TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Immunity - Tập 24 Số 2 - Trang 179-189 - 2006
Neil Hunter1, Richard J. Hocking1, Christopher J. Atkins2, Richard M. Locksley3, Brigitta Stockinger1
1Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
2Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
3Howard Hughes Medical Institute, Departments of Medicine and Microbiology/Immunology, University of California, San Francisco, San Francisco, California 94143

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aggarwal, 2003, Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17, J. Biol. Chem., 278, 1910, 10.1074/jbc.M207577200

Allen, 1990, Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta, J. Exp. Med., 171, 231, 10.1084/jem.171.1.231

Almeida, 2002, Homeostasis of peripheral CD4(+) T cells: IL-2Ralpha and IL-2 shape a population of regulatory cells that controls CD4(+) T cell numbers, J. Immunol., 169, 4850, 10.4049/jimmunol.169.9.4850

Alonzi, 1998, Interleukin 6 is required for the development of collagen-induced arthritis, J. Exp. Med., 187, 461, 10.1084/jem.187.4.461

Annacker, 2000, Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment, J. Immunol., 164, 3573, 10.4049/jimmunol.164.7.3573

Barthlott, 2005, CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production, Int. Immunol., 17, 279, 10.1093/intimm/dxh207

Belghith, 2003, TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes, Nat. Med., 9, 1202, 10.1038/nm924

Bettelli, 2004, Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis, J. Exp. Med., 200, 79, 10.1084/jem.20031819

Chen, 2003, Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation, J. Exp. Med., 197, 1689, 10.1084/jem.20021170

Chen, 2003, Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop, J. Biol. Chem., 278, 17036, 10.1074/jbc.M210429200

Cua, 2003, Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain, Nature, 421, 744, 10.1038/nature01355

de la Rosa, 2004, Interleukin-2 is essential for CD4+CD25+ regulatory T cell function, Eur. J. Immunol., 34, 2480, 10.1002/eji.200425274

Eugster, 1998, IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis, Eur. J. Immunol., 28, 2178, 10.1002/(SICI)1521-4141(199807)28:07<2178::AID-IMMU2178>3.0.CO;2-D

Fahlen, 2005, T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells, J. Exp. Med., 201, 737, 10.1084/jem.20040685

Fava, 1991, Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia, J. Exp. Med., 173, 1121, 10.1084/jem.173.5.1121

Fitch, 1993, Differential regulation of murine T lymphocyte subsets, Annu. Rev. Immunol., 11, 29, 10.1146/annurev.iy.11.040193.000333

Fontenot, 2005, A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3, Nat. Immunol., 6, 331, 10.1038/ni1179

Fontenot, 2005, Regulatory T cell lineage specification by the forkhead transcription factor foxp3, Immunity, 22, 329, 10.1016/j.immuni.2005.01.016

Fossiez, 1998, Interleukin-17, Int. Rev. Immunol., 16, 541, 10.3109/08830189809043008

Gorelik, 2000, Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease, Immunity, 12, 171, 10.1016/S1074-7613(00)80170-3

Gorelik, 2002, Transforming growth factor-beta in T-cell biology, Nat. Rev. Immunol., 2, 46, 10.1038/nri704

Gorelik, 2000, Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression, J. Immunol., 165, 4773, 10.4049/jimmunol.165.9.4773

Gorelik, 2002, Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation, J. Exp. Med., 195, 1499, 10.1084/jem.20012076

Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat. Immunol., 6, 1123, 10.1038/ni1254

Hata, 2004, Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice, J. Clin. Invest., 114, 582, 10.1172/JCI200421795

Hayashi, 1997, The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling, Cell, 89, 1165, 10.1016/S0092-8674(00)80303-7

Heath, 2000, TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression, Eur. J. Immunol., 30, 2639, 10.1002/1521-4141(200009)30:9<2639::AID-IMMU2639>3.0.CO;2-7

Kaisho, 2001, Endotoxin-induced maturation of MyD88-deficient dendritic cells, J. Immunol., 166, 5688, 10.4049/jimmunol.166.9.5688

Kinugasa, 2000, Claudins regulate the intestinal barrier in response to immune mediators, Gastroenterology, 118, 1001, 10.1016/S0016-5085(00)70351-9

Kolls, 2004, Interleukin-17 family members and inflammation, Immunity, 21, 467, 10.1016/j.immuni.2004.08.018

Kulkarni, 1993, Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death, Proc. Natl. Acad. Sci. USA, 90, 770, 10.1073/pnas.90.2.770

Langrish, 2005, IL-23 drives a pathogenic T cell population that induces autoimmune inflammation, J. Exp. Med., 201, 233, 10.1084/jem.20041257

