Advances in the development of biomarkers for epilepsy

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chronic seizures, Epilepsia, 40, 127, 10.1111/j.1528-1157.1999.tb02065.x Andrade-Valenca, 2011, Interictal scalp fast oscillations as a marker of the seizure onset zone, Neurology, 77, 524, 10.1212/WNL.0b013e318228bee2 Labate, 2015, White matter abnormalities differentiate severe from benign temporal lobe epilepsy, Epilepsia, 56, 1109, 10.1111/epi.13027 Noebels, 2015, Pathway-driven discovery of epilepsy genes, Nat Neurosci, 18, 344, 10.1038/nn.3933 Kauffman, 2008, GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence, Seizure, 17, 567, 10.1016/j.seizure.2007.12.006 Xi, 2011, GABBR1 gene polymorphism(G1465A) is associated with temporal lobe epilepsy, Epilepsy Res, 96, 58, 10.1016/j.eplepsyres.2011.04.014 Gambardella, 2003, GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy, Neurology, 60, 560, 10.1212/01.WNL.0000046520.79877.D8 Wang, 2008, Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population, Epilepsy Res, 81, 198, 10.1016/j.eplepsyres.2008.06.001 Pernhorst, 2011, Promoter variants determine gamma-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi, J Neuropathol Exp Neurol, 70, 1080, 10.1097/NEN.0b013e318238b9af Haerian, 2015, Contribution of GABRG2 polymorphisms to risk of epilepsy and febrile seizure: a multicenter cohort study and meta-analysis, Mol Neurobiol Balan, 2013, GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures, Pharmacogenet Genomics, 23, 605, 10.1097/FPC.0000000000000000 Darrah, 2013, Genetic variability in glutamic acid decarboxylase genes: associations with post-traumatic seizures after severe TBI, Epilepsy Res, 103, 180, 10.1016/j.eplepsyres.2012.07.006 Stefulj, 2010, Epilepsy and serotonin (5HT): variations of 5HT-related genes in temporal lobe epilepsy, Neurosci Lett, 478, 29, 10.1016/j.neulet.2010.04.060 Manna, 2007, Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy, Neurosci Lett, 421, 52, 10.1016/j.neulet.2007.05.022 Li, 2012, Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population, Eur J Neurol, 19, 351, 10.1111/j.1468-1331.2011.03521.x 2014, Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies, Lancet Neurol, 13, 893, 10.1016/S1474-4422(14)70171-1 Stogmann, 2002, A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy, Ann Neurol, 51, 260, 10.1002/ana.10108 Scher, 2011, MTHFR C677T genotype as a risk factor for epilepsy including post-traumatic epilepsy in a representative military cohort, J Neurotrauma, 28, 1739, 10.1089/neu.2011.1982 Lv, 2011, ASIC1a polymorphism is associated with temporal lobe epilepsy, Epilepsy Res, 96, 74, 10.1016/j.eplepsyres.2011.05.002 Zhang, 2014, Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy, Neurosci Lett, 567, 6, 10.1016/j.neulet.2014.03.003 Kanemoto, 2003, Increased frequency of interleukin-1beta-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion, Epilepsia, 44, 796, 10.1046/j.1528-1157.2003.43302.x Kanemoto, 2000, Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy, Ann Neurol, 47, 571, 10.1002/1531-8249(200005)47:5<571::AID-ANA3>3.0.CO;2-A Salzmann, 2008, Candidate genes for temporal lobe epilepsy: a replication study, Neurol Sci, 29, 397, 10.1007/s10072-008-1060-9 Yang, 2014, The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels, PLoS One, 9, e109634, 10.1371/journal.pone.0109634 Liu, 2015, Association of KEAP1 and NFE2L2 polymorphisms with temporal lobe epilepsy and drug resistant epilepsy, Gene, 571, 231, 10.1016/j.gene.2015.06.055 Labate, 2007, Association between the M129V variant allele of PRNP gene and mild temporal lobe epilepsy in women, Neurosci Lett, 421, 1, 10.1016/j.neulet.2006.10.020 Nwaobi, 2016, The role of glial-specific Kir4.1 in normal and pathological states of the CNS, Acta Neuropathol, 10.1007/s00401-016-1553-1 Buono, 2004, Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility, Epilepsy Res, 58, 175, 10.1016/j.eplepsyres.2004.02.003 Heuser, 2010, Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy, Epilepsy Res, 88, 55, 10.1016/j.eplepsyres.2009.09.023 Lv, 2011, A polymorphism in CALHM1 is associated with temporal lobe epilepsy, Epilepsy Behav, 20, 681, 10.1016/j.yebeh.2011.02.007 Zhu, 2016, Contribution of NRG1 gene polymorphisms in temporal lobe epilepsy, J Child Neurol, 31, 271, 10.1177/0883073815589757 Shen, 2016, Role of BDNF Val66Met functional polymorphism in temporal lobe epilepsy, Int J Neurosci, 126, 436, 10.3109/00207454.2015.1026967 Jamali, 2010, Functional variant in complement C3 gene promoter and genetic susceptibility to temporal lobe epilepsy and febrile seizures, PLoS One, 5, e12740, 10.1371/journal.pone.0012740 Leu, 2016, Progress from genome-wide association studies and copy number variant studies in epilepsy, Curr Opin Neurol, 29, 158, 10.1097/WCO.0000000000000296 Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 