Experience-dependent, asymmetric expansion of hippocampal place fields

Proceedings of the National Academy of Sciences of the United States of America - Tập 94 Số 16 - Trang 8918-8921 - 1997
Mayank Mehta1, Carol A. Barnes2, Bruce L. McNaughton2
1ARL Division of Neural Systems, Memory and Aging, Department of Psychology, University of Arizona, Tucson, AZ 85724, USA.
2ARL Division of Neural Systems, Memory and Aging, Department of Psychology, University of Arizona, Tucson, AZ 85724

Tóm tắt

Theories of sequence learning based on temporally asymmetric, Hebbian long-term potentiation predict that during route learning the spatial firing distributions of hippocampal neurons should enlarge in a direction opposite to the animal’s movement. On a route AB, increased synaptic drive from cells representing A would cause cells representing B to fire earlier and more robustly. These effects appeared within a few laps in rats running on closed tracks. This provides indirect evidence for Hebbian synaptic plasticity and a functional explanation for why place cells become directionally selective during route following, namely, to preserve the synaptic asymmetry necessary to encode the sequence direction.

Từ khóa


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Thông tin
Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 94 Số 16

8918-8921

Thông tin tác giả