, 1999, The levels of soluble versus insoluble brain abeta distinguish Alzheimer's disease from normal and pathologic aging, Exp Neurol, 158, 328, 10.1006/exnr.1999.7085 Zhang, 2006, Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms, FASEB J, 20, 1431, 10.1096/fj.05-5223com Liu, 2003, Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory, J Neurochem, 87, 1333, 10.1046/j.1471-4159.2003.02070.x Morris, 1984, Developments of a water-maze procedure for studying spatial learning in the rat, J Neurosci Methods, 11, 47, 10.1016/0165-0270(84)90007-4 DeGiorgio, 2002, Transient appearance of amyloid precursor protein plaques in the brain of thymectomized rats after human leptomeningeal cell grafts, Neurosci Letters, 322, 62, 10.1016/S0304-3940(02)00065-4 Sastre, 2004, Binding of cystatin C to Alzheimer's amyloid β inhibits in vitro amyloid fibril formation, Neurobiol Aging, 25, 1033, 10.1016/j.neurobiolaging.2003.11.006 Gouras, 2000, Testosterone reduces neuronal secretion of Alzheimer's β -amyloid peptides, Proc Natl Acad Sci USA, 97, 1202, 10.1073/pnas.97.3.1202 Yan, 1999, Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity, Nature, 402, 533, 10.1038/990107 Busciglio, 1992, Methodological variables in the assessmen of beta amyloid neurotoxicity, Neurobiol Aging, 13, 609, 10.1016/0197-4580(92)90065-6 Gottfties, 1998, Early diagnosis of cognitive impairment in the elderly with the focus on Alzheimer's disease, J Neural Transm, 105, 773, 10.1007/s007020050094 Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994 Sisodia, 2002, Gamma-secretase, notch, abeta and Alzheimer's disease: where do the presenilins fit in?, Nat Rev Neurosci, 3, 281, 10.1038/nrn785 Edbauer, 2003, Reconstitution of γ -secretase activity, Nat Cell Biol, 5, 486, 10.1038/ncb960 Kimberly, 2003, Identity and function of gamma-secretase, J Neurosci Res, 74, 353, 10.1002/jnr.10736 Bergman, 1998, DNA demethylation: turning genes on, J Biol Chem, 379, 401 Razin, 1998, CpG methylation, chromatin structure and gene silencing-a three-way connection, EMBO J, 17, 4905, 10.1093/emboj/17.17.4905 Scarpa, 2003, Presenilin 1 gene silencing by S- adenosylmethionine: a treatment for Alzheimer disease?, FEBS Lett, 541, 145, 10.1016/S0014-5793(03)00277-1 Fuso, 2005, S-adenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production, Mol Cell Neurosci, 28, 195, 10.1016/j.mcn.2004.09.007 Hasegawa, 2005, Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease, J Neurosci Res, 80, 869, 10.1002/jnr.20514 Heredia, 2004, Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein, Neurobiol Dis, 16, 617, 10.1016/j.nbd.2004.04.015 Iijima, 2000, Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5, J Neurochem, 75, 1085, 10.1046/j.1471-4159.2000.0751085.x Dewji, 1998, Specific intercellular binding of the beta-amyloid precursor protein to the presenilins induces intercellular signaling: Its significance for Alzheimer's disease, Proc Natl Acad Sci USA, 95, 5055, 10.1073/pnas.95.25.15055 Kimberly, 2005, Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation, J Neurosci, 25, 5533, 10.1523/JNEUROSCI.4883-04.2005 Rockenstein, 2007, Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation, J Neurosci, 27, 1981, 10.1523/JNEUROSCI.4321-06.2007 Ryder, 2003, Divergent roles of GSK-3 and Cdk-5 in APP processing, Biochem Biophys Res Commun, 312, 922, 10.1016/j.bbrc.2003.11.014 Standen, 2001, Phosphorylation of thr (668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3), J Neurochem, 76, 316, 10.1046/j.1471-4159.2001.00102.x Holzer, 2000, Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons, J Neural Transm, 107, 451, 10.1007/s007020070087 Sontag, 2007, Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation, J Neurosci, 27, 2751, 10.1523/JNEUROSCI.3316-06.2007 Wang, 2008, Microtubule-associated protein tau in development, degeneration and protection of neurons, Prog Neurobiol, 85, 148, 10.1016/j.pneurobio.2008.03.002 Elias, 2000, The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort, Arch Neurol, 57, 808, 10.1001/archneur.57.6.808 Blaise, 2007, Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats, Am J Pathol, 170, 667, 10.2353/ajpath.2007.060339 Cleary, 2005, Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function, Nat Neurosci, 8, 79, 10.1038/nn1372 McDonald, 1994, Effects of an exogenous beta-amyloid peptide on retention for spatial learning, Behav Neural Biol, 62, 60, 10.1016/S0163-1047(05)80059-7 McDonald, 1996, Reversal of beta-amyloid-induced retention deficit after exposure to training and state cues, Neurobiol Learn Mem, 65, 35, 10.1006/nlme.1996.0004 Sweeney, 1997, Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze, Neurobiol Learn Mem, 68, 97, 10.1006/nlme.1997.3770 Yankner, 1990, Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides, Science, 250, 279, 10.1126/science.2218531 Arriagada, 1992, Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease, Neurology, 42, 631, 10.1212/WNL.42.3.631 Featy, 1996, Neurodegenerative disorders with extensive tau pathology: a comparative study and review, Ann Neurol, 40, 139, 10.1002/ana.410400204 Selhub, 1995, Association between plasma homocysteine concentrations andextracranial carotid-artery stenosis, N Engl J Med, 332, 286, 10.1056/NEJM199502023320502 Kim, 2002, Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain, J Nutr, 132, 3418, 10.1093/jn/132.11.3418 Lee, 2004, Effects of dietary folic acid supplementation on cerebro- vascular endothelial dysfunction in rats with induced hyperhomocysteinemia, Brain Res, 996, 139, 10.1016/j.brainres.2003.10.027 Kamath, 2006, Elevated levels of homocysteine compromise blood-brain barrier integrity in mice, Blood, 107, 591, 10.1182/blood-2005-06-2506 Schnyder, 2001, Decreased rate of coronary restenosis after lowering of plasma homocysteine levels, N Engl J Med, 345, 1593, 10.1056/NEJMoa011364 Mattson, 2003, Folacin and homocysteine metabolism in neural plasticity and neurodegenerative disorders, Trends Neurosci, 26, 137, 10.1016/S0166-2236(03)00032-8