Prevention of Venous Thromboembolism

Chest - Tập 126 - Trang 338S-400S - 2004
William H. Geerts, Graham F. Pineo, John A. Heit, David Bergqvist, Michael R. Lassen, Clifford W. Colwell, Joel G. Ray

Tài liệu tham khảo

Second Thromboembolic Risk Factors (THRiFT II) Consensus Group, 1998, Risk of and prophylaxis for venous thromboembolism in hospital patients, Phlebology, 13, 87, 10.1177/026835559801300302 Geerts, 2001, Prevention of venous thromboembolism, Chest, 119, 132S, 10.1378/chest.119.1_suppl.132S Scottish Intercollegiate Guidelines Network (SIGN) Schünemann, 2004, Methodology for guideline development for the Seventh American College of Chest Physicians conference on antithrommbotic and thrombolytic therapy, Chest, 126, 174S, 10.1378/chest.126.3_suppl.174S Sullivan, 2003, Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopaedic surgery, Pharmacoeconomics, 21, 477, 10.2165/00019053-200321070-00003 Anderson, 1992, The prevalence of risk factors for venous thromboembolism among hospital patients, Arch Intern Med, 152, 1660, 10.1001/archinte.1992.00400200092017 Rosendaal, 1999, Risk factors for venous thrombotic disease, Thromb Haemost, 82, 610, 10.1055/s-0037-1615887 Kearon, 2001, Epidemiology, pathogenesis, and natural history of venous thrombosis, 1153 Heit, 2002, Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study, Arch Intern Med, 162, 1245, 10.1001/archinte.162.11.1245 Anderson, 2003, Risk factors for venous thromboembolism, Circulation, 107, I9, 10.1161/01.CIR.0000078469.07362.E6 Rosendaal, 1999, Venous thrombosis: a multicausal disease, Lancet, 353, 1167, 10.1016/S0140-6736(98)10266-0 Anderson, 1991, A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT Study, Arch Intern Med, 151, 933, 10.1001/archinte.1991.00400050081016 Prothero, 1966, Complications after low-back fusion in 1000 patients: a comparison of two series one decade apart, J Bone Joint Surg Am, 48, 57, 10.2106/00004623-196648010-00004 Lindblad, 1991, Autopsy-verified pulmonary embolism in a surgical department: analysis of the period from 1951 to 1968, Br J Surg, 78, 849, 10.1002/bjs.1800780725 Stein, 1995, Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy, Chest, 108, 978, 10.1378/chest.108.4.978 Todd, 1995, Differences in mortality after fracture of hip: the East Anglian audit, BMJ, 310, 904, 10.1136/bmj.310.6984.904 Baglin, 1997, Fatal pulmonary embolism in hospitalised medical patients, J Clin Pathol, 50, 609, 10.1136/jcp.50.7.609 Fender, 1997, Mortality and fatal pulmonary embolism after primary total hip replacement: results from a regional hip register, J Bone Joint Surg Br, 79, 896, 10.1302/0301-620X.79B6.7677 Chang, 2002, Complications of spinal fusion in treatment of adult spinal deformity [abstract], Spine J, 2, 55S, 10.1016/S1529-9430(02)00289-9 White, 2003, Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures, Thromb Haemost, 90, 446, 10.1160/TH03-03-0152 Sandler, 1989, Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis?, J R Soc Med, 82, 203, 10.1177/014107688908200407 Kakkar, 1969, Natural history of postoperative deep-vein thrombosis, Lancet, 2, 230, 10.1016/S0140-6736(69)90002-6 Lotke, 1984, Indications for the treatment of deep venous thrombosis following total knee replacement, J Bone Joint Surg Am, 66, 202, 10.2106/00004623-198466020-00006 Philbrick, 1988, Calf deep venous thrombosis: a wolf in sheep's clothing?, Arch Intern Med, 148, 2131, 10.1001/archinte.1988.00380100029007 Agnelli, 1993, Features of thrombi and diagnostic accuracy of impedance plethysmography in symptomatic and asymptomatic deep vein thrombosis, Thromb Haemost, 70, 266, 10.1055/s-0038-1649563 Hedlund, 1975, Postoperative venous thrombosis in benign prostatic disease: a study of 316 patients, using the125I-fibrinogen uptake test, Scand J Urol Nephrol Suppl, 27, 1 Lohr, 1991, Lower extremity calf thrombosis: to treat or not to treat?, J Vasc Surg, 14, 618, 10.1016/0741-5214(91)90184-V Maynard, 1991, Progression and regression of deep vein thrombosis after total knee arthroplasty, Clin Orthop, 273, 125, 10.1097/00003086-199112000-00018 Solis, 1992, Is anticoagulation indicated for asymptomatic postoperative calf vein thrombosis?, J Vasc Surg, 16, 414, 10.1016/0741-5214(92)90376-J Kearon, 2003, Natural history of venous thromboembolism, Circulation, 107, I22, 10.1161/01.CIR.0000078464.82671.78 Stamatakis, 1977, Femoral vein thrombosis and total hip replacement, BMJ, 2, 223, 10.1136/bmj.2.6081.223 Cruickshank, 1989, An evaluation of impedance plethysmography and125I-fibrinogen leg scanning in patients following hip surgery, Thromb Haemost, 62, 830, 10.1055/s-0038-1651012 Ascani, 1996, Distribution and occlusiveness of thrombi in patients with surveillance detected deep vein thrombosis after hip surgery, Thromb Haemost, 75, 239, 10.1055/s-0038-1650251 Turpie, 2003, Relevance of venographic distal thrombus assessment in venous thromboembolism (VTE) prophylaxis studies: lessons from the fondaparinux (Arixtra) database in major orthopedic surgery [abstract], J Thromb Haemost, 1, P2066 Moser, 1981, Is embolic risk conditioned by location of deep venous thrombosis?, Ann Intern Med, 94, 439, 10.7326/0003-4819-94-4-439 Haas, 1992, The significance of calf thrombi after total knee arthroplasty, J Bone Joint Surg Br, 74, 799, 10.1302/0301-620X.74B6.1447236 Kalodiki, 1995, V/Q defects and deep venous thrombosis following total hip replacement, Clin Radiol, 50, 400, 10.1016/S0009-9260(05)83138-1 Eikelboom, 2001, Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials, Lancet, 358, 9, 10.1016/S0140-6736(00)05249-1 Hull, 2001, Extended out-of-hospital low-molecular-weight heparin prophylaxis against deep venous thrombosis in patients after elective hip arthroplasty: a systematic review, Ann Intern Med, 135, 858, 10.7326/0003-4819-135-10-200111200-00006 Mismetti, 2001, Meta-analysis of low molecular weight heparin in the prevention of venous thromboembolism in general surgery, Br J Surg, 88, 913, 10.1046/j.0007-1323.2001.01800.x Douketis, 2002, Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes, Arch Intern Med, 162, 1465, 10.1001/archinte.162.13.1465 Ibrahim, 2002, Deep vein thrombosis during prolonged mechanical ventilation despite prophylaxis, Crit Care Med, 30, 771, 10.1097/00003246-200204000-00008 Heit, 1999, Predictors of survival after deep vein thrombosis and pulmonary embolism: a population-based, cohort study, Arch Intern Med, 159, 445, 10.1001/archinte.159.5.445 Goldhaber, 1982, Factors associated with correct antemortem diagnosis of major pulmonary embolism, Am J Med, 73, 822, 10.1016/0002-9343(82)90764-1 Rubinstein, 1988, Fatal pulmonary emboli in hospitalized patients: an autopsy study, Arch Intern Med, 148, 1425, 10.1001/archinte.1988.00380060189033 Karwinski, 1989, Comparison of clinical and postmortem diagnosis of pulmonary embolism, J Clin Pathol, 42, 135, 10.1136/jcp.42.2.135 Morganthaler, 1995, Clinical characteristics of fatal pulmonary embolism in a referral hospital, Mayo Clin Proc, 70, 417, 10.4065/70.5.417 Ryu, 1998, Clinical recognition of pulmonary embolism: problems of unrecognized and asymptomatic cases, Mayo Clin Proc, 73, 873, 10.4065/73.9.873 Wen, 1998, Complications of subcutaneous low-dose heparin therapy in neurosurgical patients, Surg Neurol, 50, 521, 10.1016/S0090-3019(98)00083-4 International Multicentre Trial, 1975, Prevention of fatal pulmonary embolism by low doses of heparin, Lancet, 2, 45 White, 1998, Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty, Arch Intern Med, 158, 1525, 10.1001/archinte.158.14.1525 Eriksson, 2003, Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study, Arch Intern Med, 163, 1337, 10.1001/archinte.163.11.1337 Franzeck, 1996, Prospective 12-year follow-up study of clinical and hemodynamic sequelae of deep vein thrombosis in low-risk patients (Zurich Study), Circulation, 93, 74, 10.1161/01.CIR.93.1.74 Prandoni, 1996, The long-term clinical course of acute deep venous thrombosis, Ann Intern Med, 125, 1, 10.7326/0003-4819-125-1-199607010-00001 Becker, 1970, Occurrence and course of thrombosis following prostatectomy: a phlebographic investigation, Acta Radiol Diagn (Stockh), 10, 513, 10.1177/028418517001000608 Lindner, 1986, Long-term hemodynamic and clinical sequellae of lower extremity deep vein thrombosis, J Vasc Surg, 4, 436, 10.1016/0741-5214(86)90377-0 Bergqvist, 1997, Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden, Ann Intern Med, 126, 454, 10.7326/0003-4819-126-6-199703150-00006 Heit, 2001, Trends in the incidence of venous stasis syndrome and venous ulcer: a 25-year population-based study, J Vasc Surg, 33, 1022, 10.1067/mva.2001.113308 Kahn, 2002, Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis, Arch Intern Med, 162, 1144, 10.1001/archinte.162.10.1144 Caprini, 2003, Economic burden of long-term complications of deep vein thrombosis after total hip replacement surgery in the United States, Value Health, 6, 59, 10.1046/j.1524-4733.2003.00204.x Paiement, 1991, Cost-effectiveness of prophylaxis in total hip replacement, Am J Surg, 161, 519, 10.1016/0002-9610(91)91124-2 Geerts, 1994, A prospective study of venous thromboembolism after major trauma, N Engl J Med, 331, 1601, 10.1056/NEJM199412153312401 Meyer, 1995, Surveillance venous scans for deep venous thrombosis in multiple trauma patients, Ann Vasc Surg, 9, 109, 10.1007/BF02015324 Robinson, 1997, Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the Post-Arthroplasty Screening Study; a randomized, controlled trial, Ann Intern Med, 127, 439, 10.7326/0003-4819-127-6-199709150-00004 Leclerc, 1998, The incidence of symptomatic venous thromboembolism during and after prophylaxis with enoxaparin: a multi-institutional cohort study of patients who underwent hip or knee arthroplasty, Arch Intern Med, 158, 873, 10.1001/archinte.158.8.873 Dearborn, 1999, Thromboembolic complications after major thoracolumbar spine surgery, Spine, 24, 1471, 10.1097/00007632-199907150-00013 Cipolle, 2002, The role of surveillance duplex scanning in preventing venous thromboembolism in trauma patients, J Trauma, 52, 453, 10.1097/00005373-200203000-00007 Sevitt, 1959, Prevention of venous thrombosis and pulmonary embolism in injured patients: a trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur, Lancet, ii, 981, 10.1016/S0140-6736(59)91464-3 Sagar, 1975, Low-dose heparin prophylaxis against fatal pulmonary embolism, BMJ, 2, 257, 10.1136/bmj.4.5991.257 Halkin, 1982, Reduction of mortality in general medical in-patients by low-dose heparin prophylaxis, Ann Intern Med, 96, 561, 10.7326/0003-4819-96-5-561 Collins, 1988, Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomized trials in general, orthopedic, and urologic surgery, N Engl J Med, 318, 1162, 10.1056/NEJM198805053181805 Shojania Bergqvist, 1996, Cost-effectiveness of preventing postoperative deep vein thrombosis, 228 Mamdani, 1996, Thromboembolic prophylaxis in moderate-risk patients undergoing elective abdominal surgery: decision and cost-effectiveness analyses, Pharmacotherapy, 16, 1111 Bick, 2000, Proficient and cost-effective approaches for the prevention and treatment of venous thrombosis and thromboembolism, Drugs, 60, 575, 10.2165/00003495-200060030-00005 van Ooijen, 1986, Subcutaneous heparin and postoperative wound hematomas: a prospective, double-blind, randomized study, Arch Surg, 121, 937, 10.1001/archsurg.1986.01400080083015 Clagett, 1988, Prevention of venous thromboembolism in general surgical patients: results of meta-analysis, Ann Surg, 208, 227, 10.1097/00000658-198808000-00016 Nurmohamed, 1992, Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis, Lancet, 340, 152, 10.1016/0140-6736(92)93223-A Kakkar, 1993, Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery, Lancet, 341, 259, 10.1016/0140-6736(93)92614-Y Jorgensen, 1993, Prophylaxis of postoperative thromboembolism with low molecular weight heparins, Br J Surg, 80, 689, 10.1002/bjs.1800800607 Koch, 1997, Low molecular weight heparin and unfractionated heparin in thrombosis prophylaxis after major surgical intervention: update of previous meta-analyses, Br J Surg, 84, 750, 10.1002/bjs.1800840605 Koch, 2001, Low molecular weight heparin and unfractionated heparin in thrombosis prophylaxis: meta-analysis based on original patient data, Thromb Res, 102, 295, 10.1016/S0049-3848(01)00251-1 Thomas, 1997, Does low molecular weight heparin cause less bleeding?, Thromb Haemost, 78, 1422, 10.1055/s-0038-1665426 Oster, 1987, A cost-effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery, JAMA, 257, 203, 10.1001/jama.1987.03390020069029 Brandjes, 1990, Pre-surgical identification of the patient at risk for developing venous thromboembolism post-operatively, Acta Chir Scand Suppl, 556, 18 Caprini, 1991, Clinical assessment of venous thromboembolic risk in surgical patients, Semin Thromb Hemost, 17, 304 Thromboembolic Risk Factors (THRIFT) Consensus Group, 1992, Risk of and prophylaxis for venous thromboembolism in hospital patients, BMJ, 305, 567, 10.1136/bmj.305.6853.567 Greenfield, 1997, Posttrauma thromboembolism prophylaxis, J Trauma, 42, 100, 10.1097/00005373-199701000-00017 Nicolaides, 1997, Prevention of venous thromboembolism: International consensus statement, Int Angiol, 16, 3 Ageno, 1999, Applying risk assessment models in general surgery: overview of our clinical experience, Blood Coagul Fibrinolysis, 10, S71 Samama, 1999, Applying risk assessment models in general surgery: effective risk stratification, Blood Coagul Fibrinolysis, 10, S79 Cohen, 2003, A risk assessment model for identifying medical patients who should receive thromboprophylaxis [abstract], J Thromb Haemost, 1, OC437 Samama, 2003, Individualizing the risk of venous thromboembolism in medical and surgical patients: development of the decision matrix for VTE prophylaxis [abstract], J Thromb Haemost, 1, OC436 Lassen, 1999, Clinical limitations of risk assessment models, Blood Coagul Fibrinolysis, 10, S45 Kearon, 2001, Noninvasive diagnosis of deep vein thrombosis in postoperative patients, Semin Thromb Haemost, 27, 3, 10.1055/s-2001-12842 Kakkar, 1972, The diagnosis of deep vein thrombosis using the125I fibrinogen test, Arch Surg, 104, 152, 10.1001/archsurg.1972.04180020032006 Moskovitz, 1978, Low-dose heparin for prevention of venous thromboembolism in total hip arthroplasty and surgical repair of hip fractures, J Bone Joint Surg Am, 60, 1065, 10.2106/00004623-197860080-00008 Fauno, 1990, The use of fibrinogen uptake test in screening for deep vein thrombosis in patients with hip fracture, Thromb Res, 60, 185, 10.1016/0049-3848(90)90179-G Lensing, 1993, 125I-fibrinogen leg scanning: reassessment of its role for the diagnosis of venous thrombosis in post-operative patients, Thromb Haemost, 69, 2, 10.1055/s-0038-1651177 Agnelli, 1995, Diagnosis of deep vein thrombosis in asymptomatic high-risk patients, Haemostasis, 25, 40 Bergqvist, 1995, Low molecular weight heparin started before surgery as prophylaxis against deep vein thrombosis: 2500 versus 5000 XaI units in 2070 patients, Br J Surg, 82, 496, 10.1002/bjs.1800820421 Nurmohamed, 1995, A comparative trial of a low molecular weight heparin (enoxaparin) versus standard heparin for the prophylaxis of postoperative deep vein thrombosis in general surgery, Am J Surg, 169, 567, 10.1016/S0002-9610(99)80222-0 Flordal, 1995, Clinical relevance of the fibrinogen uptake test in patients undergoing elective general abdominal surgery: relation to major thromboembolism and mortality, Thromb Res, 80, 491, 10.1016/0049-3848(95)00204-9 Paiement, 1988, Surveillance of deep vein thrombosis in asymptomatic total hip replacement patients: impedance plethysmography and fibrinogen scanning versus roentgenographic phlebography, Am J Surg, 155, 400, 10.1016/S0002-9610(88)80099-0 Agnelli, 1991, Impedance plethysmography in the diagnosis of asymptomatic deep vein thrombosis in hip surgery: a venography-controlled study, Arch Intern Med, 151, 2167, 10.1001/archinte.1991.00400110031007 Kearon, 1998, Noninvasive diagnosis of deep venous thrombosis, Ann Intern Med, 128, 663, 