Advancing dental implant surface technology – From micron- to nanotopography

Biomaterials - Tập 29 - Trang 3822-3835 - 2008
Gustavo Mendonça1,2, Daniela B.S. Mendonça1,2, Francisco J.L. Aragão1,3, Lyndon F. Cooper2
1Universidade Católica de Brasília, Pós-Graduação em Ciências Genômicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte 70.790-160 Brasília, DF, Brazil
2Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB #7450, Chapel Hill, NC 27511, USA
3Embrapa Recursos Genéticos e Biotecnologia, Laboratório de Introdução e Expressão de Genes, PqEB W5 Norte, 70770-900 Brasília, DF, Brazil

Tài liệu tham khảo

Branemark, 1969, Intra-osseous anchorage of dental prostheses. I. Experimental studies, Scand J Plast Reconstr Surg, 3, 81, 10.3109/02844316909036699 Linder, 1983, Electron microscopic analysis of the bone–titanium interface, Acta Orthop Scand, 54, 45, 10.3109/17453678308992868 Albrektsson, 1990, Direct bone anchorage of oral implants: clinical and experimental considerations of the concept of osseointegration, Int J Prosthodont, 3, 30 Adell, 1990, Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws, Int J Oral Maxillofac Implants, 5, 347 Adell, 1981, A 15-year study of osseointegrated implants in the treatment of the edentulous jaw, Int J Oral Surg, 10, 387, 10.1016/S0300-9785(81)80077-4 Albrektsson, 1988, Osseointegrated oral implants. A Swedish multicenter study of 8139 consecutively inserted Nobelpharma implants, J Periodontol, 59, 287, 10.1902/jop.1988.59.5.287 Goodacre, 1999, Clinical complications of osseointegrated implants, J Prosthet Dent, 81, 537, 10.1016/S0022-3913(99)70208-8 Zarb, 1990, The longitudinal clinical effectiveness of osseointegrated dental implants: the Toronto study. Part III: problems and complications encountered, J Prosthet Dent, 64, 185, 10.1016/0022-3913(90)90177-E Morton, 2004, Immediate restoration and loading of dental implants: clinical considerations and protocols, Int J Oral Maxillofac Implants, 19, 103 Tolstunov, 2006, Dental implant success–failure analysis: a concept of implant vulnerability, Implant Dent, 15, 341, 10.1097/01.id.0000239333.24384.5d Jaffin, 1991, The excessive loss of Branemark fixtures in type IV bone: a 5-year analysis, J Periodontol, 62, 2, 10.1902/jop.1991.62.1.2 Bain, 1996, Smoking and implant failure–benefits of a smoking cessation protocol, Int J Oral Maxillofac Implants, 11, 756 Fiorellini, 2000, A retrospective study of dental implants in diabetic patients, Int J Periodontics Restorative Dent, 20, 366 Cooper, 1998, Biologic determinants of bone formation for osseointegration: clues for future clinical improvements, J Prosthet Dent, 80, 439, 10.1016/S0022-3913(98)70009-5 Nanci, 1998, Chemical modification of titanium surfaces for covalent attachment of biological molecules, J Biomed Mater Res, 40, 324, 10.1002/(SICI)1097-4636(199805)40:2<324::AID-JBM18>3.0.CO;2-L Boyan, 1993, Response of bone and cartilage cells to biomaterials in vivo and in vitro, J Oral Implantol, 19, 116 Schwartz, 1992, Modulation of matrix vesicle enzyme activity and phosphatidylserine content by ceramic implant materials during endosteal bone healing, Calcif Tissue Int, 51, 429, 10.1007/BF00296676 Stanford, 2006, Outcomes of a fluoride modified implant one year after loading in the posterior-maxilla when placed with the osteotome surgical technique, Appl Osseointegration Res, 5, 50 Masuda, 1997, Cell and matrix reactions at titanium implants in surgically prepared rat tibiae, Int J Oral