Omega-3 PUFA metabolism and brain modifications during aging
Tóm tắt
Từ khóa
Tài liệu tham khảo
Aarsetoey, 2009, (n-3) Fatty acid content of red blood cells does not predict risk of future cardiovascular events following an acute coronary syndrome, J. Nutr., 139, 507, 10.3945/jn.108.096446
Archer, 2016, A comprehensive analysis of connectivity and aging over the adult life span, Brain Connect, 6, 169, 10.1089/brain.2015.0345
Arterburn, 2006, Distribution, interconversion, and dose response of n-3 fatty acids in humans, Am. J. Clin. Nutr., 83, S1467, 10.1093/ajcn/83.6.1467S
Asciutti-Moura, 1988, Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population, Am. J. Clin. Nutr., 48, 980, 10.1093/ajcn/48.4.980
Austin, 1998, Hypertriglyceridemia as a cardiovascular risk factor, Am. J. Cardiol., 81, 7B, 10.1016/S0002-9149(98)00031-9
B., B, 2006, Stress oxydant et pathologies cardiovasculaires, Méd. Thér. Cardiol., 2, 43
Barberger-Gateau, 2002, Fish, meat, and risk of dementia: cohort study, Bmj, 325, 932, 10.1136/bmj.325.7370.932
Barberger-Gateau, 2011, Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype, Curr. Alzheimer Res., 8, 479, 10.2174/156720511796391926
Bisgaier, 1983, Intestinal synthesis, secretion, and transport of lipoproteins, Annu. Rev. Physiol., 45, 625, 10.1146/annurev.ph.45.030183.003205
Blasbalg, 2011, Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century, Am. J. Clin. Nutr., 93, 950, 10.3945/ajcn.110.006643
Block, 2008, Determinants of blood cell omega-3 fatty acid content, Open Biomark. J., 1, 1, 10.2174/1875318300801010001
Block, 2008, EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls, Atherosclerosis, 197, 821, 10.1016/j.atherosclerosis.2007.07.042
Bourisly, 2015, A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21-45 years old, Neuroradiol. J., 28, 450, 10.1177/1971400915598078
Brenna, 2018, Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids, Am. J. Clin. Nutr., 108, 211, 10.1093/ajcn/nqy089
Brossard, 1996, Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols, Am. J. Clin. Nutr., 64, 577, 10.1093/ajcn/64.4.577
Brossard, 1997, Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells, J. Lipid Res., 38, 1571, 10.1016/S0022-2275(20)37175-3
Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311
Calder, 2006, Polyunsaturated fatty acids and inflammation, Prostaglandins Leukot. Essent. Fat. Acids, 75, 197, 10.1016/j.plefa.2006.05.012
Callaghan, 2014, Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging, Neurobiol. Aging, 35, 1862, 10.1016/j.neurobiolaging.2014.02.008
Caprari, 1999, Aging and red blood cell membrane: a study of centenarians, Exp. Gerontol., 34, 47, 10.1016/S0531-5565(98)00055-2
Carver, 2001, The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects, Brain Res. Bull., 56, 79, 10.1016/S0361-9230(01)00551-2
Chouinard-Watkins, 2013, Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE epsilon4 allele, Br. J. Nutr., 110, 1751, 10.1017/S0007114513001268
Chouinard-Watkins, 2015, Interactive impact of BMI and APOE genotype on the plasma long chain polyunsaturated fatty acid response to a fish oil supplement in healthy participants, Am. J. Clin. Nutr., 102, 505, 10.3945/ajcn.114.103507
Christie, 1985, Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection, J. Lipid Res., 26, 507, 10.1016/S0022-2275(20)34367-4
Coffey, 1998, Sex differences in brain aging: a quantitative magnetic resonance imaging study, Arch. Neurol., 55, 169, 10.1001/archneur.55.2.169
