Injectable chitosan hydrogels tailored with antibacterial and antioxidant dual functions for regenerative wound healing

Aeridou, 2020, Advanced functional hydrogel biomaterials based on dynamic B-O bonds and polysaccharide building blocks, Biomacromolecules, 21, 3984, 10.1021/acs.biomac.0c01139 Albright, 2017, Self-defensive antibiotic-loaded layer-by-layer coatings: Imaging of localized bacterial acidification and pH-triggering of antibiotic release, Acta Biomaterialia, 61, 66, 10.1016/j.actbio.2017.08.012 Belbekhouche, 2019, Glucose-sensitive capsules based on hydrogen-bonded (polyvinylpyrrolidone / phenylboronic -modified alginate) system, Colloids and Surfaces, B: Biointerfaces, 177, 416, 10.1016/j.colsurfb.2019.02.006 Brubaker, 2011, Enzymatically degradable mussel-inspired adhesive hydrogel, Biomacromolecules, 12, 4326, 10.1021/bm201261d Burdick, 2012, Moving from static to dynamic complexity in hydrogel design, Nature Communications, 3, 1269, 10.1038/ncomms2271 Chen, 2021, Tannic acid–thioctic acid hydrogel: A novel injectable supramolecular adhesive gel for wound healing, Green Chemistry, 23, 1794, 10.1039/D0GC02909B Deng, 2021, A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing, ACS Sustainable Chemistry & Engineering, 9, 3070, 10.1021/acssuschemeng.0c06672 Ding, 2021, Injectable self-healing hydrogel wound dressing with cysteine-specific on-demand dissolution property based on tandem dynamic covalent bonds, Advanced Functional Materials, 31, 10.1002/adfm.202011230 Gan, 2019, Mussel-inspired contact-active antibacterial hydrogel with high cell affinity, toughness, and recoverability, Advanced Functional Materials, 29, 10.1002/adfm.201805964 Hamedi, 2018, Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review, Carbohydrate Polymers, 199, 445, 10.1016/j.carbpol.2018.06.114 Han, 2017, Chronic wound healing: A review of current management and treatments, Advances in Therapy, 34, 599, 10.1007/s12325-017-0478-y Harsha, 2020, Role of collagen in wound healing, Drug Invention Today, 13, 55 Hu, 2018, Polyphenol-binding amyloid fibrils self-assemble into reversible hydrogels with antibacterial activity, ACS Nano, 12, 3385, 10.1021/acsnano.7b08969 Hu, 2021, Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release, Chemical Engineering Journal, 411, 10.1016/j.cej.2021.128564 Huang, 2018, Injectable dynamic covalent hydrogels of boronic acid polymers cross-linked by bioactive plant-derived polyphenols, Biomaterials Science, 6, 2487, 10.1039/C8BM00453F Kim, 2020, Enzyme-mediated one-pot synthesis of hydrogel with the polyphenol cross-linker for skin regeneration, Materials Today Bio, 8, 10.1016/j.mtbio.2020.100079 Lei, 2021, Conductive, adaptive, multifunctional hydrogel combined with electrical stimulation for deep wound repair, Chemical Engineering Journal, 421, 10.1016/j.cej.2021.129578 Li, 2022, Polyphenol-based hydrogels: Pyramid evolution from crosslinked structures to biomedical applications and the reverse design, Bioactive Materials, 17, 49, 10.1016/j.bioactmat.2022.01.038 Liang, 2021, Functional hydrogels as wound dressing to enhance wound healing, ACS Nano, 15, 12687, 10.1021/acsnano.1c04206 Liang, 2019, Mussel-inspired, antibacterial, conductive, antioxidant, injectable composite hydrogel wound dressing to promote the regeneration of infected skin, Journal of Colloid and Interface Science, 556, 514, 10.1016/j.jcis.2019.08.083 Liu, 2018, A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing, RSC Advances, 8, 7533, 10.1039/C7RA13510F Madni, 2021, Recent advancements in applications of chitosan-based biomaterials for skin tissue engineering, Journal of Bioresources and Bioproducts, 6, 11, 10.1016/j.jobab.2021.01.002 Moeini, 2020, Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review, Carbohydrate Polymers, 233, 10.1016/j.carbpol.2020.115839 Mohandas, 2018, Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings, Bioactive Materials, 3, 267, 10.1016/j.bioactmat.2017.11.003 Ni, 2021, Polyphosphazene and non-catechol-based antibacterial injectable hydrogel for adhesion of wet tissues as wound dressing, Advanced Healthcare