Maxillofac Implants, 12, 472 Meyer, 2004, Ultrastructural characterization of the implant/bone interface of immediately loaded dental implants, Biomaterials, 25, 1959, 10.1016/j.biomaterials.2003.08.070 Berglundh, 2003, De novo alveolar bone formation adjacent to endosseous implants, Clin Oral Implants Res, 14, 251, 10.1034/j.1600-0501.2003.00972.x Le Guéhennec, 2007, Surface treatments of titanium dental implants for rapid osseointegration, Dent Mater, 23, 844, 10.1016/j.dental.2006.06.025 Kasemo, 1983, Biocompatibility of titanium implants: surface science aspects, J Prosthet Dent, 49, 832, 10.1016/0022-3913(83)90359-1 Johansson, 1991, A removal torque and histomorphometric study of commercially pure niobium and titanium implants in rabbit bone, Clin Oral Implants Res, 2, 24, 10.1034/j.1600-0501.1991.020103.x Suska, 2005, In vivo cytokine secretion and NF-kappaB activation around titanium and copper implants, Biomaterials, 26, 519, 10.1016/j.biomaterials.2004.02.066 Buser, 1991, Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs, J Biomed Mater Res, 25, 889, 10.1002/jbm.820250708 Gotfredsen, 1990, Clinical and radiographic evaluation of submerged and nonsubmerged implants in monkeys, Int J Prosthodont, 3, 463 Hansson, 1999, The relation between surface roughness and interfacial shear strength for bone-anchored implants. A mathematical model, J Biomech, 32, 829, 10.1016/S0021-9290(99)00058-5 Davies, 2003, Understanding peri-implant endosseous healing, J Dent Educ, 67, 932, 10.1002/j.0022-0337.2003.67.8.tb03681.x Puleo, 1999, Understanding and controlling the bone–implant interface, Biomaterials, 20, 2311, 10.1016/S0142-9612(99)00160-X Schwartz, 1999, Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage, Adv Dent Res, 13, 38, 10.1177/08959374990130011301 Albrektsson, 2004, Oral implant surfaces: part 1 – review focusing on topographic and chemical properties of different surfaces and in vivo responses to them, Int J Prosthodont, 17, 536 Albrektsson, 2004, Oral implant surfaces: part 2 – review focusing on clinical knowledge of different surfaces, Int J Prosthodont, 17, 544 Burger, 1999, Mechanotransduction in bone – role of the lacuno-canalicular network, FASEB J, 13, S101, 10.1096/fasebj.13.9001.s101 Hansson, 2006, The dental implant meets bone – a clash of two paradigms, Appl Osseointegration Res, 1, 15 Wong, 1995, Effect of surface topology on the osseointegration of implant materials in trabecular bone, J Biomed Mater Res, 29, 1567, 10.1002/jbm.820291213 Wennerberg, 1997, A 1-year follow-up of implants of differing surface roughness placed in rabbit bone, Int J Oral Maxillofac Implants, 12, 486 Park, 2001, Platelet interactions with titanium: modulation of platelet activity by surface topography, Biomaterials, 22, 2671, 10.1016/S0142-9612(01)00009-6 Ricci, 2007, Connective-tissue responses to defined biomaterial surfaces. I. Growth of rat fibroblast and bone marrow cell colonies on microgrooved substrates, J Biomed Mater Res A Schneider, 2003, Implant surface roughness affects osteoblast gene expression, J Dent Res, 82, 372, 10.1177/154405910308200509 Isa, 2006, Effects of fluoride modified titanium surfaces on osteoblast proliferation and gene expression, Int J Oral Maxillofac Implants, 21, 203 Ogawa, 2003, Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes, Int J Oral Maxillofac Implants, 18, 200 Ogawa, 2006, Genes differentially expressed in titanium implant healing, J Dent Res, 85, 566, 10.1177/154405910608500617 Abron, 