Natural molecules as tumour inhibitors: Promises and prospects

Aggarwal, 2004, Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies, Anticancer Res, 24, 2783 Aggarwal, 2004, Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors, Vitam Horm, 67, 453, 10.1016/S0083-6729(04)67023-3 Ahmad, 2010, Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells, J Cell Biochem, 109, 1134 Ahmad, 2011, Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF-kappaB signaling, Front Biosci, 3, 1483 Ahmad, 2012, Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling, Carcinogenesis, 33, 2450, 10.1093/carcin/bgs290 Bagchi, 2004, Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula, Biochemistry, 69, 75 Bai, 1990, Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain, Biochem Pharmacol, 39, 1941, 10.1016/0006-2952(90)90613-P Balasubramanyam, 2004, Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression, J Biol Chem, 279, 33716, 10.1074/jbc.M402839200 Baliga, 2011, The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): a review, Food Res Int, 44, 1790, 10.1016/j.foodres.2011.01.064 Beidler, 1999, Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells, Biochem Pharmacol, 58, 1067, 10.1016/S0006-2952(99)00193-8 Ben-Amotz, 1996, Bioavailability of a natural isomer mixture compared with synthetic all-trans beta-carotene in human serum, Am J Clin Nutr, 63, 729, 10.1093/ajcn/63.5.729 Biscardi, 2005, VEGF inhibition and cytotoxic effect of aplidin in leukemia cell lines and cells from acute myeloid leukemia, Ann Oncol, 16, 1667, 10.1093/annonc/mdi311 Bishayee, 2009, Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials, Cancer Prev Res, 2, 409, 10.1158/1940-6207.CAPR-08-0160 Boocock, 2007, Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent, Cancer Epidemiol Biomark Prev, 16, 1246, 10.1158/1055-9965.EPI-07-0022 Broggini, 2003, Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4, Leukemia, 17, 52, 10.1038/sj.leu.2402788 Brown, 2010, Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis, Cancer Res, 70, 9003, 10.1158/0008-5472.CAN-10-2364 Butt, 1999, The IGF axis and programmed cell death, Immunol Cell Biol, 77, 256, 10.1046/j.1440-1711.1999.00822.x Chen, 2012, Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol, Nutr Cancer, 64, 1211, 10.1080/01635581.2012.718032 Chun, 1986, Didemnin B, Invest New Drugs, 4, 279, 10.1007/BF00179597 Cooke, 2005, Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity?, Eur J Cancer, 41, 1931, 10.1016/j.ejca.2005.06.009 Cuadrado, 2003, Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK, J Biol Chem, 278, 241, 10.1074/jbc.M201010200 da Silva, 2007, Anthocyanin pigments in strawberry, LWT Food Sci Technol, 40, 374, 10.1016/j.lwt.2005.09.018 Delmas, 2000, Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines, Oncol Rep, 7, 847 Delmas, 2003, Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells, J Biol Chem, 278, 41482, 10.1074/jbc.M304896200 Depenbrock, 1998, In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells, Br J Cancer, 78, 739, 10.1038/bjc.1998.570 Ding, 2002, Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells, Pancreas, 25, e71, 10.1097/00006676-200211000-00024 Doi, 2009, Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer, Anticancer Res, 29, 2485 Eisen, 2009, Phase II study of weekly plitidepsin as second-line therapy for small cell lung cancer, Lung Cancer, 64, 60, 10.1016/j.lungcan.2008.06.017 Eisen, 2009, Phase II study of biweekly plitidepsin as second-line therapy in patients with advanced malignant melanoma, Melanoma Res, 19, 185, 10.1097/CMR.0b013e32832bbde6 Faltynek, 1995, Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity, Biochemistry, 34, 12404, 10.1021/bi00038a038 Forester, 2010, Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells, J Agric Food Chem, 58, 5320, 10.1021/jf9040172 Furusawa, 2003, Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice, Phytother Res, 17, 1158, 10.1002/ptr.1307 Garcia-Fernandez, 