Materials, 11, 10.1002/adhm.202101421 Pan, 2020, A bionic tactile plastic hydrogel-based electronic skin constructed by a nerve-like nanonetwork combining stretchable, compliant, and self-healing properties, Chemical Engineering Journal, 379, 10.1016/j.cej.2019.122271 Parvez, 2019, Antibacterial activities of green tea crude extracts and synergistic effects of epigallocatechingallate (EGCG) with gentamicin against MDR pathogens, Heliyon, 5, 10.1016/j.heliyon.2019.e02126 Qu, 2019, Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing, Chemical Engineering Journal, 362, 548, 10.1016/j.cej.2019.01.028 Qu, 2021, Skin-inspired highly stretchable, tough and adhesive hydrogels for tissue-attached sensor, Chemical Engineering Journal, 425, 10.1016/j.cej.2021.131523 Roberts, 2007, Dynamically restructuring hydrogel networks formed with reversible covalent crosslinks, Advanced Materials, 19, 2503, 10.1002/adma.200602649 Schneider, 2007, Influence of pH on wound-healing: A new perspective for wound-therapy?, Archives of Dermatological Research, 298, 413, 10.1007/s00403-006-0713-x Seidi, 2020, Self-healing polyol/borax hydrogels: Fabrications, properties and applications, The Chemical Record, 20, 1142, 10.1002/tcr.202000060 Sun, 2022, Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique, Chemical Engineering Journal, 427, 10.1016/j.cej.2021.130843 Sun, 2021, Green regenerative hydrogel wound dressing functionalized by natural drug-food homologous small molecule self-assembled nanospheres, Advanced Functional Materials, 32, 10.1002/adfm.202106572 Wang, 2021, Advances of hydrogel dressings in diabetic wounds, Biomaterials Science, 9, 1530, 10.1039/D0BM01747G Wang, 2020, Biocompatible and self-healing ionic gel skin as shape-adaptable and skin-adhering sensor of human motions, Chemical Engineering Journal, 398, 10.1016/j.cej.2020.125540 Xu, 2021, Beneficial effects of green tea EGCG on skin wound healing: A comprehensive review, Molecules, 26, 6123, 10.3390/molecules26206123 Xu, 2020, Advances and impact of antioxidant hydrogel in chronic wound healing, Advanced Healthcare Materials, 9, 10.1002/adhm.201901502 Yao, 2022, A shape memory and antibacterial cryogel with rapid hemostasis for noncompressible hemorrhage and wound healing, Chemical Engineering Journal, 428 Yavvari, 2015, Robust, self-healing hydrogels synthesised from catechol rich polymers, Journal of Materials Chemistry B, 3, 899, 10.1039/C4TB01307G Yen, 2008, Antioxidant properties of chitosan from crab shells, Carbohydrate Polymers, 74, 840, 10.1016/j.carbpol.2008.05.003 Yesilyurt, 2016, Injectable self-healing glucose-responsive hydrogels with pH-regulated mechanical properties, Advanced Materials, 28, 86, 10.1002/adma.201502902 Yoda, 2004, Different susceptibilities of staphylococcus and gram-negative rods to epigallocatechin gallate, Journal of Infection and Chemotherapy, 10, 55, 10.1007/s10156-003-0284-0 Zhang, 2020, Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration, Chemical Engineering Journal, 400 Zhang, 2021, Multifunctional injectable hydrogel dressings for effectively accelerating wound healing: Enhancing biomineralization strategy, Advanced Functional Materials, 31, 10.1002/adfm.202100093 Zhang, 2020, Catechol-functionalized hydrogels: Biomimetic design, adhesion mechanism, and biomedical applications, Chemical Society Reviews, 49, 433, 10.1039/C9CS00285E Zhao, 2017, pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing, ACS Applied Materials & Interfaces, 9, 37563, 10.1021/acsami.7b09395 Zhao, 2021, Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment, Advanced Functional Materials, 31 Zhao, 2017, Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing, Biomaterials, 122, 34, 10.1016/j.biomaterials.2017.01.011 Zhong, 2021, Antimicrobial/biocompatible hydrogels dual-reinforced by cellulose as ultrastretchable and rapid self-healing wound dressing, Biomacromolecules, 22, 1654, 10.1021/acs.biomac.1c00086 Zhong, 2020, Natural polymer-based antimicrobial hydrogels without synthetic antibiotics as wound dressings, Biomacromolecules, 21, 2983, 10.1021/acs.biomac.0c00760