Letterio, 2005, TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia, Oncogene, 24, 5701, 10.1038/sj.onc.1208922

Letterio, 1998, Regulation of immune responses by TGF-beta, Annu. Rev. Immunol., 16, 137, 10.1146/annurev.immunol.16.1.137

Lin, 2005, TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet, J. Immunol., 174, 5950, 10.4049/jimmunol.174.10.5950

Lovett-Racke, 2004, Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes, Immunity, 21, 719, 10.1016/j.immuni.2004.09.010

Lugo-Villarino, 2005, The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells, Proc. Natl. Acad. Sci. USA, 102, 13248, 10.1073/pnas.0506638102

Maloy, 2001, Regulatory T cells in the control of immune pathology, Nat. Immunol., 2, 816, 10.1038/ni0901-816

McKarns, 2000, TGF-beta 1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3 epsilon mAb- and CD28 mAb-activated splenocytes and thymocytes, Immunopharmacology, 48, 101, 10.1016/S0162-3109(00)00183-1

Moore, 2001, Interleukin-10 and the interleukin-10 receptor, Annu. Rev. Immunol., 19, 683, 10.1146/annurev.immunol.19.1.683

Mullen, 2002, Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction, Nat. Immunol., 3, 652, 10.1038/ni807

Murphy, 2003, Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation, J. Exp. Med., 198, 1951, 10.1084/jem.20030896

Nakae, 2002, Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses, Immunity, 17, 375, 10.1016/S1074-7613(02)00391-6

Nakamura, 2001, Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta, J. Exp. Med., 194, 629, 10.1084/jem.194.5.629

Nakao, 1997, Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling, Nature, 389, 631, 10.1038/39369

O'Garra, 2004, IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage, J. Clin. Invest., 114, 1372, 10.1172/JCI23215

Ogawa, 2004, Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice, Clin. Immunol., 110, 55, 10.1016/j.clim.2003.09.013

Ohshima, 1998, Interleukin 6 plays a key role in the development of antigen-induced arthritis, Proc. Natl. Acad. Sci. USA, 95, 8222, 10.1073/pnas.95.14.8222

Okuda, 1998, IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein, Int. Immunol., 10, 703, 10.1093/intimm/10.5.703

Oppmann, 2000, Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12, Immunity, 13, 715, 10.1016/S1074-7613(00)00070-4

Park, 2005, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nat. Immunol., 6, 1133, 10.1038/ni1261

Pasare, 2003, Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells, Science, 299, 1033, 10.1126/science.1078231

Piccirillo, 2002, CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness, J. Exp. Med., 196, 237, 10.1084/jem.20020590

Powrie, 1995, T cells in inflammatory bowel disease: protective and pathogenic roles, Immunity, 3, 171, 10.1016/1074-7613(95)90086-1

Reis e Sousa, 2004, Toll-like receptors and dendritic cells: for whom the bug tolls, Semin. Immunol., 16, 27, 10.1016/j.smim.2003.10.004

Rochman, 2005, IL-6 increases primed cell expansion and survival, J. Immunol., 174, 4761, 10.4049/jimmunol.174.8.4761

Sakaguchi, 2005, Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self, Nat. Immunol., 6, 345, 10.1038/ni1178

Shi, 2003, Mechanisms of TGF-beta signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X

Shull, 1992, Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease, Nature, 359, 693, 10.1038/359693a0

Stetson, 2003, Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function, J. Exp. Med., 198, 1069, 10.1084/jem.20030630

Stockinger, 1994, Functional recognition of in vivo processed self antigen, Int. Immunol., 6, 247, 10.1093/intimm/6.2.247

Szabo, 1997, Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells, J. Exp. Med., 185, 817, 10.1084/jem.185.5.817

Szabo, 2000, A novel transcription factor, T-bet, directs Th1 lineage commitment, Cell, 100, 655, 10.1016/S0092-8674(00)80702-3

Taga, 1997, Gp130 and the interleukin-6 family of cytokines, Annu. Rev. Immunol., 15, 797, 10.1146/annurev.immunol.15.1.797

Thornton, 1998, CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production, J. Exp. Med., 188, 287, 10.1084/jem.188.2.287

Ulloa, 1999, Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway, Nature, 397, 710, 10.1038/17826

Vanden Eijnden, 2005, IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human, Eur. J. Immunol., 35, 469, 10.1002/eji.200425677

Wahl, 1994, Transforming growth factor beta: the good, the bad, and the ugly, J. Exp. Med., 180, 1587, 10.1084/jem.180.5.1587

Wahl, 1993, Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta, J. Exp. Med., 177, 225, 10.1084/jem.177.1.225

Zheng, 1997, The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells, Cell, 89, 587, 10.1016/S0092-8674(00)80240-8