The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver

Journal of Lipid Research - Tập 46 - Trang 2151-2167 - 2005
Steven L. Sabol1, H. Bryan Brewer1, Silvia Santamarina-Fojo1
1Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892

Tài liệu tham khảo

Dean, 2001, The human ATP-binding cassette (ABC) transporter superfamily, Genome Res., 11, 1156, 10.1101/gr.184901 Dean, 2001, The human ATP-binding cassette (ABC) transporter superfamily, J. Lipid Res., 42, 1007, 10.1016/S0022-2275(20)31588-1 Savary, 1996, Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene, Mamm. Genome., 7, 673, 10.1007/s003359900203 Chen, 1996, Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3, Am. J. Hum. Genet., 59, 66 Croop, 1997, Isolation and characterization of a mammalian homolog of the Drosophila white gene, Gene., 185, 77, 10.1016/S0378-1119(96)00633-6 Cserepes, 2004, Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization, Biochem. Biophys. Res. Commun., 320, 860, 10.1016/j.bbrc.2004.06.037 Su, 2002, Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction, J. Lipid Res., 43, 2180, 10.1194/jlr.D200020-JLR200 Langmann, 2003, Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues, Clin. Chem., 49, 230, 10.1373/49.2.230 Hoekstra, 2003, Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells, J. Biol. Chem., 278, 25448, 10.1074/jbc.M301189200 Klucken, 2000, ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport, Proc. Natl. Acad. Sci. USA., 97, 817, 10.1073/pnas.97.2.817 Wang, 2004, ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins, Proc. Natl. Acad. Sci. USA., 101, 9774, 10.1073/pnas.0403506101 Nakamura, 2004, Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein, J. Biol. Chem., 279, 45980, 10.1074/jbc.M408652200 Ito, 2000, Adenovirus-mediated expression establishes an in vivo role for human ABCG1 (ABC8) in lipoprotein metabolism, Circulation., 102, 1525 Ito, 2003, Physiological function of ABCG1, Drug News Perspect., 16, 490, 10.1358/dnp.2003.16.8.829346 Neufeld, 2001, Cellular localization and trafficking of human ABCG1, Circulation., 104, 708 Brewer, 2003, New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport, Am. J. Cardiol., 91, 3E, 10.1016/S0002-9149(02)03382-9 Venkateswaran, 2000, Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols, J. Biol. Chem., 275, 14700, 10.1074/jbc.275.19.14700 Fu, 2001, 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells, J. Biol. Chem., 276, 38378, 10.1074/jbc.M105805200 Repa, 2000, Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers, Science., 289, 1524, 10.1126/science.289.5484.1524 Venkateswaran, 2000, Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha, Proc. Natl. Acad. Sci. USA., 97, 12097, 10.1073/pnas.200367697 Tontonoz, 2003, Liver X receptor signaling pathways in cardiovascular disease, Mol. Endocrinol., 17, 985, 10.1210/me.2003-0061 Willy, 1995, LXR, a nuclear receptor that defines a distinct retinoid response pathway, Genes Dev., 9, 1033, 10.1101/gad.9.9.1033 Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha, Nature., 383, 728, 10.1038/383728a0 Edwards, 2002, BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis, J. Lipid Res., 43, 2, 10.1016/S0022-2275(20)30180-2 Schultz, 2000, Role of LXRs in control of lipogenesis, Genes Dev., 14, 2831, 10.1101/gad.850400 Mangelsdorf, 1995, The RXR heterodimers and orphan receptors, Cell., 83, 841, 10.1016/0092-8674(95)90200-7 Willy, 1997, Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR, Genes Dev., 11, 289, 10.1101/gad.11.3.289 Steffensen, 2004, Putative metabolic effects of the liver X receptor (LXR), Diabetes., 53, 36, 10.2337/diabetes.53.2007.S36 Peet, 1998, The LXRs: a new class of oxysterol receptors, Curr. Opin. Genet. Dev., 8, 571, 10.1016/S0959-437X(98)80013-0 Hu, 2003, Liver X receptors interact with corepressors to regulate gene expression, Mol. Endocrinol., 17, 1019, 10.1210/me.2002-0399 Wagner, 2003, Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression, Mol. Cell. Biol., 23, 5780, 10.1128/MCB.23.16.5780-5789.2003 Huuskonen, 2004, Role of