Huntingtin is degraded to small fragments by calpain after ischemic injury☆
Tài liệu tham khảo
Aronin, 1995, CAG expansion affects the expression of mutant huntingtin in the Huntington’s disease brain, Neuron, 15, 1193, 10.1016/0896-6273(95)90106-X
Bhide, 1996, Expression of normal and mutant huntingtin in the developing brain, J. Neurosci., 16, 5523, 10.1523/JNEUROSCI.16-17-05523.1996
Block-Gallarza, 1997, Fast transport and retrograde movement of huntingtin and HAP 1 in axons, NeuroReport, 8, 2247, 10.1097/00001756-199707070-00031
Blomgren, 2001, Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia, J. Biol. Chem., 276, 10191, 10.1074/jbc.M007807200
Castejon, 1999, Generation of spectrin breakdown products in peripheral nerves by addition of M-calpain, Muscle Nerve, 22, 905, 10.1002/(SICI)1097-4598(199907)22:7<905::AID-MUS14>3.0.CO;2-W
Chan, 1999, Caspase and calpain substrates, J. Neurosci. Res., 58, 167, 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K
Chen, 1999, Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin, J. Neurochem., 72, 1890, 10.1046/j.1471-4159.1999.0721890.x
Davies, 1997, Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation, Cell, 90, 537, 10.1016/S0092-8674(00)80513-9
DiFiglia, 1990, Excitotoxic injury of the neostriatum. A model for Huntington’s disease, TINS, 13, 286
DiFiglia, 1995, Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons, Neuron, 14, 1075, 10.1016/0896-6273(95)90346-1
DiFiglia, 1997, Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990
duBois, 1985, Cell proliferation after ischemic injury in gerbil brain. An immunocytochemical and autoradiographic study, Cell Tissue Res., 242, 17, 10.1007/BF00225558
Dyer, 2001, Mutant protein in Huntington disease is resistant to proteolysis in affected brain, Nat. Genet., 29, 270, 10.1038/ng745
Faddis, 1997, Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro, J. Neurosci., 17, 951, 10.1523/JNEUROSCI.17-03-00951.1997
Gafni, 2002, Calpain activation in Huntington’s disease, J. Neurosci., 22, 4842, 10.1523/JNEUROSCI.22-12-04842.2002
Goffredo, D., Rigamonti, D., Tartari, M., DeMicheli, A., Verderio, C., Matteoli, M., Zuccato, C., Cattaneo, E., 2002. Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons. J Biol. Chem. 277, 39594–39598
Grynspan, 1997, Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth, J. Neurosci. Res., 48, 181, 10.1002/(SICI)1097-4547(19970501)48:3<181::AID-JNR1>3.0.CO;2-B
Hackam, 1998, The influence of huntingtin protein size on nuclear localization and cellular toxicity, J. Cell Biol., 141, 1097, 10.1083/jcb.141.5.1097
Hewitt, 1998, Selective coupling of μ-calpain activation with the NMDA receptor is independent of translocation and autolysis in primary cortical neurons, J. Neurosci. Res., 54, 223, 10.1002/(SICI)1097-4547(19981015)54:2<223::AID-JNR10>3.0.CO;2-5
Hong, 1994, Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia, Stroke, 25, 663, 10.1161/01.STR.25.3.663
1993, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes, Cell, 72, 971, 10.1016/0092-8674(93)90585-E
Katchanov, 2001, Loss of striatal spiny projection neurons but not interneurons following mild focal brain ischemia, Soc. Neurosci. Abstr., 27, 1163
Kim, 2001, Caspase 3 cleaved N-terminal fragments of wt and mutant huntingtin are present in normal and Huntington’s disease brains, associate with membranes, and undergo calpain-dependent proteolysis, Proc. Natl. Acad. Sci. USA, 98, 12784, 10.1073/pnas.221451398
Laforet, 2001, Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington’s disease, J. Neurosci., 21, 9112, 10.1523/JNEUROSCI.21-23-09112.2001
