COMPARATIVE EFFICACY OF 1% CURCUMIN NANOMICELLE GEL AND 2% CURCUMIN GEL FOR TREATMENT OF RECURRENT APHTHOUS STOMATITIS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Journal of Evidence Based Dental Practice - Tập 22 - Trang 101708 - 2022
Mahin Bakhshi1, Arash Mahboubi2, Mahmoud Reza Jaafari3, Faezeh Ebrahimi4, Maryam Tofangchiha5, Ahad Alizadeh6
1Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Food Safety Research Center, Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4Shahid Beheshti University of Medical Sciences, Tehran, Iran
5Department of Oral and Maxillofacial Radiology, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
6Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

Tài liệu tham khảo

Deshmukh, 2014, Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: a randomized clinical trial, Int J Pharm Investig, 4, 138, 10.4103/2230-973X.138346 Chavan, 2012, Recurrent aphthous stomatitis: a review, J Oral Pathol Med, 41, 577, 10.1111/j.1600-0714.2012.01134.x Nivetha, 2014, Effects of natural products on oral health: a review, Asian J Pharm Clin Res, 7, 279 Manifar, 2012, Curcumin gel in the treatment of minor aphthous ulcer: a randomized, placebo- controlled trial, J Med Plants, 1, 40 Farid, 2016, A focus on curcumin local application in oral diseases management: mini review, IOSR J Pharm, 6, 30 Belenguer-Guallar, 2014, Treatment of recurrent aphthous stomatitis. A literature review, J Clin Exp Dent, 6, e168, 10.4317/jced.51401 Keshari, 2015, Efficacy of topical curcumin in the management of oral lichen planus: a randomized controlled-trial, J Adv Clin Res Insights, 2, 197, 10.15713/ins.jcri.78 Ofluoglu, 2017, An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: a randomized, double-blind, placebo-controlled clinical trial, Med Oral Patol Oral Cir Bucal, 22, e159 Nagpal, 2013, Role of curcumin in systemic and oral health: an overview, J Nat Sci Biol Med, 4, 3, 10.4103/0976-9668.107253 Halim, 2013, Novel material in the treatment of minor oral recurrent aphthous stomatitis, Int Medical J, 20, 392 Al-Maweri, 2020, Efficacy of curcumin for recurrent aphthous stomatitis: a systematic review, J Dermatolog Treat, 9, 1 Raman, 2020, Topical curcumin and triamcinolone acetonide in recurrent minor aphthous ulcers: a pilot trial, J Contemp Dent Pract, 21, 884, 10.5005/jp-journals-10024-2901 Kuwatada, 2017, Turmeric: a boon to oral health, Int J Oral Care Res, 5, 338, 10.5005/jp-journals-10051-0128 Sneha, 2017, Curcumin - a novel ayurvedic treatment for oral lichen planus, IJCMPR, 3, 1507 Rahimi, 2016, Novel delivery system for natural products: nano-curcumin formulations, Avicenna J Phytomed, 6, 383 Krausz, 2014, Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent, Nanomedicine, 11, 195, 10.1016/j.nano.2014.09.004 Bakhshi, 2020, Combination therapy with 1% nanocurcumin gel and 0.1% triamcinolone acetonide mouth rinse for oral lichen planus: a randomized double-blind placebo controlled clinical trial, Dermatol Res Pract, 2020, 10.1155/2020/4298193 Reddy Hv, 2021, In vitro evaluation of mucoadhesive in situ nanogel of celecoxib for buccal delivery, Ann Pharm Fr, 27, S0003 Woo S.B., Greenberg M.S. Ulcerative, vesicular and bullous lesions. In: Green Berg MS, Glick M, Ship J., Eds. Burket's Oral Medical, Diagnosis and Treatment. 12th ed. Hamilton: BC Decker; 2015. 73. Singh, 2018, Comparative analysis of therapeutic efficacy of curcumin & triamcinolone acetonide in recurrent aphthous stomatitis - A clinical study, J Adv Med Dent Scie Res, 6, 136 Kia, 2020, New concentration of curcumin orabase in recurrent aphthous stomatitis: a randomized, controlled clinical trial, J Herb Med, 22, 10.1016/j.hermed.2020.100336 Ranjitha, 2018, Curcumin as a herbal remedy for oral maladies-an updated review, J Adv Med Dent Scie Res, 6, 19 Chainani-Wu, 2003, Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa), J Altern Complement Med, 9, 161, 10.1089/107555303321223035 Jurge, 2006, Mucosal disease series. Number VI. Recurrent aphthous stomatitis, Oral Dis, 12, 1, 10.1111/j.1601-0825.2005.01143.x Devaraj, 2014, Curcumin-pharmacological actions and its role in dentistry, Asian J Pharm, Res. Health Care, 6, 19 Nurdiana, 2016, Effect of 2 percent turmeric extract gel on minor recurrent aphthous stomatitis, Padjadjaran J Dent, 28, 1 Dai, 2017, Nano-formulated curcumin accelerates acute wound healing through Dkk-1-mediated fibroblast mobilization and MCP-1-mediated anti-inflammation, NPG Asia Mater, 9, e368, 10.1038/am.2017.31 Tejada, 2016, Wound healing effects of curcumin: a short review, Curr Pharm Biotechnol, 17, 1002, 10.2174/1389201017666160721123109 Delavarian, 2019, Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers, Spec Care Dentist, 39, 166, 10.1111/scd.12358 Ghalandarlaki, 2014, Nanotechnology-applied curcumin for different diseases therapy, Biomed Res Int, 2014, 10.1155/2014/394264