2001, Evaluation of a predictive model for implant surface topography effects on early osseointegration in the rat tibia model, J Prosthet Dent, 85, 40, 10.1067/mpr.2001.112415 Buser, 2004, Enhanced bone apposition to a chemically modified SLA titanium surface, J Dent Res, 83, 529, 10.1177/154405910408300704 Ellingsen, 2004, Improved retention and bone-to-implant contact with fluoride-modified titanium implants, Int J Oral Maxillofac Implants, 19, 659 Gutwein, 2004, Increased viable osteoblast density in the presence of nanophase compared to conventional alumina and titania particles, Biomaterials, 25, 4175, 10.1016/j.biomaterials.2003.10.090 Oh, 2005, Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes, Biomaterials, 26, 4938, 10.1016/j.biomaterials.2005.01.048 Price, 2003, Osteoblast function on nanophase alumina materials: influence of chemistry, phase, and topography, J Biomed Mater Res A, 67, 1284, 10.1002/jbm.a.20011 Price, 2003, Enhanced functions of osteoblasts on nanostructured surfaces of carbon and alumina, Med Biol Eng Comput, 41, 372, 10.1007/BF02348445 Webster, 1999, Osteoblast adhesion on nanophase ceramics, Biomaterials, 20, 1221, 10.1016/S0142-9612(99)00020-4 Webster, 2000, Enhanced functions of osteoblasts on nanophase ceramics, Biomaterials, 21, 1803, 10.1016/S0142-9612(00)00075-2 Webster, 2001, Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin, Tissue Eng, 7, 291, 10.1089/10763270152044152 Webster, 2004, Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo, Biomaterials, 25, 4731, 10.1016/j.biomaterials.2003.12.002 Schwartz, 2005, Surface microtopography regulates osteointegration: the role of implant surface microtopography in osteointegration, Alpha Omegan, 98, 9 Webster, 2005, Increased osteoblast functions on theta+delta nanofiber alumina, Biomaterials, 26, 953, 10.1016/j.biomaterials.2004.03.040 Zhao, 2005, High surface energy enhances cell response to titanium substrate microstructure, J Biomed Mater Res A, 74, 49, 10.1002/jbm.a.30320 Dike, 1999, Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates, In Vitro Cell Dev Biol Anim, 35, 441, 10.1007/s11626-999-0050-4 García, 2005, Bio-adhesive surfaces to promote osteoblast differentiation and bone formation, J Dent Res, 84, 407, 10.1177/154405910508400502 Trisi, 2003, Bone–implant contact on machined and dual acid-etched surfaces after 2 months of healing in the human maxilla, J Periodontol, 74, 945, 10.1902/jop.2003.74.7.945 Wang, 2006, Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3, Biomaterials, 27, 3716, 10.1016/j.biomaterials.2006.02.022 Cochran, 1999, A comparison of endosseous dental implant surfaces, J Periodontol, 70, 1523, 10.1902/jop.1999.70.12.1523 Shalabi, 2006, Implant surface roughness and bone healing: a systematic review, J Dent Res, 85, 496, 10.1177/154405910608500603 Becker, 2006, Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs, Clin Oral Investig, 10, 217, 10.1007/s00784-006-0049-0 Schliephake, 2005, Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation, Clin Oral Implants Res, 16, 563, 10.1111/j.1600-0501.2005.01143.x Christenson, 2007, Nanobiomaterial applications in orthopedics, J Orthop Res, 25, 11, 10.1002/jor.20305 Liu, 2006, Increased osteoblast functions among nanophase titania/poly(lactide-co-glycolide) composites of the highest nanometer surface roughness, J Biomed Mater Res A, 78, 798, 10.1002/jbm.a.30734 Scotchford, 2002, Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers, J Biomed Mater Res, 59, 84, 