10.7326/0003-4819-128-8-199804150-00011 Kahn, 2001, A randomized management study of impedance plethysmography vs. contrast venography in patients with a first episode of clinically suspected deep vein thrombosis, Thromb Res, 102, 15, 10.1016/S0049-3848(01)00222-5 Rabinov, 1972, Roentgen diagnosis of venous thrombosis in the leg, Arch Surg, 104, 134, 10.1001/archsurg.1972.04180020014004 Picolet, 1990, Reliability of phlebography in the assessment of venous thrombosis in a clinical trial, Haemostasis, 20, 362 Couson, 1993, Influence of variability of interpretation of contrast venography for screening of postoperative deep venous thrombosis on the results of a thromboprophylactic study, Thromb Haemost, 70, 573, 10.1055/s-0038-1649629 Kalebo, 1996, Percentage of inadequate phlebograms and observer agreement in thromboprophylactic multicenter trials using standardized methodology and central assessment, Thromb Haemost, 76, 893, 10.1055/s-0038-1650682 Leizorovicz, 2003, The assessment of deep vein thromboses for therapeutic trials, Angiology, 54, 19, 10.1177/000331970305400103 Garino, 1996, Deep venous thrombosis after total joint arthroplasty: the role of compression ultrasonography and the importance of the experience of the technician, J Bone Joint Surg Am, 78, 1359, 10.2106/00004623-199609000-00010 Davidson, 1992, Low accuracy of color Doppler ultrasound in the detection of proximal leg vein thrombosis in asymptomatic high-risk patients, Ann Intern Med, 117, 735, 10.7326/0003-4819-117-9-735 Grady-Benson, 1994, Postoperative surveillance for deep venous thrombosis with duplex ultrasonography after total knee arthroplasty, J Bone Joint Surg Am, 76, 1649, 10.2106/00004623-199411000-00008 Wells, 1995, Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery: a meta-analysis, Ann Intern Med, 122, 47, 10.7326/0003-4819-122-1-199501010-00008 Ciccone, 1998, Ultrasound surveillance for asymptomatic deep venous thrombosis after total joint replacement, J Bone Joint Surg Am, 80, 1167, 10.2106/00004623-199808000-00010 Eskandari, 2000, Is color-flow duplex a good diagnostic test for detection of isolated calf vein thrombosis in high-risk patients?, Angiology, 51, 705, 10.1177/000331970005100901 Bressollette, 2001, Diagnostic accuracy of compression ultrasonography for the detection of asymptomatic deep venous thrombosis in medical patients: the TADEUS project, Thromb Haemost, 86, 529, 10.1055/s-0037-1616081 Cronan, 1987, Deep venous thrombosis: US assessment using vein compression, Radiology, 162, 191, 10.1148/radiology.162.1.3538148 Wright, 1990, Pitfalls in lower extremity venous duplex scanning, J Vasc Surg, 11, 675, 10.1016/0741-5214(90)90213-T Kujath, 1993, Incidence and prophylaxis of deep venous thrombosis in outpatients with injury of the lower limb, Haemostasis, 23, 20 Rodgers, 1995, Systematic underestimation of treatment effects as a result of diagnostic test inaccuracy: Implications for the interpretation and design of thromboprophylaxis trials, Thromb Haemost, 73, 167, 10.1055/s-0038-1653746 Sonaglia, 2001, End points in studies on the prevention of deep vein thrombosis, Semin Thromb Hemost, 27, 41, 10.1055/s-2001-12850 Mismetti, 2000, Prevention of venous thromboembolism in internal medicine with unfractionated or low-molecular-weight heparins: a meta-analsis of randomised clinical trials, Thromb Haemost, 83, 14, 10.1055/s-0037-1613749 Coe, 1978, Prevention of deep vein thrombosis in urological patients: a controlled, randomized trial of low-dose heparin and external pneumatic compression boots, Surgery, 83, 230 Turpie, 1989, Prevention of deep vein thrombosis in potential neurosurgical patients: a randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control, Arch Intern Med, 149, 679, 10.1001/archinte.1989.00390030131025 Vanek, 1998, Meta-analysis of effectiveness of intermittent pneumatic compression devices with a comparison of thigh-high to knee-high sleeves, Am Surg, 64, 1050 Warwick, 1998, Comparison of the use of a foot pump with the use of low-molecular-weight heparin for the prevention of deep-vein thrombosis after total hip replacement, J Bone Joint Surg Am, 80, 1158, 10.2106/00004623-199808000-00009 Agu, 1999, Graduated compression stockings in the prevention of venous thromboembolism, Br J Surg, 86, 992, 10.1046/j.1365-2168.1999.01195.x Freedman, 2000, A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty, J Bone Joint Surg Am, 82, 929, 10.2106/00004623-200007000-00004 Westrich, 2000, Meta-analysis of thromboembolic prophylaxis after total knee arthroplasty, J Bone Joint Surg Br, 82, 795, 10.1302/0301-620X.82B6.9869 Amarigiri SV, Lees TA. Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev (database online). Issue 1, 2001 Hull, 1990, Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement, JAMA, 263, 2313, 10.1001/jama.1990.03440170035032 Blanchard, 1999, Prevention of deep-vein thrombosis after total knee replacement. randomised comparison between a low-molecular-weight heparin (nadroparin) and mechanical prophylaxis with a foot-pump system, J Bone Joint Surg Br, 81, 654, 10.1302/0301-620X.81B4.9464 Iorio, 2000, Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis, Arch Intern Med, 160, 2327, 10.1001/archinte.160.15.2327 Gallus, 1983, Venous thrombosis after elective hip replacement-the influence of preventive intermittent calf compression and of surgical technique, Br J Surg, 70, 17, 10.1002/bjs.1800700106 Comerota, 1992, Why does prophylaxis with external pneumatic compression for deep vein thrombosis fail?, Am J Surg, 164, 265, 10.1016/S0002-9610(05)81083-9 Haddad, 2001, Unanticipated variations between expected and delivered pneumatic compression therapy after elective hip surgery: a possible source of variation in reported patient outcomes, J Arthroplasty, 16, 37, 10.1054/arth.2001.19155 Cornwell, 2002, Compliance with sequential compression device prophylaxis in at-risk trauma patients: a prospective analysis, Am Surg, 68, 470, 10.1177/000313480206800515 Kay, 1986, Heel ulcers in patients with long-standing diabetes who wear antiembolism stockings, Med J Aust, 145, 290, 10.5694/j.1326-5377.1986.tb101128.x Heath, 1987, Arterial thrombosis associated with graduated pressure antiembolic stockings, BMJ, 295, 580, 10.1136/bmj.295.6598.580 Merrett, 1993, Ischaemic complications of graduated compression stockings in the treatment of deep venous thrombosis, Postgrad Med J, 69, 232, 10.1136/pgmj.69.809.232 Wille-Jorgensen, 1996, Prophylaxis of postoperative thromboembolism with a combination of heparin and graduated compression stockings, Int Angiol, 15, 15 Kalodiki, 1996, Deep venous thrombosis prophylaxis with low molecular weight heparin and elastic compression in patients having total hip replacement: a randomised controlled trial, Int Angiol, 15, 162 Ramos, 1996, The efficacy of pneumatic compression stockings in the prevention of pulmonary embolism after cardiac surgery, Chest, 109, 82, 10.1378/chest.109.1.82 Best, 2000, Graded compression stockings in elective orthopaedic surgery: an assessment of thein vivoperformance of commercially available stockings in patients having hip and knee arthroplasty, J Bone Joint Surg Br, 82, 116, 10.1302/0301-620X.82B1.9694 Patrono, 2001, Platelet-active drugs: the relationships among dose, effectiveness, and side effects, Chest, 119, 39S, 10.1378/chest.119.1_suppl.39S Antiplatelet Trialists' Collaboration, 1994, Collaborative overview of randomised trials of antiplatelet therapy: III. Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients, BMJ, 308, 235, 10.1136/bmj.308.6923.235 Lotke, 1996, Aspirin and warfarin for thromboembolic disease after total joint arthroplasty, Clin Orthop, 324, 251, 10.1097/00003086-199603000-00031 Pulmonary Embolism Prevention (PEP) Trial Collaborative Group, 2000, Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) Trial, Lancet, 355, 1295, 10.1016/S0140-6736(00)02110-3 Cohen, 1994, Antiplatelet treatment for thromboprophylaxis: a step forward or backwards?, BMJ, 309, 1213, 10.1136/bmj.309.6963.1213 Butterfield, 1972, Effect of aspirin on postoperative venous thrombosis, Lancet, 2, 441 McKenna, 1980, Prevention of venous thromboembolism after total knee replacement by high-dose aspirin or intermittent calf and thigh compression, BMJ, 280, 514, 10.1136/bmj.280.6213.514 Powers, 1989, A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip, Arch Intern Med, 149, 771, 10.1001/archinte.1989.00390040013003 Westrich, 1996, Prophylaxis against deep venous thrombosis after total knee arthroplasty: pneumatic planter compression and aspirin compared with aspirin alone, J Bone Joint Surg Am, 78, 826, 10.2106/00004623-199606000-00004 Graor, 1992, RD heparin (ardeparin sodium) vs aspirin to prevent deep venous thrombosis after hip or knee replacement surgery [abstract], Chest, 102, 118S Gent, 1996, Low-molecular-weight heparinoid orgaran is more effective than aspirin in the prevention of venous thromboembolism after surgery for hip fracture, Circulation, 93, 80, 10.1161/01.CIR.93.1.80 Cestac, 2003, Utilisation and safety of low molecular weight heparins: prospective observational study in medical inpatients, Drug Saf, 26, 197, 10.2165/00002018-200326030-00005 Turpie, 2003, Efficacy and safety of fondaparinux in major orthopedic surgery according to the timing of its first administration, Thromb Haemost, 90, 364, 10.1055/s-0037-1613491 Nagge, 2002, Is impaired renal function a contraindication to the use of low-molecular-weight heparin?, Arch Intern Med, 162, 2605, 10.1001/archinte.162.22.2605 Rodgers, 2000, Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials, BMJ, 321, 1493, 10.1136/bmj.321.7275.1493 Beattie, 2001, Epidural analgesia reduces postoperative myocardial infarction: a meta-analysis, Anesth Analg, 93, 853, 10.1097/00000539-200110000-00010 Wu, 2001, Measurement of patient satisfaction as an outcome of regional anesthesia and analgesia: a systematic review, Reg Anesth Pain Med, 26, 196 Carli, 2002, Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery: results of a randomized trial, Anesthesiology, 97, 540, 10.1097/00000542-200209000-00005 Dolin, 2002, Effectiveness of acute postoperative pain management: I. Evidence from published data, Br J Anaesth, 89, 409, 10.1093/bja/89.3.409 Rigg, 2002, Epidural anaesthesia and analgesia and outcome of major surgery: a randomised trial, Lancet, 359, 1276, 10.1016/S0140-6736(02)08266-1 Vandermeulen, 1994, Anticoagulants and spinal-epidural anesthesia, Anesth Analg, 79, 1165, 10.1213/00000539-199412000-00024 Horlocker, 2003, Regional anesthesia in the anticoagulated patient: defining the risks (The Second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation), Reg Anesth Pain Med, 28, 172 Lumpkin, 1998, FDA public health advisory, Anesthesiology, 88, 27A, 10.1097/00000542-199802000-00001 Wysowski, 1998, Spinal and epidural hematoma and low-molecular-weight heparin [letter], N Engl J Med, 338, 1774, 10.1056/NEJM199806113382415 Horlocker, 1997, Low molecular weight heparin: biochemistry, pharmacology, perioperative prophylaxis regimens, and guidelines for regional anesthetic management, Anesth Analg, 85, 874, 10.1213/00000539-199710000-00031 Horlocker, 1998, Neuraxial block and low-molecular-weight heparin: balancing perioperative analgesia and thromboprophylaxis, Reg Anesth Pain Med, 23, 164 Pezzuoli, 1989, Prophylaxis of fatal pulmonary embolism in general surgery using low-molecular-weight heparin Cy 216: a multicentre, double-blind, randomized, controlled, clinical trial versus placebo (STEP), Int Surg, 74, 205 Nicolaides, 1973, The risk of deep-vein thrombosis in surgical patients, Br J Surg, 60, 312 Wille-Jorgensen, 1990, Predicting failure of low-dose heparin in general surgical procedures, Surg Gynecol Obstet, 171, 126 Huber, 1992, Postoperative pulmonary embolism after hospital discharge: an underestimated risk, Arch Surg, 127, 310, 10.1001/archsurg.1992.01420030076014 Flordal, 1996, Risk factors for major thromboembolism and bleeding tendency after elective general surgical operations, Eur J Surg, 162, 783 Riber, 1996, Postoperative thromboembolism after day-case herniorrhaphy, Br J Surg, 83, 420, 10.1002/bjs.1800830341 Hendolin, 1981, The effect of lumbar epidural analgesia on the development of deep vein thrombosis of the legs after open prostatectomy, Acta Chir Scand, 147, 425 Prins, 1990, A comparison of general anesthesia and regional anesthesia as a risk factor for deep vein thrombosis following hip surgery: a critical review, Thromb Haemost, 64, 497, 10.1055/s-0038-1647346 Lassen, 2001, Pentasaccharide (fondapainux, Arixtra) versus enoxaparin for the prevention of venous thromboembolism (VTE) in major orthopedic surgery: subgroup analyses on efficacy [abstract], Blood, 98, 266a Kakkar, 1985, Efficacy and safety of low-molecular-weight heparin (CY216) in preventing postoperative venous thrombo-embolism: a co-operative study, Br J Surg, 72, 786, 10.1002/bjs.1800721006 Bergqvist, 1986, Low molecular weight heparin once daily compared with conventional low-dose heparin twice daily: a prospective double-blind multicentre trial on prevention of postoperative thrombosis, Br J Surg, 73, 204, 10.1002/bjs.1800730316 Bergqvist, 1988, Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis, Br J Surg, 75, 888, 10.1002/bjs.1800750920 Caen, 1988, A randomized double-blind study between a low molecular weight heparin Kabi 2165 and standard heparin in the prevention of deep vein thrombosis in general surgery: a French multicenter trial, Thromb Haemost, 59, 216, 10.1055/s-0038-1642757 European Fraxiparin Study (EFS) Group, 1988, Comparison of a low molecular weight heparin and unfractionated heparin for the prevention of deep vein thrombosis in patients undergoing abdominal surgery, Br J Surg, 75, 1058, 10.1002/bjs.1800751105 Samama, 1988, Low molecular weight heparin compared with unfractionated heparin in prevention of postoperative thrombosis, Br J Surg, 75, 128, 10.1002/bjs.1800750213 Hartl, 1990, Prophylaxis of thromboembolism in general surgery: comparison between standard heparin and Fragmin, Thromb Res, 57, 577, 10.1016/0049-3848(90)90074-M Liezorovicz, 1991, Prevention of perioperative deep vein thrombosis in general surgery: a multicentre double blind study comparing two doses of Logiparin and standard heparin, Br J Surg, 78, 412, 10.1002/bjs.1800780410 Wolf, 1991, Comparison of the efficacy and safety of Sandoz low molecular weight heparin and unfractionated heparin: interim analysis of a multicenter trial, Semin Thromb Haemost, 17, 343, 10.1055/s-2007-1002632 Koppenhagen, 1992, Low molecular weight heparin and prevention of postoperative thrombosis in abdominal surgery, Thromb Haemost, 67, 627, 10.1055/s-0038-1648513 Boneu, 1993, An international multicentre study: clivarin in the prevention of venous thromboembolism in patients undergoing general surgery; report of the International Clivarin Assessment Group, Blood Coagul Fibrinolysis, 4, S21 Gazzaniga, 1993, Enoxaparin in the prevention of deep venous thrombosis after major surgery: multicentric study, Int Surg, 78, 271 ENOXACAN Study Group, 1997, Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep vein thrombosis in elective cancer surgery: a double-blind randomized multicentre trial with venographic assessment, Br J Surg, 84, 1099, 10.1002/bjs.1800840817 Kakkar, 1997, Efficacy and safety of a low-molecular-weight heparin and standard unfractionated heparin for prophylaxis of postoperative venous thromboembolism: European multicenter trial, World J Surg, 21, 2, 10.1007/s002689900185 Haas, 1999, Prevention of fatal postoperative pulmonary embolism by low molecular weight heparin: a double blind comparison of certoparin and unfractionated heparin [abstract], Thromb Haemost, 82, 491 Egger, 2000, Efficacy and safety of weight-adapted nadroparin calcium vs. heparin sodium in prevention of clinically evident thromboembolic complications in 1,190 general surgical patients, Dig Surg, 17, 602, 10.1159/000051969 McLeod, 2001, Subcutaneous heparin versus low-molecular-weight heparin as thromboprophylaxis in patients undergoing