Jimenez-Mateos, 2013, Epilepsy and microRNA, Neuroscience, 238, 218, 10.1016/j.neuroscience.2013.02.027 Aronica, 2010, Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy, Eur J Neurosci, 31, 1100, 10.1111/j.1460-9568.2010.07122.x Kaalund, 2014, Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance, Epilepsia, 55, 2017, 10.1111/epi.12839 Miller-Delaney, 2015, Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy, Brain, 138, 616, 10.1093/brain/awu373 Zucchini, 2014, Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology, PLoS One, 9, e105521, 10.1371/journal.pone.0105521 Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat Biotechnol, 29, 341, 10.1038/nbt.1807 Haqqani, 2013, Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells, Fluids Barriers CNS, 10, 4, 10.1186/2045-8118-10-4 Jin, 2013, Circulating microRNAs: a novel class of potential biomarkers for diagnosing and prognosing central nervous system diseases, Cell Mol Neurobiol, 33, 601, 10.1007/s10571-013-9940-9 Gorter, 2014, Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy, Neurobiol Dis, 62, 508, 10.1016/j.nbd.2013.10.026 Roncon, 2015, MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy—comparison with human epileptic samples, Sci Rep, 5, 14143, 10.1038/srep14143 McDonald, 2011, Analysis of circulating microRNA: preanalytical and analytical challenges, Clin Chem, 57, 833, 10.1373/clinchem.2010.157198 Immonen, 2013, MRI biomarkers for post-traumatic epileptogenesis, J Neurotrauma, 30, 1305, 10.1089/neu.2012.2815 Lewis, 2014, Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study, Ann Neurol, 75, 178, 10.1002/ana.24081 Lehto, 2012, Detection of calcifications in vivo and ex vivo after brain injury in rat using SWIFT, Neuroimage, 61, 761, 10.1016/j.neuroimage.2012.03.002 Fisher, 2005, Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE), Epilepsia, 46, 470, 10.1111/j.0013-9580.2005.66104.x Fisher, 2014, ILAE official report: a practical clinical definition of epilepsy, Epilepsia, 55, 475, 10.1111/epi.12550 Jacobs, 2012, High-frequency oscillations (HFOs) in clinical epilepsy, Prog Neurobiol, 98, 302, 10.1016/j.pneurobio.2012.03.001 Bragin, 2004, High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis, Epilepsia, 45, 1017, 10.1111/j.0013-9580.2004.17004.x Haegelen, 2013, High-frequency oscillations, extent of surgical resection, and surgical outcome in drug-resistant focal epilepsy, Epilepsia, 54, 848, 10.1111/epi.12075 Weiss, 2013, Ictal high frequency oscillations distinguish two types of seizure territories in humans, Brain, 136, 3796, 10.1093/brain/awt276 Akiyama, 2011, Focal resection of fast ripples on extraoperative intracranial EEG improves seizure outcome in pediatric epilepsy, Epilepsia, 52, 1802, 10.1111/j.1528-1167.2011.03199.x Kerber, 2014, Differentiation of specific ripple patterns helps to identify epileptogenic areas for surgical procedures, Clin Neurophysiol, 125, 1339, 10.1016/j.clinph.2013.11.030 Salami, 2014, Dynamics of interictal spikes and highfrequency oscillations during epileptogenesis in temporal lobe epilepsy, Neurobiol Dis, 67, 97, 10.1016/j.nbd.2014.03.012 Levesque, 2012, Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy, J Neurosci, 32, 13264, 10.1523/JNEUROSCI.5086-11.2012 Jacobs, 2016, The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes, Clin Neurophysiol, 127, 129, 10.1016/j.clinph.2015.04.053 Xiang, 2015, Quantification of interictal neuromagnetic activity in absence epilepsy with accumulated source imaging, Brain Topogr, 28, 904, 10.1007/s10548-014-0411-5 Tenney, 2014, Low- and 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impact and lateral fluid-percussion-induced brain injury in the mouse, J Neurotrauma, 29, 789, 10.1089/neu.2011.1954 Rattka, 2012, Do proconvulsants modify or halt epileptogenesis? 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hyperexcitability and seizures, Brain Behav Immun, 25, 1281, 10.1016/j.bbi.2011.03.018 Vezzani, 2011, The role of inflammation in epilepsy, Nat Rev Neurol, 7, 31, 10.1038/nrneurol.2010.178 Vezzani, 2013, Epilepsy and brain inflammation, Exp Neurol, 244, 11, 10.1016/j.expneurol.2011.09.033 Ravizza, 2011, Inflammation and prevention of epileptogenesis, Neurosci Lett, 497, 223, 10.1016/j.neulet.2011.02.040 Vezzani, 2016, Infections, inflammation and epilepsy, Acta Neuropathol, 131, 211, 10.1007/s00401-015-1481-5 Tomkins, 2011, Blood–brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsy, Cardiovasc Psychiatry Neurol, 2011, 765923, 10.1155/2011/765923 Pulli, 2014, Imaging neuroinflammation—from bench to bedside, J Clin Cell Immunol, 5, 226 Amhaoul, 2014, Imaging brain inflammation in epilepsy, Neuroscience, 279, 238, 10.1016/j.neuroscience.2014.08.044 Barry, 2015, T2 relaxation time post febrile status epilepticus predicts cognitive outcome, Exp 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