10.1002/jbm.1220 Germanier, 2006, Enhanced bone apposition around biofunctionalized sandblasted and acid-etched titanium implant surfaces. A histomorphometric study in miniature pigs, Clin Oral Implants Res, 17, 251, 10.1111/j.1600-0501.2005.01222.x Zhou, 2007, Hydrogels prepared from unsubstituted cellulose in NaOH/urea aqueous solution, Macromol Biosci, 7, 804, 10.1002/mabi.200700007 Kim, 2000, Bioactive macroporous titanium surface layer on titanium substrate, J Biomed Mater Res, 5, 553, 10.1002/1097-4636(20001205)52:3<553::AID-JBM14>3.0.CO;2-X Wang, 2001, A comparative study of in vitro apatite deposition on heat-, H(2)O(2)-, and NaOH-treated titanium surfaces, J Biomed Mater Res, 54, 172, 10.1002/1097-4636(200102)54:2<172::AID-JBM3>3.0.CO;2-# Uchida, 2002, Apatite formation on zirconium metal treated with aqueous NaOH, Biomaterials, 23, 313, 10.1016/S0142-9612(01)00110-7 Wang, 2002, Bioactive titania-gel layers formed by chemical treatment of Ti substrate with a H2O2/HCl solution, Biomaterials, 23, 1353, 10.1016/S0142-9612(01)00254-X Mante, 2004, Oxidation of titanium, RGD peptide attachment, and matrix mineralization rat bone marrow stromal cells, J Oral Implantol, 30, 343, 10.1563/0.667.1 Ellingsen, 2000, Advances in dental implant materials and tissue regeneration, Periodontology, 2006, 136 Cooper, 2006, Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit blasted c.p. titanium endosseous implants, Biomaterials, 27, 926, 10.1016/j.biomaterials.2005.07.009 Guo, 2007, Modification of TiO2 grit blasted titanium implants by hydrofluoric acid treatment alters adherent osteoblast gene expression in vitro and in vivo, Biomaterials, 28, 5418, 10.1016/j.biomaterials.2007.08.032 Berglundh, 2007, Bone healing at implants with a fluoride-modified surface: an experimental study in dogs, Clin Oral Implants Res, 18, 147, 10.1111/j.1600-0501.2006.01309.x Ben-Nissan, 2006, Sol–gel production of bioactive nanocoatings for medical applications. Part 1: an introduction, Nanomed, 1, 311, 10.2217/17435889.1.3.311 Liu, 2001, Water-based sol–gel synthesis of hydroxyapatite: process development, Biomaterials, 22, 1721, 10.1016/S0142-9612(00)00332-X Kim, 2004, Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol–gel method, Biomaterials, 25, 2533, 10.1016/j.biomaterials.2003.09.041 Lee, 2006, Hydroxyapatite-TiO2 hybrid coating on Ti implants, J Biomater Appl, 20, 195, 10.1177/0885328206050518 Piveteau, 2000, Evaluating mechanical adhesion of sol–gel titanium dioxide coatings containing calcium phosphate for metal implant application, Biomaterials, 21, 2193, 10.1016/S0142-9612(00)00160-5 Arias, 2003, Micro- and nano-testing of calcium phosphate coatings produced by pulsed laser deposition, Biomaterials, 24, 3403, 10.1016/S0142-9612(03)00202-3 Choi, 2007, Sol–gel production of bioactive nanocoatings for medical applications. Part II: current research and development, Nanomed, 2, 51, 10.2217/17435889.2.1.51 Nishimura, 2007, Discrete deposition of hydroxyapatite nanoparticles on a titanium implant with predisposing substrate microtopography accelerated osseointegration, Nanotechnology, 18, 245101, 10.1088/0957-4484/18/24/245101 Mendes, 2007, The effect of discrete calcium phosphate nanocrystals on bone-bonding to titanium surfaces, Biomaterials, 28, 4748, 10.1016/j.biomaterials.2007.07.020 Ricci, 2000, Bone response to laser microtextured surfaces, 8 Coelho, 2005, Evaluation of an ibad thin-film process as an alternative method for surface incorporation of