A genomics-guided approach for discovering and expressing cryptic metabolic pathways
Tóm tắt
Từ khóa
Tài liệu tham khảo
Bentley, S.D. et al. Complete genome sequence of the model actinomycetes Streptomyces coelicolor A3(2). Nature 417, 141–147 (2002).
Omura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl. Acad. Sci. USA 98, 12215–12220 (2001).
Liu, W. Christenson, S.D., Standage, S. & Shen, B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science 297, 1170–1173 (2002).
Ahlert, J. et al. The calicheamicin gene cluster and its iterative type I enediyne PKS. Science 297, 1173–1176 (2002).
Martin, J.F. & Liras, P. Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites. Annu. Rev. Microbiol. 43, 173–206 (1989).
Beyer, S., Distler, J. & Piepersberg, W. The str gene cluster for the biosynthesis of 5′-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR. Mol. Gen. Genet. 250, 775–784 (1996).
Schwecke, T. et al. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. USA 92, 7839–7843 (1995).
Doyle, T.W. & Borders, D.B. Enediyne antitumor antibiotics. in Enediyne Antibiotics as Antitumor Agents (eds. Borders, D.B. & Doyle, T.W.) 1–15 (Marcel Dekker, New York, 1995).
Walsh, C.T., Gehring, A.M., Weinreb, P.H., Quadri, L.E. & Flugel, R.S. Post-translational modification of polyketide and nonribosomal peptide synthases. Curr. Opin. Chem. Biol. 1, 309–315 (1997).
Benning, M.M. et al. The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3. J. Biol. Chem. 273, 33572–33579 (1998).
Elespuru, R.K. & Yarmolinsky, M.B. A colorimetric assay of lysogenic induction designed for screening potential carcinogenic and carcinostatic agents. Environ. Mutagen. 1, 65–78 (1979).
Maeda, H. The clinical effects of neocarzinostatin and its polymer conjugate, SMANCS. in Enediyne Antibiotics as Antitumor Agents (eds. Borders, D.B. & Doyle, T.W.) 363–380 (Marcel Dekker, New York, 1995).
Sievers, E.L. & Lineberger M. Mylotarg: antibody-targeted chemotherapy comes of age. Curr. Opin. Oncol. 13, 522–527 (2001).
Brukner, I. C-1027 Taiho Pharmaceutical Co. Ltd. Curr. Opinion Oncologic, Endocrine & Met. Invest. Drugs 2, 344–352 (2000).
Chater, K.F. & Bibb, M.J. Regulation of bacterial antibiotic production. In Biotechnology vol. 7: Products of Secondary Metabolism (eds. Kleinkauf, H. & von Döhren, H.) 57–105 (VCH Press, Weinheim, Germany, 1997).
Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F. & Hopwood, D.A. Practical Streptomyces Genetics (The John Innes Foundation, Norwich, UK, 2000).
Kelley, L.A., MacCallum, R.M. & Sternberg M.J. Enhanced genome annotation using structural profiles in the program 3D-PSSM. J. Mol. Biol. 299, 499–520 (2000).
Reuter, K., Mofid, M.R., Marahiel, M.A. & Ficner, R. Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4′-phosphopantetheinyl transferase superfamily. EMBO 18, 6823–6831 (1999).