MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation

Kidney Foundation, 2002, K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification, Am. J. Kidney Dis., 39, S1 Levey, 2003, National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification, Ann. Intern. Med., 139, 137, 10.7326/0003-4819-139-2-200307150-00013 Moe, 2006, Vascular calcification and renal osteodystrophy relationship in chronic kidney disease, Eur. J. Clin. Investig., 36, 51, 10.1111/j.1365-2362.2006.01665.x Foley, 1998, Clinical epidemiology of cardiovascular disease in chronic renal disease, Am. J. Kidney Dis., 32, S112, 10.1053/ajkd.1998.v32.pm9820470 Rennenberg, 2009, Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis, Vasc. Health Risk Manag., Volume 5, 185, 10.2147/VHRM.S4822 Moe, 2006, Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO), Kidney Int., 69, 1945, 10.1038/sj.ki.5000414 Disthabanchong, 2012, Vascular calcification in chronic kidney disease: pathogenesis and clinical implication, World J. Nephrol., 1, 43, 10.5527/wjn.v1.i2.43 Moe, 2002, Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins, Kidney Int., 61, 638, 10.1046/j.1523-1755.2002.00170.x Moe, 2003, Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels, Kidney Int., 63, 1003, 10.1046/j.1523-1755.2003.00820.x Chen, 2015, Low bone turnover in chronic kidney disease is associated with decreased VEGF-A expression and osteoblast differentiation, Am. J. Nephrol., 41, 464, 10.1159/000438461 D. Jalal, M. Chonchol, T. Etgen, D. Sander, C-reactive protein as a predictor of cardiovascular events in elderly patients with chronic kidney disease, J. Nephrol. 25 719–25 http://dx.doi.org/10.5301/jn.5000047 Lee, 2015, Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease, BMC Nephrol., 16, 77, 10.1186/s12882-015-0068-7 Kiu Weber, 2014, Cardiovascular risk markers associated with arterial calcification in patients with chronic kidney disease stages 3 and 4, Clin. Kidney J., 7, 167, 10.1093/ckj/sfu017 Trionfini, 2015, MicroRNAs in kidney physiology and disease, Nat. Rev. Nephrol., 11, 23, 10.1038/nrneph.2014.202 Chen, 2013, Decreased microRNA is involved in the vascular remodeling abnormalities in Chronic Kidney Disease (CKD), PLoS One, 8 Neal, 2011, Circulating microRNA expression is reduced in chronic kidney disease, Nephrol. Dial. Transplant., 26, 3794, 10.1093/ndt/gfr485 Mitchell, 2008, Circulating microRNAs as stable blood-based markers for cancer detection, Proc. Natl. Acad. Sci. U. S. A., 105, 10513, 10.1073/pnas.0804549105 Creemers, 2012, Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?, Circ. Res., 110, 483, 10.1161/CIRCRESAHA.111.247452 Zampetaki, 2010, Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes, Circ. Res., 107, 810, 10.1161/CIRCRESAHA.110.226357 Kapinas, 2011, MicroRNA biogenesis and regulation of bone remodeling, Arthritis Res. Ther., 13, 220, 10.1186/ar3325 Hackl, 2016, Circulating microRNAs as novel biomarkers for bone diseases – complex signatures for multifactorial diseases?, Mol. Cell. Endocrinol., 432, 83, 10.1016/j.mce.2015.10.015 Heilmeier, 2016, Serum microRNAs are indicative of skeletal fractures in postmenopausal women with and without type 2 diabetes and influence osteogenic and adipogenic differentiation of adipose-tissue derived mesenchymal stem cells in vitro, J. Bone Miner. Res., 10.1002/jbmr.2897 Weilner, 2015, Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation, Bone, 79, 43, 10.1016/j.bone.2015.05.027 Levey, 2009, A new equation to estimate glomerular filtration rate, Ann. Intern. Med., 150, 604, 10.7326/0003-4819-150-9-200905050-00006 Schmittgen, 2008, Analyzing real-time PCR data by the comparative C(T) method, Nat. Protoc., 3, 1101, 10.1038/nprot.2008.73 Taïbi, 2014, miR-223: an inflammatory oncomiR enters the cardiovascular field, Biochim. Biophys. Acta, 1842, 1001, 10.1016/j.bbadis.2014.03.005 Taïbi, 2014, Possible involvement of microRNAs in vascular damage in experimental chronic kidney disease, Biochim. Biophys. Acta, 1842, 88, 10.1016/j.bbadis.2013.10.005 Rangrez, 2012, Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evidence for the involvement of miR-223, PLoS One, 7, 10.1371/journal.pone.0047807 Salas-Pérez, 2013, MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes, Immunobiology, 218, 733, 10.1016/j.imbio.2012.08.276 Long, 2010, Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions, J. Biol. Chem., 285, 23457, 10.1074/jbc.M110.136168 Yang, 2012, miR-93/Sp7 function loop mediates osteoblast mineralization, J. Bone Miner. Res., 27, 1598, 10.1002/jbmr.1621 Goettsch, 2011, miR-125b regulates calcification of vascular smooth muscle cells, Am. J. Pathol., 179, 1594, 10.1016/j.ajpath.2011.06.016 Seeliger, 2014, Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures, J. Bone