Diphenyl Diselenide Reduces Mechanical and Thermal Nociceptive Behavioral Responses After Unilateral Intrastriatal Administration of 6-Hydroxydopamine in Rats

Biological Trace Element Research - Tập 154 - Trang 372-378 - 2013
Juliana Trevisan da Rocha1, Simone Pinton1, Bibiana Mozzaquatro Gai1, Cristina Wayne Nogueira1,2
1Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil
2Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil

Tóm tắt

Parkinson’s disease (PD) patients, in addition to motor dysfunction, also present alterations in pain sensation. The present study characterized the antinociceptive effects of diphenyl diselenide ((PhSe)2) in a model of nociception induced by unilateral, intrastriatal 6-hydroxydopamine (6-OHDA) injection in rats. Male adult Wistar rats received 20 μg/3 μl of 6-OHDA (in saline solution containing 0.02 % of ascorbic acid) or 3 μl of vehicle into the right striatum (1.0 mm anterior, 3.0 mm lateral, and 5.0 mm ventral—with respect to the bregma). Thirty days after injection, rats received (PhSe)2 intragastrically at a dose of 10 mg/kg 1 h before behavioral tests (von Frey hairs, hot plate, tail immersion, formalin, and open field). Our results demonstrated that 6-OHDA injection to rats augmented the response frequency of von Frey hairs (VHF) stimulation, besides reducing the thermal withdrawal latency in the hot plate test. Importantly, the (PhSe)2 treatment decreased the mechanical allodynia measured by the response frequency of VHF stimulation and diminished the thermal nociception in the hot plate test in 6-OHDA-injected rats. In conclusion, these results revealed that a single oral administration of (PhSe)2 1 h prior to the accomplishment of the behavioral tests was effective to attenuate the increased mechanical and thermal nociception caused by a single intrastriatal 6-OHDA injection to rats. Furthermore, other clarifying studies are warranted to improve the evidence bases for future clinical use of (PhSe)2 as a new alternative therapy for the treatment of painful symptoms associated to PD.

