Roles of IL-18 in Basophils and Mast Cells

Okamura, 1995, Cloning of a new cytokine that induces IFN-gamma production by T cells, Nature, 378, 88, 10.1038/378088a0

Yoshimoto, 1997, Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells, Proc. Natl. Acad. Sci. U. S. A., 94, 3948, 10.1073/pnas.94.8.3948

Yoshimoto, 1998, IL-12 upregulates IL-18 receptor expression on T cells, Th1 cells, and B cells:synergism with IL-18 for IFN-gamma production, J. Immunol., 161, 3400, 10.4049/jimmunol.161.7.3400

Robinson, 1997, IGIF does not drive Th1 development but synergizes with IL-12 for interferongamma production and activates IRAK and NFkappaB, Immunity, 7, 571, 10.1016/S1074-7613(00)80378-7

Munder, 1998, Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL) -12 and IL-18: A novel pathway of autocrine macrophage activation, J. Exp. Med., 187, 2103, 10.1084/jem.187.12.2103

Tominaga, 2000, IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells, Int. Immunol., 12, 151, 10.1093/intimm/12.2.151

Nakanishi, 2001, Interleukin-18 regulates both Th1 and Th2 responses, Annu. Rev. Immunol., 19, 423, 10.1146/annurev.immunol.19.1.423

Tsutsui, 2004, Induction of allergic inflammation by interleukin-18 in experimental animal models, Immunol. Rev., 202, 115, 10.1111/j.0105-2896.2004.00205.x

Miller, 1999, A novel function for transforming growth factor-beta 1: upregulation of the expression and the IgE-independent extracellular release of a mucosal mast cell granule-specific betachymase, mouse mast cell protease-1, Blood, 93, 3473, 10.1182/blood.V93.10.3473.410k01_3473_3486

Wei, 1999, Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice, J. Immunol., 163, 2821, 10.4049/jimmunol.163.5.2821

Ohkusu, 2000, Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection, Infect. Immun., 68, 2449, 10.1128/IAI.68.5.2449-2456.2000

Kawakami, 2001, Enhanced gamma interferon production through activation of Valpha14 (+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis, Infect. Immun., 69, 6643, 10.1128/IAI.69.11.6643-6650.2001

Chikano, 2000, IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner, Gut., 47, 779, 10.1136/gut.47.6.779

Yoshimoto, 1999, IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils, Proc. Natl. Acad. Sci. U. S. A., 96, 13962, 10.1073/pnas.96.24.13962

Yoshimoto, 2000, IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6, Nat. Immunol., 1, 132, 10.1038/77811

Yoshimoto, 2003, Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice, J. Exp. Med., 197, 997, 10.1084/jem.20021701

Yamanaka, 2000, Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18, J. Immunol., 165, 997, 10.4049/jimmunol.165.2.997

Konishi, 2002, IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/ stat6 under specific pathogen-free conditions, Proc. Natl. Acad. Sci. U. S. A., 99, 11340, 10.1073/pnas.152337799

Kawakami, 2002, Regulation of mast-cell and basophil function and survival by IgE, Nat. Rev. Immunol., 2, 773, 10.1038/nri914

Coffman, 1988, The role of helper T cell products in mouse B cell differentiation and isotype regulation, Immunol. Rev., 102, 5, 10.1111/j.1600-065X.1988.tb00739.x

Finkelman, 1990, Lymphokine control of in vivo immunoglobulin isotype selection, Annu. Rev. Immunol., 8, 303, 10.1146/annurev.iy.08.040190.001511

Hamelmann, 2001, IL-5-induced airway eosinophilia-the key to asthma?, Immunol. Rev., 179, 182, 10.1034/j.1600-065X.2001.790118.x

McKenzie, 1998, A distinct role for interleukin-13 in Th2-cell-mediated immune responses, Curr. Biol., 8, 339, 10.1016/S0960-9822(98)70134-4

Temann, 1998, Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness, J. Exp. Med., 188, 1307, 10.1084/jem.188.7.1307

Grunig, 1998, Requirement for IL-13 independently of IL-4 in experimental asthma, Science, 282, 2261, 10.1126/science.282.5397.2261

Kuperman, 2002, Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma, Nat. Med., 8, 885, 10.1038/nm734

Wills-Karp, 2003, Interleukin-13 in asthma, Curr. Opin. Pulm. Med., 9, 21, 10.1097/00063198-200301000-00004

Wills-Karp, 1998, Interleukin-13: central mediator of allergic asthma, Science, 282, 2258, 10.1126/science.282.5397.2258

Takeda, 2003, Toll-like receptors, Annu. Rev. Immunol., 21, 335, 10.1146/annurev.immunol.21.120601.141126

