The Enzyme Cyp26b1 Mediates Inhibition of Mast Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis
Yosuke Kurashima1,2,3,4, Takeaki Amiya1,2,4,5, Kumiko Fujisawa1,2, Naoko Shibata1,2,4,5, Yuji Suzuki1, Yuta Kogure1,4,5, Eri Hashimoto1,4, Atsushi Otsuka6, Kenji Kabashima6, Shintaro Sato1,2, Takeshi Sato1,4,5, Masato Kubo7,8, Shizuo Akira9, Kensuke Miyake3, Jun Kunisawa1,2,4,5,10,11, Hiroshi Kiyono1,2,5,10
1Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan
3Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
4Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan
5Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8561, Japan
6Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
7Laboratory for Cytokine Regulation, Research Center for Integrative Medical Science, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan
8Division of Molecular Pathology, Research Institute for Biological Sciences, Tokyo University of Sciences, Chiba 278-0022, Japan
9Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
10International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
11Department of Microbiology and Immunology, Kobe University School of Medicine, Kobe 650-0017, Japan