THE ACTION IN VIVO OF A STRUCTURAL ANALOGUE OF GABA: HYDRAZINOPROPIONIC ACID1

Journal of Neurochemistry - Tập 16 Số 9 - Trang 1355-1360 - 1969
N. M. van Gelder1
1Medical Research Council Group in the Neurological Sciences, Department of Physiology University of Montreal, Montreal, Canada

Tóm tắt

Abstract— The action of hydrazinopropionic acid in vivo on the metabolism of amino acids in the CNS of mice was studied over a period of 24 hr. At 82 μmoles/kg, a transient fourfold rise in the levels of tyrosine occurred followed by a more moderate and prolonged increase in the levels of GABA. When the dose of hydrazinopropionate was raised to 123 μmoles/kg, the changes in the levels of tyrosine were identical with those at the lower dose, while levels of GABA rose further before reaching a steady state. Levels of glutamate decreased concomitantly. In addition, the concentrations of alanine, β‐aminoisobutyric acid and an unknown compound tended to rise. A doubling of the dose to 246 μmoles/kg enhanced the effects obtained with the lower doses but did not produce any new changes in the patterns of amino acids of the CNS.The elevation in the concentrations of alanine paralleled changes in the levels of tyrosine. The changes in the concentrations of the unknown compound, tentatively identified as α‐aminoadipate, and of β‐aminoisobutyric acid resembled those of GABA. The results are interpreted to indicate an inhibition by hydrazinopropionic acid of tyrosine aminotransferase and aminobutyrate aminotransferase.

Từ khóa


Tài liệu tham khảo

10.1042/bj0940131

10.1111/j.1471-4159.1960.tb13458.x

10.1111/j.1471-4159.1956.tb12071.x

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10.1016/0006-291X(64)90266-9

10.1111/j.1471-4159.1968.tb10319.x

10.1111/j.1471-4159.1965.tb06759.x

Thông tin
Thông tin xuất bản

Journal of Neurochemistry

Tập 16 Số 9

1355-1360

Thông tin tác giả