Adachi, 1998, Targeted disruption of the MyD 88 gene results in loss of IL-1- and IL-18-mediated function, Immunity, 9, 143, 10.1016/S1074-7613(00)80596-8

Kawai, 1999, Unresponsiveness of MyD88-deficient mice to endotoxin, Immunity, 11, 115, 10.1016/S1074-7613(00)80086-2

Seki, 2001, Lipopolysaccharideinduced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1 beta, J.Immunol, 166, 2651, 10.4049/jimmunol.166.4.2651

Masuda, 2002, Th 2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways, J. Immunol., 169, 3801, 10.4049/jimmunol.169.7.3801

Supajatura, 2002, Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity, J. Clin. Invest., 109, 1351, 10.1172/JCI0214704

Supajatura, 2001, Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4, J. Immunol., 167, 2250, 10.4049/jimmunol.167.4.2250

Varadaradjalou, 2003, Toll-like receptor 2 (TLR2) and TLR4 differentially activate human mast cells, Eur. J. Immunol., 33, 899, 10.1002/eji.200323830

Hoshino, 1999, Cutting edge: Tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product, J. Immunol., 162, 3749, 10.4049/jimmunol.162.7.3749

Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3

Sabroe, 2002, Toll-like receptor (TLR) 2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses, J. Immunol., 168, 4701, 10.4049/jimmunol.168.9.4701

Bieneman, 2005, Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion, J. Allergy Clin. Immunol., 115, 295, 10.1016/j.jaci.2004.10.018

Dahl, 2004, Viralinduced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells, Nat. Immunol., 5, 337, 10.1038/ni1041

Schwarze, 2002, Respiratory viral infections as promoters of allergic sensitization and asthma in animal models, Eur. Respir. J., 19, 341, 10.1183/09031936.02.00254302

Grencis, 1997, Th2-mediated host protective immunity to intestinal nematode infections, Philos. Trans. R. Soc. Lond. B. Biol. Sci., 352, 1377, 10.1098/rstb.1997.0123

Urban, 1998, IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis, Immunity, 8, 255, 10.1016/S1074-7613(00)80477-X

Lantz, 1998, Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites, Nature, 392, 90, 10.1038/32190

Maruyama, 2000, A role of mast cell glycosaminoglycans for the immunological expulsion of intestinal nematode. Strongyloides venezuelensis, J. Immunol., 164, 3749, 10.4049/jimmunol.164.7.3749

Faulkner, 1998, Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris, Infect. Immun., 66, 3832, 10.1128/IAI.66.8.3832-3840.1998

Helmby, 2002, IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection, J. Immunol., 169, 2553, 10.4049/jimmunol.169.5.2553

Faulkner, 1997, Interleukin-9 is involved in host protective immunity to intestinal nematode infection, Eur. J. Immunol., 27, 2536, 10.1002/eji.1830271011

Knight, 2000, Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1, J. Exp. Med., 192, 1849, 10.1084/jem.192.12.1849

Scudamore, 1997, Mast cell heterogeneity in the gastrointestinal tract: variable expression of mouse mast cell protease-1 (mMCP-1) in intraepithelial mucosal mast cells in nematode-infected and normal BALB/c mice, Am. J. Pathol., 150, 1661

Urban, 2000, Stat 6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism, J. Immunol., 164, 2046, 10.4049/jimmunol.164.4.2046

Wastling, 1997, Constitutive expression of mouse mast cell protease-1 in normal BALB / c mice and its upregulation during intestinal nematode infection, Immunology, 90, 308, 10.1046/j.1365-2567.1997.00155.x

Galli, 1994, Mast cell and basophil development, Curr. Opin. Hematol., 1, 33

Hultner, 1990, Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9), Eur. J. Immunol., 20, 1413, 10.1002/eji.1830200632

Madden, 1991, Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis, J. Immunol., 147, 1387, 10.4049/jimmunol.147.4.1387

Sasaki, 2005, IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity, J. Exp. Med., 202, 607, 10.1084/jem.20042202

Bird, 1998, Helper T cell differentiation is controlled by the cell cycle, Immunity, 9, 229, 10.1016/S1074-7613(00)80605-6

Paliard, 1988, Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones, J. Immunol., 141, 849, 10.4049/jimmunol.141.3.849

Yoshimoto, 1995, Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production, Science, 270, 1845, 10.1126/science.270.5243.1845

Bradding, 1992, Interleukin 4 is localized to and released by human mast cells, J. Exp. Med., 176, 1381, 10.1084/jem.176.5.1381

Conrad, 1990, Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells, J. Exp. Med., 171, 1497, 10.1084/jem.171.5.1497

Seder, 1991, Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils, Proc. Natl. Acad. Sci. U. S. A., 88, 2835, 10.1073/pnas.88.7.2835

Min, 2004, Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite, J. Exp. Med., 200, 507, 10.1084/jem.20040590