p160 coactivator complex in the activation of liver X receptor, Arterioscler. Thromb. Vasc. Biol., 24, 703, 10.1161/01.ATV.0000121202.72593.da Tangirala, 2002, Identification of macrophage liver X receptors as inhibitors of atherosclerosis, Proc. Natl. Acad. Sci. USA., 99, 11896, 10.1073/pnas.182199799 Ulven, 2004, Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue, J. Lipid Res., 45, 2052, 10.1194/jlr.M400119-JLR200 Quinet, 2004, Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor, J. Lipid Res., 45, 1929, 10.1194/jlr.M400257-JLR200 Schwartz, 2000, ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR, Biochem. Biophys. Res. Commun., 274, 794, 10.1006/bbrc.2000.3243 Costet, 2000, Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor, J. Biol. Chem., 275, 28240, 10.1074/jbc.M003337200 Langmann, 2000, Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene, Biochim. Biophys. Acta., 1494, 175, 10.1016/S0167-4781(00)00215-3 Lorkowski, 2001, Genomic sequence and structure of the human ABCG1 (ABC8) gene, Biochem. Biophys. Res. Commun., 280, 121, 10.1006/bbrc.2000.4089 Kennedy, 2001, Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein, J. Biol. Chem., 276, 39438, 10.1074/jbc.M105863200 Schmitz, 2001, Role of ABCG1 and other ABCG family members in lipid metabolism, J. Lipid Res., 42, 1513, 10.1016/S0022-2275(20)32205-7 Margulies, 2003, Identification and characterization of multi-species conserved sequences, Genome Res., 13, 2507, 10.1101/gr.1602203 Dermitzakis, 2002, Numerous potentially functional but non-genic conserved sequences on human chromosome 21, Nature., 420, 578, 10.1038/nature01251 Nobrega, 2003, Scanning human gene deserts for long-range enhancers, Science., 302, 413, 10.1126/science.1088328 Carey, 2000, 124 Mayor, 2000, VISTA: visualizing global DNA sequence alignments of arbitrary length, Bioinformatics., 16, 1046, 10.1093/bioinformatics/16.11.1046 Couronne, 2003, Strategies and tools for whole-genome alignments, Genome Res., 13, 73, 10.1101/gr.762503 Quandt, 1995, MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data, Nucleic Acids Res., 23, 4878, 10.1093/nar/23.23.4878 Loots, 2002, rVista for comparative sequence-based discovery of functional transcription factor binding sites, Genome Res., 12, 832, 10.1101/gr.225502 2004, Finishing the euchromatic sequence of the human genome, Nature., 431, 931, 10.1038/nature03001 Waterston, 2002, Initial sequencing and comparative analysis of the mouse genome, Nature., 420, 520, 10.1038/nature01262 Gibbs, 2004, Genome sequence of the Brown Norway rat yields insights into mammalian evolution, Nature., 428, 493, 10.1038/nature02426 2004, Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution, Nature., 432, 695, 10.1038/nature03154 Jaillon, 2004, Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype, Nature., 431, 946, 10.1038/nature03025 Kent, 2002, The human genome browser at UCSC, Genome Res., 12, 996, 10.1101/gr.229102 Karolchik, 2003, The UCSC genome browser database, Nucleic Acids Res., 31, 51, 10.1093/nar/gkg129 Shinar, 1994, NER, a new member of the gene family encoding the human steroid hormone nuclear receptor, Gene., 147, 273, 10.1016/0378-1119(94)90080-9 Mangelsdorf, 1990, Nuclear receptor that identifies a novel retinoic acid response pathway, Nature., 345, 224, 10.1038/345224a0 Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res., 11, 1475, 10.1093/nar/11.5.1475 Kaplan, 2002, Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway, J. Lipid Res., 43, 952, 10.1016/S0022-2275(20)30470-3 Strausberg, 1999, The mammalian gene collection, Science., 286, 455, 10.1126/science.286.5439.455 Hattori, 2000, The DNA sequence of human chromosome 21, Nature., 405, 311, 10.1038/35012518 Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc. Natl. Acad. Sci. USA., 98, 507, 10.1073/pnas.98.2.507 Zhang, 2001, Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta, J. Biol. Chem., 276, 43018, 10.1074/jbc.M107823200 Thompson, 1994, CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res., 22, 4673, 10.1093/nar/22.22.4673