Stretch-Sensitive KCNQ1Mutation

Kannel, 1998, Prevalence, incidence, prognosis and predisposing conditions for atrial fibrillation: population-based estimates, Am J Cardiol, 82, 2N, 10.1016/S0002-9149(98)00583-9 Benjamin, 1998, Impact of atrial fibrillation on the risk of death, Circulation, 98, 946, 10.1161/01.CIR.98.10.946 Wijffels, 1995, Atrial fibrillation begets atrial fibrillation, Circulation, 92, 1954, 10.1161/01.CIR.92.7.1954 Nattel, 2002, New ideas about atrial fibrillation 50 years on, Nature, 415, 219, 10.1038/415219a Darbar, 2003, Familial atrial fibrillation is a genetically heterogeneous disorder, J Am Coll Cardiol, 41, 2185, 10.1016/S0735-1097(03)00465-0 Fox, 2004, Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring, JAMA, 291, 2851, 10.1001/jama.291.23.2851 Chen, 2003, KCNQ1 gain-of-function mutation in familial atrial fibrillation, Science, 299, 251, 10.1126/science.1077771 Keating, 2001, Molecular and cellular mechanisms of cardiac arrhythmias, Cell, 104, 569, 10.1016/S0092-8674(01)00243-4 Hong, 2005, De novo KCNQ1mutation responsible for atrial fibrillation and short QT syndrome in utero, Cardiovasc Res, 68, 433, 10.1016/j.cardiores.2005.06.023 Yang, 2004, Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation, Am J Hum Genet, 75, 899, 10.1086/425342 Lu, 2001, Effects of premature stimulation on HERG K+channels, J Physiol, 537, 843, 10.1113/jphysiol.2001.012690 Clarke, 2006, Effect of S5P α-helix charge mutants on inactivation of hERG K+channels, J Physiol, 573, 291, 10.1113/jphysiol.2006.108332 Nygren, 1998, Mathematical model of an adult human atrial cell: the role of K+currents in repolarization, Circ Res, 82, 63, 10.1161/01.RES.82.1.63 Courtemanche, 1998, Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model, Am J Physiol, 275, H301 Terrenoire, 2005, Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation, Circ Res, 96, e25, 10.1161/01.RES.0000160555.58046.9a Kneller, 2002, Time-dependent transients in an ionically based mathematical model of the canine atrial action potential, Am J Physiol Heart Circ Physiol, 282, H1437, 10.1152/ajpheart.00489.2001 Varghese, 1997, A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells, J Theor Biol, 189, 33, 10.1006/jtbi.1997.0487 Ackerman, 2003, Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome, Mayo Clin Proc, 78, 1479, 10.4065/78.12.1479 Rees, 1995, Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes, J Gen Physiol, 106, 1151, 10.1085/jgp.106.6.1151 Wang, 1994, Rapid and slow components of delayed rectifier current in human atrial myocytes, Cardiovasc Res, 28, 1540, 10.1093/cvr/28.10.1540 Tester, 2005, Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing, Heart Rhythm, 2, 507, 10.1016/j.hrthm.2005.01.020 Marx, 2002, Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel, Science, 295, 496, 10.1126/science.1066843 Kurokawa, 2004, Regulatory actions of the A-kinase anchoring protein yotiao on a heart potassium channel downstream of PKA phosphorylation, Proc Natl Acad Sci U S A, 101, 16374, 10.1073/pnas.0405583101 Grunnet, 2003, KCNQ1 channels sense small changes in cell volume, J Physiol, 549, 419, 10.1113/jphysiol.2003.038455 Sasaki, 1994, Increase of the delayed rectifier K+and Na+-K+pump currents by hypotonic solutions in guinea pig cardiac myocytes, Circ Res, 75, 887, 10.1161/01.RES.75.5.887 Wang, 1995, Cell distension-induced increase of the delayed rectifier K+current in guinea pig ventricular myocytes, Circ Res, 78, 466, 10.1161/01.RES.78.3.466 Melnyk, 2005, Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium, Cardiovasc Res, 65, 104, 10.1016/j.cardiores.2004.08.014 Yamane, 2002, Dilation as a marker of pulmonary veins initiating atrial fibrillation, J Interv Card Electrophysiol, 6, 245, 10.1023/A:1019561820830 Herweg, 2005, Hypertension and hypertensive heart disease are associated with increased ostial pulmonary vein diameter, J Cardiovasc Electrophysiol, 16, 2, 10.1046/j.1540-8167.2005.04283.x Ellinor, 2004, Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation, Heart, 90, 1487, 10.1136/hrt.2003.027227 Bauer, 2005, The new selective IKs-blocking agent HMR 1556 restores sinus rhythm and prevents heart failure in pigs with persistent atrial fibrillation, Basic Res Cardiol, 100, 270, 10.1007/s00395-005-0522-y Zhang, 2005, KCNE3 R53H substitution in familial atrial fibrillation, Chin Med J, 118, 1735