bioceramics on dental implants. A study in dogs, J Appl Oral Sci, 13, 87, 10.1590/S1678-77572005000100018 Brody, 2006, Characterizing nanoscale topography of the aortic heart valve basement membrane for tissue engineering heart valve scaffold design, Tissue Eng, 12, 413, 10.1089/ten.2006.12.413 Hansen, 2007, Effect of surface nanoscale topography on elastic modulus of individual osteoblastic cells as determined by atomic force microscopy, J Biomech, 40, 2865, 10.1016/j.jbiomech.2007.03.018 Lim, 2005, Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces, J R Soc Interface, 2, 97, 10.1098/rsif.2004.0019 Lim, 2007, The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography, Biomaterials, 28, 1787, 10.1016/j.biomaterials.2006.12.020 Palin, 2005, Mimicking the nanofeatures of bone increases bone-forming cell adhesion and proliferation, Nanotechnology, 16, 1828, 10.1088/0957-4484/16/9/069 Park, 2005, The effects of ion beam-assisted deposition of hydroxyapatite on the grit-blasted surface of endosseous implants in rabbit tibiae, Int J Oral Maxillofac Implants, 20, 31 Klabunde, 1996, Nanocrystals as stoichiometric reagents with unique surface chemistry, J Phys Chem, 100, 12141, 10.1021/jp960224x Wu, 1996, Sintering of nanophase γ-Al2O3 powder, J Am Ceram Soc, 79, 2207, 10.1111/j.1151-2916.1996.tb08962.x Baraton, 1997, FTIR study of nanostructured alumina nitride powder surface: determination of the acidic/basic sites by CO, CO2, and acetic acid adsorptions, Nanostruct Mater, 8, 435, 10.1016/S0965-9773(97)00189-X Zreiqat, 2005, The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts, Biomaterials, 26, 7579, 10.1016/j.biomaterials.2005.05.024 Monsees, 2005, Effects of different titanium alloys and nanosize surface patterning on adhesion, differentiation, and orientation of osteoblast-like cells, Cells Tissues Organs, 180, 81, 10.1159/000086749 Hart, 2005, Filapodial sensing of nanotopography in osteoprogenitor cells, Eur Cell Mater, 10, 65 Hart, 2007, Osteoprogenitor response to low-adhesion nanotopographies originally fabricated by electron beam lithography, J Mater Sci Mater Med, 18, 1211, 10.1007/s10856-007-0157-7 Washburn, 2004, High-throughput investigation of osteoblast response to polymer crystallinity: influence of nanometer-scale roughness on proliferation, Biomaterials, 25, 1215, 10.1016/j.biomaterials.2003.08.043 Eisenbarth, 2007, Biomimetic implant coatings, Biomol Eng, 24, 27, 10.1016/j.bioeng.2006.05.016 Webster, 2003, Increased osteoblast adhesion on titanium-coated hydroxylapatite that forms CaTiO3, J Biomed Mater Res A, 67, 975, 10.1002/jbm.a.10160 Ergun, 2007, Increased osteoblast adhesion on nanograined hydroxyapatite and tricalcium phosphate containing calcium titanate, J Biomed Mater Res A, 80, 990, 10.1002/jbm.a.30923 Balasundaram, 2006, Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD, Biomaterials, 27, 2798, 10.1016/j.biomaterials.2005.12.008 Webster, 2000, Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics, J Biomed Mater Res, 51, 475, 10.1002/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9 Chun, 2005, Helical rosette nanotubes: a biomimetic coating for orthopedics?, Biomaterials, 26, 7304, 10.1016/j.biomaterials.2005.05.080 Dong, 2007, Multifunctional nanowire bioscaffolds on titanium, Chem Mater, 19, 4454, 10.1021/cm070845a Advincula, 2006, Osteoblast adhesion and matrix mineralization on sol–gel-derived titanium oxide, Biomaterials, 27, 2201, 10.1016/j.biomaterials.2005.11.014 Webster, 2005, Increased