Coffler, 2003, Enhanced granulosa cell responsiveness to follicle-stimulating hormone during insulin infusion in women with polycystic ovary syndrome treated with pioglitazone, J. Clin. Endocrinol. Metab., 88, 5624, 10.1210/jc.2003-030745
Conway, 2014, Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?, Lipids Health Dis., 13, 148, 10.1186/1476-511X-13-148
Coon, 2007, A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease, J. Clin. Psychiatry, 68, 613, 10.4088/JCP.v68n0419
Cooper, 1997, Hepatic uptake of chylomicron remnants, J. Lipid Res., 38, 2173, 10.1016/S0022-2275(20)34932-4
Croteau, 2018, A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease, Exp. Gerontol., 107, 18, 10.1016/j.exger.2017.07.004
Croteau, 2018, Ketogenic medium chain triglycerides increase brain energy metabolism in Alzheimer's disease, J. Alzheimers Dis., 64, 551, 10.3233/JAD-180202
Crowe, 2008, Serum n-3 long-chain PUFA differ by sex and age in a population-based survey of New Zealand adolescents and adults, Br. J. Nutr., 99, 168, 10.1017/S000711450779387X
Cunnane, 2009, Fish, docosahexaenoic acid and Alzheimer's disease, Prog. Lipid Res., 48, 239, 10.1016/j.plipres.2009.04.001
Daneault, 2014, Aging reduces the stimulating effect of blue light on cognitive brain functions, Sleep, 37, 85, 10.5665/sleep.3314
D'Aquila, 2016, Recent discoveries on absorption of dietary fat: presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes, Biochim. Biophys. Acta, 1861, 730, 10.1016/j.bbalip.2016.04.012
de Groot, 2009, Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations, Br. J. Nutr., 102, 1058, 10.1017/S0007114509359103
DeFronzo, 1987, The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM, Diabetes, 37, 667, 10.2337/diab.37.6.667
Dewailly, 2001, n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik, Am. J. Clin. Nutr., 74, 464, 10.1093/ajcn/74.4.464
Dewailly, 2001, Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers, Am. J. Clin. Nutr., 74, 603, 10.1093/ajcn/74.5.603
Dewailly, 2002, Cardiovascular disease risk factors and n-3 fatty acid status in the adult population of James Bay Cree, Am. J. Clin. Nutr., 76, 85, 10.1093/ajcn/76.1.85
Draganski, 2011, Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ), Neuroimage, 55, 1423, 10.1016/j.neuroimage.2011.01.052
Einarsson, 1985, Influence of age on secretion of cholesterol and synthesis of bile acids by the liver, N. Engl. J. Med., 313, 277, 10.1056/NEJM198508013130501
Ericsson, 1997, The influence of age on low density lipoprotein metabolism: effects of cholestyramine treatment in young and old healthy male subjects, J. Intern. Med., 242, 329, 10.1046/j.1365-2796.1997.00238.x
Erten-Lyons, 2013, Neuropathologic basis of age-associated brain atrophy, JAMA Neurol., 70, 616, 10.1001/jamaneurol.2013.1957
Farzaneh-Far, 2009, Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: the heart and soul study, Atherosclerosis, 205, 538, 10.1016/j.atherosclerosis.2008.12.013
Fernandez, 2005, Mechanisms by which dietary fatty acids modulate plasma lipids, J. Nutr., 135, 2075, 10.1093/jn/135.9.2075
Fink, 1983, Mechanisms of insulin resistance in aging, J. Clin. Invest., 71, 1523, 10.1172/JCI110908
Fjell, 2013, Critical ages in the life course of the adult brain: nonlinear subcortical aging, Neurobiol. Aging, 34, 2239, 10.1016/j.neurobiolaging.2013.04.006
Flock, 2013, Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial, J. Am. Heart Assoc., 2, e000513, 10.1161/JAHA.113.000513