colorectal surgery: results of the Canadian Colorectal DVT Prophylaxis Trial: a randomized, double-blind trial, Ann Surg, 233, 438, 10.1097/00000658-200103000-00020 Bounameaux, 1993, Unexpectedly high rate of phlebographic deep venous thrombosis following elective general abdominal surgery among patients given prophylaxis with low-molecular-weight heparin, Arch Surg, 128, 326, 10.1001/archsurg.1993.01420150082015 Kakkar, 1986, Efficacy and safety of two regimens of low molecular weight heparin fragment (Fragmin) in preventing postoperative venous thrombolism, Haemostasis, 16, 19 Haas, 1993, Prevention of postoperative thromboembolism with enoxaparin in general surgery: a German multicenter trial, Semin Thromb Haemost, 19, 164 Bjerkeset, 1997, Evaluation of enoxaparin given before and after operation to prevent venous thromboembolism during digestive surgery: play-the-winner designed study, World J Surg, 21, 584, 10.1007/s002689900277 Lausen, 1998, Incidence and prevention of deep venous thrombosis occurring late after general surgery: randomised controlled study of prolonged thromboprophylaxis, Eur J Surg, 164, 657, 10.1080/110241598750005534 Bergqvist, 2002, Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer, N Engl J Med, 346, 975, 10.1056/NEJMoa012385 Rasmussen, 2002, Preventing thromboembolic complications in cancer patients after surgery: a role for prolonged thromboprophylaxis, Cancer Treat Rev, 28, 141, 10.1016/S0305-7372(02)00043-9 Leizorovicz, 1992, Low molecular weight heparin in prevention of perioperative thrombosis, BMJ, 305, 913, 10.1136/bmj.305.6859.913 Palmer, 1997, Low molecular weight heparin and unfractionated heparin for prevention of thrombo-embolism in general surgery: a meta-analysis of randomised clinical trials, Haemostasis, 27, 65 Breddin, 1999, Low molecular weight heparins in the prevention of deep-vein thrombosis in general surgery, Semin Thromb Haemost, 25, 83 Wille-Jorgensen P, Rasmussen MS, Andersen BR, et al. Heparins and mechanical methods for thromboprophylaxis in colorectal surgery. Cochrane Database Syst Rev (database online). Issue 1, 2003 Wicky, 1993, Postoperative deep venous thrombosis (DVT) and low-molecular weight heparin (LMWH) type and dosage, Thromb Haemost, 69, 402, 10.1055/s-0038-1651622 Wiig, 1995, Prophylaxis of venographically diagnosed deep vein thrombosis in gastrointestinal surgery: multicentre trials 20 mg and 40 mg enoxaparin versus dextran, Eur J Surg, 161, 663 Warkentin, 1995, Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin, N Engl J Med, 332, 1330, 10.1056/NEJM199505183322003 Agnelli, 2003, Randomized double-blind study to compare the efficacy and safety of postoperative fondaparinux (Arixtra) and preoperative dalteparin in the prevention of venous thromboembolism after high-risk abdominal surgery: the PEGASUS Study [abstract], Blood, 102, 15a Wells, 1994, Graduated compression stockings in the prevention of postoperative venous thromboembolism: a meta-analysis, Arch Intern Med, 154, 67, 10.1001/archinte.1994.00420010095011 Moser, 1981, Mechanical versus pharmacologic prevention of deep venous thrombosis, Surg Gynecol Obstet, 152, 448 Nicolaides, 1983, Intermittent sequential pneumatic compression of the legs and thromboembolism-deterrent stockings in the prevention of postoperative deep venous thrombosis, Surgery, 94, 21 Scurr, 1987, Regimen for improved effectiveness of intermittent pneumatic compression in deep venous thrombosis prophylaxis, Surgery, 102, 816 Butson, 1981, Intermittent pneumatic calf compression for prevention of deep venous thrombosis in general abdominal surgery, Am J Surg, 142, 525, 10.1016/0002-9610(81)90391-3 Heit, 2001, The epidemiology of venous thromboembolism in the community, Thromb Haemost, 86, 452, 10.1055/s-0037-1616243 Scurr, 1988, Deep venous thrombosis: a continuing problem, BMJ, 297, 28, 10.1136/bmj.297.6640.28 Rasmussen, 2003, Prolonged thromboprophylaxis with low molecular weight heparin (dalteparin) following major abdominal surgery for malignancy [abstract], Blood, 102, 56a Dutch Bypass Oral Anticoagulants or Aspirin (BOA) Study Group, 2000, Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (The Dutch Bypass Oral Anticoagulants or Aspirin Study): a randomised trial, Lancet, 355, 346, 10.1016/S0140-6736(99)07199-8 Jackson, 2001, Antithrombotic therapy in peripheral arterial occlusive disease, Chest, 119, 283S, 10.1378/chest.119.1_suppl.283S Jackson, 2002, The effect of anticoagulation therapy and graft selection on the ischemic consequences of femoropopliteal bypass graft occlusion: results from a multicenter randomized clinical trial, J Vasc Surg, 35, 292, 10.1067/mva.2002.120383 Prandoni, 2003, An association between atherosclerosis and venous thrombosis, N Engl J Med, 348, 1435, 10.1056/NEJMoa022157 Angelides, 1977, Deep venous thrombosis in patients having aorto-iliac reconstruction, Br J Surg, 64, 517, 10.1002/bjs.1800640719 Belch, 1979, Low dose heparin in the prevention of deep-vein thrombosis after aortic bifurcation graft surgery, Thromb Haemost, 42, 1429, 10.1055/s-0038-1657043 Cass, 1986, Leg swelling after aortic surgery, Int Angiol, 5, 207 Hollyoak, 2001, Deep venous thrombosis in postoperative vascular surgical patients: a frequent finding without prophylaxis, J Vasc Surg, 34, 656, 10.1067/mva.2001.116803 Santiani, 1980, Deep venous thrombosis following operations upon the abdominal aorta, Surg Gynecol Obstet, 151, 241 Reilly, 1982, Deep venous thrombophlebitis following aortoiliac reconstructive surgery, Arch Surg, 117, 1210, 10.1001/archsurg.1982.01380330068016 Hamer, 1972, Investigation of oedema of the lower limb following successful femoropopliteal by-pass surgery: the role of phlebography in demonstrating venous thrombosis, Br J Surg, 59, 979, 10.1002/bjs.1800591212 Porter, 1972, Leg edema following femoropopliteal autogenous vein bypass, Arch Surg, 105, 883, 10.1001/archsurg.1972.04180120064012 Olin, 1993, The incidence of deep venous thrombosis in patients undergoing abdominal aortic aneurysm resection, J Vasc Surg, 18, 1037, 10.1016/0741-5214(93)90559-5 Killewich, 1997, A randomized, prospective trial of deep venous thrombosis prophylaxis in aortic surgery, Arch Surg, 132, 499, 10.1001/archsurg.1997.01430290045007 Fletcher, 1997, Incidence of deep vein thrombosis following vascular surgery, Int Angiol, 16, 65 Farkas, 1993, A randomised controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing vascular surgery, Eur J Vasc Surg, 7, 554, 10.1016/S0950-821X(05)80369-X Saarinen, 1995, The incidence of postoperative deep vein thrombosis in vascular procedures: FINNVASC Study Group, Vasa, 24, 126 Libertiny, 1999, Deep venous thrombosis in peripheral vascular disease, Br J Surg, 86, 907, 10.1046/j.1365-2168.1999.01129.x Passman, 2000, Prospective screening for postoperative deep venous thrombosis in patients undergoing infrainguinal revascularization, J Vasc Surg, 32, 669, 10.1067/mva.2000.109749 Eagleton, 2002, Endovascular treatment of abdominal aortic aneurysm is associated with a low incidence of deep venous thrombosis, J Vasc Surg, 36, 912, 10.1067/mva.2002.128640 Spebar, 1981, Perioperative heparin prophylaxis of deep venous thrombosis in patients with peripheral vascular disease, Am J Surg, 142, 649, 10.1016/0002-9610(81)90303-2 Greer, 1997, Epidemiology, risk factors and prophylaxis of venous thrombo-embolism in obstetrics and gynaecology, Baillieres Clin Obstet Gynaecol, 11, 403, 10.1016/S0950-3552(97)80019-3 Heilmann, 1998, Prevention of thrombosis prophylaxis in gynecologic malignancy, Clin Appl Thromb Hemost, 4, 153, 10.1177/107602969800400302 Clarke-Pearson, 1987, Variables associated with postoperative deep venous thrombosis: a prospective study of 411 gynecology patients and creation of a prognostic model, Obstet Gynecol, 69, 146 Clarke-Pearson, 2003, Venous thromboembolism prophylaxis: patients at high risk to fail intermittent pneumatic compression, Obstet Gynecol, 101, 157 Heilmann, 1998, Comparison of unfractionated versus low molecular weight heparin for deep vein thrombosis prophylaxis during breast and pelvic cancer surgery: efficacy, safety, and follow-up, Clin Appl Thromb Hemost, 4, 268, 10.1177/107602969800400410 Clarke-Pearson, 1984, The natural history of postoperative venous thromboemboli in gynecologic oncology: a prospective study of 382 patients, Am J Obstet Gynecol, 148, 1051, 10.1016/0002-9378(84)90632-X Macklon, 1996, Venous thromboembolic disease in obstetrics and gynaecology: the Scottish experience, Scott Med J, 41, 83, 10.1177/003693309604100305 Clarke-Pearson, 1993, A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery, Am J Obstet Gynecol, 168, 1146, 10.1016/0002-9378(93)90360-U Urlep-Salinovic, 1994, Low doses of heparin and heparin dihydergot in post-operative thromboprophylaxis in gynaecological patients, Thromb Haemost, 72, 16, 10.1055/s-0038-1648804 Ward, 1998, Comparison of low molecular weight heparin (Fragmin) with sodium heparin for prophylaxis against postoperative thrombosis in women undergoing major gynaecological surgery, Aust N Z J Obstet Gynaecol, 38, 91, 10.1111/j.1479-828X.1998.tb02968.x Baykal, 2001, Comparison of enoxaparin and standard heparin in gynaecologic oncologic surgery: a randomised prospective double-blind study, Eur J Gynaecol Oncol, 22, 127 Maxwell, 2001, Pneumatic compression versus low molecular weight heparin in gynecologic oncology surgery: a randomized trial, Obstet Gynecol, 98, 989 Dubuc-Lissoir, 1999, Prevention and treatment of thromboembolic disease in gynaecological surgery, J Soc Obstet Gynaecol Can, 21, 1087 ACOG Practice Bulletin, 2000, Prevention of deep vein thrombosis and pulmonary embolism, Obstet Gynecol, 96, 1 Clarke-Pearson, 1984, Perioperative external pneumatic calf compression as thromboembolism prophylaxis in gynecologic oncology: report of a randomized controlled trial, Obstet Gynecol, 18, 226 Clarke-Pearson, 1984, Prevention of postoperative venous thromboembolism by external pneumatic calf compression in patients with gynecologic malignancy, Obstet Gynecol, 63, 92 Hohl, 1980, Prevention of postoperative thromboembolism by dextran 70 or low-dose heparin, Obstet Gynecol, 55, 497 Clarke-Pearson, 1983, Venous thromboembolism prophylaxis in gynecologic oncology: a prospective, controlled trial of low-dose heparin, Am J Obstet Gynecol, 145, 606, 10.1016/0002-9378(83)91205-X Clarke-Pearson, 1990, A controlled trial of two low-dose heparin regimens for the prevention of postoperative dep vein thrombosis, Obstet Gynecol, 75, 684 Fricker, 1988, Low dose heparin versus low molecular weight heparin (Kabi 2165, Fragmin) in the prophylaxis of thromboembolic complications of abdominal oncological surgery, Eur J Clin Invest, 18, 561, 10.1111/j.1365-2362.1988.tb01268.x Haas, 1994, Antithromboembolic efficacy and safety of enoxaparin in general surgery, Eur J Surg, 571, 37 Brenner, 1989, Venous thromboembolism, J Urol, 142, 1403, 10.1016/S0022-5347(17)39111-5 Rossignol, 1991, Radical retropubic prostatectomy: complications and quality of life (429 cases, 1983–1989), Eur Urol, 19, 186, 10.1159/000473616 Kibel, 1995, Pathogenesis and prophylaxis of postoperative thromboembolic disease in urological pelvic surgery, J Urol, 153, 1763, 10.1016/S0022-5347(01)67302-6 Koch, 1997, Low molecular weight heparin and radical prostatectomy: a prospective analysis of safety and side effects, Prostate Cancer Prostatic Dis, 1, 101, 10.1038/sj.pcan.4500214 Shekarriz, 2001, Intraoperative, perioperative, and long-term complications of radical prostatectomy, Urol Clin North Am, 28, 639, 10.1016/S0094-0143(05)70168-3 Zincke, 1994, Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer, J Urol, 152, 1850, 10.1016/S0022-5347(17)32399-6 Dillioglugil, 1997, Risk factors for complications and morbidity after radical retropubic prostatectomy, J Urol, 157, 1760, 10.1016/S0022-5347(01)64856-0 Heinzer, 1998, Thromboembolic complication rate after radical retropubic prostatectomy: impact of routine ultrasonography for the detection of pelvic lymphoceles and hematomas, Eur Urol, 33, 86, 10.1159/000019516 Leandri, 1992, Radical retropubic prostatectomy: morbidity and quality of life: experience with 620 consecutive cases, J Urol, 147, 883, 10.1016/S0022-5347(17)37412-8 Cisek, 1993, Thromboembolic complications following radical retropubic prostatectomy: influence of external sequential pneumatic compression devices, Urology, 42, 406, 10.1016/0090-4295(93)90369-L Andriole, 1994, Early complications of contemporary anatomical radical retropubic prostatectomy, J Urol, 152, 1858, 10.1016/S0022-5347(17)32400-X Hautmann, 1994, Radical retropubic prostatectomy: morbidity and urinary continence in 418 consecutive cases, Urology, 43, 47, 10.1016/0090-4295(94)90218-6 Leibovitch, 1995, Color Doppler flow imaging for deep venous thrombosis screening in patients undergoing pelvic lymphadenectomy and radical retropubic prostatectomy for prostatic carcinoma, J Urol, 153, 1866, 10.1016/S0022-5347(01)67333-6 Goldenberg, 1996, Randomized, prospective, controlled study comparing radical prostatectomy alone and neoadjuvant androgen withdrawal in the treatment of localized prostate cancer, J Urol, 156, 873, 10.1016/S0022-5347(01)65645-3 Sieber, 1997, Is heparin contraindicated in pelvic lymphadenectomy and radical prostatectomy?, J Urol, 158, 869, 10.1016/S0022-5347(01)64342-8 Donat, 2002, Incidence of thromboembolism after transurethral resection of the prostate (TURP): a study on TED stocking prophylaxis and literature review, Scand J Urol Nephrol, 36, 119, 10.1080/003655902753679409 Bergqvist, 1985, Deep vein thrombosis after renal transplantation: a prospective analysis of frequency and risk factors, Eur Surg Res, 17, 69, 10.1159/000128450 Allen, 1987, Deep venous thrombosis after renal transplantation, Surg Gynecol Obstet, 164, 137 Angermeier, 1994, Complications of the exaggerated lithotomy position: a review of 177 cases, J Urol, 151, 866, 10.1016/S0022-5347(17)35108-X Soderdahl, 1997, A comparison of intermittent pneumatic compression of the calf and whole leg in preventing deep venous thrombosis in urological surgery, J Urol, 157, 1774, 10.1016/S0022-5347(01)64861-4 Geerts, 1997, Thromboprophylaxis after radical prostatectomy: a survey of Canadian urologists [abstract], Thromb Haemost, 77, 124 Van Arsdalen, 1983, Deep vein thrombosis and prostatectomy, Urology, 21, 461, 10.1016/0090-4295(83)90040-7 Bergqvist, 1980, Prophylaxis of postoperative venous thrombosis in a controlled trial comparing dextran 70 and low-dose heparin, World J Surg, 4, 239, 10.1007/BF02393589 Vandendris, 1980, Prevention of postoperative deep-vein thrombosis by low-dose heparin in open prostatectomy, Urol Res, 8, 219, 10.1007/BF00256997 Hedlund, 1981, The effects of low-dose heparin treatment on patients undergoing transvesical prostatectomy, Urol Res, 9, 147, 10.1007/BF00254410 Bigg, 1992, Prophylactic mini-dose heparin in patients undergoing radical retropubic prostatectomy: a prospective trial, Urology, 39, 309, 10.1016/0090-4295(92)90203-9 Sebeseri, 1975, Controlled prevention of post-operative thrombosis in urological diseases with depot heparin, Eur Urol, 1, 229, 10.1159/000455630 Neal, 1997, The National Prostatectomy Audit, Br J Urol, 79, 69, 10.1111/j.1464-410X.1997.tb16924.x Allen, 1978, Surgical haemorrhage in patients given subcutaneous heparin as prophylaxis against thromboembolism, BMJ, 1, 1326, 10.1136/bmj.1.6123.1326 Sleight, 1982, The effect of prophylactic subcutaneous heparin on blood loss during and after transurethral prostatectomy, Br J Urol, 54, 164, 10.1111/j.1464-410X.1982.tb13540.x Kibel, 1997, Late venous thromboembolic disease after radical prostatectomy: effect of risk factors, warfarin and early discharge, J Urol, 158, 2211, 10.1016/S0022-5347(01)68201-6 Zacharoulis, 2003, Venous thromboembolism in laparoscopic surgery, Curr Opin Pulm Med, 9, 356, 10.1097/00063198-200309000-00003 Caprini, 1995, Postoperative hypercoagulability and deep-vein thrombosis after laparoscopic cholecystectomy, Surg Endosc, 9, 304, 10.1007/BF00187774 Dexter, 