Leist, 1998, 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis, Mol. Pharmacol., 54, 789, 10.1124/mol.54.5.789
Liebetrau, 1999, Increased intracellular calpain detection in experimental focal cerebral ischemia, NeuroReport, 10, 529, 10.1097/00001756-199902250-00016
Longa, 1989, Reversible middle cerebral artery occlusion without craniectomy in rats, Stroke, 20, 84, 10.1161/01.STR.20.1.84
Lunkes, A., Lindenberg, K.S., L., Ben-Haiem, L., Weber, C., Devys, D., Landewehrmeyer, G.B., J.L., Trottier, Y., 2002. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell 10;259–269
Meade, 2000, Transient global ischemia in rats yields striatal projection neurons and interneuron loss resembling that in Huntington’s disease, Exp. Neurol., 166, 307, 10.1006/exnr.2000.7530
Mende-Mueller, 2001, Tissue-specific proteolysis of huntingtin (htt) in human brain, J. Neurosci., 2, 1830, 10.1523/JNEUROSCI.21-06-01830.2001
Neumar, 2001, Calpain activity in the rat brain after transient forebrain ischemia, Exp. Neurol., 170, 27, 10.1006/exnr.2001.7708
Pettigrew, 1996, Microtubular proteolysis in focal cerebral ischemia, J. Cereb. Blood Flow Metab., 16, 1189, 10.1097/00004647-199611000-00013
Pike, 2000, Stretch injury causes calpain and caspase-3 activation and necrotic and apoptotic cell death in septo-hippocampal cell cultures, J. Neurotrauma, 17, 283, 10.1089/neu.2000.17.283
Rami, 2000, mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage, Brain Res., 866, 299, 10.1016/S0006-8993(00)02301-5
Roberts-Lewis, 1994, Immunolocalization of calpain 1-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain, J. Neurosci., 14, 3934, 10.1523/JNEUROSCI.14-06-03934.1994
Ruan, 2001, Both necrosis and apoptosis occur in the striatum following transient global ischemia, Soc. Neurosci. Abstr., 27, 547
Saatman, 1996, Prolonged calpain-mediated spectrin breakdown occurs regionally following experimental brain injury in the rat, J. Neuropathol. Exp. Neurol., 55, 850, 10.1097/00005072-199607000-00010
Saito, 1993, Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90, 2628, 10.1073/pnas.90.7.2628
Saito, 1994, The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells, FEBS Lett., 353, 327, 10.1016/0014-5793(94)01075-7
Saudou, 1998, Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions, Cell, 95, 55, 10.1016/S0092-8674(00)81782-1
Scherzinger, 1997, Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo, Cell, 90, 549, 10.1016/S0092-8674(00)80514-0
Schumacher, 2000, Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury, J. Neurochem., 74, 1646, 10.1046/j.1471-4159.2000.0741646.x
Sun, 2001, Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-d-aspartate receptors via post-synaptic density 95, J. Biol. Chem., 276, 24713, 10.1074/jbc.M103501200
Vanderklish, 2000, The pathogenic activation of calpain, Int. J. Exp. Pathol., 81, 323, 10.1046/j.1365-2613.2000.00169.x
Wang, 2000, Calpain and caspase, Trends Neurosci., 23, 20, 10.1016/S0166-2236(99)01479-4
Wellington, 1998, Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract, J. Biol. Chem., 273, 9158, 10.1074/jbc.273.15.9158
Wellington, 2000, Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells, J. Biol. Chem., 275, 19831, 10.1074/jbc.M001475200
Yamashima, 2000, Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates, Prog. Neurobiol., 62, 273, 10.1016/S0301-0082(00)00006-X
Zeron, 2001, Mutant huntingtin enhances excitotoxic cell death, Mol. Cell. Neurosci., 17, 41, 10.1006/mcne.2000.0909