osteoblast function on PLGA composites containing nanophase titania, J Biomed Mater Res A, 74, 677, 10.1002/jbm.a.30358 Popat, 2007, Influence of engineered titania nanotubular surfaces on bone cells, Biomaterials, 28, 3188, 10.1016/j.biomaterials.2007.03.020 Popat, 2007, Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfaces, J Biomed Mater Res A, 80, 955, 10.1002/jbm.a.31028 Dalby, 2006, Osteoprogenitor response to defined topographies with nanoscale depths, Biomaterials, 27, 1306, 10.1016/j.biomaterials.2005.08.028 Oliveira, 2004, Nanotexturing of titanium-based surfaces upregulates expression of bone sialoprotein and osteopontin by cultured osteogenic cells, Biomaterials, 25, 403, 10.1016/S0142-9612(03)00539-8 Bigi, 2007, In vitro culture of mesenchymal cells onto nanocrystalline hydroxyapatite-coated Ti13Nb13Zr alloy, J Biomed Mater Res A, 82, 213, 10.1002/jbm.a.31132 Tan, 2004, Biomaterials with hierarchically defined micro- and nanoscale structure, Biomaterials, 25, 3593, 10.1016/j.biomaterials.2003.10.034 Oliveira, 2007, Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography, J Biomed Mater Res A, 80, 554, 10.1002/jbm.a.30955 Berry, 2006, The interaction of human bone marrow cells with nanotopographical features in three dimensional constructs, J Biomed Mater Res A, 79, 431, 10.1002/jbm.a.30960 Price, 2004, Nanometer surface roughness increases select osteoblast adhesion on carbon nanofiber compacts, J Biomed Mater Res A, 70, 129, 10.1002/jbm.a.30073 McManus, 2005, Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites, J Biomed Mater Res A, 72, 98, 10.1002/jbm.a.30204 Kay, 2002, Nanostructured polymer/nanophase ceramic composites enhance osteoblast and chondrocyte adhesion, Tissue Eng, 8, 753, 10.1089/10763270260424114 Briggs, 2004, Formation of highly adherent nano-porous alumina on Ti-based substrates: a novel bone implant coating, J Mater Sci Mater Med, 15, 1021, 10.1023/B:JMSM.0000042688.33507.12 Chiesa, 2007, In vitro and in vivo performance of a novel surface treatment to enhance osseointegration of endosseous implants, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103, 745, 10.1016/j.tripleo.2006.09.025 Lickorish, 2007, A three-phase, fully resorbable, polyester/calcium phosphate scaffold for bone tissue engineering: evolution of scaffold design, Biomaterials, 28, 1495, 10.1016/j.biomaterials.2006.11.025 Kubota, 2004, Titanium oxide nanotubes for bone regeneration, J Mater Sci Mater Med, 15, 1031, 10.1023/B:JMSM.0000042689.78768.77 Jung, 2001, Effects of ion beam-assisted deposition of hydroxyapatite on the osseointegration of endosseous implants in rabbit tibiae, Int J Oral Maxillofac Implants, 16, 809 Fath, 1989, The distribution of distinct integrins in focal contacts is determined by the substratum composition, J Cell Sci, 92, 67, 10.1242/jcs.92.1.67 Tosatti, 2004, RGD-containing peptide GCRGYGRGDSPG reduces enhancement of osteoblast differentiation by poly(l-lysine)-graft-poly(ethylene glycol)-coated titanium surfaces, J Biomed Mater Res A, 68, 458, 10.1002/jbm.a.20082 Sinha, 1996, Regulation of human osteoblast integrin expression by orthopedic implant materials, Bone, 18, 451, 10.1016/8756-3282(96)00044-0 Cavalcanti-Adam, 2007, Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands, Biophys J, 92, 2964, 10.1529/biophysj.106.089730 Rodrigues, 2006, Fibrinogen adsorption, platelet adhesion and activation on mixed hydroxyl-/methyl-terminated self-assembled monolayers, Biomaterials, 27, 5357, 