1996, Activation of coagulation and fibrinolysis in open and laparoscopic cholecystectomy, Surg Endosc, 10, 1069, 10.1007/s004649900242 Dabrowiecki, 1997, The influence of laparoscopic cholecystectomy on perioperative blood clotting and fibrinolysis, Blood Coagul Fibrinolysis, 8, 1, 10.1097/00001721-199701000-00001 Rahr, 1999, Coagulation and fibrinolysis during laparoscopic cholecystectomy, Thromb Res, 93, 121, 10.1016/S0049-3848(98)00177-7 Lindberg, 2000, Coagulation activation after laparoscopic cholecystectomy in spite of thromboembolism prophylaxis, Surg Endosc, 14, 858, 10.1007/s004640000213 Prisco, 2000, Videolaparoscopic cholecystectomy induces a hemostasis activation of lower grade than does open surgery, Surg Endosc, 14, 170, 10.1007/s004649900093 Yol, 2000, Effect of laparoscopic cholecystectomy on platelet aggregation, World J Surg, 24, 734, 10.1007/s002689910118 Larsen, 2001, Randomized study of coagulation and fibrinolysis during and after gasless and conventional laparoscopic cholecystectomy, Br J Surg, 88, 1001, 10.1046/j.0007-1323.2001.01783.x Vander Velpen, 1994, Interleukin-6 and coagulation-fibrinolysis fluctuations after laparoscopic and conventional cholecystectomy, Surg Endosc, 8, 1216, 10.1007/BF00591054 Martinez-Ramos, 1999, Changes in hemostasis after laparoscopic cholecystectomy, Surg Endosc, 13, 476, 10.1007/s004649901016 Jorgensen, 1994, Venous stasis during laparoscopic cholecystectomy, Surg Laparosc Endosc, 4, 128 Wilson, 1994, Influence of compression stockings on lower-limb venous haemodynamics during laparoscopic cholecystectomy, Br J Surg, 81, 841, 10.1002/bjs.1800810616 Sobolewski, 1995, Venous hemodynamic changes during laparoscopic cholecystectomy, J Laparosc Surg, 5, 363, 10.1089/lps.1995.5.363 Bradbury, 1997, Thromboembolism prophylaxis during laparoscopic cholecystectomy, Br J Surg, 84, 962, 10.1002/bjs.1800840715 Tvedskov, 2001, Survey of the use of thromboprophylaxis in laparoscopic surgery in Denmark, Br J Surg, 88, 1413, 10.1046/j.0007-1323.2001.01856.x Blake, 2001, Deep venous thrombosis prophylaxis is not indicated for laparosocopic cholecystectomy, J Soc Laparosc Surg, 5, 215 Bounameaux, 1997, Antithrombotic prophylaxis in patients undergoing laparoscopic cholecystectomy, Thromb Res, 86, 271 Catheline, 1999, Thromboembolism in laparoscopic surgery: risk factors and preventive measures, Surg Laparosc Endosc Percutan Tech, 9, 135, 10.1097/00019509-199904000-00011 Chamberlain, 1978 Scott, 1992, Laparoscopic cholecystectomy: a review of 12,397 patients, Surg Laparosc Endosc, 2, 191 Lindberg, 1997, Incidence of thromboembolic complications after laparoscopic cholecystectomy: review of the literature, Surg Laparosc Endosc, 7, 324, 10.1097/00019509-199708000-00014 Hjelmqvist, 2000, Complications of laparoscopic cholecystectomy as recorded in the Swedish Laparoscopy Registry, Eur J Surg, 585, 18, 10.1080/110241500750009645 Patel, 1996, The incidence of deep venous thrombosis after laparoscopic cholecystectomy, Med J Aust, 164, 652, 10.5694/j.1326-5377.1996.tb122233.x Baca, 1997, Prevention of venous thromboembolism in patients undergoing minimally invasive surgery with a short-term hospital stay: results of a multicentric, prospective, randomised, controlled clinical trial with a low-molecular-weight heparin, Chirurg, 68, 1275, 10.1007/s001040050359 Healey, 1998, The risk of venous thrombosis following gynaecological laparoscopic surgery, Med J Aust, 168, 524, 10.5694/j.1326-5377.1998.tb141429.x Lord, 1998, Incidence of deep vein thrombosis after laparoscopic vs minilaparotomy cholecystectomy, Arch Surg, 133, 967, 10.1001/archsurg.133.9.967 Wazz, 2000, Influence of pneumoperitoneum on the deep venous system during laparoscopy, JSLS, 4, 291 Mall, 2001, Blinded prospective study of the incidence of deep venous thrombosis following conventional or laparoscopic colorectal resection, Br J Surg, 88, 99, 10.1046/j.1365-2168.2001.01635.x Schaepkens van Riempst, 2002, Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin, Surg Endosc, 16, 184, 10.1007/s004640090048 Schwenk, 1998, Intermittent pneumatic sequential compression (ISC) of the lower extremities prevents venous stasis during laparoscopic cholecystectomy: a prospective randomized study, Surg Endosc, 12, 7, 10.1007/s004649900583 Isoda, 2000, Femoral vein stasis during laparoscopic cholecystectomy: effect of an intermittent sequential pneumatic compression device, Digest Endosc, 12, 225, 10.1046/j.1443-1661.2000.00047.x Neudecker, 2002, The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery, Surg Endosc, 16, 1121, 10.1007/s00464-001-9166-7 Society of American Gastrointestinal Endoscopic Surgeons Bergqvist, 2002, Venous thromboembolism in patients undergoing laparoscopic and arthroscopic surgery and in leg casts, Arch Intern Med, 162, 2173, 10.1001/archinte.162.19.2173 NIH Consensus Conference, 1986, Prevention of venous thrombosis and pulmonary embolism, JAMA, 256, 744, 10.1001/jama.1986.03380060070028 Turpie, 1986, A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients underoging elective hip surgery, N Engl J Med, 315, 925, 10.1056/NEJM198610093151503 Beisaw, 1988, Dihydroergotamine/heparin in the prevention of deep-vein thrombosis after total hip replacement: a controlled, prospective randomized multicenter trial, J Bone Joint Surg Am, 70, 2, 10.2106/00004623-198870010-00002 Haake, 1989, Venous thromboembolic disease after hip surgery: risk factors, prophylaxis, and diagnosis, Clin Orthop, 242, 212, 10.1097/00003086-198905000-00022 Lassen, 1991, Prevention of thromboembolism in 190 hip arthroplasties: comparison of LMW heparin and placebo, Acta Orthop Scand, 62, 33, 10.3109/17453679108993088 Hoek, 1992, Prevention of deep vein thrombosis following total hip replacement by low molecular weight heparinoid, Thromb Haemost, 67, 28, 10.1055/s-0038-1648374 Eriksson, 1991, Prevention of deep-vein thrombosis and pulmonary embolism after total hip or knee replacement: a meta-analysis fo prospective studies investigating symptomatic outcomes, J Bone Joint Surg Am, 73, 484, 10.2106/00004623-199173040-00002 Warwick, 1995, Perioperative low-molecular-weight heparin: is it effective and safe?, J Bone Joint Surg Br, 77, 715, 10.1302/0301-620X.77B5.7559695 Mahomed, 2003, Rates and outcomes of primary and revision total hip replacement in the United States Medicare population, J Bone Joint Surg Am, 85, 27, 10.2106/00004623-200301000-00005 Phillips, 2003, Incidence rates of dislocation, pulmonary embolism, and deep infection during the first six months after elective total hip replacement, J Bone Joint Surg Am, 85, 20, 10.2106/00004623-200301000-00004 Mohr, 1992, Venous thromboembolism associated with hip and knee arthroplasty: current proplylactic practices and outcomes, Mayo Clin Proc, 67, 861, 10.1016/S0025-6196(12)60825-8 Murray, 1996, Thromboprophylaxis and death after total hip replacement, J Bone Joint Surg Br, 78, 863, 10.1302/0301-620X78B6.6714 Colwell, 1999, Comparison of enoxaparin and warfarin for the prevention of venous thrombeombolic disease after total hip arthroplasty: evaluation during hospitalization and three months after discharge, J Bone Joint Surg Am, 81, 932, 10.2106/00004623-199907000-00005 Stulberg, 1984, Deep-vein thrombosis following total knee replacement: an analysis of six hundred and thrity-eight arthroplasties, J Bone Joint Surg Am, 66, 194, 10.2106/00004623-198466020-00005 Lynch, 1988, Deep-vein thrombosis and continuous passive motion after total knee arthroplasty, J Bone Joint Surg Am, 70, 11, 10.2106/00004623-198870010-00003 Stringer, 1989, Deep vein thrombosis after elective knee surgery: an incidence study in 312 patients, J Bone Joint Surg Br, 71, 492, 10.1302/0301-620X.71B3.2785998 Leclerc, 1992, Prevention of deep vein thrombosis after major knee surgery: a randomized, double-blind trial comparing a low molecular weight heparin fragment [enoxaparin] to placebo, Thromb Haemost, 67, 417, 10.1055/s-0038-1648463 Levine, 1996, Ardeparin (low-molecular-weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism: a randomized trial in patients undergoing knee surgery, Arch Intern Med, 156, 851, 10.1001/archinte.1996.00440080039005 Warwick, 2002, A randomised comparison of a foot pump and low-molecular-weight heparin in the prevention of deep-vein thrombosis after total knee replacement, J Bone Joint Surg Br, 84, 344, 10.1302/0301-620X.84B3.12372 Khaw, 1993, The incidence of fatal pulmonary embolism after knee replacement with no prophylactic anticoagulation, J Bone Joint Surg Br, 75, 940, 10.1302/0301-620X.75B6.8245087 Ansari, 1997, Incidence of fatal pulmonary embolism after 1,390 knee arthroplasties without routine prophylactic anticoagulation, except in high-risk cases, J Arthroplasty, 12, 599, 10.1016/S0883-5403(97)90131-5 Snook, 1981, Thromboembolism after surgical treatment of hip fractures, Clin Orthop, 155, 21, 10.1097/00003086-198103000-00003 Agnelli, 1992, A randomised, double-blind, placebo-controlled trial of dermatan sulphate for prevention of deep vein thrombosis in hip fracture, Thromb Haemost, 67, 203, 10.1055/s-0038-1648413 Dahl, 1997, Prolonged thromboprophylaxis following hip replacement surgery: results of a double-blind, prospective, randomised, placebo-controlled study with dalteparin (Fragmin), Thromb Haemost, 77, 26, 10.1055/s-0038-1655901 Seagroatt, 1991, Elective total hip replacement: incidence, emergency readmission rate, and postoperative mortality, BMJ, 303, 1431, 10.1136/bmj.303.6815.1431 Turpie, 2002, Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies, Arch Intern Med, 162, 1833, 10.1001/archinte.162.16.1833 Warwick, 1997, Sympotomatic venous thromboembolism after total knee replacement, J Bone Joint Surg Br, 78, 780, 10.1302/0301-620X.79B5.7761 Dahl, 2000, Late occurring clinical deep vein thrombosis in joint-operated patients, Acta Orthop Scand, 71, 47, 10.1080/00016470052943883 Heit, 2000, Ardeparin sodium for extended out-of-hospital prophylaxis against venous thromboembolism after total hip or knee replacement: a randomized, double-blind, placebo-controlled trial, Ann Intern Med, 132, 853, 10.7326/0003-4819-132-11-200006060-00002 Anderson, 2002, Comparison of a nomogram and physician-adjusted dosage of warfarin for prophylaxis against deep-vein thrombosis after arthroplasty, J Bone Joint Surg Am, 84, 1992, 10.2106/00004623-200211000-00013 Pellegrini, 1996, Natural history of thromboembolic disease after total hip arthroplasty, Clin Orthop, 333, 27, 10.1097/00003086-199612000-00004 Ginsberg, 2000, Postthrombotic syndrome after hip or knee arthroplasty: a cross-sectional study, Arch Intern Med, 160, 669, 10.1001/archinte.160.5.669 Kim, 2003, Incidence and natural history of deep-vein thrombosis after total hip arthroplasty, J Bone Joint Surg Br, 85, 661, 10.1302/0301-620X.85B5.14012 Buehler, 1999, Late deep venous thrombosis and delayed weight bearing after total hip arthroplasty, Clin Orthop, 361, 123, 10.1097/00003086-199904000-00017 Lindahl, 1999, APC-resistance is a risk factor for postoperative thromboembolism in elective replacement of the hip or knee: a prospective study, Thromb Haemost, 81, 18, 10.1055/s-0037-1614410 Westrich, 2002, Correlation of thrombophilia and hypofibrinolysis with pulmonary embolism following total hip arthroplasty: an analysis of genetic factors, J Bone Joint Surg Am, 84, 2161, 10.2106/00004623-200212000-00006 Wilson, 2002, Altered venous function and deep venous thrombosis following proximal femoral fracture, Injury, 33, 33, 10.1016/S0020-1383(01)00137-1 Planes, 1996, Risk of deep-venous thrombosis after hospital discharge in patients having undergone total hip replacement: double-blind randomised comparison of enoxaparin versus placebo, Lancet, 348, 224, 10.1016/S0140-6736(96)01453-5 Salvati, 2000, Recent advances in venous thromboembolic prophylaxis during and after total hip replacement, J Bone Joint Surg Am, 82, 252, 10.2106/00004623-200002000-00010 Warwick, 1995, Death and thromboembolic disease after total hip replacement: a series of 1162 cases with no routine chemical prophylaxis, J Bone Joint Surg Br, 77, 6, 10.1302/0301-620X.77B1.7822397 Gillespie, 2000, Risks and benefits of prophylaxis against venous thromboembolism in orthopaedic surgery, J Bone Joint Surg Br, 82, 475, 10.1302/0301-620X.82B4.10452 Wroblewski, 1998, Fatal pulmonary embolism after total hip arthroplasty: diurnal variations, Orthopedics, 21, 1269, 10.3928/0147-7447-19981201-07 Borris, 1989, Comparison of real-time B-mode ultrasonography and bilateral ascending phlebography for detection of postoperative deep vein thrombosis following elective hip surgery, Thromb Haemost, 61, 363, 10.1055/s-0038-1646596 Heit, 1991, Operating characteristics of cuff impedance plethysmography in the diagnosis of deep-vein thrombosis following total hip or knee arthroplasty [abstract], Blood, 78, 214a Agnelli, 1992, Detection of asymptomatic deep vein thrombosis by real-time B-mode ultrasonography in hip surgery paitents, Thromb Haemost, 68, 257, 10.1055/s-0038-1656360 Crippa, 1995, Diagnostic value of compression ultrasonography and fibrinogen-related parameters for the detection of postoperative deep vein thrombosis following elective hip replacement: a pilot study, Thromb Haemost, 74, 1235, 10.1055/s-0038-1649918 Magnusson, 1996, Is colour Doppler ultrasound a sensitive screening method in diagnosing deep vein thrombosis after hip surgery?, Thromb Haemost, 75, 242, 10.1055/s-0038-1650252 Lensing, 1997, A comparison of compression ultrasound with color Doppler ultrasound for the diagnosis of symptomless postoperative deep vein thrombosis, Arch Intern Med, 157, 765, 10.1001/archinte.1997.00440280085007 Comp, 1998, A comparison of danaparoid and warfarin for prophylaxis against deep vein thrombosis after total hip replacement, Orthopedics, 21, 1123, 10.3928/0147-7447-19981001-11 Barnes, 1978, Efficacy of graded-compression antiembolism stockings in patients undergoing total hip arthroplasty, Clin Orthop, 132, 61 Nilsen, 1984, Graded pressure stockings in prevention of deep vein thrombosis following total hip replacement, Acta Chir Scand, 150, 531 Fordyce, 1992, A venous foot pump reduces thrombosis after total hip replacement, J Bone Joint Surg Br, 74, 45, 10.1302/0301-620X.74B1.1732264 Samama, 1997, Low molecular weight heparin associated with spinal anaesthesia and gradual compression stockings in total hip replacment surgery, Br J Anaesth, 78, 660, 10.1093/bja/78.6.660 Paiement, 1987, Low-dose warfarin versus external pneumatic compression for prophylaxis against venous thromboembolism following total hip replacement, J Arthroplasty, 2, 23, 10.1016/S0883-5403(87)80027-X Bailey, 1991, Prospective randomized trial of sequential compression devices vs low-dose warfarin for deep venous thrombosis prophylaxis in total hip arthroplasty, J Arthroplasty, 6, S29, 10.1016/S0883-5403(08)80053-8 Kaempffe, 1991, Intermittent pneumatic compression versus Coumadin: prevention of deep vein thrombosis in low-extremity total joint arthroplasty, Clin Orthop, 269, 89, 10.1097/00003086-199108000-00014 Francis, 1992, Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement, JAMA, 267, 2911, 10.1001/jama.1992.03480210073035 Norgren, 1996, Low incidence of deep vein thrombosis after total hip replacement: an interim analysis of patients on low molecular weight heparin vs sequential gradient compression prophylaxis, Int Angiol, 15, 11 Ryan, 2002, Effect of mechanical compression on the prevalence of proximal deep venous thrombosis as assessed by magnetic resonance venography, J Bone Joint Surg Am, 84, 1998, 10.2106/00004623-200211000-00014 Sarmiento, 1999, Thromboembolic prophylaxis with use of aspirin, exercise, and graded elastic stockings or intermittent compression devices in patients managed with total hip arthroplasty, J Bone Joint Surg Am, 81, 339, 10.2106/00004623-199903000-00005 Eriksson, 1997, Thromb Haemost, 77, 487 Harris, 1974, Comparison of warfarin, low-molecular-weight dextran, aspirin, and subcutaneous heparin in prevention of venous thrombombolism following total hip