14-3-3 proteins in cell cycle regulation

Seminars in Cancer Biology - Tập 16 - Trang 183-192 - 2006
Heiko Hermeking1, Anne Benzinger1
1Molecular Oncology, Independent Max-Planck Research Group, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried/Munich, Germany

Tài liệu tham khảo

van Heusden, 1995, The 14-3-3 proteins encoded by the BMH1 and BMH2 genes are essential in the yeast Saccharomyces cerevisiae and can be replaced by a plant homologue, Eur J Biochem, 229, 45, 10.1111/j.1432-1033.1995.0045l.x Skoulakis, 1996, Olfactory learning deficits in mutants for leonardo, a Drosophila gene encoding a 14-3-3 protein, Neuron, 17, 931, 10.1016/S0896-6273(00)80224-X Martens, 1992, Evolutionary conservation of the 14-3-3 protein, Biochem Biophys Res Commun, 184, 1456, 10.1016/S0006-291X(05)80046-4 Boston, 1980, Purification and properties of a brain-specific protein, human 14-3-3 protein, Biochem Soc Trans, 8, 617, 10.1042/bst0080617 Jones, 1995, Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins, FEBS Lett, 368, 55, 10.1016/0014-5793(95)00598-4 Tzivion, 1998, A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity, Nature, 394, 88, 10.1038/27938 Yaffe, 1997, The structural basis for 14-3-3:phosphopeptide binding specificity, Cell, 91, 961, 10.1016/S0092-8674(00)80487-0 Rittinger, 1999, Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding, Mol Cell, 4, 153, 10.1016/S1097-2765(00)80363-9 Subramanian, 2001, Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis, Exp Cell Res, 271, 142, 10.1006/excr.2001.5376 Fujita, 2003, Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization, J Biol Chem, 278, 49254, 10.1074/jbc.M306614200 Zhang, 1997, Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49, J Biol Chem, 272, 13717, 10.1074/jbc.272.21.13717 Henriksson, 2002, A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo, Eur J Biochem, 269, 4921, 10.1046/j.1432-1033.2002.03191.x Pozuelo Rubio, 2004, 14-3-3-Affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking, Biochem J, 379, 395, 10.1042/bj20031797 Meek, 2004, Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins, J Biol Chem, 279, 32046, 10.1074/jbc.M403044200 Jin, 2004, Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization, Curr Biol, 14, 1436, 10.1016/j.cub.2004.07.051 Benzinger, 2005, Targeted proteomic analysis of 14-3-3sigma, a p53 effector commonly silenced in cancer, Mol Cell Proteomics, 4, 785, 10.1074/mcp.M500021-MCP200 Tzivion, 2001, 14-3-3 proteins; bringing new definitions to scaffolding, Oncogene, 20, 6331, 10.1038/sj.onc.1204777 Yaffe, 2002, How do 14-3-3 proteins work?—gatekeeper phosphorylation and the molecular anvil hypothesis, FEBS Lett, 513, 53, 10.1016/S0014-5793(01)03288-4 Hermeking, 2003, The 14-3-3 cancer connection, Nat Rev Cancer, 3, 931, 10.1038/nrc1230 Fu, 2000, 14-3-3 proteins: structure, function, and regulation, Annu Rev Pharmacol Toxicol, 40, 617, 10.1146/annurev.pharmtox.40.1.617 van Hemert, 2001, 14-3-3 proteins: key regulators of cell division, signalling and apoptosis, Bioessays, 23, 936, 10.1002/bies.1134 Bridges, 2004, 14-3-3 proteins: a number of functions for a numbered protein, Sci STKE, 2004, re10, 10.1126/stke.2422004re10 Fu, 1994, Interaction of the protein kinase Raf-1 with 14-3-3 proteins, Science, 266, 126, 10.1126/science.7939632 Kosaki, 1998, 14-3-3Beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes, J Biol Chem, 273, 940, 10.1074/jbc.273.2.940 Yoshida, 2005, JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage, Nat Cell Biol, 7, 278, 10.1038/ncb1228 Datta, 2000, 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation, Mol Cell, 6, 41, 10.1016/S1097-2765(00)00006-X Samuel, 2001, The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax, J Biol Chem, 276, 45201, 10.1074/jbc.M106427200 Masters, 2001, 14-3-3 proteins mediate an essential anti-apoptotic signal, J Biol Chem, 276, 45193, 10.1074/jbc.M105971200 Brunet, 2002, 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport, J Cell Biol, 156, 817, 10.1083/jcb.200112059 Grozinger, 2000, Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization, Proc Natl Acad Sci USA, 97, 7835, 10.1073/pnas.140199597 Garcia-Guzman, 1999, Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins, J Biol Chem, 274, 5762, 10.1074/jbc.274.9.5762 Zhu, 2003, The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading, Biochem Biophys Res Commun, 301, 991, 10.1016/S0006-291X(03)00056-1 Santoro, 2003, The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration, Dev Cell, 5, 257, 10.1016/S1534-5807(03)00201-6 Nguyen, 2004, Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function, Nat Biotechnol, 22, 993, 10.1038/nbt997 Harper, 2005, The mammalian cell