2002, Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta, Oncogene, 21, 7533, 10.1038/sj.onc.1205972 Gelderblom, 2001, Cremophor EL, Eur J Cancer, 37, 1590, 10.1016/S0959-8049(01)00171-X Gianolio, 2012, Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates, Cancer Chemother Pharmacol, 70, 439, 10.1007/s00280-012-1925-8 Giusti, 1996, Characterization of red radish anthocyanins, J Food Sci, 61, 322, 10.1111/j.1365-2621.1996.tb14186.x Gonzalez-Santiago, 2006, Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation, Cell Death Differ, 13, 1968, 10.1038/sj.cdd.4401898 Grant, 1998, Phase Ib trial of bryostatin 1 in patients with refractory malignancies, Clin Cancer Res, 4, 611 Haritunians, 2008, Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells, Leuk Res, 32, 1366, 10.1016/j.leukres.2008.01.019 Harvey, 2000, Strategies for discovering drugs from previously unexplored natural products, Drug Discov Today, 5, 294, 10.1016/S1359-6446(00)01511-7 Hirazumi, 1999, An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia(Noni) with antitumour activity, Phytother Res, 13, 380, 10.1002/(SICI)1099-1573(199908/09)13:5<380::AID-PTR463>3.0.CO;2-M Holian, 2002, Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide, Am J Physiol Gastrointest Liver Physiol, 282, G809, 10.1152/ajpgi.00193.2001 Horti, 2008, Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer, Cancer Chemother Pharmacol, 62, 173, 10.1007/s00280-007-0665-7 Hsieh, 1999, Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines, Exp Cell Res, 249, 109, 10.1006/excr.1999.4471 Ibrahim, 2004, Insulin-like growth factor-I and cancer risk, Growth Horm IGF Res, 14, 261, 10.1016/j.ghir.2004.01.005 Isakov, 1993, Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C, J Immunol, 150, 1195, 10.4049/jimmunol.150.4.1195 Issell, 2005, Quality of life measures in a phase I trial of noni, J Clin Oncol ASCO Annu Meet Proc, 23, 8217 Issell, 2009, Using quality of life measures in a phase I clinical trial of noni in patients with advanced cancer to select a phase II dose, J Diet Suppl, 6, 347, 10.3109/19390210903280272 Izquierdo, 2008, Phase I clinical and pharmacokinetic study of plitidepsin as a 1-hour weekly intravenous infusion in patients with advanced solid tumors, Clin Cancer Res, 14, 3105, 10.1158/1078-0432.CCR-07-1652 Jing, 2005, Characterization of anthocyanin-rich waste from purple corncobs (Zea mays L.) and its application to color milk, J Agric Food Chem, 53, 8775, 10.1021/jf051247o Jordan, 1991, Mechanism of inhibition of cell proliferation by vinca alkaloids, Cancer Res, 51, 2212 Juan, 2012, Colorectal cancer chemoprevention by trans-resveratrol, Pharmacol Res, 65, 584, 10.1016/j.phrs.2012.03.010 Kalemkerian, 1999, Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification, Cancer Chemother Pharmacol, 43, 507, 10.1007/s002800050931 Karlsen, 2007, Anthocyanins inhibit nuclear factor-κB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults, J Nutr, 137, 1951, 10.1093/jn/137.8.1951 Kerbrat, 2003, Phase II study of LU 103793 (dolastatin analogue) in patients with metastatic breast cancer, Eur J Cancer, 39, 317, 10.1016/S0959-8049(02)00531-2 Kim, 2003, Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells, Int J Oncol, 23, 1143 Kobayashi, 1997, Antitumor activity of TZT-1027, a novel dolastatin 10 derivative, Jpn J Cancer Res, 88, 316, 10.1111/j.1349-7006.1997.tb00383.x Koeberle, 2009, Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol, Biochem Pharmacol, 77, 1513, 10.1016/j.bcp.2009.02.005 Kortmansky, 2003, Bryostatin-1: a novel PKC inhibitor in clinical development, Cancer Invest, 21, 924, 10.1081/CNV-120025095 Kumar, 1981, Taxol-induced polymerization of purified tubulin. Mechanism of action, J Biol Chem, 256, 10435, 10.1016/S0021-9258(19)68639-4 Leifert, 2008, Cardioprotective actions of grape polyphenols, Nutr Res, 28, 729, 10.1016/j.nutres.2008.08.007 Lin, 2011, Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways, Eur J Pharmacol, 650, 120, 10.1016/j.ejphar.2010.10.005 Liu, 2000, Mechanism of action of camptothecin, Ann N Y Acad Sci, 922, 1, 10.1111/j.1749-6632.2000.tb07020.x Longo, 2006, Extraction and identification of anthocyanins from Smilax aspera L. berries, Food Chem, 94, 226, 10.1016/j.foodchem.2004.11.008 Lopez, 2002, Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis, Cancer Cell, 1, 339, 10.1016/S1535-6108(02)00055-7 Lv, 2011, Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects, Fitoterapia, 82, 704, 10.1016/j.fitote.2011.02.008 Madhusudan, 2003, A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer, Br J Cancer, 89, 1418, 10.1038/sj.bjc.6601321 Malfetano, 1993, A phase II trial of Didemnin B (NSC #335319) in patients with previously treated epithelial ovarian cancer. A Gynecologic Oncology Group Study, Am J Clin Oncol, 16, 47, 10.1097/00000421-199302000-00012 Maroun, 1998, Phase I clinical study of didemnin B, Invest New Drugs, 16, 51, 10.1023/A:1006099401417 Mateos, 2010, Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma, Clin Cancer Res, 16, 3260, 10.1158/1078-0432.CCR-10-0469 Mgbonyebi, 1998, Antiproliferative effect of synthetic resveratrol on human breast epithelial cells, Int J Oncol, 12, 865 Mimeault, 2011, Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy, Chin Med, 6, 31, 10.1186/1749-8546-6-31 Mittelman, 1999, Phase II clinical trial of didemnin B in patients with recurrent or refractory anaplastic astrocytoma or glioblastoma multiforme (NSC 325319), Invest New Drugs, 17, 179, 10.1023/A:1006379402114 Munoz-Alonso, 2008, Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells, J Pharmacol Exp Ther, 324, 1093, 10.1124/jpet.107.132662 Murthy, 2012, Anti-diabetic potentials of red beet pigments and other constituents, 155 Neelwarne, 2007 Newman, 2007, Natural products as sources of new drugs over the last 25 years, J Nat Prod, 70, 461, 10.1021/np068054v Niles, 2003, Resveratrol is a potent inducer of apoptosis in human melanoma cells, Cancer Lett, 190, 157, 10.1016/S0304-3835(02)00676-6 Nualsanit, 2011, Damnacanthal-induced anti-inflammation is associated with inhibition of NF-kappaB activity, Inflamm Allergy Drug Targets, 10, 455, 10.2174/187152811798104908 Nualsanit, 2012, Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells, J Nutr Biochem, 23, 915, 10.1016/j.jnutbio.2011.04.017 Opipari, 2004, Resveratrol-induced autophagocytosis in ovarian cancer cells, Cancer Res, 64, 696, 10.1158/0008-5472.CAN-03-2404 Ordaz-Galindo, 1999, Purification and identification of Capulin (Prunus serotina Ehrh) anthocyanins, Food Chem, 65, 201, 10.1016/S0308-8146(98)00196-4 Padhye, 2010, Fluorinated 2′-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities, Bioorg Med Chem Lett, 20, 5818, 10.1016/j.bmcl.2010.07.128 Pan, 2001, Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells, J Agric Food Chem, 49, 1464, 10.1021/jf001129v Patel, 2011, Clinical trials of resveratrol, Ann N Y Acad Sci, 1215, 161, 10.1111/j.1749-6632.2010.05853.x Pazmino-Duran, 2001, Anthocyanins from banana bracts (Musa×paradisiaca) as a potential food colorants, Food Chem, 73, 327, 10.1016/S0308-8146(00)00305-8 Perez, 2005, Phase II trial of dolastatin-10 in patients with advanced breast cancer, Invest New Drugs, 23, 257, 10.1007/s10637-005-6735-y Pettit, 1997, The dolastatins, Fortschr Chem Org Naturst, 70, 1, 10.1007/978-3-7091-6551-5_1 Prasad, 2010, Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins, Mol Cancer Ther, 9, 856, 10.1158/1535-7163.MCT-09-1113 Prior, 2006, Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities, Free Radic Res, 40, 1014, 10.1080/10715760600758522 Ribrag, 2012, Multicenter phase II study of plitidepsin in patients with relapsed/refractory non-Hodgkin's lymphoma, Haematologica Roman, 2002, Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia, Br J Haematol, 117, 842, 10.1046/j.1365-2141.2002.03520.x Saiko, 2008, Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?, Mutat Res Rev Mutat Res, 658, 68, 10.1016/j.mrrev.2007.08.004 Sato, 2007, A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells, Int