Fortier, 2010, Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Quebec: higher fish intake or aging-related change in n-3 fatty acid metabolism?, Prostaglandins Leukot. Essent. Fat. Acids, 82, 277, 10.1016/j.plefa.2010.02.010
Fraser, 2015, A systematic review and meta-analysis of longitudinal hippocampal atrophy in healthy human ageing, Neuroimage, 112, 364, 10.1016/j.neuroimage.2015.03.035
Fusar-Poli, 2009, Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies, J. Psychiatry Neurosci., 34, 418
Geerligs, 2014, Reduced specificity of functional connectivity in the aging brain during task performance, Hum. Brain Mapp., 35, 319, 10.1002/hbm.22175
Gellert, 2017, Low long chain omega-3 fatty acid status in middle-aged women, Prostaglandins Leukot. Essent. Fat. Acids, 117, 54, 10.1016/j.plefa.2017.01.009
Gonneaud, 2017, Functional dedifferentiation and reduced task-related deactivations underlie the age-related decline of prospective memory, Brain Imaging Behav., 11, 1873, 10.1007/s11682-016-9661-z
Grady, 2002, Age-related differences in face processing: a meta-analysis of three functional neuroimaging experiments, Can. J. Exp. Psychol., 56, 208, 10.1037/h0087398
Gruffat, 1996, Regulation of VLDL synthesis and secretion in the liver, Reprod. Nutr. Dev., 36, 375, 10.1051/rnd:19960404
Grundy, 1999, Cholesterol lowering in the elderly population. Coordinating committee of the national cholesterol education program, Arch. Intern. Med., 159, 1670, 10.1001/archinte.159.15.1670
Gu, 2016, White matter integrity as a mediator in the relationship between dietary nutrients and cognition in the elderly, Ann. Neurol., 79, 1014, 10.1002/ana.24674
Gunning-Dixon, 2000, The cognitive correlates of white matter abnormalities in normal aging: a quantitative review, Neuropsychology, 14, 224, 10.1037/0894-4105.14.2.224
Hafkemeijer, 2014, Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults, Aging Cell, 13, 1068, 10.1111/acel.12271
Hancock, 2017, The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging, Geroscience, 39, 73, 10.1007/s11357-017-9961-2
Harris, 2012, Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study, Atherosclerosis, 225, 425, 10.1016/j.atherosclerosis.2012.05.030
Harris, 2013, Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients, Prostaglandins Leukot. Essent. Fat. Acids, 88, 257, 10.1016/j.plefa.2012.12.004
Harris, 2017, Red blood cell polyunsaturated fatty acids and mortality in the Women's Health Initiative Memory Study, J. Clin. Lipidol., 11, 10.1016/j.jacl.2016.12.013
Havel, 1984, The formation of LDL: mechanisms and regulation, J. Lipid Res., 25, 1570, 10.1016/S0022-2275(20)34434-5
Hedman, 2012, Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies, Hum. Brain Mapp., 33, 1987, 10.1002/hbm.21334
Heuninckx, 2008, Systems neuroplasticity in the aging brain: recruiting additional neural resources for successful motor performance in elderly persons, J. Neurosci., 28, 91, 10.1523/JNEUROSCI.3300-07.2008
Hodson, 2008, Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake, Prog. Lipid Res., 47, 348, 10.1016/j.plipres.2008.03.003
Holtzer, 2014, Neuroimaging of mobility in aging: a targeted review, J. Gerontol. A Biol. Sci. Med. Sci., 69, 1375, 10.1093/gerona/glu052
Holub, 2004, Omega-3 fatty acids from fish oils and cardiovascular disease, Mol. Cell. Biochem., 263, 217, 10.1023/B:MCBI.0000041863.11248.8d
Honda, 2015, Volumetric analyses of cerebral white matter hyperintensity lesions on magnetic resonance imaging in a Japanese population undergoing medical check-up, Geriatr Gerontol Int, 15, 43, 10.1111/ggi.12672