10.1016/j.biomaterials.2006.06.010 Arima, 2007, Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers, Biomaterials, 28, 3074, 10.1016/j.biomaterials.2007.03.013 Park, 2005, A review of nanotechnology for the development of better orthopedic implants, J Biomed Nanotechnol, 1, 18, 10.1166/jbn.2005.003 Brunette, 1988, The effects of implant surface topography on the behavior of cells, Int J Oral Maxillofac Implants, 3, 231 Andersson, 2003, Nanoscale features influence epithelial cell morphology and cytokine production, Biomaterials, 24, 3427, 10.1016/S0142-9612(03)00208-4 Wan, 2005, Adhesion and proliferation of OCT-1 osteoblast-like cells on micro- and nano-scale topography structured poly(l-lactide), Biomaterials, 26, 4453, 10.1016/j.biomaterials.2004.11.016 Teixeira, 2003, Epithelial contact guidance on well-defined micro- and nanostructured substrates, J Cell Sci, 116, 1881, 10.1242/jcs.00383 Cai, 2006, Does the nanometre scale topography of titanium influence protein adsorption and cell proliferation?, Colloids Surf B Biointerfaces, 49, 136, 10.1016/j.colsurfb.2006.02.016 Teixeira, 2006, The effect of environmental factors on the response of human corneal epithelial cells to nanoscale substrate topography, Biomaterials, 27, 3945, 10.1016/j.biomaterials.2006.01.044 Alsberg, 2006, Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering, Tissue Eng, 12, 3247, 10.1089/ten.2006.12.3247 Dalby, 2007, The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder, Nat Mater, 6, 997, 10.1038/nmat2013 Zhao, 2006, Osteoblast-like cells are sensitive to submicron-scale surface structure, Clin Oral Implants Res, 17, 258, 10.1111/j.1600-0501.2005.01195.x Schwartz, 2002, Networks and crosstalk: integrin signalling spreads, Nat Cell Biol, 4, E65, 10.1038/ncb0402-e65 Colon, 2006, Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2, J Biomed Mater Res A, 78, 595, 10.1002/jbm.a.30789 Meirelles, 2007, Increased bone formation to unstable nano rough titanium implants, Clin Oral Implants Res, 18, 326, 10.1111/j.1600-0501.2006.01308.x Meirelles L. On nano size structures for enhanced early bone formation [Ph.D.]. Gothenburg: Gothenburg University; 2007. Davies, 2007, Bone bonding at natural and biomaterial surfaces, Biomaterials, 28, 5058, 10.1016/j.biomaterials.2007.07.049 Tasker, 2007, Applications of nanotechnology in orthopaedics, Clin Orthop Relat Res, 456, 243, 10.1097/BLO.0b013e31803125f4 Ellingsen, 2000, On the properties of surface-modified titanium, 183 Ellingsen, 2003, Increasing biocompatibility by chemical modification of titanium surfaces, 323 Ward, 2006, The effect of nanotopography on calcium and phosphorus deposition on metallic materials in vitro, Biomaterials, 27, 3064, 10.1016/j.biomaterials.2005.12.027 Zhu, 2005, Alignment of osteoblast-like cells and cell-produced collagen matrix induced by nanogrooves, Tissue Eng, 11, 825, 10.1089/ten.2005.11.825 Oxby, 2006, Early loading of Astra Tech OsseoSpeed implants placed in thin alveolar ridges and fresh extraction sockets, Appl Osseointegration Res, 5, 68 Orsini, 2007, Randomized, controlled histologic and histomorphometric evaluation of implants with nanometer-scale calcium phosphate added to the dual acid-etched surface in the human posterior maxilla, J Periodontol, 78, 209, 10.1902/jop.2007.060297 Goené, 2007, Influence of a nanometer-scale surface enhancement on de novo bone formation on titanium implants: a histomorphometric study in human maxillae, Int J Periodontics Restorative Dent, 27, 211