J Oncol, 30, 1453 Schoffski, 2004, Phase I and pharmacokinetic study of TZT-1027, a novel synthetic dolastatin 10 derivative, administered as a 1-hour intravenous infusion every 3 weeks in patients with advanced refractory cancer, Ann Oncol, 15, 671, 10.1093/annonc/mdh141 Shih, 2005, Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells, Food Chem Toxicol, 43, 1557, 10.1016/j.fct.2005.05.001 Shih, 2010, Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease, J Nutr Biochem, 21, 598, 10.1016/j.jnutbio.2009.03.008 Shin, 1991, Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting, Cancer Chemother Pharmacol, 29, 145, 10.1007/BF00687325 Straight, 2006, Aplidin reduces growth of anaplastic thyroid cancer xenografts and the expression of several angiogenic genes, Cancer Chemother Pharmacol, 57, 7, 10.1007/s00280-005-0014-7 Suarez-Jimenez, 2012, Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals, Marine Drugs, 10, 963, 10.3390/md10050963 Subramani, 2012, Marine actinomycetes: an ongoing source of novel bioactive metabolites, Microbiol Res, 167, 571, 10.1016/j.micres.2012.06.005 Tan, 2007, Bioactive natural products from marine cyanobacteria for drug discovery, Phytochemistry, 68, 954, 10.1016/j.phytochem.2007.01.012 Tian, 2006, Characterization of a new anthocyanin in black raspberries (Rubus occidentalis) by liquid chromatography electrospray ionization tandem mass spectrometry, Food Chem, 94, 465, 10.1016/j.foodchem.2005.01.020 Tosa, 1998, Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II, Biol Pharm Bull, 21, 641, 10.1248/bpb.21.641 Tsai, 2002, Anthocyanin and antioxidant capacity in Roselle (Hibiscus Sabdariffa L.) extract, Food Res Int, 35, 351, 10.1016/S0963-9969(01)00129-6 Ushio-Fukai, 2008, Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy, Cancer Lett, 266, 37, 10.1016/j.canlet.2008.02.044 van Maanen, 1988, Mechanism of Action of antitumor drug etoposide: a review, J Nat Cancer Inst, 80, 1526, 10.1093/jnci/80.19.1526 Varterasian, 1998, Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia, J Clin Oncol, 16, 56, 10.1200/JCO.1998.16.1.56 Vasques, 2008, Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity, Phytother Res, 22, 1135, 10.1002/ptr.2323 von Mehren, 2004, Phase II trial of dolastatin-10, a novel anti-tubulin agent, in metastatic soft tissue sarcomas, Sarcoma, 8, 107, 10.1155/2004/924913 Wall, 1999, Bax: Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh, Leuk Res, 23, 881, 10.1016/S0145-2126(99)00108-3 Wang, 2008, Anthocyanins and their role in cancer prevention, Cancer Lett, 269, 281, 10.1016/j.canlet.2008.05.020 Wang, 1999, Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL, Leukemia, 13, 1564, 10.1038/sj.leu.2401532 Wang, 2002, Morinda citrifolia (Noni): a literature review and recent advances in Noni research, Acta Pharmacol Sin, 23, 1127 Wang, 2009, Antioxidant activity of noni juice in heavy smokers, Chem Cent J, 3, 1 Wang, 2013, Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells, Nutr Cancer, 65, 118, 10.1080/01635581.2013.741759 Weitman, 1999, A Phase I trial of bryostatin-1 in children with refractory solid tumors: a Pediatric Oncology Group study, Clin Cancer Res, 5, 2344 Wender, 1988, Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C, Proc Natl Acad Sci U S A, 85, 7197, 10.1073/pnas.85.19.7197 West, 2006, A safety review of noni fruit juice, J Food Sci, 71, R100, 10.1111/j.1750-3841.2006.00164.x Wu, 2013, Resveratrol: botanical origin, pharmacological activity and applications, Chin J Nat Med, 11, 1, 10.3724/SP.J.1009.2013.00001 Xu, 2012, Bacterial biosynthesis and maturation of the didemnin anti-cancer agents, J Am Chem Soc, 134, 8625, 10.1021/ja301735a Yonei, 2008, Effects on the human body of a dietary supplement containing l-carnitine and Garcinia cambogia extract: a study using double-blind tests, J Clin Biochem Nutr, 42, 89, 10.3164/jcbn.2008014 Zou, 1999, Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells, Int J Oncol, 15, 647