Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

Developmental Cell - Tập 33 - Trang 729-736 - 2015
Wendy R. Gordon1,2, Brandon Zimmerman1,3, Li He4, Laura J. Miles1,5, Jiuhong Huang4,6, Kittichoat Tiyanont5, Debbie G. McArthur5, Jon C. Aster7, Norbert Perrimon4,8, Joseph J. Loparo1, Stephen C. Blacklow1,5,7
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
2Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
3Dana-Farber Cancer Institute, Boston, MA 02215, USA
4Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
5Dana Farber Cancer Institute, Boston, MA 02215, USA
6School of Life Science and Technology, Tongji University, Shanghai 200092, China
7Brigham and Women's Hospital, Boston, MA 02115 USA
8Howard Hughes Medical Institute, Boston, MA 02115, USA

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