Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer

European Journal of Medicinal Chemistry - Tập 209 - Trang 112866 - 2021
Md Ashraf-Uz-Zaman1, Sadisna Shahi1, Racheal Akwii1, Md Sanaullah Sajib1, Mohammad Jodeiri Farshbaf2, Raja Reddy Kallem3, William Putnam3, Wei Wang4, Ruiwen Zhang4, Karina Alvina5,2,6, Paul C. Trippier7,8,9, Constantinos M. Mikelis1, Nadezhda A. German1,5
1Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA
2Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA
3Clinical Pharmacology & Experimental Therapeutics Center, Texas Tech University Health Sciences Center, Dallas, TX, USA
4College of Pharmacy, University of Houston, Houston, TX, USA
5Center of Excellence for Translational Neuroscience and Therapeutics, Texas Tech University Health Sciences Center, Lubbock, TX, USA
6Department of Neuroscience, University of Florida, Gainesville, FL USA
7Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA
8Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA
9UNMC Center for Drug Discovery, University of Nebraska Medical Center, Omaha, NE, USA

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European Journal of Medicinal Chemistry

Tập 209

112866

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