Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells
Michael Boice1,2, Darin Salloum1, Frederic Mourcin3, Viraj Sanghvi1, Rada Amin3, Elisa Oricchio4, Man Jiang1, Anja Mottok5, Nicolas Denis-Lagache6, Giovanni Ciriello7,8, Wayne Tam9, Julie Teruya-Feldstein10, Elisa de Stanchina11, Wing C. Chan12, Sami N. Malek13, Daisuke Ennishi5, Renier J. Brentjens14, Randy D. Gascoyne5, Michel Cogné6, Karin Tarte3
1Cancer Biology & Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
2Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA
3INSERM U917, Equipe labellisée Ligue contre le Cancer, Université Rennes 1, EFS Bretagne, CHU Rennes, 35000 Rennes, France
4Swiss Institute for Cancer Research (ISREC), EPFL SV-Batiment 19, 1003 Lausanne, Switzerland
5Centre for Lymphoid Cancer, British Columbia Cancer Agency and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V5Z 1L3, Canada
6Centre National de la Recherche Scientifque, UMR 7276, Université de Limoges, 8700 Limoges, France
7Department of Computational Biology, University of Lausanne, Rue du Bugnon 27, 1005 Lausanne, Switzerland
8The Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
9Department of Pathology and Laboratory Medicine, Weill Cornell Medical School, New York, NY 10065, USA
10Department of Pathology, Mount Sinai Health System, New York, NY 10029, USA
11Antitumor Assessment Core Facility and Molecular Pharmacology Department, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA
12Department of Pathology, City of Hope, Duarte, CA 91010, USA
13Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
14Department of Medicine, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA