Huntingtin is degraded to small fragments by calpain after ischemic injury☆

Experimental Neurology - Tập 183 - Trang 109-115 - 2003
Manho Kim1, Jae-Kyu Roh1, Byung Woo Yoon1, Lami Kang1, Yun J Kim2, Neil Aronin3, Marian DiFiglia1
1Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
2Department of Cellular Neurobiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
3Department of Medicine and Cell Biology, University of Massachusetts Medical Center, Worcester, MA 01655, USA

Tài liệu tham khảo

Aronin, 1995, CAG expansion affects the expression of mutant huntingtin in the Huntington’s disease brain, Neuron, 15, 1193, 10.1016/0896-6273(95)90106-X Bhide, 1996, Expression of normal and mutant huntingtin in the developing brain, J. Neurosci., 16, 5523, 10.1523/JNEUROSCI.16-17-05523.1996 Block-Gallarza, 1997, Fast transport and retrograde movement of huntingtin and HAP 1 in axons, NeuroReport, 8, 2247, 10.1097/00001756-199707070-00031 Blomgren, 2001, Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia, J. Biol. Chem., 276, 10191, 10.1074/jbc.M007807200 Castejon, 1999, Generation of spectrin breakdown products in peripheral nerves by addition of M-calpain, Muscle Nerve, 22, 905, 10.1002/(SICI)1097-4598(199907)22:7<905::AID-MUS14>3.0.CO;2-W Chan, 1999, Caspase and calpain substrates, J. Neurosci. Res., 58, 167, 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K Chen, 1999, Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin, J. Neurochem., 72, 1890, 10.1046/j.1471-4159.1999.0721890.x Davies, 1997, Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation, Cell, 90, 537, 10.1016/S0092-8674(00)80513-9 DiFiglia, 1990, Excitotoxic injury of the neostriatum. A model for Huntington’s disease, TINS, 13, 286 DiFiglia, 1995, Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons, Neuron, 14, 1075, 10.1016/0896-6273(95)90346-1 DiFiglia, 1997, Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990 duBois, 1985, Cell proliferation after ischemic injury in gerbil brain. An immunocytochemical and autoradiographic study, Cell Tissue Res., 242, 17, 10.1007/BF00225558 Dyer, 2001, Mutant protein in Huntington disease is resistant to proteolysis in affected brain, Nat. Genet., 29, 270, 10.1038/ng745 Faddis, 1997, Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro, J. Neurosci., 17, 951, 10.1523/JNEUROSCI.17-03-00951.1997 Gafni, 2002, Calpain activation in Huntington’s disease, J. Neurosci., 22, 4842, 10.1523/JNEUROSCI.22-12-04842.2002 Goffredo, D., Rigamonti, D., Tartari, M., DeMicheli, A., Verderio, C., Matteoli, M., Zuccato, C., Cattaneo, E., 2002. Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons. J Biol. Chem. 277, 39594–39598 Grynspan, 1997, Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth, J. Neurosci. Res., 48, 181, 10.1002/(SICI)1097-4547(19970501)48:3<181::AID-JNR1>3.0.CO;2-B Hackam, 1998, The influence of huntingtin protein size on nuclear localization and cellular toxicity, J. Cell Biol., 141, 1097, 10.1083/jcb.141.5.1097 Hewitt, 1998, Selective coupling of μ-calpain activation with the NMDA receptor is independent of translocation and autolysis in primary cortical neurons, J. Neurosci. Res., 54, 223, 10.1002/(SICI)1097-4547(19981015)54:2<223::AID-JNR10>3.0.CO;2-5 Hong, 1994, Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia, Stroke, 25, 663, 10.1161/01.STR.25.3.663 1993, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes, Cell, 72, 971, 10.1016/0092-8674(93)90585-E Katchanov, 2001, Loss of striatal spiny projection neurons but not interneurons following mild focal brain ischemia, Soc. Neurosci. Abstr., 27, 1163 Kim, 2001, Caspase 3 cleaved N-terminal fragments of wt and mutant huntingtin are present in normal and Huntington’s disease brains, associate with membranes, and undergo calpain-dependent proteolysis, Proc. Natl. Acad. Sci. USA, 98, 12784, 10.1073/pnas.221451398 Laforet, 2001, Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington’s disease, J. Neurosci., 21, 9112, 10.1523/JNEUROSCI.21-23-09112.2001 Leist, 1998, 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis, Mol. Pharmacol., 54, 789, 10.1124/mol.54.5.789 Liebetrau, 1999, Increased intracellular calpain detection in experimental focal cerebral ischemia, NeuroReport, 10, 529, 10.1097/00001756-199902250-00016 Longa, 1989, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, 20, 84, 10.1161/01.STR.20.1.84 Lunkes, A., Lindenberg, K.S., L., Ben-Haiem, L., Weber, C., Devys, D., Landewehrmeyer, G.B., J.L., Trottier, Y., 2002. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell 10;259–269 Meade, 2000, Transient global ischemia in rats yields striatal projection neurons and interneuron loss resembling that in Huntington’s disease, Exp. Neurol., 166, 307, 10.1006/exnr.2000.7530 Mende-Mueller, 2001, Tissue-specific proteolysis of huntingtin (htt) in human brain, J. Neurosci., 2, 1830, 10.1523/JNEUROSCI.21-06-01830.2001 Neumar, 2001, Calpain activity in the rat brain after transient forebrain ischemia, Exp. Neurol., 170, 27, 10.1006/exnr.2001.7708 Pettigrew, 1996, Microtubular proteolysis in focal cerebral ischemia, J. Cereb. Blood Flow Metab., 16, 1189, 10.1097/00004647-199611000-00013 Pike, 2000, Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures, J. Neurotrauma, 17, 283, 10.1089/neu.2000.17.283 Rami, 2000, mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage, Brain Res., 866, 299, 10.1016/S0006-8993(00)02301-5 Roberts-Lewis, 1994, Immunolocalization of calpain 1-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain, J. Neurosci., 14, 3934, 10.1523/JNEUROSCI.14-06-03934.1994 Ruan, 2001, Both necrosis and apoptosis occur in the striatum following transient global ischemia, Soc. Neurosci. Abstr., 27, 547 Saatman, 1996, Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat, J. Neuropathol. Exp. Neurol., 55, 850, 10.1097/00005072-199607000-00010 Saito, 1993, Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90, 2628, 10.1073/pnas.90.7.2628 Saito, 1994, The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells, FEBS Lett., 353, 327, 10.1016/0014-5793(94)01075-7 Saudou, 1998, Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions, Cell, 95, 55, 10.1016/S0092-8674(00)81782-1 Scherzinger, 1997, Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo, Cell, 90, 549, 10.1016/S0092-8674(00)80514-0 Schumacher, 2000, Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury, J. Neurochem., 74, 1646, 10.1046/j.1471-4159.2000.0741646.x Sun, 2001, Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-d-aspartate receptors via post-synaptic density 95, J. Biol. Chem., 276, 24713, 10.1074/jbc.M103501200 Vanderklish, 2000, The pathogenic activation of calpain, Int. J. Exp. Pathol., 81, 323, 10.1046/j.1365-2613.2000.00169.x Wang, 2000, Calpain and caspase, Trends Neurosci., 23, 20, 10.1016/S0166-2236(99)01479-4 Wellington, 1998, Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract, J. Biol. Chem., 273, 9158, 10.1074/jbc.273.15.9158 Wellington, 2000, Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells, J. Biol. Chem., 275, 19831, 10.1074/jbc.M001475200 Yamashima, 2000, Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates, Prog. Neurobiol., 62, 273, 10.1016/S0301-0082(00)00006-X Zeron, 2001, Mutant huntingtin enhances excitotoxic cell death, Mol. Cell. Neurosci., 17, 41, 10.1006/mcne.2000.0909