Tài liệu tham khảo

Blandini F, Nappi G, Tassorelli C, Martigno E (2000) Functional changes of the basal ganglia circuitry in Parkinson’s disease. Prog Neurobiol 62:63–88 Ford B (1998) Pain in Parkinson’s disease. Clin Neurosci 5:63–72 Giuffrida R, Vingerhoets FJ, Bogousslavsky J, Ghika J (2005) Pain in Parkinson’s disease. Rev Neurol (Paris) 161:407–418 Lee MA, Walker RW, Hildreth TJ, Prentice WM (2006) A survey of pain in idiopathic Parkinson’s disease. J Pain Symptom Manag 32:462–469 Mylius V, Engau I, Teepker M, Stiasny-Kolster K, Schepelmann K, Oertel WH, Lautenbacher S, Möller JC (2009) Pain sensitivity and descending inhibition of pain in Parkinson’s disease. J Neurol Neurosurg Psychiatry 80:24–28 Defazio G, Berardelli A, Fabbrini G, Martino D, Fincati E, Fiaschi A, Moretto G, Abbruzzese G, Marchese R, Bonuccelli U, Del Dotto P, Barone P, De Vivo E, Albanese A, Antonini A, Canesi M, Lopiano L, Zibetti M, Nappi G, Martignoni E, Lamberti P, Tinazzi M (2008) Pain as a nonmotor symptom of Parkinson disease: evidence from a case–control study. Arch Neurol 65(9):1191–1194 Brefel-Courbon C, Payoux P, Thalamas C, Ory F, Quelven I, Chollet F, Montastruc JL, Rascol O (2005) Effect of levodopa on pain threshold in Parkinson’s disease: a clinical and positron emission tomography study. Mov Disord 20(12):1557–1563 Ungerstedt U (1968) 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 5:107–110 Sauer H, Oertel WH (1994) Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59:401–415 Deumens R, Blokland A, Prickaerts J (2002) Modeling Parkinson’s disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175:303–317 Chudler EH, Dong WK (1995) The role of the basal ganglia in nociception and pain. Pain 60:3–38 Prigol M, Brüning CA, Martini F, Nogueira CW (2012) Comparative excretion and tissue distribution of selenium in mice and rats following treatment with diphenyl diselenide. Biol Trace Elem Res 150:272–277. doi:10.1007/s12011-012-9464-z Nogueira CW, Quinhones EB, Jung EAC, Zeni G, Rocha JBT (2003) Anti-inflammatory and antinociceptive activity of diphenyl diselenide. Inflamm Res 52:56–63 Zasso FB, Gonçales CE, Jung EA, Araldi D, Zeni G, Rocha JB, Nogueira CW (2005) On the mechanisms involved in antinociception induced by diphenyl diselenide. Environ Toxicol Pharmacol 19(2):283–289 Savegnago L, Pinto LG, Jesse CR, Alves D, Rocha JBT, Nogueira CW, Zeni G (2007) Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol 555:129–138 Savegnago L, Jesse CR, Nogueira CW (2008) Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice. Neurosci Lett 436:120–123 Savegnago L, Jesse CR, Santos ARS, Rocha JBT, Nogueira CW (2008) Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test. J Pharm Pharmacol 60:1679–1686 Paulmier C (1986) Selenoorganic functional groups. In: Paulmier C (ed) Selenium reagents and intermediates in organic synthesis, 1st edn. Pergamon, Oxford Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, San Diego Greco R, Tassorelli C, Armentero MT, Sandrini G, Nappi G, Blandini F (2008) Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia. Brain Res 1238:215–223 Fang X, Sugiyama K, Akamine S, Namba H (2006) The stepping test and its learning process in different degrees of unilateral striatal lesions by 6-hydroxydopamine in rats. Neurosc Res 55:403–409 Nogueira CW, Zeni G, Rocha JBT (2004) Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 104:6255–6286. doi:10.1021/cr0406559 Bortolanza LB, Ferreira J, Hess SC, Delle Monache F, Yunes RA, Calixto JB (2002) Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice. Eur J Pharmacol 53:203–208 Woolfre HG, MacDonald AD (1944) The evaluation of the analgesic action of pethidine hydrochloride. J Pharmacol Exp Ther 80:300–307 Janssen PAJ, Niemegeers CJE, Dony JHG (1963) The inhibitory effect of fentanyl and other morphine-like analgesics on the warn water induced tail withdrawal reflex in rats. Arzeneimittelforschung 13:502–507 Pinardi G, Sierralta F, Miranda HF (2003) Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice. Pharmacol Biochem Behav 74:603–608 Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30:103–114 Santos ARS, Calixto JB (1997) Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides 37:381–389 Hall CS (1934) Emotional behavior in the rat: defecation and urination as measures of individual differences in emotionality. J Comp Psychol 18:385–403 Hall CS, Ballechey ELA (1932) A study of the rat’s behavior in a field: a contribution to method in comparative psychology. Univ Calif Publ Psychol 6:1–12 Walsh RN, Cummins RA (1976) Open-field test—critical review. Psychol Bull 83:482–504 Chaudhuri KR, Healy DG, Schapira AHV (2006) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5:235–245 Chudler EH, Sugiyama K, Dong WK (1995) Multisensory convergence and integration in the neostriatum and globus pallidus of the rat. Brain Res 674:33–45 Saade NE, Atweh SF, Bahuth NB, Jabbur SJ (1997) Augmentation of nociceptive reflexes and chronic differentiation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons. Brain Res 751:1–12 Chudler EH, Lu Y (2008) Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine. Brain Res 41–47 Fruhstorfer H, Gross W, Selbmann O (2001) Von Frey hairs: new materials for a new design. Eur J Pain Lond 5:341–342 Lambert GA, Mallos G, Zagami AS (2009) Von Frey’s hairs—a review of their technology and use—a novel automated von Frey device for improved testing for hyperalgesia. J Neurosc Meth 177:420–426 Jensen TS, Yaksh TL (1986) Examination of spinal monoamine receptors through which brainstem opiate-sensitive act in the rat. Brain Res 363:99–113 Savegnago L, Jesse CR, Moro AV, Borges VC, Santos FW, Rocha JBT, Nogueira CW (2006) Bis selenide alkene derivatives: a class of potential antioxidant and antinociceptive agents. Pharmacol Biochem Behav 83:221–229 Magnusson JE, Fisher K (2000) The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum. Brain Res 855:260–266 Jesse CR, Rocha JBT, Nogueira CW, Savegnago L (2009) Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice. Pharmacol Biochem Behav 91(4):573–580 Savegnago L, Jesse CR, Pinto LG, Rocha JBT, Nogueira CW (2007) Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice. Brain Res 1175:54–59 Prigol M, Schumacher RF, Nogueira CW, Zeni G (2009) Convulsant effect of diphenyl diselenide in rats and mice and its relationship to plasma levels. Toxicol Lett 189:35–39