Hoyer, 2002, The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review, J. Neural Transm., 109, 991, 10.1007/s007020200082
Itomura, 2008, Factors influencing EPA+DHA levels in red blood cells in Japan, In Vivo, 22, 131
Kim, 2010, Functional magnetic resonance imaging reveals age-related alterations to motor networks in weighted elbow flexion-extension movement, Neurol. Res., 32, 995, 10.1179/016164110X12670144737693
Kiortsis, 2000, Factors associated with low compliance with lipid-lowering drugs in hyperlipidemic patients, J. Clin. Pharm. Ther., 25, 445, 10.1046/j.1365-2710.2000.00315.x
Kunisaki, 2015, Ultrasound growth patterns of fetal lung malformations: implications on prenatal care and postnatal outcome, Prenat. Diagn., 35, 89
Lehtisalo, 2018, Dietary changes and cognition over 2 years within a multidomain intervention trial-the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), Alzheimers Dement., 15, 410, 10.1016/j.jalz.2018.10.001
Lehto, 1997, Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM, Diabetes, 46, 1354, 10.2337/diab.46.8.1354
Lemaitre-Delaunay, 1999, Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine, J. Lipid Res., 40, 1867, 10.1016/S0022-2275(20)34903-8
Leveille, 2017, Metabolism of uniformly labeled 13C-eicosapentaenoic acid and 13C-arachidonic acid in young and old men, Am. J. Clin. Nutr., 106, 467, 10.3945/ajcn.117.154708
Linortner, 2014, Aging associated changes in the motor control of ankle movements in the brain, Neurobiol. Aging, 35, 2222, 10.1016/j.neurobiolaging.2014.04.013
Liu, 2016, A voxel-based morphometric study of age- and sex-related changes in white matter volume in the normal aging brain, Neuropsychiatr. Dis. Treat., 12, 453
Loef, 2013, The omega-6/omega-3 ratio and dementia or cognitive decline: a systematic review on human studies and biological evidence, J. Nutr. Gerontol. Geriatr., 32, 1, 10.1080/21551197.2012.752335
Mansbach, 1998, Intracellular movement of triacylglycerols in the intestine, J. Lipid Res., 39, 963, 10.1016/S0022-2275(20)33863-3
Mattson, 1964, The digestion and absorption of triglycerides, J. Biol. Chem., 239, 2772, 10.1016/S0021-9258(18)93813-5
Mc Auley, 2015, Computationally modeling lipid metabolism and aging: a mini-review, Comput. Struct. Biotechnol. J., 13, 38, 10.1016/j.csbj.2014.11.006
Meusel, 2017, Brain-behavior relationships in source memory: effects of age and memory ability, Cortex, 91, 221, 10.1016/j.cortex.2016.12.023
Meydani, 1991, Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women, J. Nutr., 121, 484, 10.1093/jn/121.4.484
Meydani, 1991, Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women, J. Nutr., 121, 547, 10.1093/jn/121.4.547
Minkova, 2017, Gray matter asymmetries in aging and neurodegeneration: a review and meta-analysis, Hum. Brain Mapp., 38, 5890, 10.1002/hbm.23772
Morris, 2005, Fish consumption and cognitive decline with age in a large community study, Arch. Neurol., 62, 1849, 10.1001/archneur.62.12.noc50161
Mu, 2004, The digestion of dietary triacylglycerols, Prog. Lipid Res., 43, 105, 10.1016/S0163-7827(03)00050-X
Murphy, 1996, Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging, Arch. Gen. Psychiatry, 53, 585, 10.1001/archpsyc.1996.01830070031007
Naber, 1979, Protein and nucleic acid content in the aging human brain, Neuropathol. Appl. Neurobiol., 5, 17, 10.1111/j.1365-2990.1979.tb00610.x
Nock, 2017, Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline, Biochim. Biophys. Acta, 1862, 1068, 10.1016/j.bbalip.2017.07.004
