Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Radisic, M. et al. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 286, H507–H516 (2004).

Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920–926 (1993).

Griffith, L. G. & Swartz, M. A. Capturing complex 3D tissue physiology in vitro. Nature Rev. Mol. Cell Biol. 7, 211–224 (2006).

Vunjak-Novakovic, G. & Scadden, D. T. Biomimetic platforms for human stem cell research. Cell Stem Cell 8, 252–261 (2011).

Schmidt-Nielsen, K. Scaling in biology: The consequences of size. J. Exp. Zool. 194, 287–307 (1975).

Golden, A. P. & Tien, J. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 7, 720–725 (2007).

Ling, Y. et al. A cell-laden microfluidic hydrogel. Lab Chip 7, 756–762 (2007).

Choi, N. W. et al. Microfluidic scaffolds for tissue engineering. Nature Mater. 6, 908–915 (2007).

Cuchiara, M. P., Allen, A. C. B., Chen, T. M., Miller, J. S. & West, J. L. Multilayer microfluidic PEGDA hydrogels. Biomaterials 31, 5491–5497 (2010).

Visconti, R. P. et al. Towards organ printing: Engineering an intra-organ branched vascular tree. Exp. Opin. Biol. Therapy 10, 409–420 (2010).

Therriault, D., White, S. R. & Lewis, J. A. Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly. Nature Mater. 2, 265–271 (2003).

Bellan, L. M. et al. Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures. Soft Matter 5, 1354–1357 (2009).

Wu, W. et al. Direct-write assembly of biomimetic microvascular networks for efficient fluid transport. Soft Matter 6, 739–742 (2010).

Reinheimer, M. A., Mussati, S. & Scenna, N. J. Influence of product composition and operating conditions on the unsteady behavior of hard candy cooling process. J. Food Eng. 101, 409–416 (2010).

Lutolf, M. P. & Hubbell, J. A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nature Biotechnol. 23, 47–55 (2005).

Tibbitt, M. W. & Anseth, K. S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 103, 655–663 (2009).

Heiber, J., Clemens, F., Graule, T. & Hülsenberg, D. Thermoplastic extrusion to highly-loaded thin green fibres containing Pb(Zr,Ti)O3 . Adv. Eng. Mater. 7, 404–408 (2005).

Miller, J. S. et al. Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials 31, 3736–3743 (2010).

Moon, J. J., Hahn, M. S., Kim, I., Nsiah, B. A. & West, J. L. Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. Tissue Eng. Part A 15, 579–585 (2009).

DeLong, S. A., Moon, J. J. & West, J. L. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26, 3227–3234 (2005).

Stefonek, T. J. & Masters, K. S. Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Wound Repair Regen. 15, 847–855 (2007).

Leslie-Barbick, J. E., Moon, J. J. & West, J. L. Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. J. Biomater. Sci. Poly. Edn 20, 1763–1779 (2009).

Sundararaghavan, H. G., Monteiro, G. A., Firestein, B. L. & Shreiber, D. I. Neurite growth in 3D collagen gels with gradients of mechanical properties. Biotechnol. Bioeng. 102, 632–643 (2009).

Nemir, S., Hayenga, H. N. & West, J. L. PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. Biotechnol. Bioeng. 105, 636–644 (2010).

Tsang, V. L. et al. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J. 21, 790–801 (2007).

Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic large-scale integration. Science 298, 580–584 (2002).

Atencia, J. & Beebe, D. J. Controlled microfluidic interfaces. Nature 437, 648–655 (2005).