cycle: an overview, Methods Mol Biol, 296, 113 Sherr, 1995, Inhibitors of mammalian G1 cyclin-dependent kinases, Genes Dev, 9, 1149, 10.1101/gad.9.10.1149 Ford, 1994, 14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast, Science, 265, 533, 10.1126/science.8036497 Norbury, 1991, Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates, EMBO J, 10, 3321, 10.1002/j.1460-2075.1991.tb04896.x Parker, 1992, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase, Science, 257, 1955, 10.1126/science.1384126 Liu, 1997, The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex, Mol Cell Biol, 17, 571, 10.1128/MCB.17.2.571 Gautier, 1991, cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2, Cell, 67, 197, 10.1016/0092-8674(91)90583-K Takizawa, 2000, Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C, Curr Opin Cell Biol, 12, 658, 10.1016/S0955-0674(00)00149-6 Donzelli, 2003, Regulating mammalian checkpoints through Cdc25 inactivation, EMBO Rep, 4, 671, 10.1038/sj.embor.embor887 Sanchez, 1997, Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25, Science, 277, 1497, 10.1126/science.277.5331.1497 Graves, 2001, Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding, Oncogene, 20, 1839, 10.1038/sj.onc.1204259 Kumagai, 1998, 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts, Mol Biol Cell, 9, 345, 10.1091/mbc.9.2.345 Kumagai, 1999, Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25, Genes Dev, 13, 1067, 10.1101/gad.13.9.1067 Peng, 1997, Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216, Science, 277, 1501, 10.1126/science.277.5331.1501 Chaturvedi, 1999, Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway, Oncogene, 18, 4047, 10.1038/sj.onc.1202925 Peng, 1998, C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding, Cell Growth Differ, 9, 197 Dalal, 2004, 14-3-3 family members act coordinately to regulate mitotic progression, Cell Cycle, 3, 672, 10.4161/cc.3.5.856 Qi, 2003, Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation, Radiat Res, 160, 217, 10.1667/RR3038 Chen, 2003, Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding, Mol Cell Biol, 23, 7488, 10.1128/MCB.23.21.7488-7497.2003 Forrest, 2001, Cdc25B activity is regulated by 14-3-3, Oncogene, 20, 4393, 10.1038/sj.onc.1204574 Bulavin, 2001, Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase, Nature, 411, 102, 10.1038/35075107 Giles, 2003, 14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity, J Biol Chem, 278, 28580, 10.1074/jbc.M304027200 Mils, 2000, Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase, Oncogene, 19, 1257, 10.1038/sj.onc.1203419 Uchida, 2004, Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B, J Cell Sci, 117, 3011, 10.1242/jcs.01086 Bulavin, 2003, Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos, Cell Cycle, 2, 263, 10.4161/cc.2.3.396 Zhou, 2000, The DNA damage response: putting checkpoints in perspective, Nature, 408, 433, 10.1038/35044005 Liu, 2000, Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint, Genes Dev, 14, 1448, 10.1101/gad.14.12.1448 Jiang, 2003, Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345, J Biol Chem, 278, 25207, 10.1074/jbc.M300070200 McGowan, 1993, Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15, EMBO J, 12, 75, 10.1002/j.1460-2075.1993.tb05633.x Wang, 2000, Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2–M cell population, Cell Growth Differ, 11, 211 Rothblum-Oviatt, 2001, 14-3-3 binding regulates catalytic activity of human Wee1 kinase, Cell Growth Differ, 12, 581 Lee, 2001, Positive regulation of Wee1 by Chk1 and 14-3-3 proteins, Mol Biol Cell, 12, 551, 10.1091/mbc.12.3.551 Katayama, 2005, Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition, Mol Cell Biol, 25, 5725, 10.1128/MCB.25.13.5725-5737.2005 Hermeking, 1997, 14-3-3Sigma is a p53-regulated inhibitor of G2/M progression, Mol Cell, 1, 3, 10.1016/S1097-2765(00)80002-7 Rohaly, 2005, A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint, Cell, 122, 21, 10.1016/j.cell.2005.04.032 Aprelikova, 2001, BRCA1 is a selective co-activator of 14-3-3sigma gene transcription in mouse embryonic stem cells, J Biol Chem, 276, 25647, 10.1074/jbc.C100265200 Yarden, 2002, BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage, Nat Genet, 30, 285, 10.1038/ng837 Chan, 1999, 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage, Nature, 401, 616, 10.1038/44188 Dhar, 2000, Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability, Mol Cell Biol, 20, 7764, 10.1128/MCB.20.20.7764-7772.2000 Laronga, 2000, Association of the cyclin-dependent kinases and 14-3-3sigma negatively regulates cell cycle progression, J Biol Chem, 275, 23106, 10.1074/jbc.M905616199 Slingerland, 2000, Regulation of the cdk inhibitor