Nogi, 2007, Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers, J. Occup. Health, 49, 205, 10.1539/joh.49.205
Norris, 2015, Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease, Neurobiol. Aging, 36, 1659, 10.1016/j.neurobiolaging.2015.01.002
Ogura, 2010, Fatty acid composition of plasma, erythrocytes and adipose: their correlations and effects of age and sex, Lipids, 45, 137, 10.1007/s11745-010-3386-3
Onozuka, 2003, Age-related changes in brain regional activity during chewing: a functional magnetic resonance imaging study, J. Dent. Res., 82, 657, 10.1177/154405910308200817
O'Shea, 2016, Cognitive aging and the hippocampus in older adults, Front. Aging Neurosci., 8, 298
Peng, 2016, A cross-sectional voxel-based morphometric study of age- and sex-related changes in gray matter volume in the Normal aging brain, J. Comput. Assist. Tomogr., 40, 307, 10.1097/RCT.0000000000000351
Plourde, 2007, Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as suppements, Appl. Physiol. Nutr. Metab., 32, 619, 10.1139/H07-034
Plourde, 2009, Eicosapentaenoic acid decreases postprandial beta-hydroxybutyrate and free fatty acid responses in healthy young and elderly, Nutrition, 25, 289, 10.1016/j.nut.2008.09.006
Plourde, 2009, Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men, Br. J. Nutr., 102, 1121, 10.1017/S000711450938215X
Plourde, 2011, Plasma incorporation, apparent retroconversion and beta-oxidation of 13C-docosahexaenoic acid in the elderly, Nutr. Metabolism, 8, 5, 10.1186/1743-7075-8-5
Raji, 2014, Regular fish consumption and age-related brain gray matter loss, Am. J. Prev. Med., 47, 444, 10.1016/j.amepre.2014.05.037
Redgrave, 1979, Quantitation of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during the catabolism of chylomicrons in the rat, J. Clin. Invest., 64, 162, 10.1172/JCI109435
Rees, 2006, Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men, Am. J. Clin. Nutr., 83, 331, 10.1093/ajcn/83.2.331
Rieckmann, 2017, Longitudinal changes in component processes of working memory, eNeuro, 4, 10.1523/ENEURO.0052-17.2017
Rosenberg, 2018, Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial, Alzheimers Dement., 14, 263, 10.1016/j.jalz.2017.09.006
Sala-Llonch, 2014, Changes in whole-brain functional networks and memory performance in aging, Neurobiol. Aging, 35, 2193, 10.1016/j.neurobiolaging.2014.04.007
Salem, 2015, The benefit of docosahexaenoic acid for the adult brain in aging and dementia, Prostaglandins Leukot. Essent. Fat. Acids, 92, 15, 10.1016/j.plefa.2014.10.003
Salthouse, 1989, Memory and age differences in spatial manipulation ability, Psychol. Aging, 4, 480, 10.1037/0882-7974.4.4.480
Salthouse, 1989, Effects of adult age and working memory on reasoning and spatial abilities, J. Exp. Psychol. Learn Mem. Cogn., 15, 507, 10.1037/0278-7393.15.3.507
Samieri, 2012, Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe, Neurology, 79, 642, 10.1212/WNL.0b013e318264e394
Sands, 2005, The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes, Lipids, 40, 343, 10.1007/s11745-006-1392-2
Schwenk, 2010, Fatty acid transport across the cell membrane: regulation by fatty acid transporters, Prostaglandins Leukot. Essent. Fat. Acids, 82, 149, 10.1016/j.plefa.2010.02.029
Sears, 2015, The role of fatty acids in insulin resistance, Lipids Health Dis., 14, 121, 10.1186/s12944-015-0123-1
Skuladottir, 1995, Plasma fatty acids and lipids in two separate, but genetically comparable, Icelandic populations, Lipids, 30, 649, 10.1007/BF02537002