replacement, J Bone Joint Surg Am, 56, 1552, 10.2106/00004623-197456080-00002 Leyvraz, 1983, Adjusted versus fixed-dose subcutaneous heparin in the prevention of deep-vein thrombosis after total hip replacement, N Engl J Med, 309, 954, 10.1056/NEJM198310203091605 Planes, 1988, Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement, Thromb Haemost, 60, 407, 10.1055/s-0038-1646980 Anderson, 1993, Efficacy and cost of low-molecular-weight heparin for the prevention of deep vein thrombosis after total hip arthroplasty, Ann Intern Med, 119, 1105, 10.7326/0003-4819-119-11-199312010-00008 Eriksson, 1996, Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393, Lancet, 347, 635, 10.1016/S0140-6736(96)91200-3 Eriksson, 1997, Prevention of thromboembolism with use of recombinant hirudin: results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement, J Bone Joint Surg Am, 79, 326, 10.2106/00004623-199703000-00002 Kakkar, 2000, A comparative, double-blind, randomised trial of a new second generation LMWH (bemiparin) and UFH in the prevention of post-operative venous thromboembolism, Thromb Haemost, 83, 523, 10.1055/s-0037-1613856 Dechavanne, 1989, Randomized trial of a low-molecular-weight heparin (Kabi 2165) versus adjusted-dose subcutaneous standard heparin in the prophylaxis of deep-vein thrombosis after elective hip surgery, Haemostasis, 19, 5 Leyvraz, 1991, Prevention of deep vein thrombosis after hip replacement: randomised comparison between unfractionated heparin and low molecular weight heparin, BMJ, 303, 543, 10.1136/bmj.303.6802.543 Rader, 1998, Low-molecular-weight heparin and partial thromboplastin time-adjusted unfractionated heparin in thromboprophylaxis after total knee and total hip arthroplasty, J Arthroplasty, 13, 180, 10.1016/S0883-5403(98)90096-1 Amstutz, 1989, Warfarin prophylaxis to prevent mortality from pulmonary embolism after total hip replacement, J Bone Joint Surg Am, 71, 321, 10.2106/00004623-198971030-00002 Paiement, 1993, Routine use of adjusted low-dose warfarin to prevent venous thromboembolism after total hip replacement, J Bone Joint Surg Am, 75, 893, 10.2106/00004623-199306000-00010 Janku, 1996, Prevention of thromboembolism in orthopaedics in the United States, Clin Orthop, 325, 313, 10.1097/00003086-199604000-00038 Lieberman, 1997, The efficacy of prophylaxis with low-dose warfarin for prevention of pulmonary embolism following total hip arthroplasty, J Bone Joint Surg Am, 79, 319, 10.2106/00004623-199703000-00001 Gross, 1999, Venous thromboembolism prophylaxis after total hip or knee arthroplasty: a survey of Canadian orthopedic surgeons, Can J Surg, 42, 457 Mesko, 2001, Venous thromboembolic disease management patterns in total hip arthroplasty and total knee arthroplasty patients: a survey of the AAHKS membership, J Arthroplasty, 16, 679, 10.1054/arth.2001.25506 RD Heparin Arthroplasty Group, 1994, RD heparin compared with warfarin for prevention of venous thromboembolic disease following total hip or knee arthroplasty, J Bone Joint Surg Am, 76, 1174, 10.2106/00004623-199408000-00008 Francis, 1997, Prevention of deep-vein thrombosis after total hip arthroplasty: comparison of warfarin and dalteparin, J Bone Joint Surg Am, 79, 1365, 10.2106/00004623-199709000-00011 Caprini, 1999, The influence of oral anticoagulation therapy on deep vein thrombosis rates four weeks after total hip replacement, J Vasc Surg, 30, 813, 10.1016/S0741-5214(99)70005-4 German Hip Arthroplasty Trial Group (GHAT), 1992, Prevention of deep vein thrombosis with low molecular-weight heparin in patients undergoing total hip replacement: a randomized trial, Arch Orthop Trauma Surg, 111, 110, 10.1007/BF00443477 Colwell, 1994, Use of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement: a clinical trial comparing efficacy and safety, J Bone Joint Surg Am, 76, 3, 10.2106/00004623-199401000-00002 Hull, 1993, A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation, N Engl J Med, 329, 1370, 10.1056/NEJM199311043291902 Hamulyak, 1995, Subcutaneous low-molecular weight heparin or oral anticoagulants for the prevention of deep-vein thrombosis in elective hip and knee replacement?, Thromb Haemost, 74, 1428, 10.1055/s-0038-1649959 Hull, 2000, Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs warfarin in hip arthroplasty patients: a double-blind, randomized comparison, Arch Intern Med, 160, 2199, 10.1001/archinte.160.14.2199 Colwell, 1995, Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep venous thrombosis after elective knee arthroplasty, Clin Orthop, 321, 19 Lassen, 2002, Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thrombeombolism in elective hip-replacement surgery: a randomised double-blind comparison, Lancet, 359, 1715, 10.1016/S0140-6736(02)08652-X Turpie, 2002, Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial, Lancet, 359, 1721, 10.1016/S0140-6736(02)08648-8 Bauer, 2001, Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery, N Engl J Med, 345, 1305, 10.1056/NEJMoa011099 Eriksson, 2001, Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery, N Engl J Med, 345, 1298, 10.1056/NEJMoa011100 Eriksson, 1997, A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement, N Engl J Med, 337, 1329, 10.1056/NEJM199711063371901 Eriksson, 2002, A dose ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared with dalteparin in the prevention of thromboembolism after hip or knee replacement: METHRO I, Thromb Haemost, 87, 231, 10.1055/s-0037-1612978 Eriksson, 2002, Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial, Lancet, 360, 1441, 10.1016/S0140-6736(02)11469-3 Eriksson, 2003, The direct thrombin inhibitor melagatran followed by oral ximelagatran compared with enoxaparin for the prevention of venous thromboembolism after total hip or total knee replacement: the EXPRESS Study, J Thromb Haemost, 1, 2490, 10.1111/j.1538-7836.2003.00494.x Eriksson, 2003, Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or total knee replacement: the METHRO III study, Thromb Haemost, 89, 288, 10.1055/s-0037-1613445 Colwell, 2003, Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement: a randomized, double-blind study, J Thromb Haemost, 2003, 2119, 10.1046/j.1538-7836.2003.00368.x Hull, 1979, Effectiveness of intermittent pulsatile elastic stockings for the prevention of calf and thigh vein thrombosis in patients undergoing elective knee surgery, Thromb Res, 16, 37, 10.1016/0049-3848(79)90267-6 Haas, 1990, Pneumatic sequential-compression boots compared with aspirin prophylaxis of deep-vein thrombosis after total knee arthroplasty, J Bone Joint Surg Am, 72, 27, 10.2106/00004623-199072010-00005 Wilson, 1992, Thrombo-embolic prophylaxis in total knee replacement: evaluation of the A-V Impulse System, J Bone Joint Surg Br, 74, 50, 10.1302/0301-620X.74B1.1732265 Norgren, 1998, Prevention of deep vein thrombosis in knee arthroplasty: preliminary results from a randomized controlled study of low molecular weight heparin vs foot pump compression, Int Angiol, 17, 93 Hui, 1996, Graded compression stockings for prevention of deep-vein thrombosis after hip and knee replacement, J Bone Joint Surg Br, 78, 550, 10.1302/0301-620X.78B4.0780550 Fauno, 1994, Prophylaxis for the prevention of venous thromboembolism after total knee arthroplasty: a comparison between unfractionated and low-molecular-weight heparin, J Bone Joint Surg Am, 76, 1814, 10.2106/00004623-199412000-00007 Francis, 1996, Comparison of two warfarin regimens in the prevention of venous thrombosis following total knee replacment, Thromb Haemost, 75, 706, 10.1055/s-0038-1650352 Leclerc, 1996, Prevention of venous thromboembolism after knee arthroplasty: a randomized, double-blind trial comparing enoxaparin with warfarin, Ann Intern Med, 124, 619, 10.7326/0003-4819-124-7-199604010-00001 Heit, 1997, Efficacy and safety of low molecular weight heparin (ardeparin sodium) compared to warfarin for the prevention of venous thromboembolism after total knee replacement surgery: a doube-blind, dose-ranging study, Thromb Haemost, 77, 32, 10.1055/s-0038-1655902 Fitzgerald, 2001, Prevention of venous thromboembolic disease following primary total knee arthroplasty: a randomized, multicenter, open-label, parallel-group comparison of enoxaparin and warfarin, J Bone Joint Surg Am, 83, 900, 10.2106/00004623-200106000-00012 Francis, 2002, Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty: a randomized, double-blind trial, Ann Intern Med, 137, 648, 10.7326/0003-4819-137-8-200210150-00008 Colwell, 2003, Randomized, double-blind comparison of ximelagatran, an oral direct thrombin inhibitor, and warfarin to prevent venous thromboembolism (VTE) after total knee replacement (TKR): EXULT B [abstract], Blood, 102, 14a Francis, 2003, Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement, N Engl J Med, 349, 1703, 10.1056/NEJMoa035162 Lieberman, 1997, Low-dose warfarin prophylaxis to prevent symptomatic pulmonary embolism after total knee arthroplasty, J Arthroplasty, 12, 180, 10.1016/S0883-5403(97)90064-4 Heit, 2001, Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study, Arch Intern Med, 161, 2215, 10.1001/archinte.161.18.2215 Navarro-Quilis, 2003, Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: a randomized, double-blind clinical trial, J Thromb Haemost, 1, 425, 10.1046/j.1538-7836.2003.00142.x Howard, 1998, Low molecular weight heparin decreases proximal and distal deep venous thrombosis folowing total knee arthroplasty: a meta-analysis of randomized trials, Thromb Haemost, 79, 902, 10.1055/s-0037-1615090 Brookenthal, 2001, A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty, J Arthroplasty, 16, 293, 10.1054/arth.2001.21499 Menzin, 1995, Cost-effectiveness of enoxaparin vs low-dose warfarin in the prevention of deep-vein thrombosis after total hip replacement surgery, Arch Intern Med, 155, 757, 10.1001/archinte.1995.00430070117013 Saltiel, 1996, Evaluation costs of a pharmacist-run thromboprophylaxis program, Formulary, 31, 276 Hull, 1997, Subcutaneous low-molecular-weight heparin vs warfarin for prophylaxis of deep vein thrombosis after hip or knee implantation: an economic perspective, Arch Intern Med, 157, 298, 10.1001/archinte.1997.00440240060009 Hawkins, 1998, A pharmacoeconomic assessment of enoxaparin and warfarin as prophylaxis for deep vein thrombosis in patients undergoing knee replacement surgery, Clin Ther, 20, 182, 10.1016/S0149-2918(98)80045-3 Friedman, 2000, Cost analyses of extended prophylaxis with enoxaparin after hip arthroplasty, Clin Orthop, 370, 171, 10.1097/00003086-200001000-00016 Hoppener, 2003, Day-care or short-stay surgery and venous thromboembolism, J Thromb Haemost, 1, 863, 10.1046/j.1538-7836.2003.t01-9-00115.x Small, 1988, Complications in arthroscopic surgery performed by experienced arthroscopists, Arthroscopy, 4, 215, 10.1016/S0749-8063(88)80030-6 Bamford, 1993, Avoidable complications of arthroscopic surgery, J R Coll Surg Edinb, 38, 92 Durica, 1997, Incidence of deep-vein thrombosis after arthroscopic knee surgery [abstract], Thromb Haemost, 77, 183 Demers, 1998, Incidence of venographically proved deep vein thrombosis after knee arthroscopy, Arch Intern Med, 158, 47, 10.1001/archinte.158.1.47 Williams, 1995, Incidence of deep vein thrombosis after arthroscopic knee surgery: a prospective study, Arthroscopy, 11, 701, 10.1016/0749-8063(95)90113-2 Cullison, 1996, The incidence of deep venous thrombosis in anterior cruciate ligament reconstruction, Arthroscopy, 12, 657, 10.1016/S0749-8063(96)90166-8 Jaureguito, 1999, The incidence of deep venous thrombosis after arthroscopic knee surgery, Am J Sports Med, 27, 707, 10.1177/03635465990270060401 Delis, 2001, Incidence, natural history and risk factors of deep vein thrombosis in elective knee arthroscopy, Thromb Haemost, 86, 817, 10.1055/s-0037-1616137 Wirth, 2001, Prevention of venous thromboembolism after knee arthroscopy with low-molecular weight heparin (reviparin): results of a randomized controlled trial, Arthroscopy, 17, 393, 10.1053/jars.2001.21247 Michot, 2002, Prevention of deep-vein thrombosis in ambulatory arthroscopic knee surgery: a randomized trial of prophylaxis with low-molecular weight heparin, Arthroscopy, 18, 257, 10.1053/jars.2002.30013 Borgstrom, 1965, Anticoagulant prophylaxis of venous thrombosis in patients with fractured neck of the femur: a controlled clinical trial using venous phlebography, Acta Chir Scand, 129, 500 Hamilton, 1970, Venous thrombosis in patients with fracture of the upper end of the femur: a phlebographic study of the effect of prophylactic anticoagulation, J Bone Joint Surg Br, 52, 268, 10.1302/0301-620X.52B2.268 Lowe, 1978, Subcutaneous ancrod in prevention of deep-vein thrombosis after operation for fractured neck of femur, Lancet, ii, 698, 10.1016/S0140-6736(78)92701-0 Rogers, 1978, Controlled trial of low-dose heparin and sulfinpyrazone to prevent venous thromboembolism after operation on the hip, J Bone Joint Surg Am, 60, 758, 10.2106/00004623-197860060-00005 Jorgensen, 1998, Early preoperative thromboprophylaxis with Klexane in hip fracture surgery: a placebo-controlled study, Clin Appl Thromb Hemost, 4, 140, 10.1177/107602969800400213 Perez, 1995, Death after proximal femoral fracture: an autopsy study, Injury, 26, 237, 10.1016/0020-1383(95)90008-L Schroder, 1993, Autopsy-verified major pulmonary embolism after hip fracture, Clin Orthop, 293, 196 Hefley, 1996, Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip, J Bone Joint Surg Am, 78, 581, 10.2106/00004623-199604000-00012 Zahn, 1999, The preoperative prevalence of deep vein thrombosis in patients with femoral neck fractures and delayed operation, Injury, 30, 605, 10.1016/S0020-1383(99)00163-1 Sorenson, 1992, Anesthetic techniques during surgical repair of femoral neck fractures: a meta-analysis, Anesthesiology, 77, 1095, 10.1097/00000542-199212000-00009 Handoll HH, Farrar MJ, McBirnie J, et al. Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures. Cochrane Database Syst Rev (database online). Issue 1, 2003 Fisher, 1995, Effectiveness of leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomized study of compression alone versus no prophylaxis, J Orthop Trauma, 9, 1, 10.1097/00005131-199502000-00001 Monreal, 1989, A prospective double-blind trial of a low molecular weight heparin once daily compared with conventional low-dose heparin three times daily to prevent pulmonary embolism and venous thrombosis in patients with hip fracture, J Trauma, 29, 873, 10.1097/00005373-198906000-00028 Barsotti, 1990, Comparative double-blind study of two dosage regimens low-molecular weight heparin in elderly patients with a fracture of the neck of the femur, J Orthop Trauma, 4, 371, 10.1097/00005131-199012000-00001 TIFDED Study Group, 1999, Thromboprophylaxis in hip fracture surgery: a pilot study comparing danaparoid, enoxaparin and dalteparin, Haemostasis, 29, 310 Roberts, 1990, The preoperative prevalence and postoperative incidence of thromboembolism in patients with hip fractures treated with dextran prophylaxis, Clin Orthop, 255, 198, 10.1097/00003086-199006000-00027 Girasole, 1994, Diagnosis of deep vein thrombosis in elderly hip-fracture patients by using the duplex scanning technique, Orthop Rev, 23, 411 Williams, 1994, Pre-operative anticoagulant prophylaxis in elderly patients with proximal femur fractures [abstract], J Bone Joint Surg Br, 76, 79 Raskob, 2003, Controversies in timing of the first dose of anticoagulant prophylaxis against venous thromboembolism after major orthopedic surgery, Chest, 124, 379S, 10.1378/chest.124.6_suppl.379S Kearon, 1995, Starting prophylaxis for venous thromboembolism postoperatively, Arch Intern Med, 155, 366, 10.1001/archinte.1995.00430040034004 Hull, 1999, Preoperative vs postoperative initiation of low-molecular-weight heparin prophylaxis against venous thromboembolism in patients undergoing elective hip replacement, Arch Intern Med, 159, 137, 10.1001/archinte.159.2.137 Hull, 2000, Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: a double-blind, randomized comparison, Arch Intern Med, 160, 2208, 10.1001/archinte.160.14.2208 Strebel, 2002, Preoperative or postoperative start of prophylaxis for venous thromboembolism with low-molecular-weight heparin in elective hip surgery?, Arch Intern Med, 162, 1451, 10.1001/archinte.162.13.1451 Hull, 2001, Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: a systematic review, Arch Intern Med, 161, 1952, 10.1001/archinte.161.16.1952 Hull, 2003, Timing of initial administration of prophylaxis against deep vein thrombosis in patients following hip or knee surgery [abstract], J Thromb Haemost, 1, P2043 Berry, 2001, Surveillance for venous thromboembolic disease after total knee arthroplasty, Clin Orthop, 392, 257, 10.1097/00003086-200111000-00033 Schmidt, 2003, Ultrasound screening for distal vein thrombosis is not beneficial after major orthopedic surgery: a randomized controlled trial, Thromb Haemost, 90, 949, 10.1160/TH03-03-0154 Verlato, 2001, The value of ultrasound screening for promixal vein thrombosis after total hip arthroplasty: a prospective cohort study, Thromb Haemost, 86, 534, 10.1055/s-0037-1616082 Kearon, 2003, Duration of venous thromboembolism prophylaxis after surgery, Chest, 124, 386S, 10.1378/chest.124.6_suppl.386S Anderson, 2002, Prolonged prophylaxis in orthopedic surgery: insights from the United States, Semin Thromb Hemost, 28, 43, 10.1055/s-2002-34075 Planes, 1999, Prevention of deep vein thrombosis after hip replacement: comparison between two low-molecular heparins, tinzaparin and enoxaparin, Thromb Haemost, 81, 22, 10.1055/s-0037-1614411 Dahl, 1995, Increased activation of coagulation and formation of late deep venous thrombosis following discontinuation of thromboprophylaxis after hip replacement surgery, Thromb Res, 80, 299, 10.1016/0049-3848(95)00180-Y Arnesen, 2003, Sustained prothrombotic profile after hip replacement surgery: the influence of prolonged prophylaxis with dalteparin, J Thromb Haemost, 1, 971, 10.1046/j.1538-7836.2003.00111.x Sikorski, 1981, The natural history and aetiology of deep vein thrombosis after total hip replacement, J Bone Joint Surg Br, 63, 171, 10.1302/0301-620X.63B2.7217137 Lotke, 1994, Significance of deep venous thrombosis in the lower extremity after total joint arthroplasty, Clin Orthop, 229, 25 Trowbridge, 1994, Incidence of posthospitalization proximal deep venous thrombosis after total hip arthroplasty: a pilot study, Clin Orthop, 299, 203, 10.1097/00003086-199402000-00028 Bergqvist, 1996, Low-molecular-weight heparin (enoxaparin) as prophylaxis against venous thromboembolism after total hip replacement, N Engl Med, 335, 696, 10.1056/NEJM199609053351002 White, 2000, Predictors of rehospitalization for symptomatic venous thromboembolism after total hip arthroplasty, N Engl J Med, 343, 1758, 10.1056/NEJM200012143432403 Heit, 2000, Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study, Arch Intern Med, 160, 809, 10.1001/archinte.160.6.809 Cohen, 2001, Extended thromboprophylaxis with low molecular weight heparin reduces symptomatic venous thromboembolism following lower limb arthroplasty: a meta-analysis, Thromb Haemost, 85, 940, 10.1055/s-0037-1615775 O'Donnell, 2003, Reduction of out-of-hospital symptomatic venous thromboembolism by extended thromboprophylaxis with low-molecular-weight heparin following elective hip arthroplasty: a systematic review, Arch Intern Med, 163, 1362, 10.1001/archinte.163.11.1362 Lassen, 1998, Efficacy and safety of prolonged thromboprophylaxis with a low molecular weight heparin (dalteparin) after total hip arthroplasty-the Danish Prolonged Prophylaxis (DaPP) Study, Thromb Res, 89, 281, 10.1016/S0049-3848(98)00018-8 Comp, 2001, Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement, J Bone Joint Surg Am, 83, 336, 10.2106/00004623-200103000-00004 Prandoni, 2002, Prolonged thromboprophylaxis with oral anticoagulants after total hip arthroplasty: a prospective controlled randomized study, Arch Intern Med, 162, 1966, 10.1001/archinte.162.17.1966 Samama, 2002, Extended venous thromboembolism prophylaxis after total hip replacement: a comparison of low-molecular-weight heparin with oral anticoagulant, Arch Intern Med, 162, 2191, 10.1001/archinte.162.19.2191 Thaler, 2001, Thromboprophylaxis with 60 mg enoxaparin is safe in hip trauma surgery, J Trauma, 51, 518, 10.1097/00005373-200109000-00015 Bergqvist, 1999, Cost-effectiveness of prolonged administration of a low molecular weight heparin for the prevention of deep venous thrombosis following total hip replacement, Value Health, 2, 288, 10.1046/j.1524-4733.1999.24003.x Davies, 2000, Economic evaluation of enoxaparin as postdischarge prophylaxis for deep vein thrombosis (DVT) in elective hip surgery, Value Health, 3, 397, 10.1046/j.1524-4733.2000.36005.x Dahl, 2003, Investment in prolonged thromboprophylaxis with dalteparin improves clinical outcomes after hip replacement, J Thromb Haemost, 1, 896, 10.1046/j.1538-7836.2003.00236.x Heit, 2001, Low-molecular-weight heparin: the optimal duration of prophylaxis against postoperative venous thromboembolism after total hip or knee replacement, Thromb Res, 101, V163, 10.1016/S0049-3848(00)00388-1 Cogo, 1994, Acquired risk factors for deep-vein thrombosis in symptomatic outpatients, Arch Intern Med, 154, 164, 10.1001/archinte.1994.00420020066008 Samama MMftSSG, 2000, An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: the Sirius study, Arch Intern Med, 160, 3415, 10.1001/archinte.160.22.3415 Catre, 1997, Anticoagulation in spinal surgery: a critical review of the literature, Can J Surg, 40, 413 West, 1992, Incidence of deep vein thrombosis in major adult spinal surgery, Spine, 17, S254, 10.1097/00007632-199208001-00007 Tetzlaff, 1994, Influence of anesthetic technique on the incidence of deep venous thrombosis after elective lumbar spine surgery [abstract], Reg Anesth Pain Med, 19, 28 Fujita, 1998, Complications of spinal fusion in adult patients more than 60 years of age, Orthop Clin North Am, 29, 669, 10.1016/S0030-5898(05)70040-7 Oda, 2000, Deep venous thrombosis after posterior spinal surgery, Spine, 25, 2962, 10.1097/00007632-200011150-00019 Turner, 1992, Patient outcomes after lumbar spinal fusions, JAMA, 268, 907, 10.1001/jama.1992.03490070089049 Andreshak, 1997, Lumbar spine surgery in the obese patient, J Spinal Disord, 10, 376, 10.1097/00002517-199710000-00003 Smith, 1994, Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine, J Bone Joint Surg Am, 76, 980, 10.2106/00004623-199407000-00004 Flinn, 1989, Duplex venous scanning for the prospective surveillance of perioperative venous thrombosis, Arch Surg, 124, 901, 10.1001/archsurg.1989.01410080031004 Ferree, 1993, Deep venous thrombosis after spinal surgery, Spine, 18, 315, 10.1097/00007632-199303000-00001 Ferree, 1993, Deep venous thrombosis following posterior lumbar spinal surgery, Spine, 18, 1079, 10.1097/00007632-199306150-00019 Ferree, 1994, Deep venous thrombosis following lumbar laminotomy and laminectomy, Orthopedics, 17, 35, 10.3928/0147-7447-19940101-06 Flinn, 1996, Prospective surveillance for perioperative venous thrombosis: experience in 2643 patients, Arch Surg, 131, 472, 10.1001/archsurg.1996.01430170018002 Nelson, 1996, Deep vein thrombosis in lumbar spinal fusion: a prospective study of antiembolic and pneumatic compression stockings, J South Orthop Assoc, 5, 181 Rokito, 1996, Deep vein thrombosis after major reconstructive spinal surgery, Spine, 21, 853, 10.1097/00007632-199604010-00016 Wood, 1997, Prevention of deep-vein thrombosis after major spinal surgery: a comparison study of external devices, J Spinal Disord, 10, 209, 10.1097/00002517-199706000-00005 Gallus, 1976, Prevention of venous thrombosis with small, subcutaneous doses of heparin, JAMA, 235, 1980, 10.1001/jama.1976.03260440032018 Macouillard, 1993, Prevention of deep venous thrombosis in spinal surgery: comparison of intermittent sequential pneumatic compression versus low molecular weight heparin [abstract], Thromb Haemost, 69, 646 Macouillard, 1995, Comparative efficacy of two dosages of a low molecular weight heparin for prevention of deep venous thrombosis in spinal surgery [abstract], Thromb Haemost, 73, 979 Leppilahti, 1998, Total Achilles tendon rupture: a review, Sports Med, 25, 79, 10.2165/00007256-199825020-00002 Hjelmstedt, 1968, Incidence of thrombosis in patients with tibial fractures: a phlebographic study, Acta Chir Scand, 134, 209 Abelseth, 1996, Incidence of deep-vein thrombosis in patients with fractures of the lower extremity distal to the hip, J Orthop Trauma, 10, 230, 10.1097/00005131-199605000-00002 Lassen, 2002, Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization, N Engl J Med, 347, 726, 10.1056/NEJMoa011327 Jorgensen, 2002, Low molecular weight heparin (Innohep) as thromboprophylaxis in outpatients with a plaster cast: a venografic controlled study, Thromb Res, 105, 477, 10.1016/S0049-3848(02)00059-2 Kock, 1995, Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg, Lancet, 346, 459, 10.1016/S0140-6736(95)91320-3 Spannagel, 1993, Low molecular weight heparin for the prevention of thromboembolism in outpatients immobilized by plaster cast, Semin Thromb Haemost, 19, 131 Hamilton, 1994, Venous thromboembolism in neurosurgery and neurology patients: a review, Neurosurgery, 34, 280, 10.1227/00006123-199402000-00012 Agnelli, 1999, Prevention of venous thromboembolism after neurosurgery, Thromb Haemost, 82, 925, 10.1055/s-0037-1615934 Chan, 1999, Venous thromboembolism occurs frequently in patients undergoing brain tumor surgery despite prophylaxis, J Thromb Thrombolysis, 8, 139, 10.1023/A:1008915202859 Van den Berg, 2003, Duplex screening for quality assurance of postoperative thomboembolism prophylaxis in neurosurgery: Krefeld Study 'Thrombo 2000′ [abstract], J Thromb Haemost, 1, P1460 Valladares, 1980, Incidence of lower extremity deep vein thrombosis in neurosurgical patients, Neurosurgery, 6, 138, 10.1227/00006123-198002000-00004 Marras, 2000, The risk of venous thromboembolism is increased throughout the course of maglignant glioma: an evidence-based review, Cancer, 89, 640, 10.1002/1097-0142(20000801)89:3<640::AID-CNCR20>3.0.CO;2-E Anderson, 2001, The continuing risk of venous thromboembolism following operation for glioma: findings from the Glioma Outcomes Project [abstract], Haemost Thromb, 86, OC902 Walsh, 2001, Thromboembolism in brain tumors, Curr Opin Pul Med, 7, 326, 10.1097/00063198-200109000-00013 Ruff, 1983, Incidence and treatment of peripheral venous thrombosis in patients with glioma, Ann Neurol, 13, 334, 10.1002/ana.410130320 Brandes, 1997, Incidence and risk of thromboembolism during treatment of high-grade gliomas: a prospective study, Eur J Cancer, 33, 1592, 10.1016/S0959-8049(97)00167-6 Anderson, 2001, Practices in prevention of venous thromboembolism following operation for glioma: findings from the Glioma Outcomes Project [abstract], Haemost Thromb, 86, OC1016 Melon, 1991, Deep venous thrombosis prophylaxis by low molecular weight heparin in neurosurgical patients [abstract], Anesthesiology, 75, A214, 10.1097/00000542-199109001-00214 Nurmohamed, 1996, Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery, Thromb Haemost, 75, 233, 10.1055/s-0038-1650250 Wautrecht, 1996, Int Angiol, 15, 5 Agnelli, 1998, Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery, N Engl J Med, 339, 80, 10.1056/NEJM199807093390204 Cerrato, 1978, Deep vein thrombosis and low-dose heparin prophylaxis in neurosurgical patients, J Neurosurg, 49, 378, 10.3171/jns.1978.49.3.0378 Goldhaber, 2002, Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis, Chest, 122, 1933, 10.1378/chest.122.6.1933 Macdonald, 2003, Randomized, pilot study of intermittent pneumatic compression devices plus dalteparin versus intermittent pneumatic compression devices plus heparin for prevention of venous thromboembolism in patients undergoing craniotomy, Surg Neurol, 59, 362, 10.1016/S0090-3019(03)00111-3 Boeer, 1991, Early heparin therapy in patients with spontaneous intracerebral haemorrhage, J Neurol Neurosurg Psychiatry, 54, 466, 10.1136/jnnp.54.5.466 Frim, 1992, Postoperative low-dose heparin decreases thromboembolic complications in neurosurgical patients, Neurosurgery, 30, 830, 10.1227/00006123-199206000-00002 Macdonald, 1999, Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing craniotomy, Neurosurgery, 45, 245, 10.1097/00006123-199908000-00008 Constantini, 2001, Safety of perioperative minidose heparin in patients undergoing brain tumor surgery: a prospective, randomized, double-blind study, J Neurosurg, 94, 918, 10.3171/jns.2001.94.6.0918 Dickinson, 1998, Enoxaparin increases the incidence of postoperative intracranial hemorrhage when initiated preoperatively for deep venous thrombosis prophylaxis in patients with brain tumors, Neurosurgery, 43, 1074, 10.1097/00006123-199811000-00039 Raabe, 2001, The risk of haemorrhage associated with early postoperative heparin administration after intracranial surgery, Acta Neurochir (Wien), 143, 1, 10.1007/s007010170131 Meissner, 1998, Deep venous thrombosis in the trauma patient, Semin Vasc Surg, 11, 274 Rogers, 2001, Venous thromboembolism in trauma patients: a review, Surgery, 130, 1, 10.1067/msy.2001.114558 Rogers, 2002, Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST Practice Management Guidelines Work Group, J Trauma, 53, 142, 10.1097/00005373-200207000-00032 Kudsk, 1989, Silent deep vein thrombosis in immobilized multiple trauma patients, Am J Surg, 158, 515, 10.1016/0002-9610(89)90182-7 O'Malley, 1990, Pulmonary embolism in major trauma patients, J Trauma, 30, 748, 10.1097/00005373-199006000-00018 Rogers, 1993, Prophylactic vena cava filter insertion in severly injured trauma patients: indications and preliminary results, J Trauma, 35, 637, 10.1097/00005373-199310000-00021 Smith, 1994, Death after major trauma: can we affect it? The changing cause of death in each phase after injury [abstract], Injury, 25, SB23 Acosta, 1998, Lethal injuries and time to death in a level I trauma center, J Am Coll Surg, 186, 528, 10.1016/S1072-7515(98)00082-9 Meissner, 2003, Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability?, J Trauma, 54, 224, 10.1097/01.TA.0000046253.33495.70 Velmahos, 2000, Prevention of venous thromboembolism after injury: an evidence-based report: Part II. Analysis of risk factors and evaluation of the role of vena caval filters, J Trauma, 49, 140, 10.1097/00005373-200007000-00021 Knudson, 1994, Prevention of venous thromboembolism in trauma patients, J Trauma, 37, 480, 10.1097/00005373-199409000-00025 Frezza, 1996, Venous thromboembolism after penetrating chest trauma is not a cause of early death, J Cardiovasc Surg, 37, 521 Bauer, 1944, Thrombosis following leg injuries, Acta Chir Scand, 90, 229 Geerts, 1996, A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma, N Engl J Med, 335, 701, 10.1056/NEJM199609053351003 Haentjens, 1996, Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium), Injury, 27, 385, 10.1016/0020-1383(96)00042-3 Knudson, 1996, Use of low molecular weight heparin in preventing thromboembolism in trauma patients, J Trauma, 41, 446, 10.1097/00005373-199609000-00010 Cohn, 1999, Prospective trial of low-molecular-weight heparin versus unfractionated heparin in moderately injured patients, Vasc Surg, 33, 219, 10.1177/153857449903300219 Elliott, 1999, Calf-thigh sequential pneumatic compression compared with plantar venous pneumatic compression to prevent deep-vein thrombosis after non-lower extremity trauma, J Trauma, 47, 25, 10.1097/00005373-199907000-00006 Montgomery, 1997, Practical management of venous thromboembolism following pelvic fractures, Orthop Clin North Am, 28, 397, 10.1016/S0030-5898(05)70297-2 Pasquale, 1998, Development atEAHCoPMG: practice management guidelines for trauma from the Eastern Association for the Surgery of Trauma, J Trauma, 44, 941, 10.1097/00005373-199806000-00001 Shackford, 1990, Venous thromboembolism in patients with major trauma, Am J Surg, 159, 365, 10.1016/S0002-9610(05)81272-3 Napolitano, 1995, Asymptomatic deep venous thrombosis in the trauma patient: is an aggressive screening protocol justified?, J Trauma, 39, 651, 