Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence

Cork, 2009, Epidermal barrier dysfunction in atopic dermatitis, J Invest Dermatol, 129, 1892, 10.1038/jid.2009.133 Rawlings, 2004, Moisturization and skin barrier function, Dermatol Ther, 17, 43, 10.1111/j.1396-0296.2004.04S1005.x Palmer, 2006, Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis, Nat Genet, 38, 441, 10.1038/ng1767 Smith, 2006, Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris, Nat Genet, 38, 337, 10.1038/ng1743 Kezic, 2008, Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum, J Invest Dermatol, 128, 2117, 10.1038/jid.2008.29 Flohr, 2010, Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age, Br J Dermatol, 163, 1333, 10.1111/j.1365-2133.2010.10068.x Lack, 2008, Epidemiologic risks for food allergy, J Allergy Clin Immunol, 121, 1331, 10.1016/j.jaci.2008.04.032 Lack, 2003, Factors associated with the development of peanut allergy in childhood, N Engl J Med, 348, 977, 10.1056/NEJMoa013536 Strid, 2004, Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response, Eur J Immunol, 34, 2100, 10.1002/eji.200425196 Fallon, 2009, A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming, Nat Genet, 41, 602, 10.1038/ng.358 Marenholz, 2009, An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma, J Allergy Clin Immunol, 123, 911, 10.1016/j.jaci.2009.01.051 Weidinger, 2008, Filaggrin mutations, atopic eczema, hay fever, and asthma in children, J Allergy Clin Immunol, 121, 1203, 10.1016/j.jaci.2008.02.014 van den Oord, 2009, Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis, BMJ, 339, b2433, 10.1136/bmj.b2433 Bisgaard, 2008, Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure, PLoS Med, 5, e131, 10.1371/journal.pmed.0050131 Schuttelaar, 2009, Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure, Allergy, 64, 1758, 10.1111/j.1398-9995.2009.02080.x Brown, 2011, Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy, J Allergy Clin Immunol, 127, 661, 10.1016/j.jaci.2011.01.031 Ziyab, 2012, Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age, PLoS One, 7, e32721, 10.1371/journal.pone.0032721 Arshad, 2001, Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study, Pediatrics, 108, E33, 10.1542/peds.108.2.e33 Roberts, 2012, Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study, Clin Exp Allergy, 42, 1501, 10.1111/j.1365-2222.2012.04074.x Pereira, 2005, Prevalence of sensitization to food allergens, reported adverse reaction to foods, food avoidance, and food hypersensitivity among teenagers, J Allergy Clin Immunol, 116, 884, 10.1016/j.jaci.2005.05.047 Food Allergen Labelling Food Standards Agency. Available at: http://www.food.gov.uk/safereating/allergyintol/label/groups. Accessed August 7, 2014. Wood, 2000 Niggemann, 2010, When is an oral food challenge positive?, Allergy, 65, 2, 10.1111/j.1398-9995.2009.02170.x Hanifin, 1980, Diagnostic features of atopic dermatitis, Acta Derm Venereol Suppl (Stockh), 92, 44, 10.2340/00015555924447 Lleras C. Path analysis. Encyclopedia of social measurement. 3. Philadelphia; Elsevier: 2005. Muthén LK, Muthén BO. Mplus User's guide (1998-2012). 7th ed. Los Angeles, CA: Muthén & Muthén. Hudson, 2006, Skin barrier function and allergic risk, Nat Genet, 38, 399, 10.1038/ng0406-399 Elias, 2009, Abnormal skin barrier in the etiopathogenesis of atopic dermatitis, Curr Opin Allergy Clin Immunol, 9, 437, 10.1097/ACI.0b013e32832e7d36 Hanifin, 2009, Evolving concepts of pathogenesis in atopic dermatitis and other eczemas, J Invest Dermatol, 129, 320, 10.1038/jid.2008.252 Fox, 2009, Household peanut consumption as a risk factor for the development of peanut allergy, J Allergy Clin Immunol, 123, 417, 10.1016/j.jaci.2008.12.014 Oyoshi, 2009, Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen, J Allergy Clin Immunol, 124, 485, 10.1016/j.jaci.2009.05.042 Flohr, 2014, Atopic dermatitis and disease severity are the main risk factors for food sensitization in exclusively breastfed infants, J Invest Dermatol, 134, 345, 10.1038/jid.2013.298