p27 and its deregulation in cancer, J Cell Physiol, 183, 10, 10.1002/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I Fujita, 2002, Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization, J Biol Chem, 277, 28706, 10.1074/jbc.M203668200 Sekimoto, 2004, 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1), EMBO J, 23, 1934, 10.1038/sj.emboj.7600198 Shin, 2002, PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization, Nat Med, 8, 1145, 10.1038/nm759 Viglietto, 2002, Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer, Nat Med, 8, 1136, 10.1038/nm762 Liang, 2002, PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest, Nat Med, 8, 1153, 10.1038/nm761 Takihara, 2000, Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation, Carcinogenesis, 21, 2073, 10.1093/carcin/21.11.2073 Qi, 2005, Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues, Int J Cancer, 113, 359, 10.1002/ijc.20492 Benzinger, 2005, The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization, Cell Res, 15, 219, 10.1038/sj.cr.7290290 Wilker, 2005, A structural basis for 14-3-3sigma functional specificity, J Biol Chem, 280, 18891, 10.1074/jbc.M500982200 Waterman, 1998, ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins, Nat Genet, 19, 175, 10.1038/542 Stavridi, 2001, Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest, Cancer Res, 61, 7030 Yang, 2003, 14-3-3Sigma positively regulates p53 and suppresses tumor growth, Mol Cell Biol, 23, 7096, 10.1128/MCB.23.20.7096-7107.2003 Okamoto, 2005, DNA damage-induced phosphorylation of MdmX at Serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation, Mol Cell Biol, 25, 9608, 10.1128/MCB.25.21.9608-9620.2005 Medema, 2000, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature, 404, 782, 10.1038/35008115 Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4 Obsil, 2003, Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding, Biochemistry, 42, 15264, 10.1021/bi0352724 Obsilova, 2005, 14-3-3 protein interacts with nuclear localization sequence of Forkhead transcription factor FoxO4, Biochemistry, 44, 11608, 10.1021/bi050618r Rena, 2001, Roles of the Forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting, Biochem J, 354, 605, 10.1042/0264-6021:3540605 Zhao, 2004, Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms, Biochem J, 378, 839, 10.1042/bj20031450 Alvarez, 2001, Forkhead transcription factors contribute to execution of the mitotic programme in mammals, Nature, 413, 744, 10.1038/35099574 Peukert, 1997, An alternative pathway for gene regulation by Myc, EMBO J, 16, 5672, 10.1093/emboj/16.18.5672 Staller, 2001, Repression of p15INK4b expression by Myc through association with Miz-1, Nat Cell Biol, 3, 392, 10.1038/35070076 Herold, 2002, Negative regulation of the mammalian UV response by Myc through association with Miz-1, Mol Cell, 10, 509, 10.1016/S1097-2765(02)00633-0 Wanzel, 2005, Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage, Nat Cell Biol, 7, 30, 10.1038/ncb1202 Milton, 2006, 14-3-3 proteins integrate E2F activity with the DNA damage response, EMBO J, 25, 1046, 10.1038/sj.emboj.7600999 Wang, 2004, A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis, J Biol Chem, 279, 54140, 10.1074/jbc.M410493200 Urano, 2002, Efp targets 14-3-3sigma for proteolysis and promotes breast tumour growth, Nature, 417, 871, 10.1038/nature00826 Hengstschlager, 2003, Tuberous sclerosis genes regulate cellular 14-3-3 protein levels, Biochem Biophys Res Commun, 312, 676, 10.1016/j.bbrc.2003.10.170 Liao, 1996, 14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor, J Cell Biol, 133, 345, 10.1083/jcb.133.2.345 Satoh, 2004, The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes, Am J Pathol, 165, 577, 10.1016/S0002-9440(10)63322-6 Tzivion, 2000, Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo, J Biol Chem, 275, 29772, 10.1074/jbc.M001207200 Su, 2001, Cell cycle roles for two 14-3-3 proteins during Drosophila development, J Cell Sci, 114, 3445, 10.1242/jcs.114.19.3445 Chang, 1997, 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila, Genes Dev, 11, 1132, 10.1101/gad.11.9.1132 Herron, 2005, A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice, Nat Genet, 37, 1210, 10.1038/ng1652 Li, 2005, Identification of 14-3-3{sigma} mutation causing cutaneous abnormality in repeated-epilation mutant mouse, Proc Natl Acad Sci USA, 102, 15977, 10.1073/pnas.0508310102 Lutzner, 1985, Multiple cutaneous papillomas and carcinomas that develop spontaneously in a mouse mutant, the repeated epilation heterozygote Er/+, J Natl Cancer Inst, 75, 161 Baudier, 1992, Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein, Proc Natl Acad Sci USA, 89, 11627, 10.1073/pnas.89.23.11627