A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy

Andrew J.M. Boulton1, Seymour R. Levin2, John P. Comstock3
1Department of Medicine, Manchester Royal Infirmary, Manchester, UK
2Wadsworth VA Medical Center, Los Angeles, California, USA
3Houston VA Medical Center, Houston, Texas, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Boulton AJM, Knight G, Drury J, Ward JD (1985) The prevalence of symptomatic diabetic neuropathy in an insulintreated population. Diabetes Care 8: 125?128

Greene DA, Lattimer SA, Sima AAF (1987) Sorbitol, phosphoinositides and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N Engl J Med 316: 599?606

Low PA (1987) Recent advances in the pathogenesis of diabetic neuropathy. Muscle Nerve 10: 121?128

Editorial (1989) Diabetic neuropathy. Lancet I: 1113?1114

Malik RA, Newrick PG, Sharma AK, Jennings A, Ah-See AK, Mayhew TM, Jakubowski J, Boulton AJM, Ward JD (1989) Microangiopathy in human diabetic neuropathy. Diabetologia 32: 92?102

Gregersen G (1967) Diabetic neuropathy: influence of age, sex, metabolic control and duration of diabetes on motor conduction velocity. Neurology 17: 972?980

Pirart J (1978) Diabetes and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabetes Care 1: 168?188 and 252?265

Greene DA, Chakrabarti S, Lattimer SA, Sima AAF (1987) Role of sorbitol accumulation and myo-inositol depletion in para-nodal swelling of large myelinated fibres in the insulin-deficient spontaneously diabetic bio-breeding rat. J Clin Invest 79: 1479?1485

Mayer JH, Tomlinson DR (1983) Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myoinositol or an aldose-reductase inhibitor. Diabetologia 25: 433?438

Judzewitsch RG, Jaspan JB, Polonsky KS, Weinberg CR, Halter JB, Halar E, Pfeifer MA, Vukadinovic C, Bernstein L, Schneider M, Liang KY, Gabbay KH, Rubenstein AH, Porte D (1983) Aldose-reductase inhibition improves nerve conduction velocity in diabetic patients. N Engl J Med 308: 119?125

Young RJ, Ewing DJ, Clarke BF (1983) A controlled trial of sorbinil, an aldose-reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes 32: 938?942

Lewin IG, O'Brien IAD, Morgan MH, Corrall RJM (1984) Clinical and neurophysiological studies with the aldose-reductase inhibitor, Sorbinil, in symptomatic diabetic neuropathy. Diabetologia 26: 445?448

Fagius J, Brattberg A, Jameson S, Berne C (1985) Limited benefit of treatment of diabetic polyneuropathy with an aldosereductase inhibitor: a 24 week controlled trial. Diabetologia 28: 323?329

Hicks DR, Kraml M, Cayen MN, Dubuc J, Ryder S, Dvornick D (1984) Tolrestat kinetics. Clin Pharmacol Ther 36: 493?499

Ryder S, Sarokhan B, Shand DG, Mullane JF (1987) Human safety profile of tolrestat: an aldose-reductase inhibitor. Drug Develop Res 11: 131?143

Boulton AJM, Ward JD (1986) Diabetic neuropathies and pain. Clin Endocrinol Metab 15: 917?931

Young RJ, Clarke BF (1985) Pain relief in diabetic neuropathy: the effectiveness of imipramine and related drugs. Diabetic Med 2: 362?366

Bischoff A (1980) The natural course of diabetic neuropathy: a follow-up. Horm Metabl Res 9 [Suppl]: 98?100

Boulton AJM, Armstrong WD, Scarpello JHB, Ward JD (1983) The natural history of painful diabetic neuropathy: a four year study. Post Med J 59: 556?559

Boulton AJM, Atiea J, de Leeuw IH, Lemkes H, MacLeod AF, MacRury S, Scarpello JHB, Somers G, Tattersall RB, van der Veen EA (1989) The efficacy and safety of the aldose-reductase inhibitor tolrestat in the treatment of chronic sensorimotor diabetic neuropathy. Diabetologia 32: 469A

Sima AAF, Bril V, Nathaniel V, McEwan AJ, Brown MB, Lattimer SA, Greene DA (1988) Regeneration and repair of myelinated fibres in sural nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. N Engl J Med 319: 548?555

Pietri A, Ehle AL, Raskin P (1980) Changes in nerve conduction velocity after six weeks of glucoregulation with portable insulin infusion pumps. Diabetes 29: 668?671

Boulton AJM, Drury J, Clarke BF, Ward JD (1982) Continuous subcutaneous insulin infusion in the management of painful diabetic neuropathy. Diabetes Care 5: 386?390

Graf RJ, Halter JB, Pfeifer MA, Halar E, Brozovich F, Porte D (1981) Glycaemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Ann Intern Med 94: 307?311

Fedele D, Negrin P, Cardone C, Bellavere F, Ferri M, Briani G, Nosadini R, Crepaldi G (1984) Influence of continuous subcutaneous insulin infusion (CSII) treatment on diabetic somatic and autonomic neuropathy. J Endocrinol Invest 7: 623?628

Daube JR (1986) Nerve conduction studies. In: Aminoff MJ (ed) Electrodiagnosis in clinical neurology, 2nd edn. Churchill Livingstone, New York, pp 265?306

Kornetsky C (1976) Pharmacology: drugs affecting behavior. John Wiley and Sons, New York, pp 22?44