Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome

Michael I Koukourakis1, Alexandra Giatromanolaki2, Stelios Kakolyris1, Efthimios Sivridis2, Vassilis Georgoulias1, George Funtzilas3, Ian D Hickson4, Kevin C Gatter4, Adrian L Harris4
1Department of Radiotherapy and Oncology, University Hospital of Iraklion, Iraklion, Crete, Greece
2Department of Pathology, Democritus University of Thrace, Alexandroupolis, Greece
3Department of Medical Oncology, Hellenic Co-operative Oncology Group, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
4Department of Cellular Science and ICRF Molecular Oncology Laboratory, Oxford Radcliffe Hospital, Oxford, England, UK

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