Soderberg, 1990, Lipid compositions of different regions of the human brain during aging, J. Neurochem., 54, 415, 10.1111/j.1471-4159.1990.tb01889.x
Stark, 2003, Fatty acid composition of serum phospholipid of premenopausal women and postmenopausal women receiving and not receiving hormone replacement therapy, Menopause, 10, 448, 10.1097/01.GME.0000059861.93639.1A
Surowka, 2014, Variability of protein and lipid composition of human subtantia nigra in aging: Fourier transform infrared microspectroscopy study, Neurochem. Int., 76, 12, 10.1016/j.neuint.2014.06.014
Suzuki, 2001, Functional magnetic resonance imaging of odor identification: the effect of aging, J. Gerontol. A Biol. Sci. Med. Sci., 56, M756, 10.1093/gerona/56.12.M756
Svennerholm, 1994, Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years, J. Neurochem., 63, 1802, 10.1046/j.1471-4159.1994.63051802.x
Thorlaksdottir, 2006, Positive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women, Lipids, 41, 119, 10.1007/s11745-006-5079-5
Tremblay, 2013, Functional and structural aging of the speech sensorimotor neural system: functional magnetic resonance imaging evidence, Neurobiol. Aging, 34, 1935, 10.1016/j.neurobiolaging.2013.02.004
van der Lee, 2018, Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies, Alzheimers Dement., 14, 707, 10.1016/j.jalz.2017.11.012
Van Der Werf, 2001, Thalamic volume predicts performance on tests of cognitive speed and decreases in healthy aging. A magnetic resonance imaging-based volumetric analysis, Brain Res. Cogn. Brain Res., 11, 377, 10.1016/S0926-6410(01)00010-6
Van Petten, 2004, Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis, Neuropsychologia, 42, 1394, 10.1016/j.neuropsychologia.2004.04.006
Vandal, 2008, Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly, Lipids, 43, 1085, 10.1007/s11745-008-3232-z
Verges, 2015, Pathophysiology of diabetic dyslipidaemia: where are we?, Diabetologia, 58, 886, 10.1007/s00125-015-3525-8
Vidgren, 1997, Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men, Lipids, 32, 697, 10.1007/s11745-997-0089-x
Walker, 2014, Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans, Br. J. Nutr., 111, 679, 10.1017/S0007114513002985
Willnow, 1997, Mechanisms of hepatic chylomicron remnant clearance, Diabet. Med., 14, S75, 10.1002/(SICI)1096-9136(199708)14:3+<S75::AID-DIA449>3.3.CO;2-0
Witt, 2010, The incorporation of marine n-3 PUFA into platelets and adipose tissue in pre- and postmenopausal women: a randomised, double-blind, placebo-controlled trial, Br. J. Nutr., 104, 318, 10.1017/S0007114510000371
Witte, 2014, Long-chain omega-3 fatty acids improve brain function and structure in older adults, Cereb. Cortex, 24, 3059, 10.1093/cercor/bht163
Xu, 2000, Gender effects on age-related changes in brain structure, AJNR Am. J. Neuroradiol., 21, 112
Yanagisawa, 2010, Polyunsaturated fatty acid levels of serum and red blood cells in apparently healthy Japanese subjects living in an urban area, J. Atheroscler. Thromb., 17, 285, 10.5551/jat.2618
Yassine, 2017, DHA brain uptake and APOE4 status: a PET study with [1-(11)C]-DHA, Alzheimers Res. Ther., 9, 23, 10.1186/s13195-017-0250-1
Yuan, 2014, Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies, Neurosci. Biobehav. Rev., 42, 180, 10.1016/j.neubiorev.2014.02.005
Zhang, 2016, Dysregulation of the low-density lipoprotein receptor pathway is involved in lipid disorder-mediated organ injury, Int. J. Biol. Sci., 12, 569, 10.7150/ijbs.14027