Miner. Res., 10.1002/jbmr.2175 Kocijan, 2016, Circulating microRNA signatures in patients with idiopathic and postmenopausal osteoporosis and fragility fractures, J. Clin. Endocrinol. Metab., jc.2016 Rudnicki, 2016, Renal microRNA- and RNA-profiles in progressive chronic kidney disease, Eur. J. Clin. Invest., 46, 213, 10.1111/eci.12585 Ben-Dov, 2014, Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline, PLoS One, 9, 10.1371/journal.pone.0086856 Zampetaki, 2010, Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes, Circ. Res., 107, 810, 10.1161/CIRCRESAHA.110.226357 Chen, 2012, Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3, PLoS One, 7 Cao, 2013, Interplay between microRNAs and the STAT3 signaling pathway in human cancers, Physiol. Genomics, 45, 1206, 10.1152/physiolgenomics.00122.2013 Xu, 2014, MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4, FEBS Lett., 588, 1692, 10.1016/j.febslet.2014.03.013 Kondo, 2014, Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats, Naunyn Schmiedeberg's Arch. Pharmacol., 387, 909, 10.1007/s00210-014-1023-z Benz, 2015, Circulating microRNA-223 serum levels do not predict sepsis or survival in patients with critical illness, Dis. Markers, 2015, 384208, 10.1155/2015/384208 Silverstein, 2009, Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease, Pediatr. Nephrol., 24, 1445, 10.1007/s00467-008-1046-0 Li, 2010, MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation, Nat. Immunol., 11, 799, 10.1038/ni.1918 Fabbri, 2014, Expression of microRNA-93 and interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses, Am. J. Respir. Cell Mol. Biol., 50, 1144, 10.1165/rcmb.2013-0160OC Rix, 1999, Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure, Kidney Int., 56, 1084, 10.1046/j.1523-1755.1999.00617.x Pritchard, 2012, Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies, Cancer Prev. Res. (Phila), 5, 492, 10.1158/1940-6207.CAPR-11-0370 Agharazii, 2015, Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification, Am. J. Hypertens., 28, 746, 10.1093/ajh/hpu225 Standal, 2014, gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation, J. Endocrinol., 223, 181, 10.1530/JOE-14-0424 Byon, 2015, Molecular mechanisms of vascular calcification in chronic kidney disease: the link between bone and the vasculature, Curr. Osteoporos. Rep., 10.1007/s11914-015-0270-3 Osorio, 2013, Biochemical markers of vascular calcification in elderly hemodialysis patients, Mol. Cell. Biochem., 374, 21, 10.1007/s11010-012-1500-y Lee, 2000, Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12, Mol. Cell. Biol., 20, 8783, 10.1128/MCB.20.23.8783-8792.2000 Nahar-Gohad, 2015, Rat aortic smooth muscle cells cultured on hydroxyapatite differentiate into osteoblast-like cells via BMP-2–SMAD-5 pathway, Calcif. Tissue Int., 96, 359, 10.1007/s00223-015-9962-z Hruska, 2005, Bone morphogenetic proteins in vascular calcification, Circ. Res., 97, 105, 10.1161/01.RES.00000175571.53833.6c Galvin, 2000, A role for smad6 in development and homeostasis of the cardiovascular system, Nat. Genet., 24, 171, 10.1038/72835 Schiffrin, 2007, Chronic kidney disease: effects on the cardiovascular system, Circulation, 116, 85, 10.1161/CIRCULATIONAHA.106.678342 Lowery, 2015, Loss of BMPR2 leads to high bone mass due to increased osteoblast activity, J. Cell Sci., 128, 1308, 10.1242/jcs.156737 Zhang, 2002, Peroxisome proliferator-activated receptor is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells, J. Biol. Chem., 277, 11505, 10.1074/jbc.M110580200 Caron, 2013, Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5, Bone, 53, 94, 10.1016/j.bone.2012.11.032 Alesutan, 2015, Inhibition of phosphate-induced vascular smooth muscle cell osteo-/chondrogenic signaling and calcification by bafilomycin A1 and methylamine, Kidney Blood Press. Res., 40, 490, 10.1159/000368524 Hu, 2013, miR-142-3p promotes osteoblast differentiation by modulating Wnt signaling, Mol. Med. Rep., 7, 689, 10.3892/mmr.2012.1207 Lian, 2012, MicroRNA control of bone formation and homeostasis, Nat. Rev. Endocrinol., 8, 212, 10.1038/nrendo.2011.234 Raitoharju, 2011, miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study, Atherosclerosis, 219, 211, 10.1016/j.atherosclerosis.2011.07.020 Van Craenenbroeck, 2015, Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise, Am. J. Physiol. Heart Circ. Physiol., 309, H2008, 10.1152/ajpheart.00346.2015 Van Craenenbroeck, 2016, Impaired vascular function contributes to exercise intolerance in chronic kidney disease, Nephrol. Dial. Transplant., 10.1093/ndt/gfw303 Goodman, 2000, Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis, N. Engl. J. Med., 342, 1478, 10.1056/NEJM200005183422003 Xu, 2013, MicroRNA transport: a new way in cell communication, J. Cell. Physiol., 228, 1713, 10.1002/jcp.24344