10.1097/00005373-199510000-00006 Velmahos, 2000, Prevention of venous thromboembolism after injury: an evidence-based report: Part I. Analysis of risk factors and evaluation of the role of vena caval filters, J Trauma, 49, 132, 10.1097/00005373-200007000-00020 Gearhart, 2000, The risk assessment profile score identifies trauma patients at risk for deep vein thrombosis, Surgery, 128, 631, 10.1067/msy.2000.108224 Huk, 1998, Compliance of sequential compression device for deep vein thrombosis prophylaxis in the adult trauma patient: surgical intensive care unit vs. intermediate care [abstract], Crit Care Med, 26, A47, 10.1097/00003246-199801001-00084 Geerts, 1999, Venous foot pump as thromboprophylaxis in major trauma [abstract], Thromb Haemost, 82, 650 Upchurch, 1995, Efficacy of subcutaneous heparin in prevention of venous thromboembolic events in trauma patients, Am Surg, 61, 749 Devlin, 1998, Cost-effectiveness of enoxaparin versus low-dose heparin for prophylaxis against venous thrombosis after major trauma, Pharmacotherapy, 18, 1335 Wade, 2000, Deep venous thrombosis prophylaxis in trauma: cost analysis, Blood Coag Fibrinolysis, 11, 101, 10.1097/00001721-200011010-00011 Selby, 2001, Venous thromboembolism prophylaxis after trauma: dollars and sense, Crit Care Med, 29, 1839, 10.1097/00003246-200109000-00033 Shorr, 2001, Enoxaparin for thromboprophylaxis after major trauma: potential cost implications, Crit Care Med, 29, 1659, 10.1097/00003246-200109000-00001 Burns, 1993, Prospective ultrasound evaluation of venous thrombosis in high-risk trauma patients, J Trauma, 35, 405, 10.1097/00005373-199309000-00012 Brasel, 1997, Cost-effective prevention of pulmonary embolus in high-risk trauma patients, J Trauma, 42, 456, 10.1097/00005373-199703000-00013 Headrick, 1997, The role of ultrasonography and inferior vena cava filter placement in high-risk trauma patients, Am Surg, 63, 1 van den Berg, 1999, Duplex screening as a method of quality assurance of perioperative thromboembolism prophylaxis, Int Angiol, 18, 210 Satiani, 1997, Screening for major deep vein thrombosis in seriously injured patients: a prospective study, Ann Vasc Surg, 11, 626, 10.1007/s100169900101 Piotrowski, 1996, Is deep vein thrombosis surveillance warranted in high-risk trauma patients?, Am J Surg, 172, 210, 10.1016/S0002-9610(96)00154-7 Hammers, 1996, Doppler color flow imaging surveillance of deep vein thrombosis in high-risk trauma patients, J Ultrasound Med, 15, 19, 10.7863/ultra.15.1.19 Stover, 2002, Prospective comparison of contrast-enhanced computed tomography versus magnetic resonance venography in the detection of occult deep pelvic vein thrombosis in patients with pelvic and acetabular fractures, J Orthop Trauma, 16, 613, 10.1097/00005131-200210000-00001 Spain, 1997, Venous thromboembolism in the high risk trauma patient: do risks justify aggressive screening and prophylaxis?, J Trauma, 42, 463, 10.1097/00005373-199703000-00014 Schwarcz, 2001, Enoxaparin treatment in high-risk trauma patients limits the utility of surveillance venous duplex scanning, J Vasc Surg, 34, 447, 10.1067/mva.2001.117146 Khansarinia, 1995, Prophylactic Greenfield filter placement in selected high-risk trauma patients, J Vasc Surg, 22, 231, 10.1016/S0741-5214(95)70135-4 Rogers, 1995, Routine prophylactic vena cava filter insertion in severly injured trauma patients decreases the incidence of pulmonary embolism, J Am Coll Surg, 180, 641 Rodriguez, 1996, Early placement of prophylactic vena caval filters in injured patients at high risk for pulmonary embolism, J Trauma, 40, 797, 10.1097/00005373-199605000-00020 Langan, 1999, Prophylactic inferior vena cava filters in trauma patients at high risk: follow-up examination and risk/benefit assessment, J Vasc Surg, 30, 484, 10.1016/S0741-5214(99)70075-3 Sing, 1999, Bedside insertion of inferior vena cava filters in the intensive care unit, J Trauma, 47, 1104, 10.1097/00005373-199912000-00021 Tola, 1999, Bedside placement of inferior vena cava filters in the intensive care unit, Am Surg, 65, 833, 10.1177/000313489906500906 Carlin, 2002, Prophylactic and therapeutic inferior vena cava filters to prevent pulmonary emboli in trauma patients, Arch Surg, 137, 521, 10.1001/archsurg.137.5.521 Girard, 2002, Medical literature and vena cava filters: so far so weak, Chest, 122, 963, 10.1378/chest.122.3.963 McMurty, 1999, Increased use of prophylactic vena cava filters in trauma patients failed to decrease overall incidence of pulmonary embolism, J Am Coll Surg, 189, 314, 10.1016/S1072-7515(99)00137-4 Becker, 1992, Inferior vena cava filters: indications, safety, effectiveness, Arch Intern Med, 152, 1985, 10.1001/archinte.1992.00400220023005 Patton, 1996, Prophylactic Greenfield filters: acute complications and long-term follow-up, J Trauma, 41, 231, 10.1097/00005373-199608000-00006 Decousus, 1998, A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis, N Engl J Med, 338, 409, 10.1056/NEJM199802123380701 Blebea, 1999, Deep venous thrombosis after percutaneous insertion of vena caval filters, J Vasc Surg, 30, 821, 10.1016/S0741-5214(99)70006-6 Greenfield, 2000, Prophylactic vena cava filters in trauma: the rest of the story, J Vasc Surg, 32, 490, 10.1067/mva.2000.108636 Wojcik, 2000, Long-term follow-up of trauma patients with a vena caval filter, J Trauma, 49, 839, 10.1097/00005373-200011000-00008 Greenfield, 1995, Discussion, J Vasc Surg, 22, 235 Rohrer, 1989, Extended indications for placement of an inferior vena cava filter, J Vasc Surg, 10, 44, 10.1016/0741-5214(89)90284-X Sekharan, 2001, Long-term follow-up of prophylactic Greenfield filters in multisystem trauma patients, J Trauma, 51, 1087, 10.1097/00005373-200112000-00012 Duperier, 2003, Acute complications associated with Greenfield filter insertion in high-risk trauma patients, J Trauma, 54, 545, 10.1097/00005373-200303000-00018 Lorch, 2000, Current practice of temporary vena cava filter insertion: a multicenter registry, J Vasc Interv Radiol, 11, 83, 10.1016/S1051-0443(07)61287-1 Ashley, 2001, Accurate deployment of vena cava filters: comparison of intravascular ultrasound and contrast venography, J Trauma, 50, 975, 10.1097/00005373-200106000-00002 Conners, 2002, Duplex scan-directed placement of inferior vena cava filters: a five-year institutional experience, J Vasc Surg, 35, 286, 10.1067/mva.2002.120372 Maxwell, 2002, Routine prophylactic vena cava filtration is not indicated after acute spinal cord injury, J Trauma, 52, 902, 10.1097/00005373-200205000-00013 Brathwaite, 1992, Continuous pulse oximetry and the diagnosis of pulmonary embolism in critically ill trauma patients, J Trauma, 33, 528, 10.1097/00005373-199210000-00007 Dennis, 1993, Efficacy of deep venous thrombosis prophylaxis in trauma patients and identification of high-risk groups, J Trauma, 35, 132, 10.1097/00005373-199307000-00021 Norwood, 2001, A potentially expanded role for enoxaparin in preventing venous thromboembolism in high risk blunt trauma patients, J Am Coll Surg, 192, 161, 10.1016/S1072-7515(00)00802-4 Norwood, 2002, Prospective evaluationof the safety of enoxaparin prophylaxis for venous thromboembolism in patients with intracranial hemorhagic injuries, Arch Surg, 137, 696, 10.1001/archsurg.137.6.696 Consortium for Spinal Cord Medicine, 1997, Prevention of thromboembolism in spinal cord injury, J Spinal Cord Med, 20, 259, 10.1080/10790268.1997.11719479 Attia, 2001, Deep vein thrombosis and its prevention in critically ill adults, Arch Intern Med, 161, 1268, 10.1001/archinte.161.10.1268 Spinal Cord Injury Thromboprophylaxis Investigators, 2003, Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: a randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin, J Trauma, 54, 1116, 10.1097/01.TA.0000066385.10596.71 Waring, 1991, Acute spinal cord injuries and the incidence of clinically occuring thromboembolic disease, Paraplegia, 29, 8, 10.1038/sc.1991.2 DeVivo, 1999, Recent trends in mortality and causes of death among persons with spinal cord injury, Arch Phys Med Rehabil, 80, 1411, 10.1016/S0003-9993(99)90252-6 Kulkarni, 1992, Prophylactic low dose heparin anticoagulant therapy in patients with spinal cord injuries: a retrospective study, Paraplegia, 30, 169, 10.1038/sc.1992.49 Powell, 1999, Duplex ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission, Arch Phys Med Rehabil, 80, 1044, 10.1016/S0003-9993(99)90058-8 Aito, 2002, Primary prevention of deep venous thrombosis and pulmonary embolism in acute spinal cord injured patients, Spinal Cord, 40, 300, 10.1038/sj.sc.3101298 Lim, 1992, Lower limb paralysis: its effect on the recanalization of deep-vein thrombosis, Arch Phys Med Rehabil, 73, 331, 10.1016/0003-9993(92)90005-H Kim, 1994, Prevalence of deep venous thrombosis in patients with chronic spinal cord injury, Arch Phys Med Rehabil, 75, 965, 10.1016/0003-9993(94)90673-4 Green, 1982, Deep vein thrombosis in spinal cord injury: effect of prophylaxis with calf compression, aspirin, and dipyridamole, Paraplegia, 20, 227, 10.1038/sc.1982.41 Green, 1988, Fixed vs adjusted-dose heparin in the prophylaxis of thromboembolism in spinal cord injury, JAMA, 260, 1255, 10.1001/jama.1988.03410090087036 Merli, 1988, Deep vein thrombosis: prophylaxis in acute spinal cord injured patients, Arch Phys Med Rehabil, 69, 661 Green, 1990, Prevention of thromboembolism after spinal cord injury using low-molecular-weight heparin, Ann Intern Med, 113, 571, 10.7326/0003-4819-113-8-571 Harris, 1996, Enoxaparin for thromboembolism prophylaxis in spinal injury: preliminary report on experience with 105 patients, Am J Phys Med Rehabil, 75, 326, 10.1097/00002060-199609000-00002 Silver, 1970, Prophylactic anticoagulant therapy against pulmonary emboli in acute paraplegia, BMJ, 2, 338, 10.1136/bmj.2.5705.338 Silver, 1974, The prophylactic use of anticoagulant therapy in the prevention of pulmonary emboli in one hundred consecutive spinal injury patients, Paraplegia, 12, 188, 10.1038/sc.1974.30 El Masri, 1981, Prophylactic anticoagulant therapy in patients with spinal cord injury, Paraplegia, 19, 334, 10.1038/sc.1981.64 Stambolis, 1995, Warfarin for the prophylaxis of thromboembolism in patients with acute traumatic spinal cord injury [abstract], Arch Phys Med Rehabil, 76, 1077, 10.1016/S0003-9993(95)81336-5 Wilson, 1994, Prophylactic vena cava filter insertion in patients with traumatic spinal cord injury: preliminary results, Neurosurgery, 35, 234, 10.1227/00006123-199408000-00008 Hadley, 2002, Deep venous thrombosis and thromoembolism inpatients with cervical spinal cord injuries, Neurosurgery, 50, S73 Balshi, 1989, Complications of caval interruption by Greenfield filter in quadriplegics, J Vasc Surg, 9, 558, 10.1016/0741-5214(89)90472-2 Kinney, 1996, Does cervical spinal cord injury induce a higher incidence of complications after prophylactic Greenfield inferior vena cava filter usage?, J Vasc Interv Radiol, 7, 907, 10.1016/S1051-0443(96)70869-2 Yelnik, 1991, Systematic lower limb phlebography in acute spinal cord injury in 147 patients, Paraplegia, 29, 253, 10.1038/sc.1991.36 Colachis, 1993, The association between deep venous thrombosis and heterotopic ossification in patients with acute traumatic spinal cord injury, Paraplegia, 31, 507, 10.1038/sc.1993.82 Gunduz, 1993, Deep vein thrombosis in spinal cord injured patients, Paraplegia, 31, 606, 10.1038/sc.1993.96 Deep, 2001, Prophylaxis of thromboembolism in spinal injuries: results of enoxaparin used in 276 patients, Spinal Cord, 39, 88, 10.1038/sj.sc.3101122 Spinal Cord Injury Thromboprophylaxis Investigators, 2003, Prevention of venous thromboembolism in the rehabilitation phase after spinal cord injury: prophylaxis with low-dose heparin or enoxaparin, J Trauma, 54, 1111, 10.1097/01.TA.0000042159.90102.C2 Chen, 1999, Medical complications during acute rehabilitation following spinal cord injury: current experience of the Model Systems, Arch Phys Med Rehabil, 80, 1397, 10.1016/S0003-9993(99)90250-2 Hull, 1992, Venous thromboembolism in spinal cord injury patients, Chest, 102, 658S, 10.1378/chest.102.6_Supplement.658S Ball, 2001, Critical care of spinal cord injury, Spine, 26, S27, 10.1097/00007632-200112151-00006 Kowal-Vern, 1992, The effect of burn wound size on hemostasis: a correlation of the hemostatic changes to the clinical state, J Trauma, 33, 50, 10.1097/00005373-199207000-00011 Wait, 1990, Duplex scanning of central vascular access sites in burn patients, Ann Surg, 211, 499, 10.1097/00000658-199004000-00019 Gnoyski, 1994, Deep venous thrombosis and the association with burns involving the lower extremities [abstract], Arch Phys Med Rehabil, 75, 1045, 10.1016/0003-9993(94)90810-9 Harrington, 2001, Thermally injured patients are at significant risk for thromboembolic complications [abstract], J Trauma, 50, 495, 10.1097/00005373-200103000-00014 Brischetto, 1998, Venous thrombosis in burn patients [abstract], Am J Respir Crit Care Med, 157, A768 Harrington, 1999, Thermally injured patients are at significant risk of thromboembolic complications [abstract], J Burn Care Rehabil, 20, S178 Wahl, 2002, Venous thrombosis incidence in burn patients preliminary results of a prospective study, J Burn Care Rehabil, 23, 97, 10.1097/00004630-200203000-00005 Wibbenmeyer, 2003, The prevalence of venous thromboembolism of the lower extremity among thermally injured patients determined by duplex sonography, J Trauma, 55, 1162, 10.1097/01.TA.0000057149.42968.1D Coleman, 1975, Pulmonary embolism: an unrecognized event in severely burned patients, Am J Surg, 130, 697, 10.1016/0002-9610(75)90423-7 Rue, 1992, Thromboembolic complications in thermally injured patients, World J Surg, 16, 1151, 10.1007/BF02067085 Wahl, 2001, Potential risk factors for deep venous thrombosis in burn patients, J Burn Care Rehabil, 22, 128, 10.1097/00004630-200103000-00008 Sheridan, 1992, Burns in morbidly obese patients, J Trauma, 33, 818, 10.1097/00005373-199212000-00004 Sorensen, 1973, Mortality and causes of death in burned patients treated by the exposure method, Plast Reconstr Surg, 51, 59, 10.1097/00006534-197301000-00011 Warden, 1973, Central venous thrombosis: a hazard of medical progress, J Trauma, 13, 620, 10.1097/00005373-197307000-00006 Evidence Based Guidelines Group American Burn Association, 2001, Deep venous thrombosis prophylaxis in burns, J Burn Care Rehabil, 22, 67S Bouthier, 1996, The venous thrombotic risk in nonsurgical patients, Drugs, 52, 16, 10.2165/00003495-199600527-00005 Goldhaber, 2000, New onset of venous thromboembolism among hospitalized patients at Brigham and Women's Hospital is caused more often by prophylaxis failure than by withholding treatment, Chest, 118, 1680, 10.1378/chest.118.6.1680 Goldhaber, 1983, Risk factors for pulmonary embolism: the Farmingham Study, Am J Med, 74, 1023, 10.1016/0002-9343(83)90805-7 Lindblad, 1991, Incidence of venous thromboembolism verified by necropsy over 30 years, BMJ, 302, 709, 10.1136/bmj.302.6778.709 Alikhan, 2002, Epidemiology of fatal pulmonary embolism in non-surgical patients [abstract], Blood, 100, 276a Haas, 2002, Venous thromboembolic risk and its prevention in hospitalized medical patients, Semin Thromb Haemost, 28, 577, 10.1055/s-2002-36702 Gallus, 1973, Small subcutaneous doses of heparin in prevention of venous thrombosis, N Engl J Med, 288, 545, 10.1056/NEJM197303152881103 Belch, 1981, Prevention of deep vein thrombosis in medical patients by low-dose heparin, Scott Med J, 26, 115, 10.1177/003693308102600205 Cade, 1982, High risk of the critically ill for venous thromboembolism, Crit Care Med, 10, 448, 10.1097/00003246-198207000-00006 Dahan, 1986, Prevention of deep vein thrombosis in elderly medical in-patients by a low molecular weight heparin: a randomized double-blind trial, Haemostasis, 16, 159 Samama, 1999, A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients, N Engl J Med, 341, 793, 10.1056/NEJM199909093411103 Oger, 2002, High prevalence of asymptomatic deep vein thrombosis on admission in a medical unit among elderly patients: the TADEUS Project, Thromb Haemost, 88, 592, 10.1055/s-0037-1613261 Leizorovicz, 