The structural basis for Ras activation of PI3Kα lipid kinase

Physical Chemistry Chemical Physics - Tập 21 Số 22 - Trang 12021-12028
Mingzhen Zhang1,2,3,4,5, Hyunbum Jang1,2,3,4,5, Ruth Nussinov1,2,6,3,4,5
1Basic Science Program
2Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
3Frederick
4Frederick National Laboratory for Cancer Research
5USA
6Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

Tóm tắt

The structure of the KRas4B–PI3Kα–RBD complex is featured by antiparallel β-sheets and PI3Kα–RBD interaction with the Switch I region of KRas4B.

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