APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

Nature - Tập 581 Số 7806 - Trang 71-76 - 2020
Axel Montagne1, Daniel A. Nation1, Abhay P. Sagare1, Giuseppe Barisano1, Melanie D. Sweeney1, Ararat Chakhoyan1, Maricarmen Pachicano1, Elizabeth Joe2, Amy R. Nelson1, Lina M. D’Orazio2, David P Buennagel3, Michael G. Harrington3, Tammie L.S. Benzinger4, Anne M. Fagan5, John M. Ringman2, Lon S. Schneider2, John C. Morris6, Eric M. Reiman7, Richard J. Caselli8, Elizabeth Fisher9, Julia TCW10, Yining Chen1, Judy Pa2, Peter S. Conti11, Meng Law2, Arthur W. Toga2, Berislav V. Zloković2
1Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
2Alzheimer’s Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
3Huntington Medical Research Institutes, Pasadena, CA USA
4Department of Radiology, Washington University School of Medicine, St. Louis, MO USA
5The Hope Center for Neurodegenerative Disorders, Washington University School of Medicine, St Louis, MO, USA
6Department of Neurology, Washington University School of Medicine, St. Louis, Mo. USA
7Banner Alzheimer Institute, Phoenix, AZ, USA
8Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA
9Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
10Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
11Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

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