2003, A randomized placebo controlled trial of dalteparin for the prevention of venous thromboembolism in 3706 acutely ill medical patients: the PREVENT medical thromboprophylaxis study [abstract], J Thromb Haemost, 1, OC396 Prescott, 1981, Venous thromboembolism in decompensated chronic obstructive pulmonary disease: a prospective study, Am Rev Respir Dis, 123, 32 Schonhofer, 1998, Prevalence of deep-vein thrombosis of the leg in patients with acute exacerbation of chronic obstructive pulmonary disease, Respiration, 65, 173, 10.1159/000029254 Schuurman, 2000, Thrombosis prophylaxis in hospitalised medical patients: does prophylaxis in all patients make sense?, Neth J Med, 56, 171, 10.1016/S0300-2977(00)00011-5 Cohen, 2000, Venous thromboembolic disease management of the nonsurgical moderate-and high-risk patient, Semin Hematol, 37, 19, 10.1016/S0037-1963(00)90096-9 Bergmann, 2002, Thromboprophylaxis in medical patients: focus on France, Semin Thromb Hemost, 28, 51, 10.1055/s-2002-34077 Cohen, 2002, Venous thromboembolism risk assessment in medical patients [abstract], Blood, 100, 280a Lutz, 2002, Venous thromboembolism in internal medicine: risk assessment and pharmaceutical prophylaxis: publication for the specialist platform, Med Welt, 53, 231 Howell, 2001, Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study, J Clin Epidemiol, 54, 810, 10.1016/S0895-4356(00)00373-5 Tveit, 2002, Chronic dialysis patients have high risk for pulmonary embolism, Am J Kidney Dis, 39, 1011, 10.1053/ajkd.2002.32774 Muir, 2000, Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke, Q J Med, 93, 359, 10.1093/qjmed/93.6.359 Alikhan, 2001, Benefit of enoxparin in medical patients: a subgroup analysis [abstract], Blood, 98, 266a Bergmann, 1996, A multicenter randomized double-blind study of enoxaparin compared with unfractionated heparin in the prevention of venous thromboembolic disease in elderly in-patients bedridden for an acute medical illness, Thromb Haemost, 76, 529, 10.1055/s-0038-1650617 Harenberg, 1996, Subcutaneous low-molecular-weight heparin versus standard heparin and the prevention of thromboembolism in medical inpatients, Haemostasis, 26, 127 Lechler, 1996, The venous thrombotic risk in non-surgical patients: epidemiological data and efficacy/safety profile of a low-molecular-weight heparin (enoxaparin), Haemostasis, 26, 49 Harenberg, 1999, Enoxaparin is superior to unfractionated heparin in the prevention of thromboembolic events in medical inpatients at increased thromboembolic risk [abstract], Blood, 94, 399a Kleber, 2003, Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease, Am Heart J, 145, 614, 10.1067/mhj.2003.189 Gardlund BftHPSG, 1996, Randomised, controlled trial of low-dose heparin for prevention of fatal pulmonary embolism in patients with infectious diseases, Lancet, 347, 1357, 10.1016/S0140-6736(96)91009-0 Bergmann, 1996, Heparin prophylaxis in bedridden patients [correspondence], Lancet, 348, 205, 10.1016/S0140-6736(05)66160-0 Wade, 1999, Cost-effectiveness analysis of deep vein thrombosis prophylaxis in internal medicine patients, Thromb Res, 94, 65, 10.1016/S0049-3848(98)00206-0 Lloyd, 2000, Economic evaluation of prophylaxis of venous thromboembolism in acute medical patients with enoxaparin in the U.K. [abstract], Blood, 96, 847a de Lissovoy, 2002, Economic evaluation of enoxaparin as prophylaxis against venous thromoembolism in seriously ill medical patients: a US perspective, Am J Manag Care, 8, 1082 Lamy, 2002, Economic evaluation of the MEDENOX trial: a Canadian perspective, Can Respir J, 9, 169, 10.1155/2002/310841 Alikhan, 2003, A safety analysis of thromboprophylaxis in acute medical illness, Thromb Haemost, 89, 590, 10.1055/s-0037-1613391 Girolami, 2003, The incidence of heparin-induced thrombocytopenia in hospitalised medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study, Blood, 101, 2955, 10.1182/blood-2002-07-2201 Cohen, 2003, Fondaparinux for the prevention of VTE in acutely ill medical patients [abstract], Blood, 102, 15a Donati, 1994, Cancer and thrombosis, Haemostasis, 24, 128 Arkel, 2000, Thrombosis and cancer, Semin Oncol, 27, 362 Levitan, 1999, Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy: risk analysis using Medicare claims data, Medicine, 78, 285, 10.1097/00005792-199909000-00001 Sallah, 2002, Venous thrombosis in patients with solid tumors: determination of frequency and characteristics, Thromb Haemost, 87, 575, 10.1055/s-0037-1613051 Thodiyil, 2002, Variation in relative risk of venous thromboembolism in different cancers, Thromb Haemost, 87, 1076, 10.1055/s-0037-1613136 Lee, 2003, Venous thromboembolism and cancer: risks and outcomes, Circulation, 107, I-17, 10.1161/01.CIR.0000078466.72504.AC Gallus, 1997, Prevention of post-operative deep leg vein thrombosis in patients with cancer, Thromb Haemost, 78, 126, 10.1055/s-0038-1657514 Kakkar, 1999, Prevention of venous thromboembolism in cancer patients, Semin Thromb Haemost, 25, 239, 10.1055/s-2007-994925 Bergqvist, 2001, Venous thromboembolism and cancer: prevention of VTE, Thromb Res, 102, V209, 10.1016/S0049-3848(01)00241-9 Kakkar, 2001, Prevention of perioperative venous thromboembolism: outcome after cancer and non-cancer surgery [abstract], Thromb Haemost, 86, OC1732 Fisher, 1989, A randomized clinical trial evaluating tamoxifen in the treatment of patients with mode-negative breast cancer who have estrogen-receptor-positive tumors, N Engl J Med, 320, 479, 10.1056/NEJM198902233200802 Fisher, 1997, Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer, J Natl Cancer Inst, 89, 1673, 10.1093/jnci/89.22.1673 Levine, 1988, The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer, N Engl J Med, 318, 404, 10.1056/NEJM198802183180703 Saphner, 1991, Venous and arterial thromosis in patients who received adjuvant therapy for breast cancer, J Clin Oncol, 9, 286, 10.1200/JCO.1991.9.2.286 Levine, 1994, Double-blind randomized trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer, Lancet, 343, 886, 10.1016/S0140-6736(94)90008-6 Rajan, 1995, Very low-dose warfarin prophylaxis to prevent thromboembolism in women with metastic breast cancer receiving chemotherapy: an economic evaluation, J Clin Oncol, 13, 42, 10.1200/JCO.1995.13.1.42 Fisher, 1998, Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study, J Natl Cancer Inst, 90, 1371, 10.1093/jnci/90.18.1371 Pritchard, 1996, Increased thromboembolic complications with concurrent tamoxifen and chemotherapy in a randomized trial of adjuvant therapy for women with metastic breast cancer, J Clin Oncol, 14, 2731, 10.1200/JCO.1996.14.10.2731 Bonnetere, 2001, Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma: results of two randomized trials designed for combined analysis, Cancer, 92, 2247, 10.1002/1097-0142(20011101)92:9<2247::AID-CNCR1570>3.0.CO;2-Y ATAC (Arimidex Tamoxifen Alone or in Combination) Trialists' Group, 2002, Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial, Lancet, 359, 2131, 10.1016/S0140-6736(02)09088-8 Kakkar, 2002, Low molecular weight heparin (LMWH) therapy and survival in advanced cancer [abstract], Blood, 100, 148a Bona, 1999, Thrombotic complications of central venous catheters in cancer patients, Semin Thromb Haemost, 25, 147, 10.1055/s-2007-994916 Randolph, 1998, Benefit of heparin in central venous and pulmonary artery catheters: a meta-analysis of randomized controlled trials, Chest, 113, 165, 10.1378/chest.113.1.165 Bern, 1990, Very low doses of warfarin can prevent thrombosis in central venous catheters: a randomized prospective trial, Ann Intern Med, 112, 423, 10.7326/0003-4819-76-3-112-6-423 Couban, 2002, A randomized double-blind placebo-controlled study of low dose warfarin for the prevention of symptomatic central venous catheter-associated thrombosis in patients with cancer [abstract], Blood, 100, 703a Heaton, 2002, Minidose (1 mg) warfarin as prophylaxis for central vein catheter thrombosis, Intern Med, 32, 84, 10.1046/j.1445-5994.2002.00171.x Masci, 2003, Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients: can it be safely associated with fluorouracil-based chemotherapy?, J Clin Oncol, 21, 736, 10.1200/JCO.2003.02.042 Monreal, 1996, Upper extremity deep venous thrombosis in cancer patients with venous access devices: prophylaxis with a low molecular weight heparin (Fragmin), Thromb Haemost, 75, 251, 10.1055/s-0038-1650254 Reichardt, 2002, Clin Oncol, 21 Walshe, 2002, Complication rates among cancer patients with peripherally inserted central catheters, J Clin Oncol, 20, 3276, 10.1200/JCO.2002.11.135 Krauth, 1987, Safety and efficacy of long-term oral anticoagulation in cancer patients, Cancer, 59, 983, 10.1002/1097-0142(19870301)59:5<983::AID-CNCR2820590522>3.0.CO;2-O Hutten, 2000, Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved International Normalized ratio: a retrospective analysis, J Clin Oncol, 18, 3078, 10.1200/JCO.2000.18.17.3078 Prandoni, 2002, Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis, Blood, 100, 3484, 10.1182/blood-2002-01-0108 Geerts, 2002, Venous thromboembolism and its prevention in critical care, J Crit Care, 17, 95, 10.1053/jcrc.2002.33941 Jain, 1997, Venous thromboembolism: prevention and prophylaxis, Semin Respir Crit Care Med, 18, 79, 10.1055/s-2007-1009334 Cook, 2000, Venous thromboembolic disease: an observational study in medical-surgical intensive care unit patients, J Crit Care, 15, 127, 10.1053/jcrc.2000.19224 Cook, 2003, Deep venous thrombosis in medical-surgical ICU patients: prevalence, incidence and risk factors [abstract], Crit Care, 7, S54 Goldberg, 1996, The prevalence of DVT among patients in respiratory failure: the role of DVT prophylaxis [abstract], Am J Respir Crit Care Med, 153, A94 Harris, 1997, Screening for asymptomatic deep vein thrombosis in surgical intensive care patients, J Vasc Surg, 26, 764, 10.1016/S0741-5214(97)70088-0 Fraisse, 2000, Nadroparin in the prevention of deep vein thrombosis in acute decompensated COPD, Am J Respir Crit Care Med, 161, 1109, 10.1164/ajrccm.161.4.9807025 Moser, 1981, Deep venous thrombosis and pulmonary embolism: frequency in a respiratory intensive care unit, JAMA, 246, 1422, 10.1001/jama.1981.03320130028018 Kapoor, 1999, Subcutaneous heparin prophylaxis significantly reduces the incidence of venous thromboembolic events in the critically ill [abstract], Crit Care Med, 27, A69, 10.1097/00003246-199912001-00165 Goldhaber, 2000, Low molecular weight heparin versus minidose unfractionated heparin for prophylaxis against venous thromboembolism in medical intensive care unit patients: a randomized controlled trial [abstract], J Am Coll Cardiol, 35, 325A Hirsch, 1995, Prevalence of deep venous thrombosis among patients in medical intensive care, JAMA, 274, 335, 10.1001/jama.1995.03530040063042 Marik, 1997, The incidence of deep venous thrombosis in ICU patients, Chest, 111, 661, 10.1378/chest.111.3.661 Dorffler-Melly, 2002, Bioavailability of subcutaneous low-molecular-weight heparin to patients on vasopressors, Lancet, 359, 849, 10.1016/S0140-6736(02)07920-5 McDonald, 2003, Relationship between peak anti-Xa levels and calculated creatinine clearance in ICU patients receiving low molecular weight heparin [abstract], Crit Care, 7, S55 McDonald, 2003, Relationship between torugh anti-Xa levels and calculated creatinine clearance in ICU patients receiving low molecular weight heparin [abstract], Crit Care Med, 31, A609 Geerts, 2003, Prevention of venous thromboembolism in the ICU, Chest, 124, 357S, 10.1378/chest.124.6_suppl.357S Levi, 1998, Computerized order entry sets and intensive education improve the rate of prophylaxis for deep vein thrombophlebitis [abstract], Chest, 114, 280S Ferrari, 1999, Travel as a risk factor for venous trhomboembolic disease: a case-control study, Chest, 115, 440, 10.1378/chest.115.2.440 Kraaijenhagen, 2000, Travel and risk of venous thrombosis, Lancet, 356, 1492, 10.1016/S0140-6736(00)02878-6 Bagshaw, 2001, Traveller's thrombosis: a review of deep vein thrombosis associated with travel, Aviat Space Environ Med, 72, 848 Belcaro, 2001, Venous thromboembolism from air travel: the LONFLIT Study, Angiology, 52, 369, 10.1177/000331970105200601 Dimberg, 2001, Deep venous thrombosis associated with corporate air travel, J Travel Med, 8, 127, 10.2310/7060.2001.24399 Hirsh, 2001, Venous thromboembolism after long flights: are airlines to blame?, Lancet, 357, 1461, 10.1016/S0140-6736(00)04669-9 Arya, 2002, Long-haul flights and deep vein thrombosis: a significant risk only when additional factors are also present, Br J Haematol, 116, 653, 10.1046/j.0007-1048.2001.03330.x Gallus, 2002, Travel and venous thrombosis, Curr Opin Pulm Med, 8, 372, 10.1097/00063198-200209000-00005 Giangrande, 2002, Air travel and thrombosis, Br J Haematol, 117, 509, 10.1046/j.1365-2141.2002.03516.x Ten Wolde, 2003, Travel and the risk of symptomatic venous thromboembolism, Thromb Haemost, 89, 499, 10.1055/s-0037-1613380 Kesteven, 2002, Incidence of symptomatic thrombosis in a stable population of 650,000: travel and other risk factors, Aviat Space Environ Med, 73, 593 Kelman, 2003, Deep vein thrombosis and air travel: record linkage study, BMJ, 327, 1072, 10.1136/bmj.327.7423.1072 Lapostolle, 2001, Severe pulmonary embolism associated with air travel, N Engl J Med, 345, 779, 10.1056/NEJMoa010378 Belcaro, 2002, Prevention of edema, flight microangiopathy and venous thrombosis in long flights with elastic stockings: a randomized trial; the LONFLIT 4 Concorde Edema-SSL Study, Angiology, 53, 635, 10.1177/000331970205300603 Cesarone, 2002, Venous thrombosis from air travel: the LONFLIT3 study: prevention with aspirin vs low-molecular-weight heparin (LMWH) in high-risk subjects; a randomized trial, Angiology, 53, 1, 10.1177/000331970205300101 Hughes, 2003, Frequency of venous thromboembolism in low to moderate risk long distance travellers: the New Zealand Air Traveller's Thrombosis (NZATT) study, Lancet, 362, 2039, 10.1016/S0140-6736(03)15097-0 Perez-Rodriguez, 2003, Incidence of air travel-related pulmonary embolism at the Madrid-Barajas Airport, Arch Interm Med, 163, 2766, 10.1001/archinte.163.22.2766 Ansell, 2001, Air travel and venous thromboembolism: is the evidence in?, N Engl J Med, 345, 828, 10.1056/NEJM200109133451110 Egermayer, 2001, The “economy class syndrome”: problems with the assessment of risk factors for venous thromboembolism, Chest, 120, 1047, 10.1378/chest.120.4.1047 Bendz, 2000, Association between acute hypocarbic hypoxia and activation of coagulation in human beings, Lancet, 356, 1657, 10.1016/S0140-6736(00)03165-2 Hodkinson, 2003, Is mild normobaric hypoxia a risk factor for venous thromboembolism?, J Thromb Haemost, 1, 2131, 10.1046/j.1538-7836.2003.00407.x Rege, 1999, Risk factors and thrombosis after airline flight, Thromb Haemost, 81, 995, 10.1055/s-0037-1614617 Arfvidsson, 2000, Risk factors for venous thromboembolism following prolonged air travel: coach class thrombosis, Hematol Oncol Clin North Am, 14, 391, 10.1016/S0889-8588(05)70140-4 Scurr, 2001, Frequency and prevention of symptomless deep-vein thrombosis in long-haul flights: a randomised trial, Lancet, 357, 1485, 10.1016/S0140-6736(00)04645-6 Martinelli, 2003, Risk of venous thromboembolism after air travel: interaction with thrombophilia and oral contraceptives, Arch Intern Med, 163, 2771, 10.1001/archinte.163.22.2771 Schwarz, 2003, Venous thrombosis after long-haul flights, Arch Intern Med, 163, 2759, 10.1001/archinte.163.22.2759 Belcaro, 2002, Prevention of flight venous thrombosis in high risk subjects with stockings or one-dose enoxaparain [abstract], Circulation, 106, II-721 Cesarone, 2003, The LONFLIT4-Concorde-Sigvaris Traveno Stockings in Long Flights (EcoTraS) Study: a randomized trial, Angiology, 54, 1, 10.1177/000331970305400101 Cesarone, 2003, The LONFLIT4-Concorde Deep Venous Thrombosis and Edema Study: prevention with travel stockings, Angiology, 54, 143, 10.1177/000331970305400202 Aviation Medicine Association Medical Guidelines Task Force, 2003, Medical guidelines for airline travel, 2nd ed, Aviat Space Environ Med, 74, A1